Dr. Bonnie Henry, British Colombia Provincial Health Officer Ministry of Health, 1515 Blanchard Street, Victoria, BC, V8W 3C9 Dear Dr. Henry, 5 April, 2021 The first dose of the Moderna vaccine has now been administered to some of my patients in the community of Lytton, BC. This began with the First Nations members of our community in mid- January, 2021. 900 doses have now been administered. I have been quite alarmed at the high rate of serious side-effects from this novel treatment. From this relatively small number of people vaccinated so far, we have had: Numerous allergic reactions, with two cases of anaphylaxis. One (presumed) vaccine induced sudden death, (in a 72 year old patient with COPD. This patient complained of being more short of breath continually after receiving the vaccine, and died very suddenly and unexpectedly on day 24, after the vaccine. He had no history of cardiovascular disease). Three people with ongoing and disabling neurological deficits, with associated chronic pain, persisting for more than 10 weeks after their first vaccine. These neurological deficits include; continual and disabling dizziness, generalised or localised neuromuscular weakness, with or without sensory loss. The chronic pain in these patients is either generalised or regional, with or without headaches. So in short, in our small community of Lytton, BC, we have one person dead, and three people who look as though they will be permanently disabled, following their first dose of the Moderna vaccine. The age of those affected ranges from 38 to 82 years of age. So I have a couple of questions and comments; Are these considered normal and acceptable long term side-effects for gene modification therapy? Judging by medical reports from around the world, our Lytton experience is not unusual. Do you have any idea what disease processes may have been initiated, to be producing these ongoing neurological symptoms? Do you have any suggestions as to how I should treat the vaccine induced neuromuscular weakness, the dizziness, the sensory loss, and the chronic pain syndromes in these people, or should they all be simply referred to a neurologist? I anticipate that many more will follow, as the vaccine is rolled out. This was only phase one, and the first dose. In stark contrast to the deleterious effects of this vaccine in our community, we have not had to give any medical care what-so-ever, to anyone with Covid-19. So in our limited experience, this vaccine is quite clearly more dangerous than Covid-19. I realise that every medical therapy has a risk-benefit ratio, and that serious disease calls for serious medicine. But we now know that the recovery rate of Covid-19, is similar to the seasonal flu, in every age category. Furthermore, it is well known that the side effects following the second shot, are significantly worse than the first. So the worst is still to come. It must be emphasised, that these people were not sick people, being treated for some devastating disease. These were previously healthy people, who were offered an experimental therapy, with unknown long-term side-effects, to protect them against an illness that has the same mortality rate as the flu. Sadly, their lives have now been ruined. It is normally considered a fundamental principal of medical ethics, to discontinue a clinical trial if significant harm is demonstrated from the treatment under investigation. So my last question is this; Is it medically ethical to continue this vaccine rollout, in view of the severity of these life altering side-effects, after just the first shot? In Lytton, BC, we have an incidence of 1 in 225 of severe life altering side-effects, from this experimental gene modification therapy. I have also noticed that these vaccine induced side effects are going almost entirely unreported, by those responsible for the vaccine rollout. I am aware that this is often a problem, with vaccines in general, and that delayed side-effects after vaccines, are sometimes labelled as being “coincidences”, as causality is often hard to prove. However, in view of the fact that this is an experimental treatment, with no long-term safety data, I think that perhaps this issue should be addressed too. Furthermore I have noticed, that the provincial vaccine injury reporting form, which was clearly designed for conventional vaccines, does not even have any place to report vaccine injuries of the nature and severity that we are seeing from this new mRNA therapy. It is now clearly apparent with medical evidence from around the world, that the side-effect profiles of the various gene modification therapies against Covid-19, have been vastly understated by their manufacturers, who were eager to prove their safety. Thank you for your attention to this critically urgent public health matter. Yours sincerely, Dr Charles Hoffe
这是一篇相关的论文 https://journals.plos.org/plosbiology/article/info:doi/10.1371/journal.pbio.1002198 大意就是不完美的疫苗，比如现在这种“不防传染防重症”的疫苗，可能会成为更强的selection force，导致更致命的变种出现。这个可能性疫苗学家Dr. Geert Vanden Bossche今年年初就讨论过。自己可以自己搜他的采访。懂进化生物学基础的同学们应该都可以理解。 Abstract Could some vaccines drive the evolution of more virulent pathogens? Conventional wisdom is that natural selection will remove highly lethal pathogens if host death greatly reduces transmission. Vaccines that keep hosts alive but still allow transmission could thus allow very virulent strains to circulate in a population. Here we show experimentally that immunization of chickens against Marek''''s disease virus enhances the fitness of more virulent strains, making it possible for hyperpathogenic strains to transmit. Immunity elicited by direct vaccination or by maternal vaccination prolongs host survival but does not prevent infection, viral replication or transmission, thus extending the infectious periods of strains otherwise too lethal to persist. Our data show that anti-disease vaccines that do not prevent transmission can create conditions that promote the emergence of pathogen strains that cause more severe disease in unvaccinated hosts. Geert Vanden Bossche received his DVM from the University of Ghent, Belgium, and his PhD degree in Virology from the University of Hohenheim, Germany. He held adjunct faculty appointments at universities in Belgium and Germany. After his career in Academia, Geert joined several vaccine companies (GSK Biologicals, Novartis Vaccines, Solvay Biologicals) to serve various roles in vaccine R&D as well as in late vaccine development. Geert then moved on to join the Bill & Melinda Gates Foundation’s Global Health Discovery team in Seattle (USA) as Senior Program Officer; he then worked with the Global Alliance for Vaccines and Immunization (GAVI) in Geneva as Senior Ebola Program Manager. At GAVI he tracked efforts to develop an Ebola vaccine. He also represented GAVI in fora with other partners, including WHO, to review progress on the fight against Ebola and to build plans for global pandemic preparedness.
Dr. Peter McCollough 美国著名的心血管方面的专家。citation数量是这个领域最高的。大家自己可以去搜搜看。他一直致力于推广早期治疗，反对在安全性未知的情况下大规模接种疫苗，尤其是孕妇和年轻人还有未成年小朋友。他说这是极其不负责任的表现。 来看看他的citations的数量。 他的早治疗，outpatient治疗（就是开药自己家里吃药）的方案，他说如果早治疗，85%的covid death都可以避免。 他的采访（大部分在YouTube上都被删了），都很值得看看，他也说过fda cdc内部监管的问题。这个疫苗的审批流程跟之前所有的疫苗都简化多了，一层一层的安全防护的regulation都被waive掉了。 https://odysee.com/@TruthPills:5/Dr-McCullough:3
Dr. Robert Malone，是RNA疫苗技术的发明人，他的paper发表在了PNAS上，最近他的twitter上也贴出来了，这一款疫苗的发明人之一的email截图承认Dr. Malone就是这个技术的发明者。 他的twitter https://twitter.com/RWMaloneMD 他最近写的关于bioethics的文章，我觉得非常值得一看。现在政府做的，完全违背bioethics的最基本的底线。 https://trialsitenews.com/bioethics-of-experimental-covid-vaccine-deployment-under-eua-its-time-we-stop-and-look-at-whats-going-down/ 他最近的podcast，讨论antibody dependent enhancement，这个现象或许可以解释为什么以色列最近的数据里，感染的人有更多比例是已经打了疫苗的人。 https://podcasts.apple.com/us/podcast/antibody-dependent-enhancement-vaccine-development/id1455413855?i=1000510671800 There are several viral videos with millions of views referencing something called Antibody-Dependent Enhancement as a potential effect of COVID-19 vaccines or vaccines in general. Some make very bold claims and it''''s difficult to sort fact from fiction from hyperbole in these videos. On today''''s episode of Causes or Cures, Dr. Eeks will chat with Dr. Robert Malone about Antibody-Dependent Enhancement and how it relates to vaccine development. He will describe it in an easy-to-understand way, discuss the specifics of vaccine development, antibodies, COVID-19 and his thoughts on herd immunity and the future of the pandemic.
Puntmann et al. (JAMA Cardiol. 2020;5:1265-1273) showed that the prospective study of 100 German patients who were recently recovered from COVID-19 revealed significant cardiac involvement on cardiac MRI scans in 78% of them, an average 2-1/2 months after their recovery from the acute illness. Two-thirds of these patients were never hospitalized, and there was ongoing myocardial inflammation in 60%. The abnormalities occurred independent of preexisting conditions, severity of the initial disease, and overall course of the acute illness. Magro et al. showed that there is complement-mediated damage even in grossly normal skin of coronavirus-infected individuals (Human Pathology 2020:106:106-116). They have also shown (Magro et al. Annals of Diagnostic Pathology 2021:50 in press ) that ACE-2 receptor expression is highest in the microvasculature of the brain and subcutaneous fat, and to a lesser degree in the liver, kidney, and heart. They have further demonstrated that the coronavirus replicates almost exclusively in the septal capillary endothelial cells of the lungs and the nasopharynx, and that viral lysis and immune destruction of those cells releases viral capsid proteins (or pseudovirions) that travel through the circulation and bind to ACE2 receptors in these other parts of the body leading to mannan-binding lectin complement pathway activation that not only damages the microvascular endothelium but also induces the production of many pro-inflammatory cytokines. Meinhardt et al. (Nature Neuroscience 2020, in press) show that the spike protein in brain endothelial cells is associated with formation of microthrombi (clots), and like Magro et al. do not find viral RNA in brain endothelium. In other words, viral proteins appear to cause tissue damage without actively replicating virus. Is it possible the spike protein itself causes the tissue damage associated with Covid-19? Nuovo et al (in press) have shown that in 13/13 brains from patients with fatal COVID-19, pseudovirions (spike, envelope, and membrane proteins) without viral RNA are present in the endothelia of cerebral microvessels. Furthermore, tail vein injection of the full length S1 spike subunit in mice led to neurologic signs (increased thirst, stressed behavior) not evident in those injected with the S2 subunit. The S1 subunit localizes to the endothelia of microvessels in the mouse brain, and is a potent neurotoxin. So the spike S1 subunit of SARS-CoV-2 alone is capable of being endocytosed by ACE2 positive endothelia in both human and mouse brain, with a concomitant pauci-cellular microencephalitis that may be the basis for the neurologic complications of COVID-19. The Pfizer/BioNTech vaccine (BNT162b2) is composed of an mRNA that produces a membrane-anchored full-length spike protein. The mouse studies suggest that an untruncated form of the S1 protein like this may cause a microvasculopathy in tissues that express much ACE2 receptor. A truncated form of S1 was much less damaging in mice. While there are pieces to this puzzle that have yet to be worked out, it appears that the viral spike protein that is the target of the major SARS-CoV-2 vaccines is also one of the key agents causing the damage to distant organs that may include the brain, heart, lung, and kidney. Before any of these vaccines are approved for widespread use in humans, it is important to assess in vaccinated subjects the effects of vaccination on the heart (perhaps using cardiac MRI, as Puntmann et al. did). Vaccinated patients could also be tested for distant tissue damage in deltoid area skin biopsies, as employed by Magro et al. As important as it is to quickly arrest the spread of the virus by immunizing the population, it would be vastly worse if hundreds of millions of people were to suffer long-lasting or even permanent damage to their brain or heart microvasculature as a result of failing to appreciate in the short-term an unintended effect of full-length spike protein-based vaccines on these other organs. Particular caution will be required with regard to the potential widespread vaccination of children before there are any real data on the safety or effectiveness of these vaccines in pediatric trials that are only now beginning.
那他们report到VAERS系统里了么？这些个大夫说他们自己的病人的adverse events，他们要report要花半个多小时填一个五六页的表格。特别麻烦，还有好几个被reject的，因为没填疫苗的vial serial number。所以under reporting是肯定了的。真实的副作用还不知道有多少。
Dr. Bonnie Henry, British Colombia Provincial Health Officer Ministry of Health, 1515 Blanchard Street, Victoria, BC, V8W 3C9 Dear Dr. Henry, 5 April, 2021 The first dose of the Moderna vaccine has now been administered to some of my patients in the community of Lytton, BC. This began with the First Nations members of our community in mid- January, 2021. 900 doses have now been administered. I have been quite alarmed at the high rate of serious side-effects from this novel treatment. From this relatively small number of people vaccinated so far, we have had: Numerous allergic reactions, with two cases of anaphylaxis. One (presumed) vaccine induced sudden death, (in a 72 year old patient with COPD. This patient complained of being more short of breath continually after receiving the vaccine, and died very suddenly and unexpectedly on day 24, after the vaccine. He had no history of cardiovascular disease). Three people with ongoing and disabling neurological deficits, with associated chronic pain, persisting for more than 10 weeks after their first vaccine. These neurological deficits include; continual and disabling dizziness, generalised or localised neuromuscular weakness, with or without sensory loss. The chronic pain in these patients is either generalised or regional, with or without headaches. So in short, in our small community of Lytton, BC, we have one person dead, and three people who look as though they will be permanently disabled, following their first dose of the Moderna vaccine. The age of those affected ranges from 38 to 82 years of age. So I have a couple of questions and comments; Are these considered normal and acceptable long term side-effects for gene modification therapy? Judging by medical reports from around the world, our Lytton experience is not unusual. Do you have any idea what disease processes may have been initiated, to be producing these ongoing neurological symptoms? Do you have any suggestions as to how I should treat the vaccine induced neuromuscular weakness, the dizziness, the sensory loss, and the chronic pain syndromes in these people, or should they all be simply referred to a neurologist? I anticipate that many more will follow, as the vaccine is rolled out. This was only phase one, and the first dose. In stark contrast to the deleterious effects of this vaccine in our community, we have not had to give any medical care what-so-ever, to anyone with Covid-19. So in our limited experience, this vaccine is quite clearly more dangerous than Covid-19. I realise that every medical therapy has a risk-benefit ratio, and that serious disease calls for serious medicine. But we now know that the recovery rate of Covid-19, is similar to the seasonal flu, in every age category. Furthermore, it is well known that the side effects following the second shot, are significantly worse than the first. So the worst is still to come. It must be emphasised, that these people were not sick people, being treated for some devastating disease. These were previously healthy people, who were offered an experimental therapy, with unknown long-term side-effects, to protect them against an illness that has the same mortality rate as the flu. Sadly, their lives have now been ruined. It is normally considered a fundamental principal of medical ethics, to discontinue a clinical trial if significant harm is demonstrated from the treatment under investigation. So my last question is this; Is it medically ethical to continue this vaccine rollout, in view of the severity of these life altering side-effects, after just the first shot? In Lytton, BC, we have an incidence of 1 in 225 of severe life altering side-effects, from this experimental gene modification therapy. I have also noticed that these vaccine induced side effects are going almost entirely unreported, by those responsible for the vaccine rollout. I am aware that this is often a problem, with vaccines in general, and that delayed side-effects after vaccines, are sometimes labelled as being “coincidences”, as causality is often hard to prove. However, in view of the fact that this is an experimental treatment, with no long-term safety data, I think that perhaps this issue should be addressed too. Furthermore I have noticed, that the provincial vaccine injury reporting form, which was clearly designed for conventional vaccines, does not even have any place to report vaccine injuries of the nature and severity that we are seeing from this new mRNA therapy. It is now clearly apparent with medical evidence from around the world, that the side-effect profiles of the various gene modification therapies against Covid-19, have been vastly understated by their manufacturers, who were eager to prove their safety. Thank you for your attention to this critically urgent public health matter. Yours sincerely, Dr Charles Hoffe
Short answer to you: 对于新冠和新冠疫苗这样的全新事物，一个科研者（就假设你是）怎么能拍着胸脯100%的把其他声音全部归为反智？ Deeper answer: 历史上每个巨大科学成就都是在反复求证的环境下产生的。如果把质疑声都拍死了，那不就是鼓励了fake science了吗？也会离真理越来越远。
我听的采访里面有好几个大夫说他们要report，花时间特别长，而且还是没有pay的，谁会花半个小时填一个case的表格，结果只是因为没有疫苗serial number就被reject的？难道不是这个系统不 user friendly么？ 系统性打压说不好，我也不清楚，但是VAERS上的data没有主流媒体报道是真的。一般的vaccine development，有25到50个death 就叫停了。这个vaccine related deaths已经这么多了，你觉得他们在好好研究数据，然后做evidence based的考量么？这可是VAERS里政府自己的数据。
之前看回帖有人说疫苗要真是有安全性的疑问，为什么医生专家都不出来说。其实不是不说，而是都被删了，一般人都看不到。所以我想写一下这个帖子，让大家看看现在整个西方社会里科学问题上搞一言堂的情况，很多专家医生发声都被禁言了，还有被辞退的，被调查的，被骚扰的，但是这些人很勇敢，依然坚持说出自己的意见。因为科学的进步就是要有不同意见的讨论，一言堂的话，怎么会有进步呢？医学史上哪个大的突破不是因为有人背离主流的意见，坚持自己的独立探索？ 我觉得把这些讨论发出来让更多人看到，也是我们现在唯一能做的了。
不是说这些专家的说法肯定就会得到证实或者正确，但是让科学家和医生们讨论可能性，然后搜集数据和证据来检测这些假设，不才是真的科学方法么？不让人发声，就是politics over science.
另外我想一上来就用fact checkers所谓的facts扣帽子说这些医生是anti vaxxer的人，劝你先看看别人说的具体内容，看看人家说的有没有道理，而不是一上来就扣帽子，人格攻击，这样真的是助纣为虐也不利于科学讨论。 那些fact checkers网站已经沦为了主流narrative的工具了。我希望从墙国出来了的人都能看清楚这一点。
还有说疫苗跟病毒两害取其轻的，这是个伪命题，early treatment可以有效降低重病率和致死率（看二楼的专家的paper），这些个大夫也都是认为早治疗就基本没有打疫苗的必要。绝大多数人都没有什么后遗症就完全恢复了的。但是early treatment也一直没有被广泛讨论，政府也没有建议到official guidelines，一直都是自己在家呆着，等喘不上气来再去医院，任何一种病，都是早治疗更有效，晚治疗就致伤致残更多。所以你能想象这些大夫为什么这么生气要发声，因为明明有很多常用的安全性已知的药可以配合在一起，早治疗，结果政府就是看着那么多人死了，也不更新guidelines，就为了让大家都打一个长期安全性未知的疫苗。
Dr. Charles Hoffe 本来是一个BC省一个小城市的家庭医生，也是当地医院的ER医生。他的病人有很大一部分是first nation native people。所以当他发现自己的病人里有好几个疫苗 adverse events之后，他给BC省的健康部门发了消息问询，但是没有结果，所以他只好把他的concerns发公开信公布出来，然后他在医院ER的职位被终止了，等于失去了一半的收入。 他在这个采访里面说的大意是（我不是医学专业，按照我的理解写的，有错误请指出谢谢），因为注射进的物质不是全呆在注射部位的，而有75%（他没说这个数据的来源）都可能会进入血液循环系统，而很多毛细血管的内壁上有ace2 receptor就会跟spike protein绑定，这样本来很光滑的内壁突然出现了一个不明凸起，就会引起血液里的反应，以为是伤口或者什么外来物质，血液在那里就会凝聚，造成一个血栓，而这种在毛细血管的微型血栓，是在各种ultra sound或者CT上根本显示不出来的，所以有很多疫苗后有反应的人，有各种症状（头疼，心慌，神经类疼痛等等），但是查不出来什么问题。但是他说有一种检测，可以测出来身体里是不是最近有过血栓，叫d-dimer test，这个检查测不出来血栓在哪里，但是能测出来有没有过，哪怕是很小的血栓。所以他就开始给他打过疫苗的病人测，结果发现62%的人里这个检测的数值都超标，就是说这些人都有了血栓，但因为大部分是microscopic clot，根本显示不出来，而且很多人也还没有显现出症状。但是官方说的blood clot是非常rare的论断是完全不靠谱的，能通过CT检测出来的rare，但是微型的检测不出来很普遍。他说他有一个病人，每周走两英里去他办公室打治疗关节炎的针，结果打完疫苗之后，走路走1/4英里就喘不上气来了，也就是说他的vaccine injury让他肺功能降低到了1/8。而且特别让人担心的是，spike protein还可以跨越血脑屏障进入大脑（所以会有头疼，brain fog等症状），这种微型血栓如果广泛存在在身体里，它对很多器官的损伤是永久性的，因为很多器官比如血管，大脑，脊髓，还有心脏，这些地方的细胞基本不会再生，损伤了就是永久性的，所以说为什么说青少年的心肌炎不是个小问题，因为损伤了的心肌细胞就是损伤了，心脏功能就是有永久的损伤，哪怕是轻微的，也是有损伤的，只不过是损伤很小，可能表现不出来，function上没有受到影响而已。
他说的这些在这个短视频里。
系统提示：若遇到视频无法播放请点击下方链接
https://www.youtube.com/embed/5sIWb9GTbbE
他的公开信我贴在下面。 https://canadahealthalliance.org/wp-content/uploads/dr_hoffes_open_letter_to_dr_bonnie_henry_apr_5_2021.pdf
Dr. Bonnie Henry, British Colombia Provincial Health Officer Ministry of Health, 1515 Blanchard Street, Victoria, BC, V8W 3C9 Dear Dr. Henry, 5 April, 2021
这是一篇相关的论文 https://journals.plos.org/plosbiology/article/info:doi/10.1371/journal.pbio.1002198
大意就是不完美的疫苗，比如现在这种“不防传染防重症”的疫苗，可能会成为更强的selection force，导致更致命的变种出现。这个可能性疫苗学家Dr. Geert Vanden Bossche今年年初就讨论过。自己可以自己搜他的采访。懂进化生物学基础的同学们应该都可以理解。
Abstract Could some vaccines drive the evolution of more virulent pathogens? Conventional wisdom is that natural selection will remove highly lethal pathogens if host death greatly reduces transmission. Vaccines that keep hosts alive but still allow transmission could thus allow very virulent strains to circulate in a population. Here we show experimentally that immunization of chickens against Marek''''s disease virus enhances the fitness of more virulent strains, making it possible for hyperpathogenic strains to transmit. Immunity elicited by direct vaccination or by maternal vaccination prolongs host survival but does not prevent infection, viral replication or transmission, thus extending the infectious periods of strains otherwise too lethal to persist. Our data show that anti-disease vaccines that do not prevent transmission can create conditions that promote the emergence of pathogen strains that cause more severe disease in unvaccinated hosts.
Geert Vanden Bossche received his DVM from the University of Ghent, Belgium, and his PhD degree in Virology from the University of Hohenheim, Germany. He held adjunct faculty appointments at universities in Belgium and Germany. After his career in Academia, Geert joined several vaccine companies (GSK Biologicals, Novartis Vaccines, Solvay Biologicals) to serve various roles in vaccine R&D as well as in late vaccine development. Geert then moved on to join the Bill & Melinda Gates Foundation’s Global Health Discovery team in Seattle (USA) as Senior Program Officer; he then worked with the Global Alliance for Vaccines and Immunization (GAVI) in Geneva as Senior Ebola Program Manager. At GAVI he tracked efforts to develop an Ebola vaccine. He also represented GAVI in fora with other partners, including WHO, to review progress on the fight against Ebola and to build plans for global pandemic preparedness.
🔥 最新回帖
不要再问了，如果你打广谱安全的灭活疫苗，他们就不会说什么了，你懂的。
所谓造谣一张嘴，辟谣跑断腿。
啥意思你能解释一下吗？和mRNA疫苗比起来是不是更安全，还有sanofi怎么样呢？
🛋️ 沙发板凳
他的早治疗，outpatient治疗（就是开药自己家里吃药）的方案，他说如果早治疗，85%的covid death都可以避免。
他的采访（大部分在YouTube上都被删了），都很值得看看，他也说过fda cdc内部监管的问题。这个疫苗的审批流程跟之前所有的疫苗都简化多了，一层一层的安全防护的regulation都被waive掉了。
https://odysee.com/@TruthPills:5/Dr-McCullough:3
Dr. Robert Malone，是RNA疫苗技术的发明人，他的paper发表在了PNAS上，最近他的twitter上也贴出来了，这一款疫苗的发明人之一的email截图承认Dr. Malone就是这个技术的发明者。 他的twitter https://twitter.com/RWMaloneMD 他最近写的关于bioethics的文章，我觉得非常值得一看。现在政府做的，完全违背bioethics的最基本的底线。 https://trialsitenews.com/bioethics-of-experimental-covid-vaccine-deployment-under-eua-its-time-we-stop-and-look-at-whats-going-down/
他最近的podcast，讨论antibody dependent enhancement，这个现象或许可以解释为什么以色列最近的数据里，感染的人有更多比例是已经打了疫苗的人。 https://podcasts.apple.com/us/podcast/antibody-dependent-enhancement-vaccine-development/id1455413855?i=1000510671800
There are several viral videos with millions of views referencing something called Antibody-Dependent Enhancement as a potential effect of COVID-19 vaccines or vaccines in general. Some make very bold claims and it''''s difficult to sort fact from fiction from hyperbole in these videos. On today''''s episode of Causes or Cures, Dr. Eeks will chat with Dr. Robert Malone about Antibody-Dependent Enhancement and how it relates to vaccine development. He will describe it in an easy-to-understand way, discuss the specifics of vaccine development, antibodies, COVID-19 and his thoughts on herd immunity and the future of the pandemic.
再加一条。看看FB是怎么不让人说话的。 120k成员的group，被删了。
Puntmann et al. (JAMA Cardiol. 2020;5:1265-1273) showed that the prospective study of 100 German patients who were recently recovered from COVID-19 revealed significant cardiac involvement on cardiac MRI scans in 78% of them, an average 2-1/2 months after their recovery from the acute illness. Two-thirds of these patients were never hospitalized, and there was ongoing myocardial inflammation in 60%. The abnormalities occurred independent of preexisting conditions, severity of the initial disease, and overall course of the acute illness.
Magro et al. showed that there is complement-mediated damage even in grossly normal skin of coronavirus-infected individuals (Human Pathology 2020:106:106-116). They have also shown (Magro et al. Annals of Diagnostic Pathology 2021:50 in press ) that ACE-2 receptor expression is highest in the microvasculature of the brain and subcutaneous fat, and to a lesser degree in the liver, kidney, and heart. They have further demonstrated that the coronavirus replicates almost exclusively in the septal capillary endothelial cells of the lungs and the nasopharynx, and that viral lysis and immune destruction of those cells releases viral capsid proteins (or pseudovirions) that travel through the circulation and bind to ACE2 receptors in these other parts of the body leading to mannan-binding lectin complement pathway activation that not only damages the microvascular endothelium but also induces the production of many pro-inflammatory cytokines. Meinhardt et al. (Nature Neuroscience 2020, in press) show that the spike protein in brain endothelial cells is associated with formation of microthrombi (clots), and like Magro et al. do not find viral RNA in brain endothelium. In other words, viral proteins appear to cause tissue damage without actively replicating virus.
Is it possible the spike protein itself causes the tissue damage associated with Covid-19? Nuovo et al (in press) have shown that in 13/13 brains from patients with fatal COVID-19, pseudovirions (spike, envelope, and membrane proteins) without viral RNA are present in the endothelia of cerebral microvessels. Furthermore, tail vein injection of the full length S1 spike subunit in mice led to neurologic signs (increased thirst, stressed behavior) not evident in those injected with the S2 subunit. The S1 subunit localizes to the endothelia of microvessels in the mouse brain, and is a potent neurotoxin. So the spike S1 subunit of SARS-CoV-2 alone is capable of being endocytosed by ACE2 positive endothelia in both human and mouse brain, with a concomitant pauci-cellular microencephalitis that may be the basis for the neurologic complications of COVID-19. The Pfizer/BioNTech vaccine (BNT162b2) is composed of an mRNA that produces a membrane-anchored full-length spike protein. The mouse studies suggest that an untruncated form of the S1 protein like this may cause a microvasculopathy in tissues that express much ACE2 receptor. A truncated form of S1 was much less damaging in mice.
While there are pieces to this puzzle that have yet to be worked out, it appears that the viral spike protein that is the target of the major SARS-CoV-2 vaccines is also one of the key agents causing the damage to distant organs that may include the brain, heart, lung, and kidney. Before any of these vaccines are approved for widespread use in humans, it is important to assess in vaccinated subjects the effects of vaccination on the heart (perhaps using cardiac MRI, as Puntmann et al. did). Vaccinated patients could also be tested for distant tissue damage in deltoid area skin biopsies, as employed by Magro et al. As important as it is to quickly arrest the spread of the virus by immunizing the population, it would be vastly worse if hundreds of millions of people were to suffer long-lasting or even permanent damage to their brain or heart microvasculature as a result of failing to appreciate in the short-term an unintended effect of full-length spike protein-based vaccines on these other organs.
Particular caution will be required with regard to the potential widespread vaccination of children before there are any real data on the safety or effectiveness of these vaccines in pediatric trials that are only now beginning.
而另一位加拿大的医生/教授 Dr. Francis Christian，他还是一个dept的director，只是因为倡导要informed consent，尤其是对青少年儿童，不能随便就给打了，要说清楚安全性未知，结果就被医院给开除了。
https://www.jccf.ca/surgeon-fired-by-college-of-medicine-for-voicing-safety-concerns-about-covid-shots-for-children/
informed consent难道不是医学和人参与的科学实验里最基本的科学底线？ 他的采访，里面说了纳粹德国和苏联极权统治下是怎么迫害知识分子和专家教授的，他说现在的手段何其相似。墙国出来的同学们，咱们看这种不也很眼熟么？
https://odysee.com/@LauraLynnTT:9/DrFrancisChristian_SOLO_EDIT:a?
Dr. Byram Bridle Viral immunologist and associate professor https://ovc.uoguelph.ca/pathobiology/people/faculty/Byram-W-Bridle https://www.collective-evolution.com/2021/06/18/dr-byram-bridle-speaks-for-100-colleagues-afraid-to-share-science-about-covid-vaccine-concerns/
Dr. Roger Hodkinson Dr Hodkinson is a medical specialist in pathology and graduate of Cambridge University, UK. He is a Fellow of the College of American Pathologists and the Royal College of Physicians and Surgeons of Canada. He was previously the President of the Alberta Society of Laboratory Physicians, an Assistant Professor in the Faculty of Medicine at the University of Alberta, and CEO of a large community based medical laboratory with a full menu of testing for infectious disease and virology. He is currently the Chairman of an American biotechnology company active in DNA sequencing. https://westernmedical.ca/employees/roger-g-hodkinson/ https://odysee.com/@AlisonMorrow:6/AP-admits-effort-to-debunk-well-known-pathologist-over-Covid-__-Dr.-Roger-Hodkinson:9
Dr. Michael Yeadon Allergy & Respiratory Therapeutic Area expert with 23 years in the pharmaceutical industry, including as Chief Science Officer for Pfizer https://odysee.com/@FearlessNation:7/Michael-Yeadon-Full-Interview-Planet-Lockdown:9
我建议大家先看这些专家的发言，自己判断他们为什么要这么说，他们的担心有没有道理和可能性，是因为有利益驱使，还是因为作为一个科学家的良心，这些人都有mainstream media的hit pieces来攻击他们，但是在他们质疑疫苗之前都是非常有成就受人尊重的专家教授。
不分青红皂白直接终止他的相关工作, 岂不成了一言堂？
Among 2377 adults hospitalized with COVID-19 and ≥1 D-dimer measurement, 1823 (76%) had elevated D-dimer at presentation.
得过ｃｏｖｉｄ的有７６％的Ｄ－ｄｉｍｅｒ高。打过疫苗的，这个医生说６２％的Ｄ－ｄｉｍｅｒ高。没啥区别。
如果不打疫苗，Ｃｏｖｉｄ是迟早得，即使假设打了疫苗后Ｄ－ｄｉｍｅｒ高，也和ｃｏｖｉｄ没啥区别。而打疫苗，有降低重症得好处，那还是打疫苗好。
所以用Ｄ－ｄｉｍｅｒ来做ｓｕｐｐｏｒｔｉｎｇ ｅｖｉｄｅｎｃｅ反疫苗，作用不大。
请继续提供新的ｓｕｐｐｏｒｔｉｎｇ evidence。
我觉得楼主写的挺客观 就是应该去study 一下这种 micro 血栓 这样的话 有研究人员会出来方法 如何处理这个问题。而不是像现在 完全不理会
对没错，就是因为是spike protein引起的血栓。而用spike protein设计的疫苗，是个design flaw！！
这首先需要得新冠，然后需要住院，机率是多少？
就是因为spike protein引起血栓啊。所以用spike protein来设计的疫苗，也会造成类似的损伤，所以这个疫苗的设计是个大大的design flaw！
机率比打疫苗高多了。
我在用ｗｏｒｓｔ ｃａｓｅ ｓｃｅｎａｒｉｏ 分析，假设那个医生说的是真的，那还是没有打疫苗好、
第一篇说调查的74%的新冠患者有d-dimer升高，而且d-dimer与病情严重程度正相关—— https://jintensivecare.biomedcentral.com/articles/10.1186/s40560-020-00466-z
第二篇说有1/4的病人在四个月之后还能检测到d-dimer升高—— https://www.healio.com/news/hematology-oncology/20210408/elevated-ddimer-levels-common-months-after-covid19-diagnosis
所以结论还是，病毒vs疫苗二选一的话，疫苗吧。
你会算吗？ 即使疫苗管2年（其实可能只有六个月），然后两年内单个人得新冠的比例有10%（高估），<50岁的人先得上新冠然后住院的可能也小于0.1*0.1=0.01
就是说得covid会伤害身体，对策不是戴口罩防止得病，反而是先给所有健康人同等伤害一下？这是什么逻辑
不知道打疫苗后几个月会不会降低那个数据？否则一直打booster shot 是很可怕的
两害取其轻
covid感染主要传播场所是家庭内部感染，你觉得这种戴口罩能防得住吗？全家都完全不出门的家庭能有几个？
问题是现在covid的害已经知道很多了，early treatment的方案也有，也很有效。而疫苗的害，没有人知道，因为实验正在进行，而他们也没有好好跟踪打了疫苗的人，收集安全性数据！ 就看openvaers.com的数据，已经很可怕了，这还是有研究发现了是有under reporting的，有可能只代表的1-30%的真实数据。
spike protein大量进入血液循环的说法一开始就是错误的，spike protein分泌出来以后是挂在细胞表面的，游离出来的是Furin酶切下来的S1，而且疫苗里面的spike protein是S-2p，被固定在prefusion状态，不会和受体结合。
Spike protein的”毒性“我已经单独开帖子解释过了，有兴趣的自己去读。不好意思业余时间有限，没法天天和你们这些antivaxxer掐。
https://forums.huaren.us/showtopic.html?topicid=2697680
Antivaxx industry是一个很大的产业，真以为一些医生跳到这条船上是为了所谓的良心啊？说来说去整个路子不就是总有刁民想害朕，政府和学术界都是和big pharma一伙的，拼命推广有利润的疫苗打压有用的便宜药，所以谁都不要信，天天看Darkhorse的小视频磕HCQ或者IVM才是正经。
https://www.nature.com/articles/s41591-021-01260-6
又是这种不要脸不要皮的说法，你的所谓early treatment有一个能在RCT里面做出正面结果的吗？HCQ臭了街再吹IVM，接下来还想吹什么？
你那个心血管专家提的治疗方案还是以HCQ为主的，话说去年一年做了多少HCQ实验了，上一点点规模的RCT还没一个能做出正面结果来的，现在大部分right wing echo chamber都不好意思再提这茬了，改行吹驱虫剂神药IVM
刚刚发了个贴扒IVM的皮就有人上来找抽，呵呵
https://forums.huaren.us/showtopic.html?topicid=2708387
antivaxxer实在太多，我的业余时间有限，说实话吵不过，大家自己做决定吧。人家随便扯一两句我需要查一堆文章截一堆图，这个负担不是一个层面上的。
你会算吗？有本事你不打疫苗，在人群里混２年，看你得不得。居然说１０％得概率。
啥逻辑，一个Ｒ这么高的流行病，有本事你一辈子不打疫苗，看你得不得这个病。
如果spike protein不进入血液循环，那心肌炎怎么得的？脑血栓怎么得的？
并不是没办法啊，中国就控制住了，要说民主国家新西兰也控制很好啊，所以不是做不来，而是不去做
most likely是自身免疫的问题，新冠病人体内的自免疫抗体非常惊人的多，有少数人打了疫苗以后也会产生一些自生免疫抗体。具体是哪一段抗原的问题需要很长时间才能查出来，因为都是概率很小的事件
现在新冠开始有多久了？版上有多少比例人得了？ 为啥一定要出去浪挤在人群里？
我妈说国内遛弯一圈，到处都是大喇叭📣打疫苗不排队，对疫苗发纪念品…
帖子里写了这个大夫他自己做的study里面，62%的有血栓。mm不放心可以去查查。不管怎么样，尽量加强自己的身体健康吧！吃的健康，多运动，晒太阳！
所以我是反对盲目给健康人群搞加强针的，如果对重症的保护能力不下降并且breakthrough case没有明显后遗症的话没有必要折腾。普通感冒的冠状病毒一开始危害性未必就小，现在没人当回事那是因为我们每个人的免疫系统每一两年都要见到这个病毒一次。
中国既然有办法控制住了，为啥还全民打疫苗？不要告诉我中国疫苗有效无害但只有mRNA无效还有害。中国还要引进呢。
mRNA逆转录的问题怎么办
mRNA又不进入细胞核。每年都会有无数的病毒往你的细胞里注射各种各样的mRNA，大家都变成病毒人了？
对，我认识的两位80+的老人打了后都存在行走困难的问题，可能就是小血管堵塞影响了腿部的血液循环。
那他们report到VAERS系统里了么？这些个大夫说他们自己的病人的adverse events，他们要report要花半个多小时填一个五六页的表格。特别麻烦，还有好几个被reject的，因为没填疫苗的vial serial number。所以under reporting是肯定了的。真实的副作用还不知道有多少。
感谢楼主 看来还是有不同的声音的
那几个有名的社媒权利太大了 这方面的信息完全没有
早期治疗是对的，但是那也得是有用的早期治疗吧？RCT一个都做不出来，几个人忽悠一下就变成早期治疗了？
我只想知道这spike蛋白会过段时间消失或者会自己繁殖吗？
而且自己感染获得的natural immunity比vaccine immunity要更强。据这些医生们说，这是个医学界的常识（我不知道，只是转述）
不会自己繁殖吧，哈哈。又不是生物。 但是会不会一直产生，也是这些专家所担心的可能性之一。不知道rna会不会逆转录到dna上，如果是的话就是有可能会长久的表达出来，让身体一直产生这个spike protein啊。
你的逻辑和判断都有错误。你说打疫苗导致的血栓危险系数和得新冠的差不多，所以可以忽略.但是，全民推广疫苗，让62%的健康人的血栓系数突然上升难道不是个非常大的health crirsis吗？ 换个角度，对于一个健康人，得新冠的机率很低（如果感染，有可能重症死亡，也有可能完全治愈），但是打了疫苗有62%的机率血栓危险（血栓致死性可以查公开数据）两边砝码都不轻，应该慎重选择。
很遗憾，现在从政府到医学科学界，都在整齐划一的推进疫苗。就算这是一个特殊情况下的无奈选择，也没有必要压制其他科研者的质疑和求证。很难让大众信服。
这是常识没错，但是为什么要小孩从小要普种各种疫苗呢？让孩子暴露在自然环境下不是更好么？什么东西都是风险收益并存，我对新冠疫苗长期安全也是有顾虑的，但现阶段两害相权取其轻。
你应该先把这个62%的人D-dimer异常的说法是从哪里来的搞清楚
自然感染的效果明显不行啊。而且没看到自然感染把医疗资源挤兑成什么样子了？这还是轻症都没去医院的情况。五月的印度和现在的印尼很多地方都50%的人群有抗体，delta来了一样大爆发。英国一开始不也想靠herd immunity，事实证明根本行不通。
跟大选舞弊的阴谋论一样，造谣一张嘴，辟谣跑断腿
谁说这是常识的？一次感染比一针疫苗的话一般都是自然感染免疫力强，但是疫苗可以多打几针，得到比自然感染更强的的免疫力是很容易的事情
你能好好说话吗？ 先不说你每次引用数据的方式和你所批评的发言方式没有什么区别，你经常性的用这种自以为是的吊打方式来蔑视别人的意见，让我很反感。
其他的疫苗我们也都打了，因为有长期安全性的数据和保证。这个疫苗的长期安全性未知，你说的两害，这个的害我们不知道。we don't know what we don't know. you can't say it is safe, because we don't know.
麻疹天花之类的很多传染病都是得病后终身免疫，而疫苗达不到这种效果
怎么打？一年一个booster?
你天天看到一堆一堆长篇大论侮辱智商的话的话脾气也不会好的，相信我
请假一下mm印度靠什么从COVID地狱恢复过来的？
麻疹疫苗98%终身免疫，还是个用了50年的减活毒株
你为什么会觉得一个健康人得新冠的概率很低？除非你在中国，或者你全家一步都不出去。否则在delta流行的情况下美国接触到病毒的几率很高。没看到delta的病毒载量是原始毒株的一千倍吗？还有到处都是不戴口罩的你也不知道他们打没打疫苗。国内好几个防护严密的工作人员都被传到了，你的防护会比他们好吗？
因为其他国家还是病毒肆虐啊，中国又不可能永远封闭 说真的，如果全世界能像中国管半年，也许covid就像sars一样早消灭了，大家已经可以完全“自由”了，而不是像现在半死不活，绵绵无绝期
就是，这疫苗看来是要年年打，每年至少三针的样子，政府应该投钱研究疗法，真不想年年打这么多针
自然感染啊，代价当然大家也都看到了
你的中国政府是傻B 吗 明明控制住了 还要强迫打你口中副作用大的不得了的疫苗 你是在骂中国政府危害人民健康吗？ 你的上司知道你这样反党言论吗？ 五毛最恶心的就是同一件事提土工辩护 骂美国
谢谢mm支持！没错，我也是这么想的，所有的立场都放下，我就是想知道到底是怎么回事，如果有更多数据出来证明这些假说是错的，我也会更新自己的认知。最看不惯的就是一言堂！不让人说话！
因为他们都没有用early treatment protocol 啊。用了就自己回家吃药，有啥医疗资源挤兑的，这些药都很好生产也便宜，早治疗重症降低85%，绝大多数人都自己在家吃药康复了，不用去住院，哪儿还会有挤兑啊？！
大选舞弊可不是造谣 几个关键州半夜先停票 后来偷偷开始计票难道不可以吗 白等哪里来的八千多万选票 你是说老黑投Biden 比Obama更积极吗？ 动点脑子 Trump没处理好和建制派的关系 结果被猪党利用邮寄选票搞了一把 美国政治就是这样 他没能力搞好和建制派的关系 疫情没处理好 下台也就算了 但你说Biden成了历史上投票率最高的总统就是天大的笑话了
可以整理成Case-study 送到NEJM 发表。
有自己的agenda就直说嘛，别遮遮掩掩的，你上次狂吹驱虫剂神药IVM的帖子我还记得呢。
任何一个对生物/医药有一点点常识的人看到IVM的那些”论文“都不会觉得这玩意能起什么大作用，翻一翻全是些open label或者回顾研究，高质量的RCT做一个死一个，好不容易有一个埃及的RCT被Darkhorse吹上了天，结果还是造假的。。。我不相信哪个没有自己agenda的人看到这些玩意会觉得“数据简直是清晰的不能再清晰了”
Short answer to you: 对于新冠和新冠疫苗这样的全新事物，一个科研者（就假设你是）怎么能拍着胸脯100%的把其他声音全部归为反智？ Deeper answer: 历史上每个巨大科学成就都是在反复求证的环境下产生的。如果把质疑声都拍死了，那不就是鼓励了fake science了吗？也会离真理越来越远。
疫苗长期副作用应该会通过大规模长时间的监测显现出来，但现在用个例观察下结论也不负责任。
要真这么好用发展中国家和穷国肯定要争着用了不会去买疫苗了。WHO一向更偏向这些国家。然而我看到的还是WHO在宣传疫苗的重要性而不是这些药。除非你有证据证明WHO也被big pharma收买了。这些药可能对某些人有点用，就像总会听到谁谁谁的癌症被中医治好了。但等到你头上了可就不一定有用了。
反对那也得有个正当理由啊，基本事实都是错误的，自己脑补一下“啊，这里一定不对劲”，然后就天天长篇大论给人家洗脑，这哪里是正常的学术争议
人家谁下结论了，就是提出质疑，呼吁政府要收集分析数据，而现在是，质疑的声音都被打压，副作用report系统极其难用还有官僚主义的一堆要求，导致有好多想report的医生和护士都report不了，导致under reporting，然后政府还没有actively collect data，也不公布，也不让媒体报道。这是真心要研究长期副作用的姿势么？看起来倒是很像根本不想研究。。。。
你说说早期治疗的有效方案是啥？那个IVM杀虫剂还是HCQ？
我周围的人也就发个烧，没听说啥别的，当然你觉得sample size不到100我也没法argue
印度很多邦都用了ivm，case就下来了，你自己可以去搜。ivm就在这些邦的官方guidelines里面。 who里面被big pharma收买没有不知道，被ccp收买的事大家都清楚吧
任何药物上市后都会有常规post-surveillance，你就说整个系统受到打压？
你如果不是学这个的，看了也是白看，根本无法判断真假。 重大的结果，等着Nature science 或者 新英格兰医学报 发表就是了。其他的新闻报道，看了也没用。
HCQ不好用吗？我记得去年疫苗还没出来前很多推HCQ的，为什么HCQ不继续推了？为什么开始推IVM？
可不可以说印度case 下来是因为几乎群免？为什么不？
实在推不下去了，太不好用了，只能换一个推。
hcq可能只有早期有用。ivm早中晚期都有一些evidence
我听的采访里面有好几个大夫说他们要report，花时间特别长，而且还是没有pay的，谁会花半个小时填一个case的表格，结果只是因为没有疫苗serial number就被reject的？难道不是这个系统不 user friendly么？ 系统性打压说不好，我也不清楚，但是VAERS上的data没有主流媒体报道是真的。一般的vaccine development，有25到50个death 就叫停了。这个vaccine related deaths已经这么多了，你觉得他们在好好研究数据，然后做evidence based的考量么？这可是VAERS里政府自己的数据。
这个去年印度很早就用，没啥大用处