This means a displacement is more likely between Omi and Delta. There is no ADE. https://secureservercdn.net/50.62.198.70/1mx.c5c.myftpupload.com/wp-content/uploads/2021/12/MEDRXIV-2021-268439v1-Sigal.pdf Omicron has been shown to be highly transmissible and have extensive evasion of neutralizing 29 antibody immunity elicited by vaccination and previous SARS-CoV-2 infection. Omicron infections 30 are rapidly expanding worldwide often in the face of high levels of Delta infections. Here we 31 characterized developing immunity to Omicron and investigated whether neutralizing immunity 32 elicited by Omicron also enhances neutralizing immunity of the Delta variant. We enrolled both 33 previously vaccinated and unvaccinated individuals who were infected with SARS-CoV-2 in the 34 Omicron infection wave in South Africa soon after symptom onset. We then measured their ability 35 to neutralize both Omicron and Delta virus at enrollment versus a median of 14 days after 36 enrollment. Neutralization of Omicron increased 14-fold over this time, showing a developing 37 antibody response to the variant. Importantly, there was an enhancement of Delta virus 38 neutralization, which increased 4.4-fold. The increase in Delta variant neutralization in individuals 39 infected with Omicron may result in decreased ability of Delta to re-infect those individuals. Along 40 with emerging data indicating that Omicron, at this time in the pandemic, is less pathogenic than 41 Delta, such an outcome may have positive implications in terms of decreasing the Covid-19 burden 42 of severe disease
“ Along with emerging data indicating that Omicron, at this time in the pandemic, is less pathogenic than Delta, such an outcome may have positive implications in terms of decreasing the Covid-19 burden of severe disease” 最后这一句让人感觉春天就要来了✌️
https://secureservercdn.net/50.62.198.70/1mx.c5c.myftpupload.com/wp-content/uploads/2021/12/MEDRXIV-2021-268439v1-Sigal.pdf
Omicron has been shown to be highly transmissible and have extensive evasion of neutralizing 29 antibody immunity elicited by vaccination and previous SARS-CoV-2 infection. Omicron infections 30 are rapidly expanding worldwide often in the face of high levels of Delta infections. Here we 31 characterized developing immunity to Omicron and investigated whether neutralizing immunity 32 elicited by Omicron also enhances neutralizing immunity of the Delta variant. We enrolled both 33 previously vaccinated and unvaccinated individuals who were infected with SARS-CoV-2 in the 34 Omicron infection wave in South Africa soon after symptom onset. We then measured their ability 35 to neutralize both Omicron and Delta virus at enrollment versus a median of 14 days after 36 enrollment. Neutralization of Omicron increased 14-fold over this time, showing a developing 37 antibody response to the variant. Importantly, there was an enhancement of Delta virus 38 neutralization, which increased 4.4-fold. The increase in Delta variant neutralization in individuals 39 infected with Omicron may result in decreased ability of Delta to re-infect those individuals. Along 40 with emerging data indicating that Omicron, at this time in the pandemic, is less pathogenic than 41 Delta, such an outcome may have positive implications in terms of decreasing the Covid-19 burden 42 of severe disease
赶紧把delta赶走吧
我把图给你贴上吧，可以看到打过疫苗再被Omicron感染过以后对delta的中和滴度甚至变得比omicron都高。南非这个地方其实大部分人都感染过新冠了，没打过疫苗的那几个不知道谁是自然感染过的谁不是，不过看上去对delta滴度暴增的那一条橙线很可能以前感染过其他的毒株。
这就是我以前在这个帖子里面说的，Omicron和Delta的交叉中和能力在seronegative和seropositive的人群里是不一样的，所以不能简单的通过O的逃逸能力来推断两者是不是会共存
https://forums.huaren.us/showtopic.html?topicid=2758705&postid=91146461#91146461
最后这一句让人感觉春天就要来了✌️
不管怎么说吧，只要赶紧把delta挤成弱势群体就行
不好意思 字都看得懂但结论没看懂 请问什么是中和滴度？所以打了疫苗再感染O的就等于抗体爆表什么都不怕了？是这个意思吗）
这个study 好烂啊，这么多confounders
中和滴度的意思是你的血清最多稀释多少倍还能阻止病毒感染细胞，比如中和滴度是1000的话意思就是稀释到1000倍的时候正好能让病毒感染细胞的能力下降50%
如果一段时间之前打了疫苗或者感染过，体内已经有足够的记忆B细胞的话，再感染O的时候被感染的细胞和APC都会把新的抗原呈递给T细胞，然后T细胞会“训练”一些新的B细胞。但是同时老的记忆B细胞也会被大量动员起来，因为以前的特异性T细胞大部分都还能识别Omicron。这样新的B细胞会分泌针对Omicron的抗体，同时记忆B细胞也会大量分泌原有毒株的抗体，所以对delta还有其他老毒株的保护能力也提高了。另外T细胞是会不断选择B细胞的，感染新毒株之后有可能会从记忆B细胞里面分化出一些能够分泌广谱中和抗体的B细胞，这些抗体结合的是比较保守的位点，不那么怕新的突变，就是所谓的super immunity
反过来，如果以前从来没被感染过也没打过疫苗的话，你体内生成的抗体都是针对Omicron的，这些抗体结合delta的能力不会很好，这样再碰到delta又会悲剧
直通车通到哪？后门在哪里？得了omicron肯定不会long covid?
真好玩儿！