M- Once the vaccine is removed from the refrigerator for administration, it can be kept at room temperature conditions for up to 12 hours.
P - Once the vaccine has been opened and diluted with saline, either vials or syringes can be stored or transported at room temperatures of up to 30°C for up to six hours.
Circulating SARS-CoV-2 Vaccine Antigen Detected in the Plasma of
Abstract
SARS-CoV-2 proteins were measured in longitudinal plasma samples collected from 13 participants who received two doses of mRNA-1273 vaccine. 11 of 13 participants showed detectable levels of SARS-CoV-2 protein as early as day one after first vaccine injection. Clearance of detectable SARS-CoV-2 protein correlated with production of IgG and IgA.
can mRNA vaccine cross the BBB (blood rain barrier)?
It seems that the LNPs (lipid nanoparticles) that contain the mRNA of Covid-19 vaccines from BioNTech and Moderna do - at low doses - pass the BBB. This is mentioned by the EMA several times in their report, for example p. 54 and discussed in the comments of an article on Derek Lowe's blog.
If that's indeed the case, what would happen once the mRNA + nanolipid reach the brain? Which cells would pick up the LNPs and for how long would they stay in the brain? If there is cells that can transform this mRNA in proteins, where will these proteins then go, and for how long will they stay in the brain? What about the LNPs: what can/will the brain do with the remaining lipids?
This is the English version "Vaccine researcher admits ‘big mist
‘Terrifying’ new research finds vaccine spike protein unexpectedly in bloodstream. The protein is linked to blood clots, heart and brain damage, and potential risks to nursing babies and fertility.
And of cause, this is the counter-argument. The truth resides in real data - which takes time.
Byram Bridle's claim that COVID-19 vaccines are toxic fails to account for key differences between the spike protein produced during infection and vaccination, misrepresents studies
mRNA疫苗进入人体后随着体液/血液流动和扩散进入身体各个层次。在这过程中在适合条件下会不断地in-situ产生抗原。这样产生的抗原是可能会分布广总数量也多。这和报告的强预防作用对应。
灭活疫苗则不同。一开始就是以抗原形式出现因为它就是抗原（没错吧？）而且体积也大。这对灭活疫苗进入人体其他部分产生一定的障碍，虽然抗原也会随着流动和扩散进入身体各个层次。但是其浓度随进入深度可能会很快衰减。其在人体的分布不如mRNA疫苗产生的抗原那么广泛。这和报告的较弱预防作用对应。
但是mRNA疫苗的分布广可能是担心的一部分。怕它进入不该去的地方产生不该产生的东西。
上面的分析没有考虑mRNA疫苗分解速度（假设传输速度保证enough的作用时间。这肯定测试过了）。下面是一些稳定性数据：
M- Once the vaccine is removed from the refrigerator for administration, it can be kept at room temperature conditions for up to 12 hours.
P - Once the vaccine has been opened and diluted with saline, either vials or syringes can be stored or transported at room temperatures of up to 30°C for up to six hours.
Abstract
SARS-CoV-2 proteins were measured in longitudinal plasma samples collected from 13 participants who received two doses of mRNA-1273 vaccine. 11 of 13 participants showed detectable levels of SARS-CoV-2 protein as early as day one after first vaccine injection. Clearance of detectable SARS-CoV-2 protein correlated with production of IgG and IgA.
https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciab465/6279075
只要注射人员按规定做，抽一下回血，可以避免许多副作用（包括心肌炎）
https://mp.weixin.qq.com/s/I0OwC1MQUd0kwPEEhv7McA
It seems that the LNPs (lipid nanoparticles) that contain the mRNA of Covid-19 vaccines from BioNTech and Moderna do - at low doses - pass the BBB. This is mentioned by the EMA several times in their report, for example p. 54 and discussed in the comments of an article on Derek Lowe's blog.
If that's indeed the case, what would happen once the mRNA + nanolipid reach the brain? Which cells would pick up the LNPs and for how long would they stay in the brain? If there is cells that can transform this mRNA in proteins, where will these proteins then go, and for how long will they stay in the brain? What about the LNPs: what can/will the brain do with the remaining lipids?
More readings:
https://www.reddit.com/r/askscience/comments/nhcl0o/mrna_vaccines_what_become_the_lnps_that_cross_the/
https://blogs.sciencemag.org/pipeline/archives/2021/01/11/rna-vaccines-and-their-lipids#comment-336216
‘Terrifying’ new research finds vaccine spike protein unexpectedly in bloodstream. The protein is linked to blood clots, heart and brain damage, and potential risks to nursing babies and fertility.
https://archive.is/dV4T4
And of cause, this is the counter-argument. The truth resides in real data - which takes time.
Byram Bridle's claim that COVID-19 vaccines are toxic fails to account for key differences between the spike protein produced during infection and vaccination, misrepresents studies
https://healthfeedback.org/claimreview/byram-bridles-claim-that-covid-19-vaccines-are-toxic-fails-to-account-for-key-differences-between-the-spike-protein-produced-during-infection-and-vaccination-misrepresents-studies/
条件下不管身体有什么特殊情况都不会进入血液吗？