Causes of vitamin D toxicity Formulation or fortification errors
studies of fortified foodstuffs revealed substantial manufacturing errors, confirming marked differences between the stated and actual doses 21. Overfortification of vitamin D in milk resulted in hypervitaminosis D in the local population, leading to at least 56 cases; 41 required hospitalization and there were two deaths 22, reinforcing the need for careful ongoing production monitoring 23.
Inappropriate prescribing or dispensing
High‐dose formulations are a particular cause for concern. Stoss therapy for vitamin D deficiency, with high doses of vitamin D over relatively short periods, progressing to much lower maintenance doses, has encouraged the development of high‐dose vitamin D therapies (60 000 IU and above). With evidence indicating that doses of 10 000 IU day–1 or below do not cause vitamin D toxicity 15, and that such doses are effective in resolving vitamin D deficiency 38, it may seem that having super‐strength doses might expose subjects to unnecessary risk through either errant prescribing or inappropriate self‐medication. Indeed, vitamin D toxicity is described in association both with high‐dose over‐the‐counter supplements 39being taken too frequently and prescribed in error by the physician
Inappropriate administration of vitamin D
A single dose of 2 000 000 IU of vitamin D was given in error to two nursing home residents67, leading to a call to replace multiple use bottles with smaller single‐unit dose formulations.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980613/
英语好的自己看吧。如果谁有时间请用中文总结一下。
日光强度和皮肤暴露的多少，户外活动时间，是否涂防晒霜，都影响身体维生素D的合成。
市售VD极少见到5000 IU以上的，如果自己买来吃，想中毒都难，除非个别特殊体质、或当糖球吃的蠢货。
制造商、食品提出厂家、不合格的医生，这些才是真正的罪魁。
LZ所给出的文章中列出的主要原因摘录：
Causes of vitamin D toxicity Formulation or fortification errorsstudies of fortified foodstuffs revealed substantial manufacturing errors, confirming marked differences between the stated and actual doses 21. Overfortification of vitamin D in milk resulted in hypervitaminosis D in the local population, leading to at least 56 cases; 41 required hospitalization and there were two deaths 22, reinforcing the need for careful ongoing production monitoring 23.
Inappropriate prescribing or dispensingHigh‐dose formulations are a particular cause for concern. Stoss therapy for vitamin D deficiency, with high doses of vitamin D over relatively short periods, progressing to much lower maintenance doses, has encouraged the development of high‐dose vitamin D therapies (60 000 IU and above). With evidence indicating that doses of 10 000 IU day–1 or below do not cause vitamin D toxicity 15, and that such doses are effective in resolving vitamin D deficiency 38, it may seem that having super‐strength doses might expose subjects to unnecessary risk through either errant prescribing or inappropriate self‐medication. Indeed, vitamin D toxicity is described in association both with high‐dose over‐the‐counter supplements 39 being taken too frequently and prescribed in error by the physician
Inappropriate administration of vitamin DA single dose of 2 000 000 IU of vitamin D was given in error to two nursing home residents 67, leading to a call to replace multiple use bottles with smaller single‐unit dose formulations.
不过赞同大家应该仔细读了再下结论。我也只是快速的过了一遍， 不算仔细读了。所以建议热心的网友给个全面的中文提要。
另外， 如以前其他网友提醒，对于肺癌患者，还是不要补VD了。 看到过这样的文献。 不过这个要用另外的关键词查。 不在这个文章范畴内。
作为消费者，其实被不负责仼的厂商、医生蒙骗，属于被动受害者。
本来就想喝杯牛奶，咋就中毒了呢，这种事防不胜，只能靠社会监管。
被打了一针，咋就那么大大大大量呢，跟那医生有仇？不能啊，刚才还谈笑风生来着。
咋“小心”呐？
另外，那篇综述的题目是
A review of the growing risk of vitamin D toxicity from inappropriate practice注意最后两个词，连在一起用时指出了谁之过，不是针对受害者。
有许多个体滥用维生素D中毒的报告，但LZ所引用这篇文章是对生产、监督、及医疗机构的指责，不适用于个体。
一天我家医问我牙齿如何？我说植牙要种骨粉，他就说：啊呀你就是缺钙，必须补钙与维D（一万IU一周两次）。我说：我血检钙也有40几虽近下限但也不很低，秋冬我会补充 2000IU。他竟然说：不行，必须听我的，我对所有病人都是这样，要是不听我的，就别来看我。我苦笑着说:你也太极端了。...
听我的吧