The determinants of serum vitamin D seems to be the environmental factors (dietary and supplementary intake and exposure to ultraviolet light) and genetic factors. We aimed to study the relationship between a vitamin D-associated genetic polymorphism and serum 25(OH)D concentrations in healthy adolescent girls in Iran, and its effects on a high-dose supplement of vitamin D.
MATERIAL AND METHOD:
A total of 616 healthy adolescent girls with mean age 15 received 50,000 IU of vitamin D3 weekly over 9 weeks. Serum vitamin D levels and other metabolic factors were measured at baseline and after the intervention. The genotyping of the CYP2R1 variant (rs10741657) was performed by TaqMan genotyping assays.
RESULTS:
Regardless of the genetic background, at baseline, 87% of adolescent girls were vitamin D deficient (serum 25(OH)D level < 50 nmol/l). High-dose supplementation with VitD reduced the proportion of girls who were deficient substantially to about 24%. The genetic analysis revealed that although at baseline there was not a gene-vitamin D association ( p trend = 0.1), the response to supplementation appeared to be modulated by this variant ( p trend < 0.001). However, other anthropometric and biochemical measures were not affected by this intervention, over this short period. Serum 25(OH)D was increased in all participants although the carriers of the minor A allele seemed to be better responders so that the percentages of the change serum vitamin D in the holder of AA and AG genotypes were 539.4 ± 443.1 and 443.7 ± 384.6, respectively, compared with those with common GG genotype (363.3 ± 354.0). Our regression analysis revealed that the probability of an increase in serum 25(OH)D in a participant with AA genotype was 2.5-fold greater than those with a GG genotype (OR = 2.5 (1.4-4.4); p value = 0.002).
CONCLUSION:
Based on our findings, it appears that the rs10741657 variant of the CYP2R1 gene modulates the response to high-dose of vitamin D supplementation.
亚裔维生素D的水平平均低于高家所人，这也许不是病态。补维生素D要合适，过度有可能促进软组织钙化。另外，除非医生建议，年龄较高不宜通过食品补充剂补钙，以免促进血管钙化。靠饮食补钙比较安全。
不觉得我污了大师的称号；或者，这个称呼侮辱了我？
我相信hhhh的说法。
对咖啡灌肠尚未了解清楚，不评价。
2015年左右每天吃非处方的最大剂量的维生素D，好像是5000国际单位的，结果造成膝盖剧痛，上楼都困难。停了以后明显好转。
那年医生让我吃是因为测量的结果是13，太低。
我D也低，吃鱼肝油和D/K2合剂
研究过一下，这个牌子不错
https://www.thorne.com/products/dp/vitamin-d-k2-liquid
对有些人来说，测量的维生素D(25[OH]D)低时，其体内起作用的1,25(OH)2D水平并不低。这些人没有必要补充维生素D。可惜目前不能很常规地测这个指标，也只好猜测。
我看到有些人补充的量好大，但是测量出来的水平还是不高。
https://www.ncbi.nlm.nih.gov/pubmed/30624776 J Cell Physiol. 2019 Aug;234(8):13977-13983. doi: 10.1002/jcp.28083. Epub 2019 Jan 9. A variant in CYP2R1 predicts circulating vitamin D levels after supplementation with high-dose of vitamin D in healthy adolescent girls. Khayyatzadeh SS1,2, Mehramiz M3,4, Esmaeily H5, Mirmousavi SJ6, Khajavi L3, Salehkhani FN3, Hanachi P7, Bahrami-Taghanaki H8, Eslami S9, Vatanparast H10, Ferns GA11, Avan A3,4, Ghayour-Mobarhan M3. Author information Abstract AIM:
The determinants of serum vitamin D seems to be the environmental factors (dietary and supplementary intake and exposure to ultraviolet light) and genetic factors. We aimed to study the relationship between a vitamin D-associated genetic polymorphism and serum 25(OH)D concentrations in healthy adolescent girls in Iran, and its effects on a high-dose supplement of vitamin D.
MATERIAL AND METHOD:A total of 616 healthy adolescent girls with mean age 15 received 50,000 IU of vitamin D3 weekly over 9 weeks. Serum vitamin D levels and other metabolic factors were measured at baseline and after the intervention. The genotyping of the CYP2R1 variant (rs10741657) was performed by TaqMan genotyping assays.
RESULTS:Regardless of the genetic background, at baseline, 87% of adolescent girls were vitamin D deficient (serum 25(OH)D level < 50 nmol/l). High-dose supplementation with VitD reduced the proportion of girls who were deficient substantially to about 24%. The genetic analysis revealed that although at baseline there was not a gene-vitamin D association ( p trend = 0.1), the response to supplementation appeared to be modulated by this variant ( p trend < 0.001). However, other anthropometric and biochemical measures were not affected by this intervention, over this short period. Serum 25(OH)D was increased in all participants although the carriers of the minor A allele seemed to be better responders so that the percentages of the change serum vitamin D in the holder of AA and AG genotypes were 539.4 ± 443.1 and 443.7 ± 384.6, respectively, compared with those with common GG genotype (363.3 ± 354.0). Our regression analysis revealed that the probability of an increase in serum 25(OH)D in a participant with AA genotype was 2.5-fold greater than those with a GG genotype (OR = 2.5 (1.4-4.4); p value = 0.002).
CONCLUSION:Based on our findings, it appears that the rs10741657 variant of the CYP2R1 gene modulates the response to high-dose of vitamin D supplementation.
© 2019 Wiley Periodicals, Inc.
KEYWORDS:CYP2R1; rs10741657; supplementation; vitamin D
PMID: 30624776 DOI: 10.1002/jcp.28083请问怎么能知道自己是不是您所说的那些容易软组织钙化的极少数人？
吃维生素D3算补钙吗？您最后一段说的通过食物补充剂补钙，是指吃钙片，还是也包括吃维生度D3？
怎样通过饮食补钙呢？多吃奶制品，虾皮，西兰花，柑橘类水果？
谢谢！
1) 这种人少见，只有通过基因测序才能最后认定。
2) 我说的补钙的食品补充剂包括钙片，含维生素D的钙片，液体钙等。维生素不算在内。
3) 比较好的补钙食品有酸奶(酸奶比鲜奶对健康有益, 如果能自己做，不加糖最好)，含鱼刺的小鱼，加钙的豆奶，豆腐等。另外，很多蔬菜里钙也不少，如绿菜花。虾皮，桔子等含钙大概不多。