【精神病 Mental Disorders 与遗传的几个要点】

偃月劃戟
楼主

 

精神病 是一个群,包括几十个类型,比如

幻想症,谵妄症,强迫症,狂躁,抑郁,精神分裂症 Schizophrenia 等。

这里以 精神分裂症为例 简说:

1,此病的世界范围流行率 Prevalence 是 1%, 美国1.2%, 中国1%.

2,年龄:20~40 是发病高峰。

3,性别:男女无显著差别。

4, 遗传:多因素诱发或导致此症。截止目前,没有发现明确的致病基因或遗传模式。不存在每代或隔代遗传特征。这是美国国立卫生署的结论:The inheritance pattern for schizophrenia is usually unknown. The risk of developing schizophrenia is somewhat higher for family members of affected individuals as compared to the general public; however, most people with a close relative who has schizophrenia will not develop the disorder themselves. -- https://ghr.nlm.nih.gov/condition/schizophrenia#inheritance?

5,治疗和预后。

对症治疗,主要包括心理疏导, 药物,环境调节等。症状可以缓解,间歇,断续,很少痊愈,鲜有根治了的。

 

 



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x
xiao-min
你崇拜关羽吕布?这两种兵器都有倒刺,杀伤力很大。
偃月劃戟
哈哈,未必~~

周末愉快~

喜欢这两样兵器~.~

y
yzout
还药物治疗呢。DSM5都承认,精神科药物是 产生精神分裂症的原因之一。
偃月劃戟
用错, 吃错药,

老天也没治!

y
yzout
没有对的药。吃安眠药都会损害神经系统,长期服用会诱发精神分裂
偃月劃戟
欲千北
很多疾病有动物模型,精神分裂症有动物模型吗?
f
fuz
有,见过。但因诱导手段过激,被限制使用。
杨别青
一个精神分裂症相关基因,DISC1

Discovery[edit]

In 1970, researchers from the University of Edinburgh performing cytogenetic research on a group of juvenile offenders in Scotland found an abnormal translocation in chromosome 1 of one of the boys, who also displayed characteristics of an affective psychological disorder.[6] After this initial observation, the boy's family was studied and it was found that 34 out of 77 family members displayed the same translocation. According to the Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) (or DSM-IV) criteria, sixteen of the 34 individuals identified as having the genetic mutation were diagnosed with psychiatric problems. In contrast, five of the 43 unaffected family members were identified to have psychological indispositions. The psychiatric illnesses observed in the family ranged from schizophrenia and major depression to bipolar disorder and adolescent conduct disorder (which the original research subject had).[7] After studying this large Scottish family for four generations, in 2000, this gene was given the name "DISC1". The name was derived from the basis of the molecular nature of the mutation: the translocation directly disrupts the gene.[5]

 

 https://en.wikipedia.org/wiki/DISC1

欲千北
谢谢回复。大概有虐待动物的嫌疑。