一个81岁的老奶奶,症状严重,发病早期给了Remdesivir x 5 days ; 另一个40多岁的墨兄,SOB 严重,血氧低,错过了Remdesivir最佳期,给了convalescent plasma 。
有症状的病人,如果Rapid test 是阴性,我们会做second test,因为如果 viral load 不够,会呈false negative。 如果病人present病程超过7天,我们会order PCR test。The duration of viral shedding varies significantly and may depend on severity (based on testing of oropharyngeal samples ranged from 8-37 days, with a median of 20 days),
即便Rapid 和 PCR 都呈阴性,CXR 显示有不正常发现(Patchy ground glass opacities), 我们会把病人做PUI 处理,一样隔离和治疗。 而且会重复CXR,因为Early in the course of the disease, there are many mildly symptomatic patients with clear chest x-rays that quickly progress over days to patchy ground glass opacities.
有的症状病人,Case-by-case,同时还会做respiratory viral panel, strep throat 和其他Labs;根据病情,有的也会做Antibody Test (IgM, IgG , but It is not necessarily confer immunity to COVID-19 and it is unknown how long antibodies last)
PS,
阎老在症状几天后,检测 covid test negative,based on cases and studies,采样的viral loading dose应该合适,采样的技术问题除外。
阎老,也许是flu造成的心肌炎导致直接死亡。 Acute myocarditis is a well-known complication of influenza infection。 Myocarditis can be life-threatening if not treated in time。(我不知道阎老病程的具体细节,无法判断)
R.I.P,阎老!
补充一个Research information for PCR test
Over the 4 days between infection (day 1) to the typical time of symptom onset (day 5), the probability of a false-negative result in an infected person decreased from 100% on day 1 (95% CI, 100%-100%) to 67% (CI, 27% - 94%) on day 4.
On the day of symptom onset (day 5), the median false-negative rate was 38% (CI, 18% to 65%).
On day 8 the median false-negative rate decreased to 20% (CI, 12%- 30%), and then began to increase again (21% [CI 13%-31%] on day 9). On day 21 the median false negative rate was 66% (CI, 54% -77%).
((润涛阎离线 十一月 18, 2020 2:00
…我感冒好多天,星期天半夜,突然间浑身发抖,难道是发烧了?头痛的要命。一量,102华氏度=39.1摄氏度。…
因为我有味觉。我觉得也是流感…
今天正常了,就去查看核检的结果。…一查,果真是阴性。
这么多年没感冒了,今年竟然三次了!这是演的哪一出啊。零件老化了无疑。可我纳闷:流感病毒是怎么接触到我呼吸道的?我出门戴口罩,还戴透明面罩,病毒得从下面往上走进入我的呼吸道。
总想吐。这也是第一次有这类流感的感觉。而且鼻子一直畅通无阻,没鼻涕,不堵塞。”))
CDC辨别冠肺病毒三大标准:剧烈咳嗽,失去嗅觉,发烧。他没有其中主要两个症状
http://rock103.com/crew/vids/missvenezuela.wmv
生活方式是否健康不得而知。
他写了916篇原创博客,每一篇都是精心而作,回帖近10万贴,肯定熬夜。
他还在万维等其他几个网站重贴这些博客,也需要回帖互动。
他是学校副研究员,不是终身教授,所以必须不断地发论文 。
因为薪水只有6万,所以注册一个屋顶公司换屋顶,考了一个电工证安装住家电源布线等。
休息时间很少。
万年薪也太低了吧,我这副研究员至少十几万。博后近6 万。
美国的PCR检测是比较准确的。但很多人不注重看采样的时间,包括ordering physician, 实际上采样时间很重要,一般来说发病后(onset of illness)的第三天起viral shedding比较多,所以那时候采样检验出的结果比较准确。发病第1-2天假阴性的不少,因为viral load不足以检测出阳性。如果你觉得有新冠症状,采样在病程的早期得出阴性结果,一定要再做第二次。如果已经在病程的7天以上,最好让医生同时开新冠PCR 和 血清抗体检测 (IgM) 这样万无一失,当然必须同时检查的还应该有流感,Strep throat (链球菌感染)。有些医院自动run respiratory viral panel 包括好多种呼吸道常见病毒,还包括不是SARS-CoV-2的其他冠状病毒。如果发高烧,到医院看病最有益的就是及时的全面的实验室检查,尤其有基础病的人。
我这些天有好几个80岁以上的病人,除了low degree fever,没有其他typical covid symptoms, 基本都是supportive treatment,预防并发症,和缓解症状治疗,大部分几天能安全出院。
一个81岁的老奶奶,症状严重,发病早期给了Remdesivir x 5 days ; 另一个40多岁的墨兄,SOB 严重,血氧低,错过了Remdesivir最佳期,给了convalescent plasma 。
有症状的病人,如果Rapid test 是阴性,我们会做second test,因为如果 viral load 不够,会呈false negative。 如果病人present病程超过7天,我们会order PCR test。The duration of viral shedding varies significantly and may depend on severity (based on testing of oropharyngeal samples ranged from 8-37 days, with a median of 20 days),
即便Rapid 和 PCR 都呈阴性,CXR 显示有不正常发现(Patchy ground glass opacities), 我们会把病人做PUI 处理,一样隔离和治疗。 而且会重复CXR,因为Early in the course of the disease, there are many mildly symptomatic patients with clear chest x-rays that quickly progress over days to patchy ground glass opacities.
有的症状病人,Case-by-case,同时还会做respiratory viral panel, strep throat 和其他Labs;根据病情,有的也会做Antibody Test (IgM, IgG , but It is not necessarily confer immunity to COVID-19 and it is unknown how long antibodies last)
PS,
阎老在症状几天后,检测 covid test negative,based on cases and studies,采样的viral loading dose应该合适,采样的技术问题除外。
阎老,也许是flu造成的心肌炎导致直接死亡。 Acute myocarditis is a well-known complication of influenza infection。 Myocarditis can be life-threatening if not treated in time。(我不知道阎老病程的具体细节,无法判断)
R.I.P,阎老!
补充一个Research information for PCR test
Over the 4 days between infection (day 1) to the typical time of symptom onset (day 5), the probability of a false-negative result in an infected person decreased from 100% on day 1 (95% CI, 100%-100%) to 67% (CI, 27% - 94%) on day 4.
On the day of symptom onset (day 5), the median false-negative rate was 38% (CI, 18% to 65%).
On day 8 the median false-negative rate decreased to 20% (CI, 12%- 30%), and then began to increase again (21% [CI 13%-31%] on day 9). On day 21 the median false negative rate was 66% (CI, 54% -77%).