Prior observation has shown differences in COVID-19 hospitalization risk between SARS-CoV-2 variants, but limited information describes hospitalization outcomes.
Methods
Inpatients with COVID-19 at five hospitals in the eastern United States were included if they had hypoxia, tachypnea, tachycardia, or fever, and SARS-CoV-2 variant data, determined from whole genome sequencing or local surveillance inference. Analyses were stratified by history of SARS-CoV-2 vaccination or infection. The average effect of SARS-CoV-2 variant on 28-day risk of severe disease, defined by advanced respiratory support needs, or death was evaluated using models weighted on propensity scores derived from baseline clinical features.
Results
Severe disease or death within 28 days occurred for 977 (29%) of 3,369 unvaccinated patients and 269 (22%) of 1,230 patients with history of vaccination or prior SARS-CoV-2 infection. Among unvaccinated patients, the relative risk of severe disease or death for Delta variant compared to ancestral lineages was 1.30 (95% confidence interval [CI] 1.11-1.49). Compared to Delta, this risk for Omicron patients was 0.72 (95% CI 0.59-0.88) and compared to ancestral lineages was 0.94 (95% CI 0.78-1.1). Among Omicron and Delta infections, patients with history of vaccination or prior SARS-CoV-2 infection had half the risk of severe disease or death (adjusted hazard ratio 0.40, 95% CI 0.30-0.54), but no significant outcome difference by variant.
Conclusions
Although risk of severe disease or death for unvaccinated inpatients with Omicron was lower than Delta, it was similar to ancestral lineages. Severe outcomes were less common in vaccinated inpatients, with no difference between Delta and Omicron infections.
Please do not cherry picking when citing the sources, especially when you are in the profession. 这种没有上下文的定义结论就是fear mongering，or for pushing some intended narratives. 不是所有人的都是那么愚蠢又懦弱的。
这篇刚发表的论文显示，尽管未接种疫苗的感染Omicron的住院患者患严重疾病或死亡的风险低于 Delta，但这种风险与原始毒株相似。接种疫苗的住院患者出现严重后果的情况较少，Delta 和 Omicron 感染之间没有差异。
https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciac957/6931752
JOURNAL ARTICLE ACCEPTED MANUSCRIPT EDITOR'S CHOICE Impact of SARS-CoV-2 variants on inpatient clinical outcome Matthew L Robinson, MD, C Paul Morris, MD, PhD, Joshua F Betz, PhD, Yifan Zhang, PhD, Robert Bollinger, MD, Natalie Wang, David R Thiemann, MD, Amary Fall, PhD, Raghda E Eldesouki, PhD, Julie M Norton, MS ... Show more Author Notes Clinical Infectious Diseases, ciac957, https://doi.org/10.1093/cid/ciac957 Published: 19 December 2022 Article historyPrior observation has shown differences in COVID-19 hospitalization risk between SARS-CoV-2 variants, but limited information describes hospitalization outcomes.
MethodsInpatients with COVID-19 at five hospitals in the eastern United States were included if they had hypoxia, tachypnea, tachycardia, or fever, and SARS-CoV-2 variant data, determined from whole genome sequencing or local surveillance inference. Analyses were stratified by history of SARS-CoV-2 vaccination or infection. The average effect of SARS-CoV-2 variant on 28-day risk of severe disease, defined by advanced respiratory support needs, or death was evaluated using models weighted on propensity scores derived from baseline clinical features.
ResultsSevere disease or death within 28 days occurred for 977 (29%) of 3,369 unvaccinated patients and 269 (22%) of 1,230 patients with history of vaccination or prior SARS-CoV-2 infection. Among unvaccinated patients, the relative risk of severe disease or death for Delta variant compared to ancestral lineages was 1.30 (95% confidence interval [CI] 1.11-1.49). Compared to Delta, this risk for Omicron patients was 0.72 (95% CI 0.59-0.88) and compared to ancestral lineages was 0.94 (95% CI 0.78-1.1). Among Omicron and Delta infections, patients with history of vaccination or prior SARS-CoV-2 infection had half the risk of severe disease or death (adjusted hazard ratio 0.40, 95% CI 0.30-0.54), but no significant outcome difference by variant.
ConclusionsAlthough risk of severe disease or death for unvaccinated inpatients with Omicron was lower than Delta, it was similar to ancestral lineages. Severe outcomes were less common in vaccinated inpatients, with no difference between Delta and Omicron infections.
Please do not cherry picking when citing the sources, especially when you are in the profession. 这种没有上下文的定义结论就是fear mongering，or for pushing some intended narratives. 不是所有人的都是那么愚蠢又懦弱的。
https://www.news.com.au/technology/science/human-body/dr-kerryn-phelps-reveals-devastating-covid-vaccine-injury-says-doctors-have-been-censored/news-story/0c1fa02818c99a5ff65f5bf852a382cf
https://spectator.com.au/2022/12/kerryn-phelps-vaccine-injuries-the-silence-is-deafening/
You may google yourself who Dr. Phelps is.
如果你是惶惶终日的layman 我还可以理解，可是你似乎是medical 业内人士，不是吗？
critical thinking
任何帖子，都可以批评和批判。
至少不是“绝大部分”
己抗疫世界第一，因为已经开放了。中国即使过完眼下第一关彻底开放了，那也是病人不断，抗疫无力，当然美国每天几万感染，几百死亡那都不叫个事。
政府以预先订购几亿剂的方式，在财力上大力支持新冠疫苗的研发和试验。
川普总统不但打过mRNA疫苗，也打过疫苗的加强针。