A possible biological explanation for the findings in the present study is not clear. The magnitude of intakes of vitamins B6 andB12 associated with an increased risk of hip fracture in our study far exceeded the recommended dietary allowances (RDAs) (1.3-1.7 mg/d for vitamin B6 and 2.4 μg/d for vitamin B12).15
Possible adverse effects of high-dose vitamin B6 supplementation have previously been suggested.24,25 High doses (≥500 mg/d) might increase the risk of falling because neurological symptoms, including ataxia, neuropathy, and decreased muscle tone, have been reported, and milder neurological symptoms have been observed at doses of approximately 100 mg/d as adverse effects.26 Preliminary work suggested that high vitamin B6 concentrations might accelerate bone loss by counteracting the modulating influence of estrogens on steroid receptors.27 A recent paradox theory proposes that large doses of pyridoxine, the inactive form of vitamin B6 included in supplements and found in foods, inhibits the active form pyridoxal phosphate.28
We do not have an explanation for the mechanism by which vitamin B12 may contribute to increased fracture risk.
问题 维生素B6和B12的大量摄入是否与髋部骨折风险增加有关？
结果 一项针对75864名美国绝经后女性的队列研究发现，2304例患有髋部骨折。维生素B6和B12的联合高摄入与髋部骨折风险增加有关。
意义 这些结果进一步证明，在没有明显缺乏维生素的情况下，应谨慎使用维生素补充剂。
Possible Mechanisms
A possible biological explanation for the findings in the present study is not clear. The magnitude of intakes of vitamins B6 andB12 associated with an increased risk of hip fracture in our study far exceeded the recommended dietary allowances (RDAs) (1.3-1.7 mg/d for vitamin B6 and 2.4 μg/d for vitamin B12).15
Possible adverse effects of high-dose vitamin B6 supplementation have previously been suggested.24,25 High doses (≥500 mg/d) might increase the risk of falling because neurological symptoms, including ataxia, neuropathy, and decreased muscle tone, have been reported, and milder neurological symptoms have been observed at doses of approximately 100 mg/d as adverse effects.26 Preliminary work suggested that high vitamin B6 concentrations might accelerate bone loss by counteracting the modulating influence of estrogens on steroid receptors.27 A recent paradox theory proposes that large doses of pyridoxine, the inactive form of vitamin B6 included in supplements and found in foods, inhibits the active form pyridoxal phosphate.28
We do not have an explanation for the mechanism by which vitamin B12 may contribute to increased fracture risk.
给出的理由是，由于现代农业中大量化肥的使用，所有的作物都长得过于肥大，果实的有效成分照比以前低。
我前阵子吃了不少Costco的ＢComplex, 最近停了。看来所有的保健品，还是吃吃停停最好。
我也吃Costco的B族维生素，我觉得量有些大，我吃四分之一粒。
https://bbs.wenxuecity.com/health/860392.html
正常摄入量：1.3-1.7 mg/d
高摄入量：≥500 mg/d
这个是几百倍，吓人