癌症医学治疗方法的错误,给人类带来巨大惨痛的代价。医学不仅仅治不好癌症,而且因过度治疗大大的缩短生命。许多研究发现,癌症被过度治疗的机率是25%至60% [Welch and Black 2010; Jahn et al. 2015; Hoffman et al. 2014; Draisma et al. 2009] 。有人估计2019年美国将诊断出1,762,450例新癌症病例,606,880例癌症死亡。我估计 (用50%或50/(100+50=33%), 因接受不必要的激进治疗而死亡达200,000人,而癌症幸存者将失去30%的寿命。在中国,每年有4.51百万案,3.04百万死亡 。 我估计,每年中国因接受不必要激进医学治疗死亡人数达1百万人。那些癌症幸存者平均寿命也会减少30% [Cupit-Link et al. 2017]。衰老的标志包括基因组不稳定性,端粒损失,表观遗传改变,线粒体功能障碍,蛋白稳定态的丧失,慢性低度炎症,细胞衰老 [López-Otín et al,2013]。 治疗会给癌症严重伤害的患者增加这些负面影响,应该预料到这些负面影响会导致某些患者在治疗期间加快死亡。 我的缩短某些患者寿命的动力学预测是无可争议的。
Cupit-Link MC, Kirkland JL, Ness KK, et al. Biology of premature ageing in survivors of cancer. ESMO Open. 2017 December 18. López-Otín C, Blasco MA, Partridge L, et al. The hallmarks of aging. Cell 2013;153:1194–217. Ogino S, Fuchs CS, Giovannucci E (2012). "How many molecular subtypes? Implications of the unique tumor principle in personalized medicine". Expert Rev Mol Diagn. 12 (6): 621–8. Ogino S, Lochhead P, Chan AT, Nishihara R, Cho E, Wolpin BM, Meyerhardt JA, Meissner A, Schernhammer ES, Fuchs CS, Giovannucci E (2013). "Molecular pathological epidemiology of epigenetics: Emerging integrative science to analyze environment, host, and disease". Mod Pathol. 26 (4): 465–84. doi:10.1038/modpathol.2012.214.
Site addresses are not allowed in the blog, so they are deleted.
ACS Early Theories about Cancer Causes, American Cancer Society. accessed at ...*cancer*cancer-basics*history-of-cancer*cancer-causes-theories-throughout-history.file Aguirre-Ghiso JA. Models, mechanisms and clinical evidence for cancer dormancy. Nat Rev Cancer. 2007;7:834–846.
Albero A, Lopéz JE, Torres A, de la Cruz L, Martín T. Effectiveness of chemotherapy in advanced differentiated thyroid cancer: a systematic review. Endocr Relat Cancer. 2016 Feb;23(2):R71-84. doi: 10.1530*ERC-15-0194.
Armitage P, Doll R. The age distribution of cancer and a multi-stage theory of carcinogenesis. Br J Cancer. 1954;8(1):1–12.
Armitage P, Doll R. A two-stage theory of carcinogenesis in relation to the age distribution of human cancer. Br J Cancer. 1957;11(2):161–9.
Ashdown ML, Robinson AP, Yatomi-Clarke SL, Ashdown ML, Allison A, Abbott D, Markovic SN, and Coventry BJ, Chemotherapy for Late-Stage Cancer Patients: Meta-Analysis of Complete Response Rates, Version 1. F1000Res. 2015; 4:232.
Attolini CS, Michor F. Evolutionary Theory of Cancer. The Year in Evolutionary Biology 2009: Ann. N.Y. Acad. Sci. 1168: 23–51 (2009).
Au DH, Castro M, and Krishnan JA. Selection of Controls in Clinical Trials, Introduction and Conference Summary. Proceedings of The American Thoracic Society Vol 4 2007
Bai ZG, Zhang ZT. A systematic review and meta-analysis on the effect of angiogenesis blockade for the treatment of gastric cancer. Onco Targets Ther. 2018 Oct 17;11:7077-7087.
Bailon-Moscoso N, Cevallos-Solorzano G, Romero-Benavides JC, and Orellana MIR. Natural Compounds as Modulators of Cell Cycle Arrest: Application for Anticancer Chemotherapies. Current Genomics, 2017, 18, 106-131
Booth FW, Roberts CK, Laye MJ. Lack of exercise is a major cause of chronic diseases. Compr Physiol. 2012;2:1143–1211.
Brigden ML. Unproven (questionable) cancer therapies. West J Med. 1995 Nov; 163(5): 463–469. Brücher B, Jamall IS. Somatic Mutation Theory - Why it’s Wrong for Most Cancers. Cell Physiol Biochem 2016;38:1663-1680
Carlsson S, Andersson T, Lichtenstein P, Michaelsson K, Ahlbom A. Physical activity and mortality: is the association explained by genetic selection? Am J Epidemiol. 2007; 166:255–259. Chang SC, Liu KH, Hung CY et al. Adjuvant Chemotherapy Improves Survival in Stage III Gastric Cancer after D2 Surgery. Journal of Cancer 2018; 9(1): 81-91.
Chen CP, Weinberg VK, Jahan TM, Jablons DM, and Yom SS. Implications of Delayed Initiation of Radiotherapy Accelerated Repopulation after Induction Chemotherapy for Stage III Non-small Cell Lung Cancer. Journal of Thoracic Oncology Volume 6, Number 11, November 2011.
Cheng L, Swartz MD, Zhao H, Kapadia AS, Lai D, Rowan PJ, Buchholz TA, Giordano SH. Hazard of recurrence among women after primary breast cancer treatment—A 10-year follow-up using data from SEER-medicare. Cancer Epidemiol. Biomarkers Prev. 21, 800–809 (2012).
Colleoni M, Sun Z, Price KN, Karlsson, Forbes JF, Thürlimann B, Gianni L, Castiglione M, Gelber RD, Coates AS, Goldhirsch A. Annual hazard rates of recurrence for breast cancer during 24 years of follow-up: Results from the international breast cancer study group trials I to V. J. Clin. Oncol. 34, 927–935 (2016).
Cormie P, Zopf EM, Zhang X, Schmitz KH. The Impact of Exercise on Cancer Mortality, Recurrence, and Treatment-Related Adverse Effects. Epidemiologic Reviews, Volume 39, Issue 1, January 2017, Pages 71–92
Davis C, Naci H, Gurpinar E, Poplavska E, Pinto A, Aggarwal A, Availability of evidence of benefits on overall survival and quality of life of cancer drugs approved by European Medicines Agency: retrospective cohort study of drug approvals 2009-13, BMJ 2017;359:j4530.
Demicheli R, Retsky MW, W. Hrushesky JM, Baum M. Tumor dormancy and surgery-driven interruption of dormancy in breast cancer: Learning from failures. Nat. Clin. Pract. Oncol. 2007; 4,699–710.
DeVita VT Jr, Chu E. A history of cancer chemotherapy. Cancer Res. 2008 Nov 1;68(21):8643-53.
Des Guetz G, Uzzan B, Bouillet T, et al. Impact of physical activity on cancer-specific and overall survival of patients with colorectal cancer. Gastroenterol Res Pract. 2013;2013: 340851.
Donaldson MS. Nutrition and cancer: A review of the evidence for an anti-cancer diet. Nutr J. 2004; 3: 19.
Dos Santos MA, Pignon JP, Blanchard P, Lefeuvre D, Levy A, Touat M, Louvel G, Dhermain F, Soria JC, Deutsch E, Le Teuff G. Systematic review and meta-analysis of phase I*II targeted therapy combined with radiotherapy in patients with glioblastoma multiforme: quality of report, toxicity, and survival. J Neurooncol. 2015 Jun;123(2):307-14. doi: 10.1007*s11060-015-1802-5.
Draisma G, Etzioni R, Tsodikov A, Mariotto A, Wever E, Gulati R, Feuer E, de Koning H. Lead time and overdiagnosis in prostate-specific antigen screening: importance of methods and context. Journal of the National Cancer Institute. 2009; 101:374–83.
Drewinko B, Alexanian R, Boyer H, Barlogie B, Rubinow SI. The growth fraction of human myeloma cells. Blood. 1981 Feb;57(2):333-8.
Friedenreich CM, Neilson HK, Farris MS, et al. Physical activity and cancer outcomes: a precision medicine approach. Clin Cancer Res. 2016;22(19):4766–4775.
Gee AW, Balogh E, Patlak M, Nass SJ (reportors), The Drug Development Paradigm in Oncology: Proceedings of a Workshop. National Academies of Sciences; National Cancer Policy Forum. Washington (DC): National Academies Press (US); 2017 Jul 24.
Gimbrone MA, Jr, Leapman SB, Cotran RS, Folkman J. Tumor dormancy in vivo by prevention of neovascularization. J Exp Med. 1972;136(2):261–276.
Greaves M, Maley CC. Clonal evolution in cancer. Nature. 2012;481(7381):306–13. Grosso G, Bella F, Godos J, Sciacca S, Del Rio D, Ray S, Galvano F, Giovannucci EL. Possible role of diet in cancer: systematic review and multiple meta-analyses of dietary patterns, lifestyle factors, and cancer risk. Nutrition Reviews, 2017; 75 (6):405–419.
Hanahan & Weinberg. The Hallmarks of Cancer. Cell, Vol. 100, 57–70, January 7, 2000.
Harv Letter. A second look at beta blockers and blood pressure. A beta blocker alone isn't usually the best choice for simple, uncomplicated high blood pressure. Harv Heart Lett. 2008 Jun;18(10):4-5.
Holmes MD, Chen WY, Feskanich D, et al. Physical activity and survival after breast cancer diagnosis. JAMA. 2005;293(20):2479–2486.
Hochberg, ME & Noble RJ. A framework for how environment contributes to cancer risk. Ecology Letters (2017) 20, 117–134.
Hoffman KE, Niu J, Shen Y, Jiang J, Davis JW, Kim J, Kuban DA, Perkins GH, Shah JB, Smith GL, Volk RJ, Buchholz TA, et al. Physician Variation in Management of Low-Risk Prostate Cancer: A Population-Based Cohort Study. JAMA Intern Med. 2014
Housman G., Byler S., Heerboth S.h, Lapinska K, Longacre M., Snyder N. and Sarkar S., Drug Resistance in Cancer: An Overview. Cancers 2014, 6, 1769-1792; doi:10.3390*cancers6031769
Ibrahim EM, Al-Homaidh A. Physical activity and survival after breast cancer diagnosis: meta-analysis of published studies. Med Oncol. 2011;28(3):753–765.
Jahn J.L., Giovannucci E.L., Stampfer M.J. The high prevalence of undiagnosed prostate cancer at autopsy: Implications for epidemiology and treatment of prostate cancer in the prostate-specific antigen-era. Int. J. Cancer. 2015;137:2795–2802. doi: 10.1002*ijc.29408.
Je Y, Jeon JY, Giovannucci EL, et al. Association between physical activity and mortality in colorectal cancer: a meta-analysis of prospective cohort studies. Int J Cancer. 2013; 133(8):1905–1913. Jones S, et al. (2008) Comparative lesion sequencing provides insights into tumor evolution. Proc Natl Acad Sci USA 105:4283– 4288.
Krall JA, Ferenc R, Mercury OA, Pattabiraman DR, Brooks MW, Dougan M, Lambert AW, Bierie B, Ploegh HL, Dougan SK, Weinberg RA. The systemic response to surgery triggers the outgrowth of distant immune-controlled tumors in mouse models of dormancy. Sci. Transl. Med. 10, eaan3464 (2018).
Lahart IM, Metsios GS, Nevill AM, et al. Physical activity, risk of death and recurrence in breast cancer survivors: a systematic review and meta-analysis of epidemiological studies. Acta Oncol. 2015;54(5):635–654. Lange MM, Rutten HJ, van de Velde CJ. One hundred years of curative surgery for rectal cancer: 1908-2008. Eur J Surg Oncol. 2009 May;35(5):456-63.
Legumes C.R. lemons and streptomycin: A short history of the clinical trial. CMAJ. 2009;180:23–24. Levine EM & Robins EB. Differential temperature sensitivity of normal and cancer cells in culture. Journal of Cellular Physiology. 1970;76(3):373 – 379·
Li T, Wei S, Shi Y, et al. The dose-response effect of physical activity on cancer mortality: findings from 71 prospective cohort studies. Br J Sports Med. 2016;50(6):339–345.
Li Y, Zhou Y, Hong Y, He M, Wei S, Yang C, Zheng D and Liu F. The Efficacy of Different Chemotherapy Regimens for Advanced Biliary Tract Cancer: A Systematic Review and Network Meta-Analysis. Frontiers in Oncology. May 2019,Volume 9,Article 441.
Lutgendorf SK, Sood AK, Anderson B, et al. Social support, psychological distress, and natural killer cell activity in ovarian cancer. Journal of Clinical Oncology 2005;23(28):7105-7113.
Lutgendorf SK, DeGeest K, Dahmoush L, et al. Social isolation is associated with elevated tumor norepinephrine in ovarian carcinoma patients. Brain, Behavior, and Immunity 2011;25(2):250-255.
Mackillop WJ, Stewart WE, Ginsburg AD, Stewart SS. Cancer patients’ perceptions of their disease and its treatment. Br J Cancer. 1988;58:355-358.
Maeda H and Khatami M. Analyses of repeated failures in cancer therapy for solid tumors: poor tumor-selective drug delivery, low therapeutic efficacy and unsustainable costs, Clin Transl Med. 2018; 7: 11.
Mathews JD, Forsythe AV, Brady Z, et al. Cancer risk in 680000 people exposed to computed tomography scans in childhood or adolescence: data linkage study of 11 million Australians. BMJ 2013;346:f2360 doi: 10.1136*bmj.f2360 (Published 22 May 2013)
Mehrara E, Forssell-Aronsson E, Ahlman H, and Bernhardt P. Specific Growth Rate versus Doubling Time for Quantitative Characterization of Tumor Growth Rate. Cancer Res 2007; 67: (8). April 15, 2007
Meyerhardt JA, Heseltine D, Niedzwiecki D, et al. Impact of physical activity on cancer recurrence and survival in patients with stage III colon cancer: findings from CALGB 89803. J Clin Oncol. 2006;24(22):3535–3541. Millimouno FM, Dong J, Yang L, Li J, and Li X. Targeting Apoptosis Pathways in Cancer and Perspectives with Natural Compounds from Mother Nature. Cancer Prev Res; 2014; 7(11); 1081–107.
Moreno-Smith M, Lutgendorf SK, Sood AK. Impact of stress on cancer metastasis. Future Oncology 2010;6(12):1863-1881. doi: 10.2217*fon.10.142
Morgan G, Ward R & Barton M. The contribution of cytotoxic chemotherapy to 5-year survival in adult malignancies. Clin. Oncol. (R. Coll. Radiol.) 16, 549–560 (2004).
Na Z, Qiao X, Hao X, Fan L, Xiao Y, Shao Y, et. al. The effects of beta-blocker use on cancer prognosis: a meta-analysis based on 319,006 patients. OncoTargets and Therapy 2018:11 4913–4944.
Naumov GN, Akslen LA, Folkman J. Role of angiogenesis in human tumor dormancy: animal models of the angiogenic switch. Cell Cycle. 2006;5(16):1779–87.
Navarro SL, Kantor ED, Song X, Milne GL, Lampe JW, Kratz M, White E. Factors associated with multiple biomarkers of systemic inflammation. Cancer Epidemiology Biomarkers and Prevention. 2016;25(3), 521 10.1158*1055-9965.EPI-15-0956
Nowell, P. C. (1976). "The clonal evolution of tumor cell populations". Science. 194 (4260): 23–28. doi:10.1126*science.959840. PMID 959840.
O'Keefe JH, Vogel R, Lavie CJ, Cordain L. Achieving Hunter-gatherer Fitness in the 21(st) Century: Back to the Future. Am J Med. 2010; 123:1082–1086.
Otto SJ, Korfage IJ, Polinder S, et al. Association of change in physical activity and body weight with quality of life and mortality in colorectal cancer: a systematic review and meta-analysis. Support Care Cancer. 2015;23(5):1237–1250.
Richman EL, Kenfield SA, Stampfer MJ, et al. Physical activity after diagnosis and risk of prostate cancer progression: data from the cancer of the prostate strategic urologic research endeavor. Cancer Res. 2011;71(11): 3889–3895.
Sagar S.M., Yance D., and Wong R.K. Natural health products that inhibit angiogenesis: a potential source for investigational new agents to treat cancer—Part 1, CURRENT ONCOLOGY — VOLUME 13, NUMBER 1.
Schmid D, Leitzmann MF. Association between physical activity and mortality among breast cancer and colorectal cancer survivors: a systematic review and meta-analysis. Ann Oncol. 2014;25(7):1293–1311.
Segerstrom SC, Miller GE. Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry. Psychological Bulletin 2004;130(4):601-630.
Sloan EK, Priceman SJ, Cox BF, et al. The sympathetic nervous system induces a metastatic switch in primary breast cancer. Cancer Research 2010;70(18):7042-7052.
Solinas G, Marchesi F, Garlanda C, Mantovani A, Allavena P. Inflammation-mediated promotion of invasion and metastasis. Cancer Metastasis Rev. 2010;29:243–248.
Sparano JA, Gray RJ, Makower DF, Pritchard KI, Albain KS, Hayes DF, et al. Adjuvant chemotherapy guided by a 21-gene expression assay in breast cancer. N Engl J Med 2018;379(2):111–121. 10.1056*NEJMoa1804710
Stemmermann GN. Unsuspected cancer in elderly Hawaiian Japanese: an autopsy study. Hum Pathol. 1982 Nov;13(11):1039–1044.
Sternfeld B, Weltzien E, Quesenberry CP Jr, et al. Physical activity and risk of recurrence and mortality in breast cancer survivors: findings from the LACE Study. Cancer Epidemiol Biomarkers Prev. 2009;18(1):87–95. Stratton MR. Exploring the genomes of cancer cells: progress and promise. Science. 2011;331:1553–1558. doi: 10.1126*science.1204040.
Su J, Cai M, Li W, Hou B, He H, Ling C, Huang T, Liu H, Guo Y. Molecularly Targeted Drugs Plus Radiotherapy and Temozolomide Treatment for Newly Diagnosed Glioblastoma: A Meta-Analysis and Systematic Review. Oncol Res. 2016;24(2):117-28.
Tipton CM. The history of “Exercise Is Medicine” in ancient civilizations. Adv Physiol Educ. 2014;38(2):109–117. Tohme S, Simmons RL, Tsung A. Surgery for Cancer: a trigger for metastases. Cancer Res. 2017;77:1548–1552. doi: 10.1158*0008-5472.CAN-16-1536.
Tournigand C, André T, Achille E, et al., FOLFIRI Followed by FOLFOX6 or the Reverse Sequence in Advanced Colorectal Cancer: A Randomized GERCOR Study. J Clin Oncol (2004) 22:229-237.
Twyman RA. A brief history of clinical trials. The Human Genome. 2004. Sep, ....*doc_WTD020948.file. Accessed on Oct 2009.
Tubiana M. Repopulation in human tumors. A biological background for fractionation in radiotherapy. Acta Oncol 1988; 27: 83-8.
Tubiana M. Tumor Cell Proliferation Kinetics and Tumor Growth Rate, Acta Oncologica, 1989;28:1, 113-121, DOI: 10.3109*02841868909111193
Verkooijen HM, Fioretta GM, Rapiti E, Bonnefoi H, Vlastos G, Kurtz J, Schaefer P, Sappino A, Schubert H. and Bouchardy C. Patients’ Refusal of Surgery Strongly Impairs Breast Cancer Survival. Ann Surg 2005;242: 276 –280. Wang TL, et al. (2002) Prevalence of somatic alterations in the colorectal cancer cell genome. Proc Natl Acad Sci USA 99:3076 –3080.
Welch HG, Black WC. Overdiagnosis in cancer. J Natl Cancer Inst. 2010 May 5;102(9):605-13. doi: 10.1093*jnci*djq099.
Adjuvant Chemotherapy Guided by a 21-Gene Expression Assay in Breast Cancer, Engl J Med 2018; 379:111-121
Afsar T, Trembley J.H., Salomon C.E., Razak S., Khan, M. R. & Ahmed K. Growth inhibition and apoptosis in cancer cells induced by polyphenolic compounds of Acacia hydaspica: Involvement of multiple signal transduction pathways. Scientific Reports 2016 6:23077
Albero A, Lopéz JE, Torres A, de la Cruz L, Martín T., Effectiveness of chemotherapy in advanced differentiated thyroid cancer: a systematic review. Endocr Relat Cancer. 2016 Feb;23(2):R71-84. doi: 10.1530*ERC-15-0194.
Alder K (2006). Kramer LS, Maza SC (eds.). A Companion to Western Historical Thought. The History of Science, Or, an Oxymoronic Theory of Relativistic Objectivity. Blackwell Companions to History. Wiley-Blackwell. p. 307. ISBN 978-1-4051-4961-7. Retrieved 2012-02-11. "Shortly after the start of the Cold War [...] double-blind reviews became the norm for conducting scientific medical research, as well as the means by which peers evaluated scholarship, both in science and in history."
Amunts K, Kedo O, Kindler M, Pieperhoff P, Mohlberg H, Shah NJ, Habel U, Schneider F, Zilles K (December 2005). "Cytoarchitectonic mapping of the human amygdala, hippocampal region and entorhinal cortex: intersubject variability and probability maps". Anatomy and Embryology. 210 (5–6): 343–52.
Ashdown M.L., Robinson A.P., Yatomi-Clarke S.L., Ashdown M. L., Allison A., Abbott D., Markovic S.N., and Coventry B.J., Chemotherapy for Late-Stage Cancer Patients: Meta-Analysis of Complete Response Rates, Version 1. F1000Res. 2015; 4: 232.
Aung T. N., Qu, Z., Kortschak R.D. and Adelson, D.L. Understanding the Effectiveness of Natural Compound Mixtures in Cancer through Their Molecular Mode of Action, Int. J. Mol. Sci. 2017, 18, 656.
Bailon-Moscoso N, Cevallos-Solorzano G., Romero-Benavides J. C. and Orellana M. I. R., Natural Compounds as Modulators of Cell Cycle Arrest: Application for Anticancer Chemotherapies. Current Genomics, 2017, 18, 106-131 Bailon-Moscoso N, Cevallos-Solorzano G, Romero-Benavides J.C., Orellana MI. Curr Genomics. Natural Compounds as Modulators of Cell Cycle Arrest: Application for Anticancer Chemotherapies. 2017 Apr; 18(2):106-131.
Ben Best (2004). "The Amygdala and the Emotions". Archived from the original on 9 March 2007. Retrieved 15 March 2007.
Brower V., Mind-body research moves towards the mainstream. EMBO Rep. 2006 Apr;7(4):358-61.
Brydon L, Magid K, Steptoe A Platelets, coronary heart disease, and stress. Brain Behav Immun (2006) 20: 113–119. Buijs RM, Scheer FA, Kreier F, Yi C, Bos N, Goncharuk VD, Kalsbeek A. Organization of circadian functions: interaction with the body. Prog Brain Res. 2006;153:341-60.
Campbell, SK. Flaws and Fallacies in Statistical Thinking. Prentice-Hall Inc, 1974.
Claire C. Conley, Brenden T. Bishop, and Barbara L. Andersen, Emotions and Emotion Regulation in Breast Cancer Survivorship, Healthcare (Basel). 2016 Sep; 4(3): 56.
Cross James, Emotional expression in cancer onset and progression, Soc. Sci. Med. Vol. 28. No. 12 pp. 1239-1248, 1989.
David C. Wraith, Lindsay B. Nicholson. The adaptive immune system in diseases of the central nervous system. J Clin Invest. 2012;122(4):1172-1179.
Davis C, Naci H, Gurpinar E, Poplavska E, Pinto A, Aggarwal A, Availability of evidence of benefits on overall survival and quality of life of cancer drugs approved by European Medicines Agency: retrospective cohort study of drug approvals 2009-13, BMJ 2017;359:j4530.
Gore SM, Jones IG, Rytter EC. Misuse of statistical methods: critical assessment of articles in BMJ from January to March 1976. Br Med J 1977;1:85-7. 10.1136*bmj.1.6053.85.
Hanahan & Weinberg, The Hallmarks of Cancer. Cell, Vol. 100, 57–70, January 7, 2000.
Limanaqi F, Biagioni F, Gaglione A, Busceti CL and Fornai F. A Sentinel in the Crosstalk Between the Nervous and Immune System: The (Immuno)-Proteasome. March 2019, Volume 10, Article 628.
Greenland S, Senn SJ., Rothman KJ., Carlin JB, Poole C, Goodman SN., Altman DG. Statistical tests, P values, confidence intervals, and power: a guide to misinterpretations. Eur J Epidemiol (2016) 31:337–350 DOI 10.1007*s10654-016-0149-3.
Hall JC, Hill D, Watts JM. Misuse of statistical methods in the Australasian surgical literature. Aust N Z J Surg 1982;52:541-3.
Han C, Rice MW, and Cai D. Neuroinflammatory and autonomic mechanisms in diabetes and hypertension. Am J Physiol Endocrinol Metab. 2016 Jul 1; 311(1): E32–E41.
Jones S, et al. (2008) Comparative lesion sequencing provides insights into tumor evolution. Proc Natl Acad Sci USA 105:4283– 4288.
Lutgendorf SK, Sood AK, Anderson B, et al. Social support, psychological distress, and natural killer cell activity in ovarian cancer. Journal of Clinical Oncology 2005;23(28):7105-7113.
Lutgendorf SK, Sood AK, Antoni MH. Host factors and cancer progression: biobehavioral signaling pathways and interventions. Journal of Clinical Oncology 2010;28(26):4094-4099.
Lutgendorf SK, DeGeest K, Dahmoush L, et al. Social isolation is associated with elevated tumor norepinephrine in ovarian carcinoma patients. Brain, Behavior, and Immunity 2011;25(2):250-255.
Kiecolt-Glaser JK, Marucha PT, Malarkey WB, Mercado AM, Glaser R (1995) Slowing of wound healing by psychological stress. Lancet 346: 1194–1196.
Kiecolt-Glaser JK, Preacher KJ, MacCallum RC, Atkinson C, Malarkey WB, Glaser R (2003). Chronic stress and age-related increases in the proinflammatory cytokine IL-6. Proc Natl Acad Sci USA 100: 9090–9095.
Kim JS, Kim DK, Hong SJ. Assessment of errors and misused statistics in dental research. Int Dent J 2011;61:163-7. 10.1111*j.1875-595X.2011.00037.x.
Koch R. "Robert Koch (1843-1910)". www.sciencemuseum.org.uk. Archived from the original on 25 January 2016. Retrieved 15 January 2019.
Levine EM & Robins EB, Differential temperature sensitivity of normal and cancer cells in culture. Journal of Cellular Physiology (1970) 76(3):373 – 379·
Maeda H and Khatami M, Analyses of repeated failures in cancer therapy for solid tumors: poor tumor-selective drug delivery, low therapeutic efficacy and unsustainable costs, Clin Transl Med. 2018; 7: 11.
Madsen MV, Gøtzsche PC, and Hróbjartsson A, Acupuncture treatment for pain: systematic review of randomised clinical trials with acupuncture, placebo acupuncture, and no acupuncture groups. BMJ. 2009; 338: a3115.
Manheimer E., Wieland S., Kimbrough E., Cheng K, and Berman B.M. Evidence from the Cochrane Collaboration for Traditional Chinese Medicine Therapies. Journal of Alternative and Complementary Medicine. J Altern Complement Med. 2009 Sep; 15(9): 1001–1014.
Moreno-Smith M, Lutgendorf SK, Sood AK. Impact of stress on cancer metastasis. Future Oncology 2010;6(12):1863-1881.
Nemeroff CB, Musselman DL, Evans DL, Depression and cardiac disease. Depress Anxiety 8 (Suppl 1): (1998) 71–79. Nowell, P. C. (1976). "The clonal evolution of tumor cell populations". Science. 194 (4260): 23–28. doi:10.1126*science.959840. PMID 959840.
Poulose SM, Miller MG, Scott T, and Shukitt-Hale B. Nutritional Factors Affecting Adult Neurogenesis and Cognitive Function. Adv Nutr 2017;8:804–11
Rivers WH, Webber HN (August 1907). "The action of caffeine on the capacity for muscular work". The Journal of Physiology. 36 (1): 33–47. doi:10.1113*jphysiol.1907.sp001215. PMC 1533733. PMID 16992882.
Noy R and Pollard JW, Tumor-associated macrophages: from mechanisms to therapy. Immunity. 2014 July 17; 41(1): 49–61. doi:10.1016*j.immuni.2014.06.010.
Safarzadeh E., Shotorbani S.S., BaradaranHerbal B. Medicine as Inducers of Apoptosis in Cancer Treatment. Advanced Pharmaceutical Bulletin, 2014, 4(Suppl 1), 421-427
Sagar S.M., Yance D., and Wong R.K. Natural health products that inhibit angiogenesis: a potential source for investigational new agents to treat cancer—Part 1, CURRENT ONCOLOGY — VOLUME 13, NUMBER 1.
Segerstrom SC, Miller GE. Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry. Psychological Bulletin 2004;130(4):601-630.
Sloan EK, Capitanio JP, Tarara RP, Mendoza SP, Mason WA, Cole SW. Social stress enhances sympathetic innervation of primate lymph nodes: mechanisms and implications for viral pathogenesis. J Neurosci 2007;27:8857–65.
Sloan EK, Priceman SJ, Cox BF, et al. The sympathetic nervous system induces a metastatic switch in primary breast cancer. Cancer Research 2010;70(18):7042-7052.
Strasak AM, Zaman Q, Pfeiffer KP, Göbel G, Ulmer H. Statistical errors in medical research – a review of common pitfalls, SWIS SMED WKLY 2007; 137:44–49.
Sundquist J, Li X, Johansson SE, Sundquist K. Depression as a predictor of hospitalization due to coronary heart disease. Am J Prev Med (2005) 29: 428–433.
Tedla F.M., Brar A., Browne R., and Brown C., Hypertension in Chronic Kidney Disease: Navigating the Evidence, International Journal of Hypertension. Volume 2011, Article ID 132405, 9 pages.
Wang TL, et al. (2002) Prevalence of somatic alterations in the colorectal cancer cell genome. Proc Natl Acad Sci USA 99:3076 –3080.
White SJ. Statistical errors in papers in the British Journal of Psychiatry. Br J Psychiatry 1979;135:336-42. 10.1192*bjp.135.4.336
Wójcikowski J, Daniel WA. The role of the nervous system in the regulation of liver cytochrome p450. Curr Drug Metab. 2011 Feb;12(2):124-38.
Wood LD, et al. (2007) The genomic landscapes of human breast and colorectal cancers. Science 318:1108 –1113. Yeung PK, Wong JT. Inhibition of cell proliferation by mechanical agitation involves transient cell cycle arrest at G1 phase in dinoflagellates. Protoplasma. 2003 Mar;220(3-4):173-8.
Albero A, Lopéz JE, Torres A, de la Cruz L, Martín T. Effectiveness of chemotherapy in advanced differentiated thyroid cancer: a systematic review. Endocr Relat Cancer. 2016 Feb;23(2):R71-84. doi: 10.1530*ERC-15-0194.
Albo D, Akay CL, Marshall CL, Wilks JA, Verstovsek G, Liu H, Agarwal N, Berger DH, Ayala GE. Neurogenesis in colorectal cancer is a marker of aggressive tumor behavior and poor outcomes. Cancer. 2011;117:4834–4845.
Aras S and Zaidi MR, TAMeless traitors: macrophages in cancer progression and metastasis. British Journal of Cancer. (2017) 117, 1583–1591 doi: 10.1038*bjc.2017.356
Artico M, Bosco S, Cavallotti C, Agostinelli E, Giuliani-Piccari G, Sciorio S, Cocco L, Vitale M. Noradrenergic and cholinergic innervation of the bone marrow. Int J Mol Med. 2002;10:77–80.
Ashdown ML, Robinson AP, Yatomi-Clarke SL, Ashdown ML, Allison A, Abbott D, Markovic SN, and Coventry BJ, Chemotherapy for Late-Stage Cancer Patients: Meta-Analysis of Complete Response Rates, Version 1. F1000Res. 2015; 4:232.
Ayala GE, Dai H, Powell M, Li R, Ding Y, Wheeler TM, Shine D, Kadmon D, Thompson T, Miles BJ, Ittmann MM, Rowley D. Cancer-related axonogenesis and neurogenesis in prostate cancer. Clin Cancer Res. 2008;14:7593–7603.
Benestad HB, Strom-Gundersen I, Iversen PO, Haug E, Nja A. No neuronal regulation of murine bone marrow function. Blood. 1998;91:1280–1287.
Bernards R, Weinberg RA (2002) A progression puzzle. Nature 418:823.
Brydon L, Magid K, Steptoe A. Platelets, coronary heart disease, and stress. Brain Behav Immun (2006) 20: 113–119. Booth FW, Roberts CK, Laye MJ. Lack of exercise is a major cause of chronic diseases. Compr Physiol. 2012;2:1143–1211.
Buijs RM, Scheer FA, Kreier F, Yi C, Bos N, Goncharuk VD, Kalsbeek A. Organization of circadian functions: interaction with the body. Prog Brain Res. 2006;153:341-60.
Calorini L, Bianchini F. Environmental control of invasiveness and metastatic dissemination of tumor cells: the role of tumor cell-host cell interactions. Cell Commun Signal. 2010;8:24.
Canaani J, Kollet O, Lapidot T. Neural regulation of bone, marrow, and the microenvironment. Front Biosci. 2011;3:1021–1031.
Chen CP, Weinberg VK, Jahan TM, Jablons DM, and Yom SS. Implications of Delayed Initiation of Radiotherapy Accelerated Repopulation after Induction Chemotherapy for Stage III Non-small Cell Lung Cancer. Journal of Thoracic Oncology Volume 6, Number 11, November 2011.
Cheng L, Swartz MD, Zhao H, Kapadia AS, Lai D, Rowan PJ, Buchholz TA, Giordano SH. Hazard of recurrence among women after primary breast cancer treatment—A 10-year follow-up using data from SEER-medicare. Cancer Epidemiol. Biomarkers Prev. 21, 800–809 (2012).
Colleoni M, Sun Z, Price KN, Karlsson, Forbes JF, Thürlimann B, Gianni L, Castiglione M, Gelber RD, Coates AS, Goldhirsch A. Annual hazard rates of recurrence for breast cancer during 24 years of follow-up: Results from the international breast cancer study group trials I to V. J. Clin. Oncol. 34, 927–935 (2016).
Cormie P, Zopf EM, Zhang X, Schmitz KH. The Impact of Exercise on Cancer Mortality, Recurrence, and Treatment-Related Adverse Effects. Epidemiologic Reviews, Volume 39, Issue 1, January 2017, Pages 71–92
Cui L, Zhao Y, Pan Y, Zheng, Shao D, Jia Y, He K, Li K, and Chen L. Chemotherapy induces ovarian cancer cell repopulation through the caspase 3-mediated arachidonic acid metabolic pathway. Onco Targets Ther. 2017; 10: 5817–5826.
Davis C, Naci H, Gurpinar E, Poplavska E, Pinto A, Aggarwal A, Availability of evidence of benefits on overall survival and quality of life of cancer drugs approved by European Medicines Agency: retrospective cohort study of drug approvals 2009-13, BMJ 2017;359:j4530.
de Visser KE, Eichten A, Coussens LM. Paradoxical roles of the immune system during cancer development. Nat Rev Cancer. 2006;6:24–37.
DeNardo DG, Johansson M, Coussens LM. Immune cells as mediators of solid tumor metastasis. Cancer Metastasis Rev. 2008;27:11–18.
Dvorak HF. Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med 1986; 315:1650-9.
Dvorak HF. Tumors: wounds that do not heal-redux. Cancer immunology research 2015; 3:1-11.
Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell. 2010;140:883–899.
Han C, Rice MW, and Cai D. Neuroinflammatory and autonomic mechanisms in diabetes and hypertension. Am J Physiol Endocrinol Metab. 2016 Jul 1; 311(1): E32–E41.
Hanahan & Weinberg. The Hallmarks of Cancer. Cell, Vol. 100, 57–70, January 7, 2000.
A second look at beta blockers and blood pressure. A beta blocker alone isn't usually the best choice for simple, uncomplicated high blood pressure. Harv Heart Lett. 2008 Jun;18(10):4-5. Hochberg, ME & Noble RJ. A framework for how environment contributes to cancer risk. Ecology Letters (2017) 20, 117–134.
Housman G., Byler S., Heerboth S.h, Lapinska K, Longacre M., Snyder N. and Sarkar S., Drug Resistance in Cancer: An Overview. Cancers 2014, 6, 1769-1792; doi:10.3390*cancers6031769 Huang YC, Feng ZP. The good and bad of microglia*macrophages: new hope in stroke therapeutics. Acta Pharmacol Sin 2013;34(1): 6–7.
Hüsemann Y, Geigl JB, Schubert F, Musiani P, Meyer M, Burghart E, Forni G, EilsR, Fehm T, Riethmüller G, Klein CA. Systemic spread is an early step in breast cancer. Cancer Cell 2008;13,58–68.
Imai S, Tokunaga Y, Maeda T, Kikkawa M, Hukuda S. Calcitonin gene-related peptide, substance P, and tyrosine hydroxylase-immunoreactive innervation of rat bone marrows: an immunohistochemical and ultrastructural investigation on possible efferent and afferent mechanisms. J Orthop Res. 1997;15:133–140.
Jones S, et al. Comparative lesion sequencing provides insights into tumor evolution. Proc Natl Acad Sci USA 2008;105:4283– 4288.
Karin M, Greten FR. NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol. 2005;5:749–759.
Khasraw M, Posner JB. Neurological complications of systemic cancer. Lancet Neurol. 2010;9:1214–1227. Kiecolt-Glaser JK, Marucha PT, Malarkey WB, Mercado AM, Glaser R (1995) Slowing of wound healing by psychological stress. Lancet 346: 1194–1196.
Kiecolt-Glaser JK, Preacher KJ, MacCallum RC, Atkinson C, Malarkey WB, Glaser R . Chronic stress and age-related increases in the proinflammatory cytokine IL-6. Proc Natl Acad Sci USA 2003;100: 9090–9095.
Kleemeyer MM, Polk TA,Schaefer S, Bodammer NC, Brechtel L, and Lindenberger U. Exercise-Induced Fitness Changes Correlate with Changes in Neural Specificity in Older Adults. Front Hum Neurosci. 2017; 11: 123. Published online 2017 Mar 16. doi: 10.3389*fnhum.2017.00123.
Lin WW, Karin M. A cytokine-mediated link between innate immunity, inflammation, and cancer. J Clin Invest. 2007;117:1175–1183.
Lumen, Boundless Anatomy and Physiology, Control of Muscle Tension, Force of Muscle Contraction. ....*boundless-ap*chapter*control-of-muscle-tension*. Last Accessed July 16, 2019. Lutgendorf SK, Sood AK, Anderson B, et al. Social support, psychological distress, and natural killer cell activity in ovarian cancer. Journal of Clinical Oncology 2005;23(28):7105-7113.
Lutgendorf SK, DeGeest K, Dahmoush L, et al. Social isolation is associated with elevated tumor norepinephrine in ovarian carcinoma patients. Brain, Behavior, and Immunity 2011;25(2):250-255.
Maeda H and Khatami M. Analyses of repeated failures in cancer therapy for solid tumors: poor tumor-selective drug delivery, low therapeutic efficacy and unsustainable costs, Clin Transl Med. 2018; 7: 11.
McDonald PG, Antoni MH, Lutgendorf SK, et al. A biobehavioral perspective of tumor biology. Discovery Medicine 2005;5(30):520-526.
Miyan JA, Broome CS, Whetton AD. Neural regulation of bone marrow. Blood. 1998;92:2971–2973.
Mravec B, Gidron Y, Hulin I. Neurobiology of cancer: Interactions between nervous, endocrine and immune systems as a base for monitoring and modulating the tumorigenesis by the brain. Semin Cancer Biol. 2008;18:150–163.
Moreno-Smith M, Lutgendorf SK, Sood AK. Impact of stress on cancer metastasis. Future Oncology 2010;6(12):1863-1881. doi: 10.2217*fon.10.142
Na Z, Qiao X, Hao X, Fan L, Xiao Y, Shao Y, et. al. The effects of beta-blocker use on cancer prognosis: a meta-analysis based on 319,006 patients. OncoTargets and Therapy 2018:11 4913–4944
Nemeroff CB, Musselman DL, Evans DL Depression and cardiac disease. Depress Anxiety (1998) 8 (Suppl 1): 71–79 Nguyen DX, Bos PD, Massague J. Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer. 2009;9:274–284.
Nowell, P. C. (1976). "The clonal evolution of tumor cell populations". Science. 194 (4260): 23–28. doi:10.1126*science.959840. PMID 959840.
Noy R and Pollard JW. Tumor-associated macrophages: from mechanisms to therapy. Immunity. 2014 July 17; 41(1): 49–61. doi:10.1016*j.immuni.2014.06.010.
Palm D, Entschladen F. Neoneurogenesis and the neuroneoplastic synapse. Prog Exp Tumor Res. 2007;39:91–98.
Phelps EA, LeDoux JE. Contributions of the Amygdala to Emotion Processing: From Animal Models to Human Behavior. Neuron, Vol. 48, 175–187, October 20, 2005. DOI 10.1016*j.neuron.2005.09.025
Salani R, Backes FJ, Fung MF, et al. Posttreatment surveillance and diagnosis of recurrence in women with gynecologic malignancies: Society of Gynecologic Oncologists recommendations. Am J Obstet Gynecol. 2011;204(6):466–478.
Segerstrom SC, Miller GE. Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry. Psychological Bulletin 2004;130(4):601-630.
Sloan EK, Priceman SJ, Cox BF, et al. The sympathetic nervous system induces a metastatic switch in primary breast cancer. Cancer Research 2010;70(18):7042-7052.
Sundquist J, Li X, Johansson SE, Sundquist K. Depression as a predictor of hospitalization due to coronary heart disease. Am J Prev Med (2005); 29: 428–433.
Solinas G, Marchesi F, Garlanda C, Mantovani A, Allavena P. Inflammation-mediated promotion of invasion and metastasis. Cancer Metastasis Rev. 2010;29:243–248.
Tipton CM. The history of “Exercise Is Medicine” in ancient civilizations. Adv Physiol Educ. 2014;38(2):109–117. Toothaker TB, Rubin M. Paraneoplastic neurological syndromes: a review. Neurologist. 2009;15:21–33. Tubiana M. Repopulation in human tumors. A biological background for fractionation in radiotherapy. Acta Oncol 1988; 27: 83-8.
Tubiana M. Tumor Cell Proliferation Kinetics and Tumor Growth Rate, Acta Oncologica, 1989;28:1, 113-121, DOI: 10.3109*02841868909111193
Varner JA. Stem cells and neurogenesis in tumors. Prog Exp Tumor Res. 2007;39:122–129. Verma R, Foster RE, Horgan K, Mounsey K, Nixon H, Natuley S, Hughes TA, Clive RD. Carter. Lymphocyte depletion and repopulation after chemotherapy for primary breast cancer. Breast Cancer Research (2016) 18:10. DOI 10.1186*s13058-015-0669-x
Wang TL, Rago C, Silliman N, Ptak J, Markowitz S, Willson JK, et al. Prevalence of somatic alterations in the colorectal cancer cell genome. Proc Natl Acad Sci USA. (2002) 99:3076–80. 10.1073*pnas.261714699
Willis RA. The Spread of Tumors in the Human Body. 3rd edition. Butterworths; London: 1973. Wójcikowski J, Daniel WA. The role of the nervous system in the regulation of liver cytochrome p450. Curr Drug Metab. 2011 Feb;12(2):124-38.
Wood LD, et al. The genomic landscapes of human breast and colorectal cancers. Science. 2007;318:1108 –1113.
Wraith DC, Nicholson LB. The adaptive immune system in diseases of the central nervous system. J Clin Invest. 2012;122(4):1172-1179.
Wu Y, Zhou BP. Inflammation: a driving force speeds cancer metastasis. Cell Cycle. 2009;8:3267–3273.
Xue J, Schmidt SV, Sander J, Draffehn A, Krebs W, Quester I, De Nardo D, Gohel TD, Emde M, Schmidleithner L, Ganesan H, Nino-Castro AMallmann MR, Labzin L, Theis H, Kraut M, Beyer M, Latz E, Freeman TC, Ulas T, Schultze JL Transcriptome-based network analysis reveals a spectrum model of human macrophage activation. Immunity. 2014; 40(2):274–288.
Yap A, Lopez-Olivo MA, Dubowitz J, Pratt G, Hiller J, Gottumukkala V, Sloan E, Riedel B, Schier R. Br J Anaesth. 2018 Jul; 121(1):45-57. Epub 2018 May 3.
Zanker KS: The neuro-neoplastic synapse: does it exist? Prog Exp Tumor Res 39: 154-161, 2007.
Wikipedia, cancer, ....*wiki*Cancer#History (WC donot take it)
Wood LD, et al. (2007) The genomic landscapes of human breast and colorectal cancers. Science 318:1108 –1113.
Wu W, Guo F, Ye J, et al. Pre- and post-dia*gnosis physical activity is associated with survival benefits of colorectal cancer patients: a systematic review and meta-analysis. Oncotarget. 2016;7(32):52095–52103.
Yap A, Lopez-Olivo MA, Dubowitz J, Pratt G, Hiller J, Gottumukkala V, Sloan E, Riedel B, Schier R. Effect of beta-blockers on cancer recurrence and survival: a meta-analysis of epidemiological and perioperative studies. Br J Anaesth. 2018 Jul; 121(1):45-57. Epub 2018 May 3.
Yeung PK, Wong JT. Inhibition of cell proliferation by mechanical agitation involves transient cell cycle arrest at G1 phase in dinoflagellates. Protoplasma. 2003 Mar;220(3-4):173-8.
Zhong S, Jiang T, Ma T, et al. Association between physical activity and mortality in breast cancer: a meta-analysis of cohort studies. Eur J Epidemiol. 2014;29(6):391–404.
Zondervan RL, Hahn PF, Sadow CA, Liu B, Lee SI. Body CT scanning in young adults: examination indications, patient outcomes, and risk of radiation-induced cancer. Radiology. 2013;267(2):460-9.
Zhou Y, Li C, H-u-i-j-b-r-e-g-t-s MAJ., Mumtaz MM, Carcinogenic Air Toxics Exposure and Their Cancer-Related Health Impacts in the United States. P-L-O-S-O-N-E ****
未来治疗癌症的方法
【前言】 非常感谢读者的关注。我的文章把“部分”医学看作伪医学,当然有大量可信的数据,我把一部分引用文献附在文章后面(其中有些部分的文献重复)。 除“癌症治疗方法的错误可以从以下事实看出:…..”【数量太大,以后只能用数据库】, 每一个观点都有大量的研究数据。很多引用文献是大规模综合研究。如 Cormie et al. 【2017】研究 包含 100 原始研究,而 Booth et al. 【2012】 包含579引用文献。说医学失败的研究不少于数百。 有的研究涉及数万人,跨越几十年的时间。少数的医学研究发现药物“统计学上有效”,但具体看数据,只能延长PFS(无进展生存期)几天到几个月, 而经济代价是 $100,000–$1000,000 (Maeda and Khatami, 2018 )。如果读者看到我下面文章中有重大的错误,请说出具体的错误。但不要用法律框架内的思维,来分析我的结论。 医学失败是由法律框架所造成的。医学的在治疗癌症方面的失败是不争的事实,这是足够让人们思考的理由。 在世界上如果有90%-99%反对我的看法,才是我要写的动力。失败的医学是需要人维护的,这非常正常。如果有读者想看我的英语原文, 我可以给你。
医学的发展显示:医学和法律框架有严重的冲突, 这可以从以下两个相互矛盾的领域看出:
A. 医学两个相互矛盾的领域
一、经典临床治疗领域
手术:发展有两个阶段:130–200 A.D./1700?年到1846年;1846年到至今
化学:1946年至今
放疗:1900 年后到至今
经典临床治疗医学是在法律框架的严格控制下形成的(二元论,还原论,群体方法,一问一答普通法模型, 以及数十个错误的普通法概念)。 手术、化学、放疗(“切毒烧” )治疗模式受到了癌症错误理论的影响。即使最具影响的“力体细胞变异理论”(1914年至今),也无法解释许多生活方式因素对癌症的影响。
二. 致病因素研究领域(1980年至2019,有成千上万的医学研究文章)
受进化理论的影响 ,主要用流行病学等等研究方法,避开二元论的限制, 在法律框架外进行研究,其研究内容包括:
饮食
生活方式
污染, 细胞伤害等
精神情绪、压力和中枢神经系统(研究主要在1980年之后发表)
运动(1990-2000年开始,研究主要在2010后发表)
致病因素研究领域实际上已经拒绝了二元论、还原论,并且与一问一答普通法模型有着巨大的摩擦,但并未明确推翻经典治疗医学模式。医学研究人员无法挑战法律的假定,因此他们只能使用流行病学的名称,例如风险因素,诱发因素,启用因素(饮食,运动等),相关因素等等。 我称它们为“致病有关因素”。这样,就避免了法律框架对他们的制约,因此成了辅助防病医学, 但不能用于临床来治病。 致病有关因素研究依赖于群体研究方法,研究精度有限(我已证明,在很多情况下弱效应负面结论是错误的)。但致病有关因素的研究代表医学的进步,其中很多发现超越古医学,将来很可能成为主流医学。
B. 错误的癌症治疗方法和惨痛代价
上述两个领域有明显的矛盾:所有危险因素,致病因素,相关因素都可以增加患病的机会,但不可以用于治疗疾病。我们在产品标签看到这样的陈述:X可以使前列腺健康,但不能治愈疾病(包括前列腺)。法律将健康与疾病看作两个不相关的概念:健康的前列腺可能患有疾病,但是没有疾病的前列腺可以是不健康的。产品标签可以说,正确的生活方式能促进健康并帮助身体抵抗疾病,然后又声明生活方式不能治病。这种自相矛盾的笑话可以在健康政策、商业资料中比比皆是,习以为常。当人类被迫接受这种荒谬的法律时,文明就处于危险之中。
癌症治疗方法的错误可以从以下事实看出: 如癌症是由重金属引起的,医学不强调去除重金属,而是切除组织或器官;如肝癌是由病毒引起,医学不强调如何对付病毒,而是切除肝脏,毒烧器官和中枢神经;如消化道癌症是由某些微生物的代谢产物引起,医学不强调如何改变饮食来建立健康的肠道菌群,而是割除胃、结肠等,毒烧器官;如癌症是由药物引起的自身免疫性疾病引起,医学不强调如何控制免疫炎症反应,而是进行手术使炎症恶化;如癌症是由免疫系统受损引起的,医学用化疗破坏免疫系统;如癌症是由系统炎症引起的,医学并不强调如何控制和减轻系统炎症,而是切除肿瘤,引起更强的炎症。医学忽视了人类祖先的千年教导:根据患者疾病的原因使用针对病因的治疗方法。
医学早就知道控制癌症的四个关键点:免疫系统、系统炎症、情绪(CNS)、组织生态系统,但医学继续通过手术引起更强系统炎症,使用化疗抑制或破坏免疫系统,使用放射线损伤器官和大脑。在几十年到半个世纪的历史,医学从未做过任何可用于临床纠正癌症原因的研究 [无法引所有文献】。
癌症医学治疗方法的错误,给人类带来巨大惨痛的代价。医学不仅仅治不好癌症,而且因过度治疗大大的缩短生命。许多研究发现,癌症被过度治疗的机率是25%至60% [Welch and Black 2010; Jahn et al. 2015; Hoffman et al. 2014; Draisma et al. 2009] 。有人估计2019年美国将诊断出1,762,450例新癌症病例,606,880例癌症死亡。我估计 (用50%或50/(100+50=33%), 因接受不必要的激进治疗而死亡达200,000人,而癌症幸存者将失去30%的寿命。在中国,每年有4.51百万案,3.04百万死亡 。 我估计,每年中国因接受不必要激进医学治疗死亡人数达1百万人。那些癌症幸存者平均寿命也会减少30% [Cupit-Link et al. 2017]。衰老的标志包括基因组不稳定性,端粒损失,表观遗传改变,线粒体功能障碍,蛋白稳定态的丧失,慢性低度炎症,细胞衰老 [López-Otín et al,2013]。 治疗会给癌症严重伤害的患者增加这些负面影响,应该预料到这些负面影响会导致某些患者在治疗期间加快死亡。 我的缩短某些患者寿命的动力学预测是无可争议的。
C. 癌症治疗渺茫的希望和巨大的障碍
与癌症斗争是每个人的事。癌症是人类进化的一部分,也是人类生长和衰老的一部分。肿瘤发生发展在每个人的一生中都必然存在。到70岁时,大多数人体内都可能有微小的瘤体。到85岁时,每个人都必然有肿瘤。“正常人”与癌症患者之间的区别是瘤体不同的生长速度。医学不可能靠切毒烧,来终止人体细胞进化的过程。
美国癌症研究所(NCI)在2019年9月3日发表一篇文章:“改变饮食可增强小鼠对癌症治疗的反应”,杜克大学Jason Locasale博士说,使用特定饮食变化以增强癌症治疗的概念,“确实处于早期阶段”。 这个癌症研究反映策略的变化,说明癌症研究更有包容性,并且首次使用饮食,作为治疗方法的一部分。 癌症研究所在半个世纪的研究中,才走出第一步。 这个策略变化是非常好的, 但这个极端缓慢的变化意味着几代人已经失去了治愈癌症的机会。
癌症研究的新通动态暗示,医生有一天要开生活方式处方,尽管有人已经提出“生活方式处方“,但是医生还没有开始实施。问题是,开生活方式处方没有人能从中赚钱,医生也无法在15分钟的时间里,写下生活方式处方。开生活方式处方可能需要几天的时间才能开出来。
用生活方式处方治癌会有很多阻力。 NCI可以使用联邦基金作研究,这种研究不会吸引私人研究机构。 如果找到了根治癌症方法,没有人能赚钱,没人会推广治癌症方法。 此外,大多数癌症研究人员会避免这类研究,因为他们无法使用双盲随机研究方法,可能无法发表文章, 如果他们发明一项治癌方案,他们无法申请专利。 目前为止世界上还没有人会做赔钱生意。这种极端缓慢研究癌症的速度,意味治愈癌症的希望很遥远。
对40到60 岁的人,防癌治癌是他们的终身大事,是生活的部分。在将来20 到60 年里,有效的防癌治癌方法对我们几代人非常重要 , 除非改变法律,根治癌症的方法不可能来自医学研究,因为它五十年才迈出第一步, 再五十年才迈出第二步。因此, 每个患者必须自己寻找防癌治癌方法。大多数人在临死前的愿望都是医学有治。如想给病人实现这个愿望,需要大家的努力。 不要指望法律会自己变。
D. 自助的治癌方案
解决癌症问题只能靠自己,人们要拒绝彻底切除肿瘤的想法,彻底切除癌细胞将导致更多的肿瘤以更快的速度生长。切毒烧策略在少数情况下可以用来应对生命紧急情况, 不可以用来控制癌症生长。对具有抗争能力的患者,我建议考虑采用以下策略(根据美国法律,我只能说它能使癌症患者更健康)。
1. 癌症患者的真正问题是肿瘤生长太快。正确的策略是制定抗癌计划,减慢其生长速度。
2. 找到减慢癌症生长速度的因素,请查看1980年至今发表的数以万计的医学研究。温度,运动,毒素,心态,饮食,生活习惯,思维习惯,工作习惯,等等都是影响癌症生长的因素。确定所有可能影响患者癌症生长的因素,可以通过检查患者的生活方式和习惯来确定可能致病因素。癌症患者致病因素都是不一样的。
3. 制定抗癌计划:措施计划调节精神情绪,饮食,运动,生活方式等等,这可能涉及数十到数百个因素。必须包括运动锻炼等措施,因为运动锻炼具有广泛、普遍、强大的效果。 但运动锻炼项目对不同的癌症有不同疗效。
4. 癌细胞可以在24小时内完成细胞分裂周期。抗癌计划的措施打造不利癌细胞分裂的组织“生态”,每天抗癌计划的措施效应达到足够的“即时”力度,每天的“时间平均”的力度,和多阶段性效应。
5. 实施计划, 必须每天坚持执行。两天打鱼三天晒网等于白忙一场,是失败的根源。需要漫长的时间,才能治愈癌症, 不要过早停止。
6. 反复评估抗癌计划的效果。 如果癌症继续生长, 加大每日“即时”的力度,每天的“时间平均”的力度,和多阶段性效应,并考虑优化运动锻炼项目和组合,如气功,太极等等。
目前, 无人敢提出完全用生活方式因素治疗癌症, 因为计划调节精神情绪心态,饮食,运动,生活方式的作用太慢。 基于癌细胞生长速度对多种因素的敏感性,我用动力学模拟计算已证明多因素结合使用,可以达到抑制癌细胞生长的效果。对癌细胞生长“即时抑制作用”最强的方法是运动锻炼。这可以从运动能够从大幅度下降的死亡率、复发率估算出来。癌症可以自愈,被抑制,或受到诸多因素控制减慢肿瘤生长的速度(正常死亡后发现)。 有数百个有据可查的成功案例,还有数百万个没有记录的传说案例。 这个方法的特点是,用特殊运动加上多因素方法取代经典临床治疗,把经典临床治疗的方法作为辅助方法。
困难在于上述的第2步,虽然运气是一个因素,但结果取决于个人的智慧,努力和艰苦的奋斗。
避免任何可能引起强烈炎症反应, 或引起持久不良情绪反应的事情、活动、事件等。
不要试图用自己感觉 ,来评估抗癌计划的效果。某人感觉良好的一天,可能是添加数百万个新癌细胞,是最糟糕的一天;但人感到不适的一天,可能是消灭数百万个癌细胞的一天。人的感觉状况与癌细胞长消状况没有关系。不懂动力学和抗癌机制的人,不能用时间点和感觉来判断措施的效果。
不要用民主方法, 来评估抗癌计划的效果和措施的利弊。如果大多数人能看到病情的本质,医学就不会无治。 网友支持可能给病人鼓舞,有利抗癌,是好事。但我必须指出,谁都不会说与法律和医学文化有抵触的建议。 因为,不好的结果概率很高, 朋友,亲人,配偶都不好说实话。“听医生”是最安全的建议。我看到多少没有智慧的人,被民主建议缩短生命,自己还不知道。
不要听取像美国癌症协会和许多法律机构发表意见,它们有法律义务保护经典临床治疗领域,竭力排除与进化论相容治疗方法,并将患者引导走上错误的老路。它们常用伪科学忽悠人, 当我揭露医学问题, 他们只能沉默 - 那是法律问题!
一般人的抗癌计划只能达到10-50%最大效能,但战胜癌症的可能性很大。同样的方法可用于治愈大多数慢性疾病。
最后,我不得不依法律说: “只有割毒烧才能治癌症和其他病; 所有与进化论相容的治疗方法如调心,调食,排毒,运动,舞蹈,气功,冥想,笑笑等等,都不能治疗癌症。上述的未来治疗癌症的方法不能治疗现在的癌症!” 这在2019年的科学时代,真是人间的一个大笑话(看看部分引用研究文章)。也许,每笑一笑能帮助某些人多消灭数十万癌细胞,请多笑笑。
我刚刚收到NIH的回复,稍后再讨论。
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A. REFERENCES
Cupit-Link MC, Kirkland JL, Ness KK, et al. Biology of premature ageing in survivors of cancer. ESMO Open. 2017 December 18.
López-Otín C, Blasco MA, Partridge L, et al. The hallmarks of aging. Cell 2013;153:1194–217.
Ogino S, Fuchs CS, Giovannucci E (2012). "How many molecular subtypes? Implications of the unique tumor principle in personalized medicine". Expert Rev Mol Diagn. 12 (6): 621–8.
Ogino S, Lochhead P, Chan AT, Nishihara R, Cho E, Wolpin BM, Meyerhardt JA, Meissner A, Schernhammer ES, Fuchs CS, Giovannucci E (2013). "Molecular pathological epidemiology of epigenetics: Emerging integrative science to analyze environment, host, and disease". Mod Pathol. 26 (4): 465–84. doi:10.1038/modpathol.2012.214.
按抑制癌细胞的力度从小到大,能吃的7种武器
1. 少吃糖和简单碳水化合物类食物,这样能够减少体内血糖的波动,减少胰岛素分泌,减少胰岛素对癌细胞的促生长作用.
2. 生酮饮食,是1的加强版。
3. 多吃十字花科蔬菜,然后是各种绿色蔬菜,一些含糖少的浆果水果。原因是蔬菜中含有抗癌成分。
4. 各类食品补充剂,它们很多在体外或动物实验抑制癌细胞,但经常是在很大剂量时才有明显效果。服用补充剂是否能达到有效浓度,是否有严重副作用,经常没有可靠的临床试验来作为依据。
5. 一些草药有抗癌作用,但多数没有临床试验支持,剂量和毒性不很明确。
6. 一些不需处方的药物和要处方但并作为治癌的药物有抑制癌细胞的作用。
7. 口服的各种化疗药物。
所谓“制定抗癌计划:措施计划调节精神情绪,饮食,运动,生活方式等等,这可能涉及数十到数百个因素”
若人人持之以恒都能做到,还有那么多病吗? 比如精神情绪,若“心灵鸡汤”管用,哪还会那么多抑郁焦虑症? 面对那些抑郁焦虑症病患们,若不借助医学干预药物治疗,你如何调节,给他们讲大道理心灵鸡汤,还是。。?
你根本不知道癌症是什么
你这一套总结概括一下,就是靠意念改变身体健康。说穿了不过是所谓原罪理论的翻版,也就是说癌症来源于罪恶,赎罪了就获得救赎了。然后把原罪换成一个诱惑人的“生活方式”。
这种欺骗方式,就是利用人性对于未知事物的恐惧心理。
他想说的是只要癌细胞被消灭的速度大于增长速度,癌症就会被消灭,。但他反对手术将癌细胞数量变为零, 他为何反对现在癌症疗法,故意偏执引用文献,目的只能靠观众去猜。
没有具体研究的癌症,也没有具体的研究手段,一个病人也没试过,一个实验也没做过,自己没有产生一个属于自己的数据,就发狂言,真是口袋里的钱多了,想担负责任。。。
B. REFERENCES RELEVANT TO CANCER TREATMENTS
Site addresses are not allowed in the blog, so they are deleted.
ACS Early Theories about Cancer Causes, American Cancer Society. accessed at ...*cancer*cancer-basics*history-of-cancer*cancer-causes-theories-throughout-history.file
Aguirre-Ghiso JA. Models, mechanisms and clinical evidence for cancer dormancy. Nat Rev Cancer. 2007;7:834–846.
Albero A, Lopéz JE, Torres A, de la Cruz L, Martín T. Effectiveness of chemotherapy in advanced differentiated thyroid cancer: a systematic review. Endocr Relat Cancer. 2016 Feb;23(2):R71-84. doi: 10.1530*ERC-15-0194.
Armitage P, Doll R. The age distribution of cancer and a multi-stage theory of carcinogenesis. Br J Cancer. 1954;8(1):1–12.
Armitage P, Doll R. A two-stage theory of carcinogenesis in relation to the age distribution of human cancer. Br J Cancer. 1957;11(2):161–9.
Ashdown ML, Robinson AP, Yatomi-Clarke SL, Ashdown ML, Allison A, Abbott D, Markovic SN, and Coventry BJ, Chemotherapy for Late-Stage Cancer Patients: Meta-Analysis of Complete Response Rates, Version 1. F1000Res. 2015; 4:232.
Attolini CS, Michor F. Evolutionary Theory of Cancer. The Year in Evolutionary Biology 2009: Ann. N.Y. Acad. Sci. 1168: 23–51 (2009).
Au DH, Castro M, and Krishnan JA. Selection of Controls in Clinical Trials, Introduction and Conference Summary. Proceedings of The American Thoracic Society Vol 4 2007
Bai ZG, Zhang ZT. A systematic review and meta-analysis on the effect of angiogenesis blockade for the treatment of gastric cancer. Onco Targets Ther. 2018 Oct 17;11:7077-7087.
Bailon-Moscoso N, Cevallos-Solorzano G, Romero-Benavides JC, and Orellana MIR. Natural Compounds as Modulators of Cell Cycle Arrest: Application for Anticancer Chemotherapies. Current Genomics, 2017, 18, 106-131
Booth FW, Roberts CK, Laye MJ. Lack of exercise is a major cause of chronic diseases. Compr Physiol. 2012;2:1143–1211.
Brigden ML. Unproven (questionable) cancer therapies. West J Med. 1995 Nov; 163(5): 463–469.
Brücher B, Jamall IS. Somatic Mutation Theory - Why it’s Wrong for Most Cancers. Cell Physiol Biochem 2016;38:1663-1680
Carlsson S, Andersson T, Lichtenstein P, Michaelsson K, Ahlbom A. Physical activity and mortality: is the association explained by genetic selection? Am J Epidemiol. 2007; 166:255–259.
Chang SC, Liu KH, Hung CY et al. Adjuvant Chemotherapy Improves Survival in Stage III Gastric Cancer after D2 Surgery. Journal of Cancer 2018; 9(1): 81-91.
Chen CP, Weinberg VK, Jahan TM, Jablons DM, and Yom SS. Implications of Delayed Initiation of Radiotherapy Accelerated Repopulation after Induction Chemotherapy for Stage III Non-small Cell Lung Cancer. Journal of Thoracic Oncology Volume 6, Number 11, November 2011.
Cheng L, Swartz MD, Zhao H, Kapadia AS, Lai D, Rowan PJ, Buchholz TA, Giordano SH. Hazard of recurrence among women after primary breast cancer treatment—A 10-year follow-up using data from SEER-medicare. Cancer Epidemiol. Biomarkers Prev. 21, 800–809 (2012).
Colleoni M, Sun Z, Price KN, Karlsson, Forbes JF, Thürlimann B, Gianni L, Castiglione M, Gelber RD, Coates AS, Goldhirsch A. Annual hazard rates of recurrence for breast cancer during 24 years of follow-up: Results from the international breast cancer study group trials I to V. J. Clin. Oncol. 34, 927–935 (2016).
Cormie P, Zopf EM, Zhang X, Schmitz KH. The Impact of Exercise on Cancer Mortality, Recurrence, and Treatment-Related Adverse Effects. Epidemiologic Reviews, Volume 39, Issue 1, January 2017, Pages 71–92
Davis C, Naci H, Gurpinar E, Poplavska E, Pinto A, Aggarwal A, Availability of evidence of benefits on overall survival and quality of life of cancer drugs approved by European Medicines Agency: retrospective cohort study of drug approvals 2009-13, BMJ 2017;359:j4530.
Demicheli R, Retsky MW, W. Hrushesky JM, Baum M. Tumor dormancy and surgery-driven interruption of dormancy in breast cancer: Learning from failures. Nat. Clin. Pract. Oncol. 2007; 4,699–710.
DeVita VT Jr, Chu E. A history of cancer chemotherapy. Cancer Res. 2008 Nov 1;68(21):8643-53.
Des Guetz G, Uzzan B, Bouillet T, et al. Impact of physical activity on cancer-specific and overall survival of patients with colorectal cancer. Gastroenterol Res Pract. 2013;2013: 340851.
Donaldson MS. Nutrition and cancer: A review of the evidence for an anti-cancer diet. Nutr J. 2004; 3: 19.
Dos Santos MA, Pignon JP, Blanchard P, Lefeuvre D, Levy A, Touat M, Louvel G, Dhermain F, Soria JC, Deutsch E, Le Teuff G. Systematic review and meta-analysis of phase I*II targeted therapy combined with radiotherapy in patients with glioblastoma multiforme: quality of report, toxicity, and survival. J Neurooncol. 2015 Jun;123(2):307-14. doi: 10.1007*s11060-015-1802-5.
Draisma G, Etzioni R, Tsodikov A, Mariotto A, Wever E, Gulati R, Feuer E, de Koning H. Lead time and overdiagnosis in prostate-specific antigen screening: importance of methods and context. Journal of the National Cancer Institute. 2009; 101:374–83.
Drewinko B, Alexanian R, Boyer H, Barlogie B, Rubinow SI. The growth fraction of human myeloma cells. Blood. 1981 Feb;57(2):333-8.
Friedenreich CM, Neilson HK, Farris MS, et al. Physical activity and cancer outcomes: a precision medicine approach. Clin Cancer Res. 2016;22(19):4766–4775.
Gee AW, Balogh E, Patlak M, Nass SJ (reportors), The Drug Development Paradigm in Oncology: Proceedings of a Workshop. National Academies of Sciences; National Cancer Policy Forum. Washington (DC): National Academies Press (US); 2017 Jul 24.
Gimbrone MA, Jr, Leapman SB, Cotran RS, Folkman J. Tumor dormancy in vivo by prevention of neovascularization. J Exp Med. 1972;136(2):261–276.
Greaves M, Maley CC. Clonal evolution in cancer. Nature. 2012;481(7381):306–13.
Grosso G, Bella F, Godos J, Sciacca S, Del Rio D, Ray S, Galvano F, Giovannucci EL. Possible role of diet in cancer: systematic review and multiple meta-analyses of dietary patterns, lifestyle factors, and cancer risk. Nutrition Reviews, 2017; 75 (6):405–419.
Hanahan & Weinberg. The Hallmarks of Cancer. Cell, Vol. 100, 57–70, January 7, 2000.
Harv Letter. A second look at beta blockers and blood pressure. A beta blocker alone isn't usually the best choice for simple, uncomplicated high blood pressure. Harv Heart Lett. 2008 Jun;18(10):4-5.
Holmes MD, Chen WY, Feskanich D, et al. Physical activity and survival after breast cancer diagnosis. JAMA. 2005;293(20):2479–2486.
Hochberg, ME & Noble RJ. A framework for how environment contributes to cancer risk. Ecology Letters (2017) 20, 117–134.
Hoffman KE, Niu J, Shen Y, Jiang J, Davis JW, Kim J, Kuban DA, Perkins GH, Shah JB, Smith GL, Volk RJ, Buchholz TA, et al. Physician Variation in Management of Low-Risk Prostate Cancer: A Population-Based Cohort Study. JAMA Intern Med. 2014
Housman G., Byler S., Heerboth S.h, Lapinska K, Longacre M., Snyder N. and Sarkar S., Drug Resistance in Cancer: An Overview. Cancers 2014, 6, 1769-1792; doi:10.3390*cancers6031769
Ibrahim EM, Al-Homaidh A. Physical activity and survival after breast cancer diagnosis: meta-analysis of published studies. Med Oncol. 2011;28(3):753–765.
Jahn J.L., Giovannucci E.L., Stampfer M.J. The high prevalence of undiagnosed prostate cancer at autopsy: Implications for epidemiology and treatment of prostate cancer in the prostate-specific antigen-era. Int. J. Cancer. 2015;137:2795–2802. doi: 10.1002*ijc.29408.
Je Y, Jeon JY, Giovannucci EL, et al. Association between physical activity and mortality in colorectal cancer: a meta-analysis of prospective cohort studies. Int J Cancer. 2013; 133(8):1905–1913.
Jones S, et al. (2008) Comparative lesion sequencing provides insights into tumor evolution. Proc Natl Acad Sci USA 105:4283– 4288.
Krall JA, Ferenc R, Mercury OA, Pattabiraman DR, Brooks MW, Dougan M, Lambert AW, Bierie B, Ploegh HL, Dougan SK, Weinberg RA. The systemic response to surgery triggers the outgrowth of distant immune-controlled tumors in mouse models of dormancy. Sci. Transl. Med. 10, eaan3464 (2018).
Lahart IM, Metsios GS, Nevill AM, et al. Physical activity, risk of death and recurrence in breast cancer survivors: a systematic review and meta-analysis of epidemiological studies. Acta Oncol. 2015;54(5):635–654.
Lange MM, Rutten HJ, van de Velde CJ. One hundred years of curative surgery for rectal cancer: 1908-2008. Eur J Surg Oncol. 2009 May;35(5):456-63.
Legumes C.R. lemons and streptomycin: A short history of the clinical trial. CMAJ. 2009;180:23–24.
Levine EM & Robins EB. Differential temperature sensitivity of normal and cancer cells in culture. Journal of Cellular Physiology. 1970;76(3):373 – 379·
Li T, Wei S, Shi Y, et al. The dose-response effect of physical activity on cancer mortality: findings from 71 prospective cohort studies. Br J Sports Med. 2016;50(6):339–345.
Li Y, Zhou Y, Hong Y, He M, Wei S, Yang C, Zheng D and Liu F. The Efficacy of Different Chemotherapy Regimens for Advanced Biliary Tract Cancer: A Systematic Review and Network Meta-Analysis. Frontiers in Oncology. May 2019,Volume 9,Article 441.
Lutgendorf SK, Sood AK, Anderson B, et al. Social support, psychological distress, and natural killer cell activity in ovarian cancer. Journal of Clinical Oncology 2005;23(28):7105-7113.
Lutgendorf SK, DeGeest K, Dahmoush L, et al. Social isolation is associated with elevated tumor norepinephrine in ovarian carcinoma patients. Brain, Behavior, and Immunity 2011;25(2):250-255.
Mackillop WJ, Stewart WE, Ginsburg AD, Stewart SS. Cancer patients’ perceptions of their disease and its treatment. Br J Cancer. 1988;58:355-358.
Maeda H and Khatami M. Analyses of repeated failures in cancer therapy for solid tumors: poor tumor-selective drug delivery, low therapeutic efficacy and unsustainable costs, Clin Transl Med. 2018; 7: 11.
Mathews JD, Forsythe AV, Brady Z, et al. Cancer risk in 680000 people exposed to computed tomography scans in childhood or adolescence: data linkage study of 11 million Australians. BMJ 2013;346:f2360 doi: 10.1136*bmj.f2360 (Published 22 May 2013)
Mehrara E, Forssell-Aronsson E, Ahlman H, and Bernhardt P. Specific Growth Rate versus Doubling Time for Quantitative Characterization of Tumor Growth Rate. Cancer Res 2007; 67: (8). April 15, 2007
Meyerhardt JA, Heseltine D, Niedzwiecki D, et al. Impact of physical activity on cancer recurrence and survival in patients with stage III colon cancer: findings from CALGB 89803. J Clin Oncol. 2006;24(22):3535–3541.
Millimouno FM, Dong J, Yang L, Li J, and Li X. Targeting Apoptosis Pathways in Cancer and Perspectives with Natural Compounds from Mother Nature. Cancer Prev Res; 2014; 7(11); 1081–107.
Moreno-Smith M, Lutgendorf SK, Sood AK. Impact of stress on cancer metastasis. Future Oncology 2010;6(12):1863-1881. doi: 10.2217*fon.10.142
Morgan G, Ward R & Barton M. The contribution of cytotoxic chemotherapy to 5-year survival in adult malignancies. Clin. Oncol. (R. Coll. Radiol.) 16, 549–560 (2004).
Na Z, Qiao X, Hao X, Fan L, Xiao Y, Shao Y, et. al. The effects of beta-blocker use on cancer prognosis: a meta-analysis based on 319,006 patients. OncoTargets and Therapy 2018:11 4913–4944.
Naumov GN, Akslen LA, Folkman J. Role of angiogenesis in human tumor dormancy: animal models of the angiogenic switch. Cell Cycle. 2006;5(16):1779–87.
Navarro SL, Kantor ED, Song X, Milne GL, Lampe JW, Kratz M, White E. Factors associated with multiple biomarkers of systemic inflammation. Cancer Epidemiology Biomarkers and Prevention. 2016;25(3), 521 10.1158*1055-9965.EPI-15-0956
Nowell, P. C. (1976). "The clonal evolution of tumor cell populations". Science. 194 (4260): 23–28. doi:10.1126*science.959840. PMID 959840.
O'Keefe JH, Vogel R, Lavie CJ, Cordain L. Achieving Hunter-gatherer Fitness in the 21(st) Century: Back to the Future. Am J Med. 2010; 123:1082–1086.
Otto SJ, Korfage IJ, Polinder S, et al. Association of change in physical activity and body weight with quality of life and mortality in colorectal cancer: a systematic review and meta-analysis. Support Care Cancer. 2015;23(5):1237–1250.
Richman EL, Kenfield SA, Stampfer MJ, et al. Physical activity after diagnosis and risk of prostate cancer progression: data from the cancer of the prostate strategic urologic research endeavor. Cancer Res. 2011;71(11): 3889–3895.
Sagar S.M., Yance D., and Wong R.K. Natural health products that inhibit angiogenesis: a potential source for investigational new agents to treat cancer—Part 1, CURRENT ONCOLOGY — VOLUME 13, NUMBER 1.
Schmid D, Leitzmann MF. Association between physical activity and mortality among breast cancer and colorectal cancer survivors: a systematic review and meta-analysis. Ann Oncol. 2014;25(7):1293–1311.
Segerstrom SC, Miller GE. Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry. Psychological Bulletin 2004;130(4):601-630.
Sloan EK, Priceman SJ, Cox BF, et al. The sympathetic nervous system induces a metastatic switch in primary breast cancer. Cancer Research 2010;70(18):7042-7052.
Solinas G, Marchesi F, Garlanda C, Mantovani A, Allavena P. Inflammation-mediated promotion of invasion and metastasis. Cancer Metastasis Rev. 2010;29:243–248.
Sparano JA, Gray RJ, Makower DF, Pritchard KI, Albain KS, Hayes DF, et al. Adjuvant chemotherapy guided by a 21-gene expression assay in breast cancer. N Engl J Med 2018;379(2):111–121. 10.1056*NEJMoa1804710
Stemmermann GN. Unsuspected cancer in elderly Hawaiian Japanese: an autopsy study. Hum Pathol. 1982 Nov;13(11):1039–1044.
Sternfeld B, Weltzien E, Quesenberry CP Jr, et al. Physical activity and risk of recurrence and mortality in breast cancer survivors: findings from the LACE Study. Cancer Epidemiol Biomarkers Prev. 2009;18(1):87–95.
Stratton MR. Exploring the genomes of cancer cells: progress and promise. Science. 2011;331:1553–1558. doi: 10.1126*science.1204040.
Su J, Cai M, Li W, Hou B, He H, Ling C, Huang T, Liu H, Guo Y. Molecularly Targeted Drugs Plus Radiotherapy and Temozolomide Treatment for Newly Diagnosed Glioblastoma: A Meta-Analysis and Systematic Review. Oncol Res. 2016;24(2):117-28.
Tipton CM. The history of “Exercise Is Medicine” in ancient civilizations. Adv Physiol Educ. 2014;38(2):109–117.
Tohme S, Simmons RL, Tsung A. Surgery for Cancer: a trigger for metastases. Cancer Res. 2017;77:1548–1552. doi: 10.1158*0008-5472.CAN-16-1536.
Tournigand C, André T, Achille E, et al., FOLFIRI Followed by FOLFOX6 or the Reverse Sequence in Advanced Colorectal Cancer: A Randomized GERCOR Study. J Clin Oncol (2004) 22:229-237.
Twyman RA. A brief history of clinical trials. The Human Genome. 2004. Sep, ....*doc_WTD020948.file. Accessed on Oct 2009.
Tubiana M. Repopulation in human tumors. A biological background for fractionation in radiotherapy. Acta Oncol 1988; 27: 83-8.
Tubiana M. Tumor Cell Proliferation Kinetics and Tumor Growth Rate, Acta Oncologica, 1989;28:1, 113-121, DOI: 10.3109*02841868909111193
Verkooijen HM, Fioretta GM, Rapiti E, Bonnefoi H, Vlastos G, Kurtz J, Schaefer P, Sappino A, Schubert H. and Bouchardy C. Patients’ Refusal of Surgery Strongly Impairs Breast Cancer Survival. Ann Surg 2005;242: 276 –280.
Wang TL, et al. (2002) Prevalence of somatic alterations in the colorectal cancer cell genome. Proc Natl Acad Sci USA 99:3076 –3080.
Welch HG, Black WC. Overdiagnosis in cancer. J Natl Cancer Inst. 2010 May 5;102(9):605-13. doi: 10.1093*jnci*djq099.
C. REFERENCES RELEVANT TO MEDICAL MODEL
Adjuvant Chemotherapy Guided by a 21-Gene Expression Assay in Breast Cancer, Engl J Med 2018; 379:111-121
Afsar T, Trembley J.H., Salomon C.E., Razak S., Khan, M. R. & Ahmed K. Growth inhibition and apoptosis in cancer cells induced by polyphenolic compounds of Acacia hydaspica: Involvement of multiple signal transduction pathways. Scientific Reports 2016 6:23077
Albero A, Lopéz JE, Torres A, de la Cruz L, Martín T., Effectiveness of chemotherapy in advanced differentiated thyroid cancer: a systematic review. Endocr Relat Cancer. 2016 Feb;23(2):R71-84. doi: 10.1530*ERC-15-0194.
Alder K (2006). Kramer LS, Maza SC (eds.). A Companion to Western Historical Thought. The History of Science, Or, an Oxymoronic Theory of Relativistic Objectivity. Blackwell Companions to History. Wiley-Blackwell. p. 307. ISBN 978-1-4051-4961-7. Retrieved 2012-02-11. "Shortly after the start of the Cold War [...] double-blind reviews became the norm for conducting scientific medical research, as well as the means by which peers evaluated scholarship, both in science and in history."
Amunts K, Kedo O, Kindler M, Pieperhoff P, Mohlberg H, Shah NJ, Habel U, Schneider F, Zilles K (December 2005). "Cytoarchitectonic mapping of the human amygdala, hippocampal region and entorhinal cortex: intersubject variability and probability maps". Anatomy and Embryology. 210 (5–6): 343–52.
Ashdown M.L., Robinson A.P., Yatomi-Clarke S.L., Ashdown M. L., Allison A., Abbott D., Markovic S.N., and Coventry B.J., Chemotherapy for Late-Stage Cancer Patients: Meta-Analysis of Complete Response Rates, Version 1. F1000Res. 2015; 4: 232.
Aung T. N., Qu, Z., Kortschak R.D. and Adelson, D.L. Understanding the Effectiveness of Natural Compound Mixtures in Cancer through Their Molecular Mode of Action, Int. J. Mol. Sci. 2017, 18, 656.
Bailon-Moscoso N, Cevallos-Solorzano G., Romero-Benavides J. C. and Orellana M. I. R., Natural Compounds as Modulators of Cell Cycle Arrest: Application for Anticancer Chemotherapies. Current Genomics, 2017, 18, 106-131
Bailon-Moscoso N, Cevallos-Solorzano G, Romero-Benavides J.C., Orellana MI. Curr Genomics. Natural Compounds as Modulators of Cell Cycle Arrest: Application for Anticancer Chemotherapies. 2017 Apr; 18(2):106-131.
Ben Best (2004). "The Amygdala and the Emotions". Archived from the original on 9 March 2007. Retrieved 15 March 2007.
Brower V., Mind-body research moves towards the mainstream. EMBO Rep. 2006 Apr;7(4):358-61.
Brydon L, Magid K, Steptoe A Platelets, coronary heart disease, and stress. Brain Behav Immun (2006) 20: 113–119.
Buijs RM, Scheer FA, Kreier F, Yi C, Bos N, Goncharuk VD, Kalsbeek A. Organization of circadian functions: interaction with the body. Prog Brain Res. 2006;153:341-60.
Campbell, SK. Flaws and Fallacies in Statistical Thinking. Prentice-Hall Inc, 1974.
Claire C. Conley, Brenden T. Bishop, and Barbara L. Andersen, Emotions and Emotion Regulation in Breast Cancer Survivorship, Healthcare (Basel). 2016 Sep; 4(3): 56.
Cross James, Emotional expression in cancer onset and progression, Soc. Sci. Med. Vol. 28. No. 12 pp. 1239-1248, 1989.
David C. Wraith, Lindsay B. Nicholson. The adaptive immune system in diseases of the central nervous system. J Clin Invest. 2012;122(4):1172-1179.
Davis C, Naci H, Gurpinar E, Poplavska E, Pinto A, Aggarwal A, Availability of evidence of benefits on overall survival and quality of life of cancer drugs approved by European Medicines Agency: retrospective cohort study of drug approvals 2009-13, BMJ 2017;359:j4530.
Gore SM, Jones IG, Rytter EC. Misuse of statistical methods: critical assessment of articles in BMJ from January to March 1976. Br Med J 1977;1:85-7. 10.1136*bmj.1.6053.85.
Hanahan & Weinberg, The Hallmarks of Cancer. Cell, Vol. 100, 57–70, January 7, 2000.
Limanaqi F, Biagioni F, Gaglione A, Busceti CL and Fornai F. A Sentinel in the Crosstalk Between the Nervous and Immune System: The (Immuno)-Proteasome. March 2019, Volume 10, Article 628.
Greenland S, Senn SJ., Rothman KJ., Carlin JB, Poole C, Goodman SN., Altman DG. Statistical tests, P values, confidence intervals, and power: a guide to misinterpretations. Eur J Epidemiol (2016) 31:337–350 DOI 10.1007*s10654-016-0149-3.
Hall JC, Hill D, Watts JM. Misuse of statistical methods in the Australasian surgical literature. Aust N Z J Surg 1982;52:541-3.
Han C, Rice MW, and Cai D. Neuroinflammatory and autonomic mechanisms in diabetes and hypertension. Am J Physiol Endocrinol Metab. 2016 Jul 1; 311(1): E32–E41.
Jones S, et al. (2008) Comparative lesion sequencing provides insights into tumor evolution. Proc Natl Acad Sci USA 105:4283– 4288.
Lutgendorf SK, Sood AK, Anderson B, et al. Social support, psychological distress, and natural killer cell activity in ovarian cancer. Journal of Clinical Oncology 2005;23(28):7105-7113.
Lutgendorf SK, Sood AK, Antoni MH. Host factors and cancer progression: biobehavioral signaling pathways and interventions. Journal of Clinical Oncology 2010;28(26):4094-4099.
Lutgendorf SK, DeGeest K, Dahmoush L, et al. Social isolation is associated with elevated tumor norepinephrine in ovarian carcinoma patients. Brain, Behavior, and Immunity 2011;25(2):250-255.
Kiecolt-Glaser JK, Marucha PT, Malarkey WB, Mercado AM, Glaser R (1995) Slowing of wound healing by psychological stress. Lancet 346: 1194–1196.
Kiecolt-Glaser JK, Preacher KJ, MacCallum RC, Atkinson C, Malarkey WB, Glaser R (2003). Chronic stress and age-related increases in the proinflammatory cytokine IL-6. Proc Natl Acad Sci USA 100: 9090–9095.
Kim JS, Kim DK, Hong SJ. Assessment of errors and misused statistics in dental research. Int Dent J 2011;61:163-7. 10.1111*j.1875-595X.2011.00037.x.
Koch R. "Robert Koch (1843-1910)". www.sciencemuseum.org.uk. Archived from the original on 25 January 2016. Retrieved 15 January 2019.
Levine EM & Robins EB, Differential temperature sensitivity of normal and cancer cells in culture. Journal of Cellular Physiology (1970) 76(3):373 – 379·
Maeda H and Khatami M, Analyses of repeated failures in cancer therapy for solid tumors: poor tumor-selective drug delivery, low therapeutic efficacy and unsustainable costs, Clin Transl Med. 2018; 7: 11.
Madsen MV, Gøtzsche PC, and Hróbjartsson A, Acupuncture treatment for pain: systematic review of randomised clinical trials with acupuncture, placebo acupuncture, and no acupuncture groups. BMJ. 2009; 338: a3115.
Manheimer E., Wieland S., Kimbrough E., Cheng K, and Berman B.M. Evidence from the Cochrane Collaboration for Traditional Chinese Medicine Therapies. Journal of Alternative and Complementary Medicine. J Altern Complement Med. 2009 Sep; 15(9): 1001–1014.
Moreno-Smith M, Lutgendorf SK, Sood AK. Impact of stress on cancer metastasis. Future Oncology 2010;6(12):1863-1881.
Nemeroff CB, Musselman DL, Evans DL, Depression and cardiac disease. Depress Anxiety 8 (Suppl 1): (1998) 71–79.
Nowell, P. C. (1976). "The clonal evolution of tumor cell populations". Science. 194 (4260): 23–28. doi:10.1126*science.959840. PMID 959840.
Poulose SM, Miller MG, Scott T, and Shukitt-Hale B. Nutritional Factors Affecting Adult Neurogenesis and Cognitive Function. Adv Nutr 2017;8:804–11
Rivers WH, Webber HN (August 1907). "The action of caffeine on the capacity for muscular work". The Journal of Physiology. 36 (1): 33–47. doi:10.1113*jphysiol.1907.sp001215. PMC 1533733. PMID 16992882.
Noy R and Pollard JW, Tumor-associated macrophages: from mechanisms to therapy. Immunity. 2014 July 17; 41(1): 49–61. doi:10.1016*j.immuni.2014.06.010.
Safarzadeh E., Shotorbani S.S., BaradaranHerbal B. Medicine as Inducers of Apoptosis in Cancer Treatment. Advanced Pharmaceutical Bulletin, 2014, 4(Suppl 1), 421-427
Sagar S.M., Yance D., and Wong R.K. Natural health products that inhibit angiogenesis: a potential source for investigational new agents to treat cancer—Part 1, CURRENT ONCOLOGY — VOLUME 13, NUMBER 1.
Segerstrom SC, Miller GE. Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry. Psychological Bulletin 2004;130(4):601-630.
Sloan EK, Capitanio JP, Tarara RP, Mendoza SP, Mason WA, Cole SW. Social stress enhances sympathetic innervation of primate lymph nodes: mechanisms and implications for viral pathogenesis. J Neurosci 2007;27:8857–65.
Sloan EK, Priceman SJ, Cox BF, et al. The sympathetic nervous system induces a metastatic switch in primary breast cancer. Cancer Research 2010;70(18):7042-7052.
Strasak AM, Zaman Q, Pfeiffer KP, Göbel G, Ulmer H. Statistical errors in medical research – a review of common pitfalls, SWIS SMED WKLY 2007; 137:44–49.
Sundquist J, Li X, Johansson SE, Sundquist K. Depression as a predictor of hospitalization due to coronary heart disease. Am J Prev Med (2005) 29: 428–433.
Tedla F.M., Brar A., Browne R., and Brown C., Hypertension in Chronic Kidney Disease: Navigating the Evidence, International Journal of Hypertension. Volume 2011, Article ID 132405, 9 pages.
Wang TL, et al. (2002) Prevalence of somatic alterations in the colorectal cancer cell genome. Proc Natl Acad Sci USA 99:3076 –3080.
White SJ. Statistical errors in papers in the British Journal of Psychiatry. Br J Psychiatry 1979;135:336-42. 10.1192*bjp.135.4.336
Wójcikowski J, Daniel WA. The role of the nervous system in the regulation of liver cytochrome p450. Curr Drug Metab. 2011 Feb;12(2):124-38.
Wood LD, et al. (2007) The genomic landscapes of human breast and colorectal cancers. Science 318:1108 –1113.
Yeung PK, Wong JT. Inhibition of cell proliferation by mechanical agitation involves transient cell cycle arrest at G1 phase in dinoflagellates. Protoplasma. 2003 Mar;220(3-4):173-8.
D. REFERENCES RELEVANT TO MIND*EMOTION*CNS
Albero A, Lopéz JE, Torres A, de la Cruz L, Martín T. Effectiveness of chemotherapy in advanced differentiated thyroid cancer: a systematic review. Endocr Relat Cancer. 2016 Feb;23(2):R71-84. doi: 10.1530*ERC-15-0194.
Albo D, Akay CL, Marshall CL, Wilks JA, Verstovsek G, Liu H, Agarwal N, Berger DH, Ayala GE. Neurogenesis in colorectal cancer is a marker of aggressive tumor behavior and poor outcomes. Cancer. 2011;117:4834–4845.
Aras S and Zaidi MR, TAMeless traitors: macrophages in cancer progression and metastasis. British Journal of Cancer. (2017) 117, 1583–1591 doi: 10.1038*bjc.2017.356
Artico M, Bosco S, Cavallotti C, Agostinelli E, Giuliani-Piccari G, Sciorio S, Cocco L, Vitale M. Noradrenergic and cholinergic innervation of the bone marrow. Int J Mol Med. 2002;10:77–80.
Ashdown ML, Robinson AP, Yatomi-Clarke SL, Ashdown ML, Allison A, Abbott D, Markovic SN, and Coventry BJ, Chemotherapy for Late-Stage Cancer Patients: Meta-Analysis of Complete Response Rates, Version 1. F1000Res. 2015; 4:232.
Ayala GE, Dai H, Powell M, Li R, Ding Y, Wheeler TM, Shine D, Kadmon D, Thompson T, Miles BJ, Ittmann MM, Rowley D. Cancer-related axonogenesis and neurogenesis in prostate cancer. Clin Cancer Res. 2008;14:7593–7603.
Benestad HB, Strom-Gundersen I, Iversen PO, Haug E, Nja A. No neuronal regulation of murine bone marrow function. Blood. 1998;91:1280–1287.
Bernards R, Weinberg RA (2002) A progression puzzle. Nature 418:823.
Brydon L, Magid K, Steptoe A. Platelets, coronary heart disease, and stress. Brain Behav Immun (2006) 20: 113–119.
Booth FW, Roberts CK, Laye MJ. Lack of exercise is a major cause of chronic diseases. Compr Physiol. 2012;2:1143–1211.
Buijs RM, Scheer FA, Kreier F, Yi C, Bos N, Goncharuk VD, Kalsbeek A. Organization of circadian functions: interaction with the body. Prog Brain Res. 2006;153:341-60.
Calorini L, Bianchini F. Environmental control of invasiveness and metastatic dissemination of tumor cells: the role of tumor cell-host cell interactions. Cell Commun Signal. 2010;8:24.
Canaani J, Kollet O, Lapidot T. Neural regulation of bone, marrow, and the microenvironment. Front Biosci. 2011;3:1021–1031.
Chen CP, Weinberg VK, Jahan TM, Jablons DM, and Yom SS. Implications of Delayed Initiation of Radiotherapy Accelerated Repopulation after Induction Chemotherapy for Stage III Non-small Cell Lung Cancer. Journal of Thoracic Oncology Volume 6, Number 11, November 2011.
Cheng L, Swartz MD, Zhao H, Kapadia AS, Lai D, Rowan PJ, Buchholz TA, Giordano SH. Hazard of recurrence among women after primary breast cancer treatment—A 10-year follow-up using data from SEER-medicare. Cancer Epidemiol. Biomarkers Prev. 21, 800–809 (2012).
Colleoni M, Sun Z, Price KN, Karlsson, Forbes JF, Thürlimann B, Gianni L, Castiglione M, Gelber RD, Coates AS, Goldhirsch A. Annual hazard rates of recurrence for breast cancer during 24 years of follow-up: Results from the international breast cancer study group trials I to V. J. Clin. Oncol. 34, 927–935 (2016).
Cormie P, Zopf EM, Zhang X, Schmitz KH. The Impact of Exercise on Cancer Mortality, Recurrence, and Treatment-Related Adverse Effects. Epidemiologic Reviews, Volume 39, Issue 1, January 2017, Pages 71–92
Cui L, Zhao Y, Pan Y, Zheng, Shao D, Jia Y, He K, Li K, and Chen L. Chemotherapy induces ovarian cancer cell repopulation through the caspase 3-mediated arachidonic acid metabolic pathway. Onco Targets Ther. 2017; 10: 5817–5826.
Davis C, Naci H, Gurpinar E, Poplavska E, Pinto A, Aggarwal A, Availability of evidence of benefits on overall survival and quality of life of cancer drugs approved by European Medicines Agency: retrospective cohort study of drug approvals 2009-13, BMJ 2017;359:j4530.
de Visser KE, Eichten A, Coussens LM. Paradoxical roles of the immune system during cancer development. Nat Rev Cancer. 2006;6:24–37.
DeNardo DG, Johansson M, Coussens LM. Immune cells as mediators of solid tumor metastasis. Cancer Metastasis Rev. 2008;27:11–18.
Dvorak HF. Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med 1986; 315:1650-9.
Dvorak HF. Tumors: wounds that do not heal-redux. Cancer immunology research 2015; 3:1-11.
Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell. 2010;140:883–899.
Han C, Rice MW, and Cai D. Neuroinflammatory and autonomic mechanisms in diabetes and hypertension. Am J Physiol Endocrinol Metab. 2016 Jul 1; 311(1): E32–E41.
Hanahan & Weinberg. The Hallmarks of Cancer. Cell, Vol. 100, 57–70, January 7, 2000.
A second look at beta blockers and blood pressure. A beta blocker alone isn't usually the best choice for simple, uncomplicated high blood pressure. Harv Heart Lett. 2008 Jun;18(10):4-5.
Hochberg, ME & Noble RJ. A framework for how environment contributes to cancer risk. Ecology Letters (2017) 20, 117–134.
Housman G., Byler S., Heerboth S.h, Lapinska K, Longacre M., Snyder N. and Sarkar S., Drug Resistance in Cancer: An Overview. Cancers 2014, 6, 1769-1792; doi:10.3390*cancers6031769
Huang YC, Feng ZP. The good and bad of microglia*macrophages: new hope in stroke therapeutics. Acta Pharmacol Sin 2013;34(1): 6–7.
Hüsemann Y, Geigl JB, Schubert F, Musiani P, Meyer M, Burghart E, Forni G, EilsR, Fehm T, Riethmüller G, Klein CA. Systemic spread is an early step in breast cancer. Cancer Cell 2008;13,58–68.
Imai S, Tokunaga Y, Maeda T, Kikkawa M, Hukuda S. Calcitonin gene-related peptide, substance P, and tyrosine hydroxylase-immunoreactive innervation of rat bone marrows: an immunohistochemical and ultrastructural investigation on possible efferent and afferent mechanisms. J Orthop Res. 1997;15:133–140.
Jones S, et al. Comparative lesion sequencing provides insights into tumor evolution. Proc Natl Acad Sci USA 2008;105:4283– 4288.
Karin M, Greten FR. NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol. 2005;5:749–759.
Khasraw M, Posner JB. Neurological complications of systemic cancer. Lancet Neurol. 2010;9:1214–1227.
Kiecolt-Glaser JK, Marucha PT, Malarkey WB, Mercado AM, Glaser R (1995) Slowing of wound healing by psychological stress. Lancet 346: 1194–1196.
Kiecolt-Glaser JK, Preacher KJ, MacCallum RC, Atkinson C, Malarkey WB, Glaser R . Chronic stress and age-related increases in the proinflammatory cytokine IL-6. Proc Natl Acad Sci USA 2003;100: 9090–9095.
Kleemeyer MM, Polk TA,Schaefer S, Bodammer NC, Brechtel L, and Lindenberger U. Exercise-Induced Fitness Changes Correlate with Changes in Neural Specificity in Older Adults. Front Hum Neurosci. 2017; 11: 123. Published online 2017 Mar 16. doi: 10.3389*fnhum.2017.00123.
Lin WW, Karin M. A cytokine-mediated link between innate immunity, inflammation, and cancer. J Clin Invest. 2007;117:1175–1183.
Lumen, Boundless Anatomy and Physiology, Control of Muscle Tension, Force of Muscle Contraction. ....*boundless-ap*chapter*control-of-muscle-tension*. Last Accessed July 16, 2019.
Lutgendorf SK, Sood AK, Anderson B, et al. Social support, psychological distress, and natural killer cell activity in ovarian cancer. Journal of Clinical Oncology 2005;23(28):7105-7113.
Lutgendorf SK, DeGeest K, Dahmoush L, et al. Social isolation is associated with elevated tumor norepinephrine in ovarian carcinoma patients. Brain, Behavior, and Immunity 2011;25(2):250-255.
Maeda H and Khatami M. Analyses of repeated failures in cancer therapy for solid tumors: poor tumor-selective drug delivery, low therapeutic efficacy and unsustainable costs, Clin Transl Med. 2018; 7: 11.
McDonald PG, Antoni MH, Lutgendorf SK, et al. A biobehavioral perspective of tumor biology. Discovery Medicine 2005;5(30):520-526.
Miyan JA, Broome CS, Whetton AD. Neural regulation of bone marrow. Blood. 1998;92:2971–2973.
Mravec B, Gidron Y, Hulin I. Neurobiology of cancer: Interactions between nervous, endocrine and immune systems as a base for monitoring and modulating the tumorigenesis by the brain. Semin Cancer Biol. 2008;18:150–163.
Moreno-Smith M, Lutgendorf SK, Sood AK. Impact of stress on cancer metastasis. Future Oncology 2010;6(12):1863-1881. doi: 10.2217*fon.10.142
Na Z, Qiao X, Hao X, Fan L, Xiao Y, Shao Y, et. al. The effects of beta-blocker use on cancer prognosis: a meta-analysis based on 319,006 patients. OncoTargets and Therapy 2018:11 4913–4944
Nemeroff CB, Musselman DL, Evans DL Depression and cardiac disease. Depress Anxiety (1998) 8 (Suppl 1): 71–79
Nguyen DX, Bos PD, Massague J. Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer. 2009;9:274–284.
Nowell, P. C. (1976). "The clonal evolution of tumor cell populations". Science. 194 (4260): 23–28. doi:10.1126*science.959840. PMID 959840.
Noy R and Pollard JW. Tumor-associated macrophages: from mechanisms to therapy. Immunity. 2014 July 17; 41(1): 49–61. doi:10.1016*j.immuni.2014.06.010.
Palm D, Entschladen F. Neoneurogenesis and the neuroneoplastic synapse. Prog Exp Tumor Res. 2007;39:91–98.
Phelps EA, LeDoux JE. Contributions of the Amygdala to Emotion Processing: From Animal Models to Human Behavior. Neuron, Vol. 48, 175–187, October 20, 2005. DOI 10.1016*j.neuron.2005.09.025
Salani R, Backes FJ, Fung MF, et al. Posttreatment surveillance and diagnosis of recurrence in women with gynecologic malignancies: Society of Gynecologic Oncologists recommendations. Am J Obstet Gynecol. 2011;204(6):466–478.
Segerstrom SC, Miller GE. Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry. Psychological Bulletin 2004;130(4):601-630.
Sloan EK, Priceman SJ, Cox BF, et al. The sympathetic nervous system induces a metastatic switch in primary breast cancer. Cancer Research 2010;70(18):7042-7052.
Sundquist J, Li X, Johansson SE, Sundquist K. Depression as a predictor of hospitalization due to coronary heart disease. Am J Prev Med (2005); 29: 428–433.
Solinas G, Marchesi F, Garlanda C, Mantovani A, Allavena P. Inflammation-mediated promotion of invasion and metastasis. Cancer Metastasis Rev. 2010;29:243–248.
Sung SY, Hsieh CL, Wu D, Chung LW, Johnstone PA. Tumor microenvironment promotes cancer progression, metastasis, and therapeutic resistance. Curr Probl Cancer. 2007;31:36–100.
Tipton CM. The history of “Exercise Is Medicine” in ancient civilizations. Adv Physiol Educ. 2014;38(2):109–117.
Toothaker TB, Rubin M. Paraneoplastic neurological syndromes: a review. Neurologist. 2009;15:21–33.
Tubiana M. Repopulation in human tumors. A biological background for fractionation in radiotherapy. Acta Oncol 1988; 27: 83-8.
Tubiana M. Tumor Cell Proliferation Kinetics and Tumor Growth Rate, Acta Oncologica, 1989;28:1, 113-121, DOI: 10.3109*02841868909111193
Varner JA. Stem cells and neurogenesis in tumors. Prog Exp Tumor Res. 2007;39:122–129.
Verma R, Foster RE, Horgan K, Mounsey K, Nixon H, Natuley S, Hughes TA, Clive RD. Carter. Lymphocyte depletion and repopulation after chemotherapy for primary breast cancer. Breast Cancer Research (2016) 18:10. DOI 10.1186*s13058-015-0669-x
Wang TL, Rago C, Silliman N, Ptak J, Markowitz S, Willson JK, et al. Prevalence of somatic alterations in the colorectal cancer cell genome. Proc Natl Acad Sci USA. (2002) 99:3076–80. 10.1073*pnas.261714699
Willis RA. The Spread of Tumors in the Human Body. 3rd edition. Butterworths; London: 1973.
Wójcikowski J, Daniel WA. The role of the nervous system in the regulation of liver cytochrome p450. Curr Drug Metab. 2011 Feb;12(2):124-38.
Wood LD, et al. The genomic landscapes of human breast and colorectal cancers. Science. 2007;318:1108 –1113.
Wraith DC, Nicholson LB. The adaptive immune system in diseases of the central nervous system. J Clin Invest. 2012;122(4):1172-1179.
Wu Y, Zhou BP. Inflammation: a driving force speeds cancer metastasis. Cell Cycle. 2009;8:3267–3273.
Xue J, Schmidt SV, Sander J, Draffehn A, Krebs W, Quester I, De Nardo D, Gohel TD, Emde M, Schmidleithner L, Ganesan H, Nino-Castro AMallmann MR, Labzin L, Theis H, Kraut M, Beyer M, Latz E, Freeman TC, Ulas T, Schultze JL Transcriptome-based network analysis reveals a spectrum model of human macrophage activation. Immunity. 2014; 40(2):274–288.
Yap A, Lopez-Olivo MA, Dubowitz J, Pratt G, Hiller J, Gottumukkala V, Sloan E, Riedel B, Schier R. Br J Anaesth. 2018 Jul; 121(1):45-57. Epub 2018 May 3.
Zanker KS: The neuro-neoplastic synapse: does it exist? Prog Exp Tumor Res 39: 154-161, 2007.
End.
Wikipedia, cancer, ....*wiki*Cancer#History (WC donot take it)
Wood LD, et al. (2007) The genomic landscapes of human breast and colorectal cancers. Science 318:1108 –1113.
Wu W, Guo F, Ye J, et al. Pre- and post-dia*gnosis physical activity is associated with survival benefits of colorectal cancer patients: a systematic review and meta-analysis. Oncotarget. 2016;7(32):52095–52103.
Yap A, Lopez-Olivo MA, Dubowitz J, Pratt G, Hiller J, Gottumukkala V, Sloan E, Riedel B, Schier R. Effect of beta-blockers on cancer recurrence and survival: a meta-analysis of epidemiological and perioperative studies. Br J Anaesth. 2018 Jul; 121(1):45-57. Epub 2018 May 3.
Yeung PK, Wong JT. Inhibition of cell proliferation by mechanical agitation involves transient cell cycle arrest at G1 phase in dinoflagellates. Protoplasma. 2003 Mar;220(3-4):173-8.
Zhong S, Jiang T, Ma T, et al. Association between physical activity and mortality in breast cancer: a meta-analysis of cohort studies. Eur J Epidemiol. 2014;29(6):391–404.
Zondervan RL, Hahn PF, Sadow CA, Liu B, Lee SI. Body CT scanning in young adults: examination indications, patient outcomes, and risk of radiation-induced cancer. Radiology. 2013;267(2):460-9.
Zhou Y, Li C, H-u-i-j-b-r-e-g-t-s MAJ., Mumtaz MM, Carcinogenic Air Toxics Exposure and Their Cancer-Related Health Impacts in the United States. P-L-O-S-O-N-E ****
大家看清了,这种标准的保健抗癌伪科学科普。中心思想差不多,就是医生都知道其实XX疗法好,这个XX可以是自然疗法,胡萝卜疗法,某中草药疗法,气功疗法,抗氧化剂疗法等等,但是就是不说,因为制药厂不赚钱,或者这篇里面说的“如果找到了根治癌症方法,没有人能赚钱,没人会推广治癌症方法“。 这要扯淡到什么程度了?!!!!
这种伪科学,基本上用阴谋论解释一切。说的好像全美国几万生物postdoc都是一条裤子,为了维护制药厂的利益,知道了最佳疗法大家都不说,宁可过着吃不饱穿不暖的日子,为了行业利益牺牲自己的利益,这要笑坏我大牙了了。一旦又任何有效疗法出现,立刻都是名利双收。
饮食涉及的内容太广,关于脂肪和癌症的关系的研究数已达2000多项。 希望研究机构能能走出第二步。
想问问那些踩楼主的,你们是得了癌症,还是你关心的人得了癌症?楼主说的运动,饮食,冥想。。。对癌症治疗和康复只有好处没有一点坏处。传统的化放疗对人伤害极大。你们不想积德也不用造孽呀。