We vaccinated K18-hACE2 (mice) with mRNA-LNP (Pfizer/BioNTech BNT162b2) by IM injection (prime), followed 14 days later by IN administration of recombinant unadjuvanted spike protein (prime and spike (P&S)). Mice were euthanized at days 21 or 28 and assessed for mucosal humoral immunity (Fig. 1A).
https://www.newswise.com/coronavirus/prime-and-spike-nasal-vaccine-strategy-helps-combat-covid/?article_id=781226
如果真的能阻止传染，中国也许还真熬到了胜利的那一天。
还是辉瑞或莫德纳的mRNA吗？
https://www.science.org/doi/10.1126/science.abo2523
最开始的一些数据也是可以减少传染。
一般的理论是德尔塔开始之后降低传染的功效大大降低，奥米克戎更是这样。
现在一些人怀疑最开始的数据就有假。
到底真相如何？需要更大规模的真实数据。
We vaccinated K18-hACE2 (mice) with mRNA-LNP (Pfizer/BioNTech BNT162b2) by IM injection (prime), followed 14 days later by IN administration of recombinant unadjuvanted spike protein (prime and spike (P&S)). Mice were euthanized at days 21 or 28 and assessed for mucosal humoral immunity (Fig. 1A).