4, 遗传:多因素诱发或导致此症。截止目前,没有发现明确的致病基因或遗传模式。不存在每代或隔代遗传特征。这是美国国立卫生署的结论:The inheritance pattern for schizophrenia is usually unknown. The risk of developing schizophrenia is somewhat higher for family members of affected individuals as compared to the general public; however, most people with a close relative who has schizophrenia will not develop the disorder themselves. -- https://ghr.nlm.nih.gov/condition/schizophrenia#inheritance?
In 1970, researchers from the University of Edinburgh performing cytogenetic research on a group of juvenile offenders in Scotland found an abnormal translocation in chromosome 1 of one of the boys, who also displayed characteristics of an affective psychological disorder.[6] After this initial observation, the boy's family was studied and it was found that 34 out of 77 family members displayed the same translocation. According to the Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) (or DSM-IV) criteria, sixteen of the 34 individuals identified as having the genetic mutation were diagnosed with psychiatric problems. In contrast, five of the 43 unaffected family members were identified to have psychological indispositions. The psychiatric illnesses observed in the family ranged from schizophrenia and major depression to bipolar disorder and adolescent conduct disorder (which the original research subject had).[7] After studying this large Scottish family for four generations, in 2000, this gene was given the name "DISC1". The name was derived from the basis of the molecular nature of the mutation: the translocation directly disrupts the gene.[5]
精神病 是一个群,包括几十个类型,比如
幻想症,谵妄症,强迫症,狂躁,抑郁,精神分裂症 Schizophrenia 等。
这里以 精神分裂症为例 简说:
1,此病的世界范围流行率 Prevalence 是 1%, 美国1.2%, 中国1%.
2,年龄:20~40 是发病高峰。
3,性别:男女无显著差别。
4, 遗传:多因素诱发或导致此症。截止目前,没有发现明确的致病基因或遗传模式。不存在每代或隔代遗传特征。这是美国国立卫生署的结论:The inheritance pattern for schizophrenia is usually unknown. The risk of developing schizophrenia is somewhat higher for family members of affected individuals as compared to the general public; however, most people with a close relative who has schizophrenia will not develop the disorder themselves. -- https://ghr.nlm.nih.gov/condition/schizophrenia#inheritance?
5,治疗和预后。
对症治疗,主要包括心理疏导, 药物,环境调节等。症状可以缓解,间歇,断续,很少痊愈,鲜有根治了的。
更多我的博客文章>>> 【颅脑外伤与精神病的关系 - 1.4百万人的大验证】 【精神病 Mental Disorders 与遗传的几个要点】 【人工授精简史 Artificial Insemination In Humans -- 兼论 毛新宇的正常孕育和出生】 【人工授精(Artificial insemination,AI)浅说】 【全自动屠宰: 猪高高兴兴跑进去,下一秒就成肉块...】
周末愉快~
喜欢这两样兵器~.~
老天也没治!
Discovery[edit]
In 1970, researchers from the University of Edinburgh performing cytogenetic research on a group of juvenile offenders in Scotland found an abnormal translocation in chromosome 1 of one of the boys, who also displayed characteristics of an affective psychological disorder.[6] After this initial observation, the boy's family was studied and it was found that 34 out of 77 family members displayed the same translocation. According to the Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) (or DSM-IV) criteria, sixteen of the 34 individuals identified as having the genetic mutation were diagnosed with psychiatric problems. In contrast, five of the 43 unaffected family members were identified to have psychological indispositions. The psychiatric illnesses observed in the family ranged from schizophrenia and major depression to bipolar disorder and adolescent conduct disorder (which the original research subject had).[7] After studying this large Scottish family for four generations, in 2000, this gene was given the name "DISC1". The name was derived from the basis of the molecular nature of the mutation: the translocation directly disrupts the gene.[5]
https://en.wikipedia.org/wiki/DISC1