【 在 cllearjks (cllearjks) 的大作中提到: 】 : 看文章学英语了，一直有人想看我翻译文章，现在出来献丑了！ : Mutated versions of ‘A’ were seen in Americans reported to have lived in : Wuhan, and a large number of A-type viruses were found in patients from the : US and Australia. : A的突变版本的病毒是在居住在武汉的美国人中发现的，并且大量的A类型病毒在美国和 : 澳大利亚被发现。 : Wuhan’s major virus type, ‘B’, was prevalent in patients from across East : Asia. However, the variant didn’t travel much beyond the region without : further mutations – implying a "founder event" in Wuhan, or “resistance ” : against this type of COVID-19 outside East Asia, say researchers. : ...................
【在 cxw360(cxw360)的大作中提到：】 ：这更支持A是从美国传到武汉的，A很弱在美国在武汉都没有传开，变异成B后在武汉中 ：国东亚爆发，之后传到欧洲变异成C在欧洲爆发,最后C又传回美国，美国爆发 ：【 在 cllearjks (cllearjks) 的大作中提到: 】 ：: 看文章学英语了，一直有人想看我翻译文章，现在出来献丑了！ ：: Mutated versions of ‘A’ were seen in Americans reported to have lived in ：: Wuhan, and a large number of A-type viruses were found in patients from ：the ：: US and Australia. ......
One of the first cases Heguy’s team sequenced, collected in early March, came from a Long Island resident with no travel history whose viral genome correlated with a strain circulating in England. That suggested the patient had contact with someone who had brought the virus over from the U.K.
The findings suggest that even after the Trump administration imposed travel restrictions from China, the virus continued to infiltrate the most populous U.S. city via daily flights from Europe.
Not all the New York virus samples have European origins. Some appear to have come from the U.S. West Coast, while others appear to link directly to Asia. That indicates that there are numerous chains of transmission in the metro area, as would be expected in such a large outbreak.
【 在 christina200 (na) 的大作中提到: 】 : 一月份开传，到3月都传了一个多月了，然后在纽约市人口密集的地方大规模 : 爆发。纽约主要是被欧洲来的传染的。意大利的零号病人就是1月从德国带 : 病毒过去的。这个病毒只要一个多月就能在密集的地方大范围蔓延。 : One of the first cases Heguy’s team sequenced, collected in early March, : came from a Long Island resident with no travel history whose viral genome : correlated with a strain circulating in England. That suggested the patient : had contact with someone who had brought the virus over from the U.K. : The findings suggest that even after the Trump administration imposed travel : restrictions from China, the virus continued to infiltrate the most : populous U.S. city via daily flights from Europe. : ...................
原文 Mutated versions of ‘A’ were seen in Americans reported to have lived in Wuhan, and a large number of A-type viruses were found in patients from the US and Australia.
而不是 Mutated versions of ‘A’ were seen in Americans reported to have lived in Wuhan, and a large number of “MUTATED” A-type viruses were found in patients from the US and Australia.
所以其实文章说的是 A large number of A-type viruses were found in patients from the US and Australia, and mutated versions of ‘A’ were seen in Americans reported to have lived in Wuhan.
原文 Wuhan’s major virus type, ‘B’, was prevalent in patients from across EastAsia. However, the variant didn’t travel much beyond the region without further mutations – implying a "founder event" in Wuhan, or “resistance” against this type of COVID-19 outside East Asia, say researchers.
其实文章说的是 Wuhan’s major virus type, ‘B’, was NOT the source of 'A' that is widely found in US and Australia. Wuhan "founded" the type 'B'.
【 在 cllearjks (cllearjks) 的大作中提到: 】 : 抄了其他网友的回复，来回答你。 : Forster and colleagues found that the closest type of COVID-19 to the one : discovered in bats – type ‘A’, the “original human virus genome” – was : present in Wuhan, but surprisingly was not the city’s predominant virus : type. : Mutated versions of ‘A’ were seen in Americans reported to have lived in : Wuhan, and a large number of A-type viruses were found in patients from the : US and Australia. : 通过翻译去接西方论文为武肺洗地也算五毛发明。 : 人家说的很清楚最接近动物的a类在武汉发现，但不是武汉的主蔟（其实是因为武汉病 : ...................
There are two subclusters of A which are distinguished by the synonymous mutation T29095C. In the T-allele subcluster, four Chinese individuals (from the southern coastal Chinese province of Guangdong) carry the ancestral genome, while three Japanese and two American patients differ from it by a number of mutations. These American patients are reported to have had a history of residence in the presumed source of the outbreak in Wuhan. The C-allele subcluster sports relatively long mutational branches and includes five individuals from Wuhan, two of which are represented in the ancestral node, and eight other East Asians from China and adjacent countries. It is noteworthy that nearly half (15/33) of the types in this subcluster, however, are found outside East Asia, mainly in the United States and Australia.
【 在 TaiHuShui (太湖-有容奶大) 的大作中提到: 】 : 原文 : Mutated versions of ‘A’ were seen in Americans reported to have lived in: Wuhan, and a large number of A-type viruses were found in patients from the : US and Australia. : 而不是 : Mutated versions of ‘A’ were seen in Americans reported to have lived in: Wuhan, and a large number of “MUTATED” A-type viruses were found in : patients from the US and Australia. : 所以其实文章说的是 : A large number of A-type viruses were found in patients from the : ...................
14 Type A cases in USA and Australia is not "widely" found by any stretch.
【 在 TaiHuShui (太湖-有容奶大) 的大作中提到: 】 : 原文 : Mutated versions of ‘A’ were seen in Americans reported to have lived in: Wuhan, and a large number of A-type viruses were found in patients from the : US and Australia. : 而不是 : Mutated versions of ‘A’ were seen in Americans reported to have lived in: Wuhan, and a large number of “MUTATED” A-type viruses were found in : patients from the US and Australia. : 所以其实文章说的是 : A large number of A-type viruses were found in patients from the : ...................
There are two subclusters of A which are distinguished by the synonymous mutation T29095C. In the T-allele subcluster, four Chinese individuals (from the southern coastal Chinese province of Guangdong) carry the ancestral genome, while three Japanese and two American patients differ from it by a number of mutations. These American patients are reported to have had a history of residence in the presumed source of the outbreak in Wuhan. The C-allele subcluster sports relatively long mutational branches and includes five individuals from Wuhan, two of which are represented in the ancestral node, and eight other East Asians from China and adjacent countries.
Twenty-three of the 263 residents were hospitalized and 19 employees now saythey are experiencing symptoms of upper respiratory illness, the health department says.
Residents in the continuing care neighborhood that have become ill are showing respiratory symptoms ranging from coughing and shortness of breath to pneumonia, according to officials.
In less than 2 weeks, a mystery virus at Springfield’s Greenspring Retirement Community has gotten 55 residents sick. Twenty have been hospitalized -- some with pneumonia
if 14 Type A but zero B would be a very different story. unless your screening method somehow preferentially pick type A for some reason. we do know the screening method when this paper published preferentially picked people with China/Wuhan contact.
【 在 SOFC (SOFC) 的大作中提到: 】 : 14 Type A cases in USA and Australia is not "widely" found by any stretch.: the
【 在 SOFC (SOFC) 的大作中提到: 】 : That is false. : "美国如此庞大的病例数，而且大量病人是A株，" Last USA data from the paper is : 2/24/2020, at that time, there is nowhere close to 庞大的病例数.
Then you need data to support your claim that there is significant amount A-type infection in US, which means tens of thousands, not mere tens or hundreds of A-type. 【 在 coronavirus (看什么看，小心盯上你) 的大作中提到: 】 : 前面都当流感了。不测当然不会有病例。 : 现在放开测了，才看出早就本地流传很久了 : is
There are two subclusters of A which are distinguished by the synonymous mutation T29095C. In the T-allele subcluster, four Chinese individuals (from the southern coastal Chinese province of Guangdong) carry the ancestral genome, while three Japanese and two American patients differ from it by a number of mutations. These American patients are reported to have had a history of residence in the presumed source of the outbreak in Wuhan. The C-allele subcluster sports relatively long mutational branches and includes five individuals from Wuhan, two of which are represented in the ancestral node, and eight other East Asians from China and adjacent countries. It is noteworthy that nearly half (15/33) of the types in this subcluster, however, are found outside East Asia, mainly in the United States and Australia.
这里面说的美国人主要也是华人。
该论文样本截至是2月24日，美帝还没爆发，主要还是从亚洲来的个例。
还是那句话，实锤的一个论文，不理解粉红们high什么劲。大力批判才对啊。
【 在 arthury (灌完水记得要删贴) 的大作中提到: 】 : 以下是论文SI的原始数据，lgw出来讲讲，里面哪个是A，哪个是mutated A？ 呵呵 : Supplementary Table 2b. Phylogenetic cluster assignment of of viral genome : variants. : Note: Sorted by date : : Type subtype GISAID genome label GISAID Accession ID Collection : date : B derived 4 BetaCov/Wuhan/IPBCAMS-WH-01/2019 EPI_ISL_402123 2019 : /12/24 : B derived 48 BetaCov/Wuhan/WH01/2019 EPI_ISL_406798 2019/12/26: ...................
This is just pure bad luck, a possibly benign virus runs amok through mutation in, most likely, Wuhan, and people there are its earliest victims. CCP's missteps including cover-up during the early stage of the outbreak aggravate the situation.
【 在 lgw (abcdefg) 的大作中提到: 】 : 他在文章中清楚地写道：A类两个subcluster : T-allele，先有四个中国人携带A祖先基因（ancestral genome）, 三个日本人和两个 : 在武汉的美国人携带了该基因的变异。 : C-allele subcluster，里面五个武汉人，祖先基因是两个武汉人。 : https://www.pnas.org/content/early/2020/04/07/2004999117 : There are two subclusters of A which are distinguished by the synonymous : mutation T29095C. In the T-allele subcluster, four Chinese individuals ( from : the southern coastal Chinese province of Guangdong) carry the ancestral : genome, while three Japanese and two American patients differ from it by a : number of mutations. These American patients are reported to have had a : ...................
【 在 SOFC (SOFC) 的大作中提到: 】 : That is false. : "美国如此庞大的病例数，而且大量病人是A株，" Last USA data from the paper is : 2/24/2020, at that time, there is nowhere close to 庞大的病例数.
CCP cover-up or not won't change the course. it is a new virus with unknown R0. assuming it is another SARS just like what Li said would not make a dent. you need a month to 45 days from the date you notice the outbreak to have a reasonable tool kits and understanding to conduct screening. CCP action was actually much faster than expected even all the western countries thought it was unnecessary.
【 在 SOFC (SOFC) 的大作中提到: 】 : This is just pure bad luck, a possibly benign virus runs amok through : mutation in, most likely, Wuhan, and people there are its earliest victims. : CCP's missteps including cover-up during the early stage of the outbreak : aggravate the situation. : : from
I disagree, at least disagree with the development within China because SARS experience would make people more cautious which helps a lot evidently in East Asia. I tend to agree it may not change the course in Europe and North America, but we will never know as we cannot relive history.
【 在 antee (蚂蚁) 的大作中提到: 】 : CCP cover-up or not won't change the course. : it is a new virus with unknown R0. : assuming it is another SARS just like what Li said would not make a dent. : you need a month to 45 days from the date you notice the outbreak to have a : reasonable tool kits and understanding to conduct screening. : CCP action was actually much faster than expected even all the western : countries thought it was unnecessary. : .
至少我没看到作者标明了 【 在 lgw (abcdefg) 的大作中提到: 】 : 他在文章中清楚地写道：A类两个subcluster : T-allele，先有四个中国人携带A祖先基因（ancestral genome）, 三个日本人和两个 : 在武汉的美国人携带了该基因的变异。 : C-allele subcluster，里面五个武汉人，祖先基因是两个武汉人。 : https://www.pnas.org/content/early/2020/04/07/2004999117 : There are two subclusters of A which are distinguished by the synonymous : mutation T29095C. In the T-allele subcluster, four Chinese individuals ( from : the southern coastal Chinese province of Guangdong) carry the ancestral : genome, while three Japanese and two American patients differ from it by a : number of mutations. These American patients are reported to have had a : ...................
【 在 lgw (abcdefg) 的大作中提到: 】 : 1，美澳发现的是A原始的变异版本。和A原始差两个变异。 : 2,A原始只在武汉发现。 : COVID-19 to the one : discovered in bats – type ‘A’, the “original human virus genome” – was : present in Wuhan, but surprisingly was not the city’s predominant virus : type. : Mutated versions of ‘A’ were seen in Americans reported to have lived in: Wuhan, and a large number of A-type viruses were found in patients from the : US and Australia.
那论文的原始病例数据里面，哪些是A的原始簇，哪些是变异的A 【 在 lgw (abcdefg) 的大作中提到: 】 : There are two subclusters of A which are distinguished by the synonymous : mutation T29095C. In the T-allele subcluster, four Chinese individuals ( from : the southern coastal Chinese province of Guangdong) carry the ancestral : genome, while three Japanese and two American patients differ from it by a : number of mutations : 原文说的很清楚，A有两蔟，原始蔟只在中国人身上发现，三个日本人两个美国身上发 : 现A的变异。
这个是正解。 【 在 TaiHuShui (太湖-有容奶大) 的大作中提到: 】 : 原文 : Mutated versions of ‘A’ were seen in Americans reported to have lived in: Wuhan, and a large number of A-type viruses were found in patients from the : US and Australia. : 而不是 : Mutated versions of ‘A’ were seen in Americans reported to have lived in: Wuhan, and a large number of “MUTATED” A-type viruses were found in : patients from the US and Australia. : 所以其实文章说的是 : A large number of A-type viruses were found in patients from the : ...................
what make you think other place is better in east Asia? TW is import cases and politicize it quickly. it would collapse if it started there. S.K. has 10K case. However, two things play to its benefit. it is known virus by then, and test kits are ready to ramp. if it started in S.K. it would means it is unknown and also no test kits to do the screening. to identify the virus, sequence it and develop the test kits, you need 4 weeks at least. this one month delay will make cases in S.K 1000X more. it will be a total disaster. even two weeks delay would make it impossible to stop. I did agree China had a slim window to shut it down. but transparency didn't play any role here. even it is cover-up, the decision maker still know the some truth. and it takes a lot of guts for any political leader to shut down a city of this scale. and don't tell me self-discipline is sufficient here. it takes a lot of coordination to make it works and human nature is jackass.
Without any reliable testing tools, only based on CT etc secondary evidence,the gov need to shut the city when known cases (hospitalized therefore only 10%) only couple hundreds. the tracking tactics SK used is not applicable here because you don't have effective testing kits for milder cases yet. Shutdown is the only way out at this time. by the time it is two weeks later and you get your kits and have some understanding of the virus, known cases will reach 5000 cases, with another 20-50K at large. it will not make a dent on the outcome.
Back to coverup, i think we could agree CCP is not stupid, maybe evil but not stupid. they would only try to cover up when they saw good chance of success. if it is SARS, the gov think they know what to do and they might. and seems to me that is the mindset for the first 3 weeks.
【 在 SOFC (SOFC) 的大作中提到: 】 : I disagree, at least disagree with the development within China because SARS : experience would make people more cautious which helps a lot evidently in : East Asia. I tend to agree it may not change the course in Europe and North : America, but we will never know as we cannot relive history. : a
我觉得mutated versions of "A" 是指那些从A伸出来的节点 而A-type viruses是指“A“节点，也就是最原始的病毒。
【 在 skyeer (看到你的眼) 的大作中提到: 】 : Mutated versions of ‘A’ were seen in Americans reported to have lived in: Wuhan, and a large number of A-type viruses were found in patients from the : US and Australia. : 没搞明白这个说的啥。Those Americans reported to have lived in : Wuhan, 和 a large number of patients from the : US and Australia有什么不同？为啥把前一组人单独提出来？那a large number of : patients是不是也有人去过欧洲，其他国家，东亚，西亚？为啥不提出来？
因为A比B更古老，中国的生物学家很清楚其中的利害关系。
包子文化程度低，真的被五毒所那些始作俑者忽悠了。
现在看来A型重症率高，而且对欧美白人更易感。
我大胆猜测，A型是某实验室的目标毒株，而B，C是亚洲人感染后适应出来的变异副产
品，结果一起泄露了。
【 在 antee (蚂蚁) 的大作中提到: 】
: 丫对founder event有误解
: founder event的意思是类似英国人到美国，然后建了美国，
: founder event这里的意思是A输入
: 但是当地不适应变异出适应的成了主流
: 论文用了个Or,就是说另外能解释B在亚洲外少的原因是某种resistance
: 如果中国始发中国大量B，美国澳大利亚看不到B的可能性很小
: 理论上，中国看不到C可能和中国停止上传有关
: 但是A少B多不可能是停止上传或者过滤的结果，中国作为最先发现的
: 不可能知道其他国家的状态当时就能做出选择性上传
: 因为最近的结果纽约美国多数是欧洲输入的，所以爆发的是C
: ...................
能追溯到的最早的A是下面三个吧：C是武汉，T是深圳
A 29095C 50 BetaCov/Wuhan/WH04/2020 EPI_ISL_406801 2020/1/5
A 29095T 28 BetaCov/Shenzhen/HKU-SZ-002/2020 EPI_ISL_406030 2020/1/10
A 29095T 27 BetaCov/Shenzhen/HKU-SZ-005/2020 EPI_ISL_405839 2020/1/11
【 在 arthury (灌完水记得要删贴) 的大作中提到: 】
: A 29095T 32 BetaCov/USA/AZ1/2020 EPI_ISL_406223 2020/1/22
: A 29095T 174 BetaCov/USA/TX1/2020 EPI_ISL_411956 2020/2/11
【 在 christina200 (na) 的大作中提到: 】
: 能追溯到的最早的A是下面三个吧：C是武汉，T是深圳
: A 29095C 50 BetaCov/Wuhan/WH04/2020 EPI_ISL_406801 2020/1/5
: A 29095T 28 BetaCov/Shenzhen/HKU-SZ-002/2020 EPI_ISL_406030
2020
: /1/10
: A 29095T 27 BetaCov/Shenzhen/HKU-SZ-005/2020 EPI_ISL_405839
2020
: /1/11
然后这三个人回去传染了美国遍地的A?
【 在 mynight01 (一束星光) 的大作中提到: 】
: 因为A比B更古老，中国的生物学家很清楚其中的利害关系。
: 包子文化程度低，真的被五毒所那些始作俑者忽悠了。
: 现在看来A型重症率高，而且对欧美白人更易感。
: 我大胆猜测，A型是某实验室的目标毒株，而B，C是亚洲人感染后适应出来的变异副产
: 品，结果一起泄露了。
BC既然都是“亚洲人感染后适应出来的变异副产品”，那就不是实验室泄露了。
是的，不过这几个A和美国那几个A，相互之间没有mutated的关系，呵呵
【 在 christina200 (na) 的大作中提到: 】
: 能追溯到的最早的A是下面三个吧：C是武汉，T是深圳
: A 29095C 50 BetaCov/Wuhan/WH04/2020 EPI_ISL_406801 2020/1/5
: A 29095T 28 BetaCov/Shenzhen/HKU-SZ-002/2020 EPI_ISL_406030
2020
: /1/10
: A 29095T 27 BetaCov/Shenzhen/HKU-SZ-005/2020 EPI_ISL_405839
2020
: /1/11
这更支持A是从美国传到武汉的，A很弱在美国在武汉都没有传开，变异成B后在武汉中
国东亚爆发，之后传到欧洲变异成C在欧洲爆发,最后C又传回美国，美国爆发
【 在 cllearjks (cllearjks) 的大作中提到: 】
: 看文章学英语了，一直有人想看我翻译文章，现在出来献丑了！
: Mutated versions of ‘A’ were seen in Americans reported to have lived in
: Wuhan, and a large number of A-type viruses were found in patients from
the
: US and Australia.
: A的突变版本的病毒是在居住在武汉的美国人中发现的，并且大量的A类型病毒在美国和
: 澳大利亚被发现。
: Wuhan’s major virus type, ‘B’, was prevalent in patients from across
East
: Asia. However, the variant didn’t travel much beyond the region without : further mutations – implying a "founder event" in Wuhan, or “resistance
”
: against this type of COVID-19 outside East Asia, say researchers.
: ...................
【 在 christina200 (na) 的大作中提到: 】
: 能追溯到的最早的A是下面三个吧：C是武汉，T是深圳
: A 29095C 50 BetaCov/Wuhan/WH04/2020 EPI_ISL_406801 2020/1/5
: A 29095T 28 BetaCov/Shenzhen/HKU-SZ-002/2020 EPI_ISL_406030
2020
: /1/10
: A 29095T 27 BetaCov/Shenzhen/HKU-SZ-005/2020 EPI_ISL_405839
2020
: /1/11
就简单把两种可能性都设想一下：这三个A回到美国传染了遍地的A，或者这三个是被美国跑出来的少数A传染上了，这两种可能性哪个更容易发生一些？
好像B欧洲也有，说不好谁传谁的
【在 cxw360(cxw360)的大作中提到：】
：这更支持A是从美国传到武汉的，A很弱在美国在武汉都没有传开，变异成B后在武汉中
：国东亚爆发，之后传到欧洲变异成C在欧洲爆发,最后C又传回美国，美国爆发
：【 在 cllearjks (cllearjks) 的大作中提到: 】
：: 看文章学英语了，一直有人想看我翻译文章，现在出来献丑了！
：: Mutated versions of ‘A’ were seen in Americans reported to have lived in
：: Wuhan, and a large number of A-type viruses were found in patients from ：the
：: US and Australia.
......
C不一定和B（A）有关系
【 在 cxw360 (cxw360) 的大作中提到: 】
: 这更支持A是从美国传到武汉的，A很弱在美国在武汉都没有传开，变异成B后在武汉中
: 国东亚爆发，之后传到欧洲变异成C在欧洲爆发,最后C又传回美国，美国爆发
: the
: East
: ”
确实没有变异关系，但是美国病例有武汉居住史，后发的。这篇文章数据截止3月2号，东海岸还没有爆发。
【 在 arthury (灌完水记得要删贴) 的大作中提到: 】
: 是的，不过这几个A和美国那几个A，相互之间没有mutated的关系，呵呵
: 2020
: 2020
然后A 在武汉生根变异成B，1月19号其中一个subclass在封城前被华盛顿的马公带入美国。
1月22号另一个subclass被带入arizona.
A 29095T 13 BetaCov/Guangdong/20SF012/2020 EPI_ISL_403932 2020/1/14
A 29095T 14 BetaCov/Guangdong/20SF013/2020 EPI_ISL_403933 2020/1/15
A 29095T 16 BetaCov/Guangdong/20SF025/2020 EPI_ISL_403935 2020/1/15
A 29095C 71 BetaCov/Sichuan/IVDC-SC-001/2020 EPI_ISL_408484 2020/1/15
A 29095C 266 BetaCov/Wuhan/HBCDC-HB-02/2020 EPI_ISL_412978 2020/1/17
A 29095C 68 BetaCov/Yu--an/IVDC-YN-003/2020 EPI_ISL_408480 2020/1/17
B derived 18 BetaCov/Guangdong/20SF040/2020 EPI_ISL_403937 2020/1/18
A 29095C 267 BetaCov/Wuhan/HBCDC-HB-03/2020 EPI_ISL_412979 2020/1/18
A 29095C 268 BetaCov/Wuhan/HBCDC-HB-04/2020 EPI_ISL_412980 2020/1/18
A 29095C 98 BetaCov/Beijing/IVDC-BJ-005/2020 EPI_ISL_408485 2020/1/18
A 29095C 25 BetaCov/USA/WA1/2020 EPI_ISL_404895 2020/1/19
A 29095C 157 BetaCov/Fujian/8/2020 EPI_ISL_411060 2020/1/21
A 29095C 93 BetaCov/Chongqing/YC01/2020 EPI_ISL_408478 2020/1/21
A 29095C 189 BetaCov/Hong Kong/VM20001061/2020 EPI_ISL_412028
2020/1/22
A 29095T 32 BetaCov/USA/AZ1/2020 EPI_ISL_406223 2020/1/22
A 29095C 30 BetaCov/USA/CA1/2020 EPI_ISL_406034 2020/1/23
A 29095C 164 BetaCov/Taiwan/3/2020 EPI_ISL_411926 2020/1/24
A 29095C 210 BetaCov/Vietnam/VR03-38142/2020 EPI_ISL_408668 2020/1/24
A 29095C 58 BetaCov/Australia/NSW01/2020 EPI_ISL_407893 2020/1/
24
A 29095C 135 BetaCov/USA/WA1-F6/2020 EPI_ISL_407215 2020/1/25
A 29095C 167 BetaCov/South Korea/KCDC03/2020 EPI_ISL_407193 2020/1/25
A 29095C 56 BetaCov/USA/WA1-A12/2020 EPI_ISL_407214 2020/1/25
A 29095C 147 BetaCov/Australia/QLD01/2020 EPI_ISL_407894 2020/1/28
A 29095C 90 BetaCov/USA/IL2/2020 EPI_ISL_410045 2020/1/28
A 29095C 54 BetaCov/England/02/2020 EPI_ISL_407073 2020/1/29
A 29095C 55 BetaCov/England/01/2020 EPI_ISL_407071 2020/1/29
A 29095T 77 BetaCov/Japan/TY-WK-012/2020 EPI_ISL_408665 2020/1/
29
A 29095C 148 BetaCov/Australia/QLD02/2020 EPI_ISL_407896 2020/1/30
A 29095C 228 BetaCov/Korea/KCDC05/2020 EPI_ISL_412869 2020/1/30
A 29095C 229 BetaCov/Korea/KCDC06/2020 EPI_ISL_412870 2020/1/30
A 29095C 230 BetaCov/Korea/KCDC07/2020 EPI_ISL_412871 2020/1/31
A 29095T 78 BetaCov/Japan/TY-WK-501/2020 EPI_ISL_408666 2020/1/
31
A 29095T 79 BetaCov/Japan/TY-WK-521/2020 EPI_ISL_408667 2020/1/
31
A 29095C 59 BetaCov/Belgium/GHB-03021/2020 EPI_ISL_407976 2020/2/3
A 29095C 143 BetaCov/Australia/QLD03/2020 EPI_ISL_410717 2020/2/
5
A 29095C 144 BetaCov/Australia/QLD04/2020 EPI_ISL_410718 2020/2/
5
A 29095C 172 BetaCov/USA/CA7/2020 EPI_ISL_411954 2020/2/6
A 29095C 232 BetaCov/Korea/KCDC24/2020 EPI_ISL_412873 2020/2/6
A 29095C 270 BetaCov/Wuhan/HBCDC-HB-06/2020 EPI_ISL_412982 2020/2/7
A 29095T 174 BetaCov/USA/TX1/2020 EPI_ISL_411956 2020/2/11
A 29095C 261 BetaCov/USA/WA2/2020 EPI_ISL_412970 2020/2/24
【 在 shorea (未注册用户) 的大作中提到: 】
: 2020
: 2020
: 然后这三个人回去传染了美国遍地的A?
确切的说是，后确诊，呵呵
【 在 branching (branching) 的大作中提到: 】
: 确实没有变异关系，但是美国病例有武汉居住史，后发的。
美国这么大规模的病毒传染，不太像是几个人从武汉传过来的。
更大的可能性是美国人把A病毒传到武汉，变异后，几个被传染的美国人回美国。看来
病毒源早就存在，不查不知道，一查1 million
【 在 branching (branching) 的大作中提到: 】
: 确实没有变异关系，但是美国病例有武汉居住史，后发的。
起源于美国，只是刚开始传染虽然厉害但杀伤力不强。被美国人带到了武汉，曲曲折折，突变后在武汉爆发。老川断航加上武汉封城所以B没能出去，被中国按死在国内。其
它的自己发挥吧
一月份开传，到3月都传了一个多月了，然后在纽约市人口密集的地方大规模
爆发。纽约主要是被欧洲来的传染的。意大利的零号病人就是1月从德国带
病毒过去的。这个病毒只要一个多月就能在密集的地方大范围蔓延。
One of the first cases Heguy’s team sequenced, collected in early March,
came from a Long Island resident with no travel history whose viral genome
correlated with a strain circulating in England. That suggested the patient had contact with someone who had brought the virus over from the U.K.
The findings suggest that even after the Trump administration imposed travel restrictions from China, the virus continued to infiltrate the most
populous U.S. city via daily flights from Europe.
Not all the New York virus samples have European origins. Some appear to
have come from the U.S. West Coast, while others appear to link directly to Asia. That indicates that there are numerous chains of transmission in the
metro area, as would be expected in such a large outbreak.
【 在 BullishSolar (绍兴老黄) 的大作中提到: 】
: 美国这么大规模的病毒传染，不太像是几个人从武汉传过来的。
: 更大的可能性是美国人把A病毒传到武汉，变异后，几个被传染的美国人回美国。看来
: 病毒源早就存在，不查不知道，一查1 million
如果A在美国很久了，最近的大规模的检查就应该能查到大量的A型。
【 在 antee (蚂蚁) 的大作中提到: 】
: 丫对founder event有误解
: founder event的意思是类似英国人到美国，然后建了美国，
: founder event这里的意思是A输入
: 但是当地不适应变异出适应的成了主流
: 论文用了个Or,就是说另外能解释B在亚洲外少的原因是某种resistance
: 如果中国始发中国大量B，美国澳大利亚看不到B的可能性很小
: 理论上，中国看不到C可能和中国停止上传有关
: 但是A少B多不可能是停止上传或者过滤的结果，中国作为最先发现的
: 不可能知道其他国家的状态当时就能做出选择性上传
: 因为最近的结果纽约美国多数是欧洲输入的，所以爆发的是C
: ...................
这楼太高了。不爬了。
一个解释是，原始的A型传染性不强，变异成B和C后，更强更致命。
【 在 SOFC (SOFC) 的大作中提到: 】
: 如果A在美国很久了，最近的大规模的检查就应该能查到大量的A型。
病毒变异这么多次，得了一个对另一个免疫吗。如果不免疫，岂不是
一波接一波的死人。然后病毒再变异成DEF。。。
【 在 christina200 (na) 的大作中提到: 】
: 一月份开传，到3月都传了一个多月了，然后在纽约市人口密集的地方大规模
: 爆发。纽约主要是被欧洲来的传染的。意大利的零号病人就是1月从德国带
: 病毒过去的。这个病毒只要一个多月就能在密集的地方大范围蔓延。
: One of the first cases Heguy’s team sequenced, collected in early March, : came from a Long Island resident with no travel history whose viral genome
: correlated with a strain circulating in England. That suggested the
patient
: had contact with someone who had brought the virus over from the U.K.
: The findings suggest that even after the Trump administration imposed
travel
: restrictions from China, the virus continued to infiltrate the most
: populous U.S. city via daily flights from Europe.
: ...................
这篇文章截止数据截止在3月2号。美国还没有爆发，主要的数据都是西海岸的。现在再分析东岸肯定不一样，以前的研究早就提到了美国各种毒株都有。
其实这篇文章基本出发点一样是按照公开发表的文章来源于蝙蝠进行分析的，只是意外发现和蝙蝠病毒最接近的毒株并不是武汉主要和东亚的主要流行毒株。上来就扯来源于美国的基本上都是别有用心，根本不是为了讨论来源。
【 在 BullishSolar (绍兴老黄) 的大作中提到: 】
: 美国这么大规模的病毒传染，不太像是几个人从武汉传过来的。
: 更大的可能性是美国人把A病毒传到武汉，变异后，几个被传染的美国人回美国。看来
: 病毒源早就存在，不查不知道，一查1 million
开始的upload就是没人管别好像习是病毒所长似的
距离上看其实武汉疾控的实验室更可能，那地方离华南海鲜才280米
而且抓蝙蝠更积极，武汉疾控的掩盖动作比较显眼
【 在 mynight01 (一束星光) 的大作中提到: 】
: 因为A比B更古老，中国的生物学家很清楚其中的利害关系。
: 包子文化程度低，真的被五毒所那些始作俑者忽悠了。
: 现在看来A型重症率高，而且对欧美白人更易感。
: 我大胆猜测，A型是某实验室的目标毒株，而B，C是亚洲人感染后适应出来的变异副产
: 品，结果一起泄露了。
原文
Mutated versions of ‘A’ were seen in Americans reported to have lived in
Wuhan, and a large number of A-type viruses were found in patients from the
US and Australia.
而不是
Mutated versions of ‘A’ were seen in Americans reported to have lived in
Wuhan, and a large number of “MUTATED” A-type viruses were found in
patients from the US and Australia.
所以其实文章说的是
A large number of A-type viruses were found in patients from the
US and Australia, and mutated versions of ‘A’ were seen in Americans
reported to have lived in Wuhan.
原文
Wuhan’s major virus type, ‘B’, was prevalent in patients from across EastAsia. However, the variant didn’t travel much beyond the region without
further mutations – implying a "founder event" in Wuhan, or “resistance”
against this type of COVID-19 outside East Asia, say researchers.
其实文章说的是
Wuhan’s major virus type, ‘B’, was NOT the source of 'A' that is widely
found in US and Australia. Wuhan "founded" the type 'B'.
武汉present不等于武汉found
【 在 cllearjks (cllearjks) 的大作中提到: 】
: 抄了其他网友的回复，来回答你。
: Forster and colleagues found that the closest type of COVID-19 to the one : discovered in bats – type ‘A’, the “original human virus genome” –
was
: present in Wuhan, but surprisingly was not the city’s predominant virus
: type.
: Mutated versions of ‘A’ were seen in Americans reported to have lived in
: Wuhan, and a large number of A-type viruses were found in patients from
the
: US and Australia.
: 通过翻译去接西方论文为武肺洗地也算五毛发明。
: 人家说的很清楚最接近动物的a类在武汉发现，但不是武汉的主蔟（其实是因为武汉病
: ...................
Paper这么难读么？
There are two subclusters of A which are distinguished by the synonymous
mutation T29095C. In the T-allele subcluster, four Chinese individuals (from the southern coastal Chinese province of Guangdong) carry the ancestral
genome, while three Japanese and two American patients differ from it by a
number of mutations. These American patients are reported to have had a
history of residence in the presumed source of the outbreak in Wuhan. The C-allele subcluster sports relatively long mutational branches and includes
five individuals from Wuhan, two of which are represented in the ancestral
node, and eight other East Asians from China and adjacent countries. It is
noteworthy that nearly half (15/33) of the types in this subcluster, however, are found outside East Asia, mainly in the United States and Australia.
【 在 TaiHuShui (太湖-有容奶大) 的大作中提到: 】
: 原文
: Mutated versions of ‘A’ were seen in Americans reported to have lived in: Wuhan, and a large number of A-type viruses were found in patients from
the
: US and Australia.
: 而不是
: Mutated versions of ‘A’ were seen in Americans reported to have lived in: Wuhan, and a large number of “MUTATED” A-type viruses were found in
: patients from the US and Australia.
: 所以其实文章说的是
: A large number of A-type viruses were found in patients from the
: ...................
还是日本人了解五毛的智商：
14 Type A cases in USA and Australia is not "widely" found by any stretch.
【 在 TaiHuShui (太湖-有容奶大) 的大作中提到: 】
: 原文
: Mutated versions of ‘A’ were seen in Americans reported to have lived in: Wuhan, and a large number of A-type viruses were found in patients from
the
: US and Australia.
: 而不是
: Mutated versions of ‘A’ were seen in Americans reported to have lived in: Wuhan, and a large number of “MUTATED” A-type viruses were found in
: patients from the US and Australia.
: 所以其实文章说的是
: A large number of A-type viruses were found in patients from the
: ...................
抗体查不出来类型
痊愈的没病毒
如果A传染不强完全可能就是一直少量存活
新品种轻松overrun
【 在 SOFC (SOFC) 的大作中提到: 】
: 如果A在美国很久了，最近的大规模的检查就应该能查到大量的A型。
CDC，包括各国早期的检测政策都是假定武汉发源
这是个典型的sampling bias。这种政策下，测到的第一例必然是中国的，甚至是武汉的
其他的肺炎连新冠检测资格都没有，就是个流感或者不明的命
回头看这个假定可能有问题还忽略一些早期的病例
【 在 branching (branching) 的大作中提到: 】
: 确实没有变异关系，但是美国病例有武汉居住史，后发的。这篇文章数据截止3月2号，
: 东海岸还没有爆发。
如果武汉10个B,1个A，在美国如果是输入也应该是1A对大概10B
武汉中国可是检测重点人群，漏掉的概率要低很多
本来感染率就是万分1的量级，武汉是1%量级，
中国入境那些人，本来就没几个是真的带毒者
基本没看到B是个很奇葩的数据结果
【 在 christina200 (na) 的大作中提到: 】
: 然后A 在武汉生根变异成B，1月19号其中一个subclass在封城前被华盛顿的马公带入美
: 国。
: 1月22号另一个subclass被带入arizona.
: A 29095T 13 BetaCov/Guangdong/20SF012/2020 EPI_ISL_403932 2020/1
: /14
: A 29095T 14 BetaCov/Guangdong/20SF013/2020 EPI_ISL_403933 2020/1
: /15
: A 29095T 16 BetaCov/Guangdong/20SF025/2020 EPI_ISL_403935 2020/1
: /15
: A 29095C 71 BetaCov/Sichuan/IVDC-SC-001/2020 EPI_ISL_408484
2020
: ...................
楼主不懂英文？
例如，他在文章中写道：先有四个中国人携带A祖先基因, 三个日本人和两个在武汉的
美国人携带了该基因的变异。https://www.pnas.org/content/early/2020/04/07/
2004999117
There are two subclusters of A which are distinguished by the synonymous
mutation T29095C. In the T-allele subcluster, four Chinese individuals (from the southern coastal Chinese province of Guangdong) carry the ancestral
genome, while three Japanese and two American patients differ from it by a
number of mutations. These American patients are reported to have had a
history of residence in the presumed source of the outbreak in Wuhan. The C-allele subcluster sports relatively long mutational branches and includes
five individuals from Wuhan, two of which are represented in the ancestral
node, and eight other East Asians from China and adjacent countries.
最基本的逻辑，A株是始祖，BC都是变异后的子族。
如果A株始发于武汉，按照群聚效应，武汉和周边应该
有大量A株的病人。而事实上武汉的大量病人却是B株。
美国如此庞大的病例数，而且大量病人是A株，
证明了美国是起源，而且在本地流行已久。
这么简单的逻辑，还要硬凹什么？
武汉所是在法国丹麦专家帮助才升级到的P4，
成立至今没有任何泄露事故。
而且国内那帮人的科研水平，他们想造新冠病毒，
难度就和让你在自己灶台上把CPU造出来一样。
直到目前，美国对去年7月马里兰泄露事故被关停不敢说明。
而泄露之后，周边两个老人院出现的不明肺炎传染也避而不谈。
两个老人院距离马里兰P4车程大概50 miles。
Fairfax 老人院当时的情况https://wamu.org/story/19/07/11/two-dead-others-hospitalized-in-virus-
outbreak-at-fairfax-county-retirement-community/
Twenty-three of the 263 residents were hospitalized and 19 employees now saythey are experiencing symptoms of upper respiratory illness, the health
department says.
Residents in the continuing care neighborhood that have become ill are
showing respiratory symptoms ranging from coughing and shortness of breath
to pneumonia, according to officials.
Greenspring 老人院当时的情况https://wjla.com/news/local/mystery-virus-greenspring-retirement-cdc-va
In less than 2 weeks, a mystery virus at Springfield’s Greenspring
Retirement Community has gotten 55 residents sick. Twenty have been
hospitalized -- some with pneumonia
还有华洲医生要求对去年疑似流感的病人测新冠抗体被CDC喊卡。
病毒起源的答案，已经呼之欲出了。
if 14 Type A but zero B would be a very different story.
unless your screening method somehow preferentially pick type A for some
reason.
we do know the screening method when this paper published preferentially
picked people with China/Wuhan contact.
【 在 SOFC (SOFC) 的大作中提到: 】
: 14 Type A cases in USA and Australia is not "widely" found by any stretch.: the
惊讶于你的理解能力
【 在 xwzxjhq (谁的帝) 的大作中提到: 】
: 你真的献丑了你的英文
: 或者
: 你真的很坏和蠢
: 第一句就是起源美国的实锤证据
: A的变异版本在一些美国人身上被发现，据报道，这些人曾在武汉居住；而大量的A型病
: 毒在美国人和澳大利亚人身上被发现。
: 麻痹的
: 这不是美国源头是什么？
: 症屁的英文烂啊
: 实锤的证据被症屁当宝
: ...................
That is false.
"美国如此庞大的病例数，而且大量病人是A株，" Last USA data from the paper is 2/24/2020, at that time, there is nowhere close to 庞大的病例数.
【 在 coronavirus (看什么看，小心盯上你) 的大作中提到: 】
: 最基本的逻辑，A株是始祖，BC都是变异后的子族。
: 如果A株始发于武汉，按照群聚效应，武汉和周边应该
: 有大量A株的病人。而事实上武汉的大量病人却是B株。
: 美国如此庞大的病例数，而且大量病人是A株，
: 证明了美国是起源，而且在本地流行已久。
: 这么简单的逻辑，还要硬凹什么？
: 武汉所是在法国丹麦专家帮助才升级到的P4，
: 成立至今没有任何泄露事故。
: 而且国内那帮人的科研水平，他们想造新冠病毒，
: 难度就和让你在自己灶台上把CPU造出来一样。
: ...................
In this paper, there are 9As, 8Bs and 1C from USA patients.
【 在 antee (蚂蚁) 的大作中提到: 】
: 如果武汉10个B,1个A，在美国如果是输入也应该是1A对大概10B
: 武汉中国可是检测重点人群，漏掉的概率要低很多
: 本来感染率就是万分1的量级，武汉是1%量级，
: 中国入境那些人，本来就没几个是真的带毒者
: 基本没看到B是个很奇葩的数据结果
: /1
: /1
: /1
: 2020
前面都当流感了。不测当然不会有病例。
现在放开测了，才看出早就本地流传很久了
【 在 SOFC (SOFC) 的大作中提到: 】
: That is false.
: "美国如此庞大的病例数，而且大量病人是A株，" Last USA data from the paper
is
: 2/24/2020, at that time, there is nowhere close to 庞大的病例数.
Then you need data to support your claim that there is significant amount A-type infection in US, which means tens of thousands, not mere tens or
hundreds of A-type.
【 在 coronavirus (看什么看，小心盯上你) 的大作中提到: 】
: 前面都当流感了。不测当然不会有病例。
: 现在放开测了，才看出早就本地流传很久了
: is
他在文章中清楚地写道：A类两个subcluster
T-allele，先有四个中国人携带A祖先基因（ancestral genome）, 三个日本人和两个
在武汉的美国人携带了该基因的变异。
C-allele subcluster，里面五个武汉人，祖先基因是两个武汉人。https://www.pnas.org/content/early/2020/04/07/2004999117
There are two subclusters of A which are distinguished by the synonymous
mutation T29095C. In the T-allele subcluster, four Chinese individuals (from the southern coastal Chinese province of Guangdong) carry the ancestral
genome, while three Japanese and two American patients differ from it by a
number of mutations. These American patients are reported to have had a
history of residence in the presumed source of the outbreak in Wuhan. The C-allele subcluster sports relatively long mutational branches and includes
five individuals from Wuhan, two of which are represented in the ancestral
node, and eight other East Asians from China and adjacent countries. It is
noteworthy that nearly half (15/33) of the types in this subcluster, however, are found outside East Asia, mainly in the United States and Australia.
这里面说的美国人主要也是华人。
该论文样本截至是2月24日，美帝还没爆发，主要还是从亚洲来的个例。
还是那句话，实锤的一个论文，不理解粉红们high什么劲。大力批判才对啊。
【 在 arthury (灌完水记得要删贴) 的大作中提到: 】
: 以下是论文SI的原始数据，lgw出来讲讲，里面哪个是A，哪个是mutated A？ 呵呵
: Supplementary Table 2b. Phylogenetic cluster assignment of of viral
genome
: variants.
: Note: Sorted by date
:
: Type subtype GISAID genome label GISAID Accession ID
Collection
: date
: B derived 4 BetaCov/Wuhan/IPBCAMS-WH-01/2019 EPI_ISL_402123
2019
: /12/24
: B derived 48 BetaCov/Wuhan/WH01/2019 EPI_ISL_406798 2019/12/26: ...................
This is just pure bad luck, a possibly benign virus runs amok through
mutation in, most likely, Wuhan, and people there are its earliest victims. CCP's missteps including cover-up during the early stage of the outbreak
aggravate the situation.
【 在 lgw (abcdefg) 的大作中提到: 】
: 他在文章中清楚地写道：A类两个subcluster
: T-allele，先有四个中国人携带A祖先基因（ancestral genome）, 三个日本人和两个
: 在武汉的美国人携带了该基因的变异。
: C-allele subcluster，里面五个武汉人，祖先基因是两个武汉人。
: https://www.pnas.org/content/early/2020/04/07/2004999117
: There are two subclusters of A which are distinguished by the synonymous
: mutation T29095C. In the T-allele subcluster, four Chinese individuals (
from
: the southern coastal Chinese province of Guangdong) carry the ancestral
: genome, while three Japanese and two American patients differ from it by a
: number of mutations. These American patients are reported to have had a
: ...................
后续好像有扩展到1000个样本
【 在 SOFC (SOFC) 的大作中提到: 】
: That is false.
: "美国如此庞大的病例数，而且大量病人是A株，" Last USA data from the paper
is
: 2/24/2020, at that time, there is nowhere close to 庞大的病例数.
在PNAS可以下载的Dataset里就一百多。
【 在 blackwinds (从良的黑师傅) 的大作中提到: 】
: 后续好像有扩展到1000个样本
: is
新闻里报道了，说最新的还没全弄完，但似乎结论不变
【 在 SOFC (SOFC) 的大作中提到: 】
: 在PNAS可以下载的Dataset里就一百多。
CCP cover-up or not won't change the course.
it is a new virus with unknown R0.
assuming it is another SARS just like what Li said would not make a dent.
you need a month to 45 days from the date you notice the outbreak to have a reasonable tool kits and understanding to conduct screening.
CCP action was actually much faster than expected even all the western
countries thought it was unnecessary.
【 在 SOFC (SOFC) 的大作中提到: 】
: This is just pure bad luck, a possibly benign virus runs amok through
: mutation in, most likely, Wuhan, and people there are its earliest victims.
: CCP's missteps including cover-up during the early stage of the outbreak
: aggravate the situation.
:
: from
so it is 1:1, still far from what Wuhan ratio.
【 在 SOFC (SOFC) 的大作中提到: 】
: In this paper, there are 9As, 8Bs and 1C from USA patients.
结论怎么会变？要得到粉红想要的结论，无非要这么几个数据，要么在北美发现某种生物，蝙蝠也好，穿山甲也罢，携带的冠状病毒比云南蝙蝠携带的更加接近COVID-19，要么就是发现北美存有至少几万的A型新冠携带者。
【 在 blackwinds (从良的黑师傅) 的大作中提到: 】
: 新闻里报道了，说最新的还没全弄完，但似乎结论不变
只看谱系不研究时间轴就是神经病
家谱上辈分小的就一定岁数小出生晚于辈分高的吗吗？你们这帮白痴要是想不清楚，还是趁早改行不要干科学了，否则就这智商迟早被科学干。
米国根本不做溯源
【 在 SOFC (SOFC) 的大作中提到: 】
: 结论怎么会变？要得到粉红想要的结论，无非要这么几个数据，要么在北美发现某种生
: 物，蝙蝠也好，穿山甲也罢，携带的冠状病毒比云南蝙蝠携带的更加接近COVID-19，要
: 么就是发现北美存有至少几万的A型新冠携带者。
【 在 xdf (消毒粉) 的大作中提到: 】
: 中国武毒，你好，对不起。
美国50万，中国8万
还好意思不说是美国病毒？？ 哈哈
威武!中国病毒，武汉病毒也罢，武汉是疫源地是不变的事实。
【 在 cllearjks(cllearjks) 的大作中提到: 】
: 看文章学英语了，一直有人想看我翻译文章，现在出来献丑了！
: Mutated versions of ‘A’ were seen in Americans reported to have
lived in
: Wuhan, and a large number of A-type viruses were found in patients
from the
: US and Australia.
: A的突变版本的病毒是在居住在武汉的美国人中发现的，并且大量的A类型病毒在美国和
: 澳大利亚被发现。
: Wuhan’s major virus type, ‘B’, was prevalent in patients from
across East
: Asia. However, the variant didn’t travel much beyond the region
without
: further mutations – implying a "founder event" in Wuhan, or “
resistance”
: against this type of COVID-19 outside East Asia, say researchers.
: ...................
I disagree, at least disagree with the development within China because SARS experience would make people more cautious which helps a lot evidently in
East Asia. I tend to agree it may not change the course in Europe and North America, but we will never know as we cannot relive history.
【 在 antee (蚂蚁) 的大作中提到: 】
: CCP cover-up or not won't change the course.
: it is a new virus with unknown R0.
: assuming it is another SARS just like what Li said would not make a dent.
: you need a month to 45 days from the date you notice the outbreak to have a
: reasonable tool kits and understanding to conduct screening.
: CCP action was actually much faster than expected even all the western
: countries thought it was unnecessary.
: .
但是在论文提供的SI的data里面，并没有看出这些A病例，哪些是你说的A祖先基因，哪些是该基因的变异
至少我没看到作者标明了
【 在 lgw (abcdefg) 的大作中提到: 】
: 他在文章中清楚地写道：A类两个subcluster
: T-allele，先有四个中国人携带A祖先基因（ancestral genome）, 三个日本人和两个
: 在武汉的美国人携带了该基因的变异。
: C-allele subcluster，里面五个武汉人，祖先基因是两个武汉人。
: https://www.pnas.org/content/early/2020/04/07/2004999117
: There are two subclusters of A which are distinguished by the synonymous
: mutation T29095C. In the T-allele subcluster, four Chinese individuals (
from
: the southern coastal Chinese province of Guangdong) carry the ancestral
: genome, while three Japanese and two American patients differ from it by a
: number of mutations. These American patients are reported to have had a
: ...................
你专门看 A的和时间就能看到，最早的几个A在广东和武汉等地。
变异成B和C看着像是在武汉变异的。
【 在 arthury (灌完水记得要删贴) 的大作中提到: 】
: 但是在论文提供的SI的data里面，并没有看出这些A病例，哪些是你说的A祖先基因，哪
: 些是该基因的变异
: 至少我没看到作者标明了
: from
那你从论文给出的全部病毒案例数据中指出一下，那些案例是你说的A原始，哪些是A变异？
原始数据我已经贴了
【 在 lgw (abcdefg) 的大作中提到: 】
: 1，美澳发现的是A原始的变异版本。和A原始差两个变异。
: 2,A原始只在武汉发现。
: COVID-19 to the one
: discovered in bats – type ‘A’, the “original human virus genome” –
was
: present in Wuhan, but surprisingly was not the city’s predominant virus
: type.
: Mutated versions of ‘A’ were seen in Americans reported to have lived in: Wuhan, and a large number of A-type viruses were found in patients from
the
: US and Australia.
我说的不是A变异成B和C
我是说lgw说的原始A和变异A
【 在 christina200 (na) 的大作中提到: 】
: 你专门看 A的和时间就能看到，最早的几个A在广东和武汉等地。
: 变异成B和C看着像是在武汉变异的。
就按你说的，A还有原始簇，和变异簇(非b，非c)
那论文的原始病例数据里面，哪些是A的原始簇，哪些是变异的A
【 在 lgw (abcdefg) 的大作中提到: 】
: There are two subclusters of A which are distinguished by the synonymous
: mutation T29095C. In the T-allele subcluster, four Chinese individuals (
from
: the southern coastal Chinese province of Guangdong) carry the ancestral
: genome, while three Japanese and two American patients differ from it by a
: number of mutations
: 原文说的很清楚，A有两蔟，原始蔟只在中国人身上发现，三个日本人两个美国身上发
: 现A的变异。
A原始，和A变异(非b非c)，如何体现在论文提供的病例列表data里面？呵呵
【 在 lgw (abcdefg) 的大作中提到: 】
: 原文只说A原始见于武汉。
: A变异在武汉居住史的美国人身上发现，A变异在美澳发现很多。
: 人家没想到和五毛深究起源，起源哪里在人看来就是一加一等于二。
这个是正解。
【 在 TaiHuShui (太湖-有容奶大) 的大作中提到: 】
: 原文
: Mutated versions of ‘A’ were seen in Americans reported to have lived in: Wuhan, and a large number of A-type viruses were found in patients from
the
: US and Australia.
: 而不是
: Mutated versions of ‘A’ were seen in Americans reported to have lived in: Wuhan, and a large number of “MUTATED” A-type viruses were found in
: patients from the US and Australia.
: 所以其实文章说的是
: A large number of A-type viruses were found in patients from the
: ...................
难得同意你一次！
【 在 Edinburgher (喜欢养牛) 的大作中提到: 】
: 你这蠢货脸被打得噼啪响还嘴硬，你的英语水平脸小学生都不到。
你没有贴原始数据，原始数据在GISAID的EpiFlu数据库。作者只是给出了数据的Index
和采集地，时间等等。你要是不愿意Take the authors' words，欢迎你去GISAID的
EpiFlu数据库排查。比方说你从那里排查发现美国的是A原始，中国的是A变异，这不就实锤了吗？祝你好运！
【 在 arthury (灌完水记得要删贴) 的大作中提到: 】
: 那你从论文给出的全部病毒案例数据中指出一下，那些案例是你说的A原始，哪些是A变
: 异？
: 原始数据我已经贴了
: was
: the
re
还有一种可能，就是论文作者表达的意思并非是lgw所解读的那样，呵呵
【 在 SOFC (SOFC) 的大作中提到: 】
: 你没有贴原始数据，原始数据在GISAID的EpiFlu数据库。作者只是给出了数据的
Index
: 和采集地，时间等等。你要是不愿意Take the authors' words，欢迎你去GISAID的
: EpiFlu数据库排查。比方说你从那里排查发现美国的是A原始，中国的是A变异，这不就
: 实锤了吗？祝你好运！
what make you think other place is better in east Asia?
TW is import cases and politicize it quickly. it would collapse if it
started there.
S.K. has 10K case. However, two things play to its benefit.
it is known virus by then, and test kits are ready to ramp.
if it started in S.K. it would means it is unknown and also no test kits to do the screening. to identify the virus, sequence it and develop the test
kits,
you need 4 weeks at least. this one month delay will make cases in S.K 1000X more.
it will be a total disaster. even two weeks delay would make it impossible
to stop.
I did agree China had a slim window to shut it down. but transparency didn't play any role here. even it is cover-up, the decision maker still know the some truth. and it takes a lot of guts for any political leader to shut down a city of this scale. and don't tell me self-discipline is sufficient here. it takes a lot of coordination to make it works and human nature is jackass.
Without any reliable testing tools, only based on CT etc secondary evidence,the gov need to shut the city when known cases (hospitalized therefore only 10%) only couple hundreds. the tracking tactics SK used is not applicable
here because you don't have effective testing kits for milder cases yet.
Shutdown is the only way out at this time. by the time it is two weeks
later and you get your kits and have some understanding of the virus, known cases will reach 5000 cases, with another 20-50K at large. it will not make a dent on the outcome.
Back to coverup, i think we could agree CCP is not stupid, maybe evil but
not stupid. they would only try to cover up when they saw good chance of
success.
if it is SARS, the gov think they know what to do and they might. and seems to me that is the mindset for the first 3 weeks.
【 在 SOFC (SOFC) 的大作中提到: 】
: I disagree, at least disagree with the development within China because
SARS
: experience would make people more cautious which helps a lot evidently in
: East Asia. I tend to agree it may not change the course in Europe and
North
: America, but we will never know as we cannot relive history.
: a
这些A啊B啊，都是假定了病毒发源于武汉病毒所从云南采集到的那个蝙蝠冠状病毒为祖先基准之后，才确立出谁先谁后的。美国第一例是武汉相亲回来的，这种古老型还有广东首例；其他中国病人大多来自海鲜市场的B，说明了海鲜市场不是最初的发源地。
【 在 shenjing (心灵捕手) 的大作中提到: 】
: 剑桥大学在PNAS发表论文。
: https://www.cam.ac.uk/research/news/covid-19-genetic-network-analysis-
: provides-snapshot-of-pandemic-origins?from=timeline&isappinstalled=0
: 武汉主要为B病毒，A病毒较少；
: 美国澳洲主要为A病毒；
: 欧洲主要为C病毒。
: 美国或为病毒源头
: A编译到B，B编译到C
: 卧槽，难怪nature发文章道歉了，老酱喜讯啊
A型传染力弱R0小的话估计也就维持个小感染人群
感染过的会有抗体但不会有病毒，病毒在人群也就是21天
所以美国大量存在A型的现行感染者可能不大
这个事情得查抗体，如果抗体阳性太多，特别是还没爆发的地方，那这事就有猫腻
等全民免疫的，这事就查不到底了
Or的医生发现自己有强抗体，朋友有弱抗体，俩都在12月底一月初流感过
这事就比较有趣了，那时候武汉才几百起，医生们还很淡定
【 在 SOFC (SOFC) 的大作中提到: 】
: 结论怎么会变？要得到粉红想要的结论，无非要这么几个数据，要么在北美发现某种生
: 物，蝙蝠也好，穿山甲也罢，携带的冠状病毒比云南蝙蝠携带的更加接近COVID-19，要
: 么就是发现北美存有至少几万的A型新冠携带者。
至于病毒，石可是和北卡分享过很多样品的
【 在 SOFC (SOFC) 的大作中提到: 】
: 结论怎么会变？要得到粉红想要的结论，无非要这么几个数据，要么在北美发现某种生
: 物，蝙蝠也好，穿山甲也罢，携带的冠状病毒比云南蝙蝠携带的更加接近COVID-19，要
: 么就是发现北美存有至少几万的A型新冠携带者。
我觉得mutated versions of "A" 是指那些从A伸出来的节点
而A-type viruses是指“A“节点，也就是最原始的病毒。
【 在 skyeer (看到你的眼) 的大作中提到: 】
: Mutated versions of ‘A’ were seen in Americans reported to have lived in: Wuhan, and a large number of A-type viruses were found in patients from
the
: US and Australia.
: 没搞明白这个说的啥。Those Americans reported to have lived in
: Wuhan, 和 a large number of patients from the
: US and Australia有什么不同？为啥把前一组人单独提出来？那a large number of : patients是不是也有人去过欧洲，其他国家，东亚，西亚？为啥不提出来？
尴尬了，你好像把人家文章正好读反了。。。
【 在 shenjing (心灵捕手) 的大作中提到: 】
: 剑桥大学在PNAS发表论文。
: https://www.cam.ac.uk/research/news/covid-19-genetic-network-analysis-
: provides-snapshot-of-pandemic-origins?from=timeline&isappinstalled=0
: 武汉主要为B病毒，A病毒较少；
: 美国澳洲主要为A病毒；
: 欧洲主要为C病毒。
: 美国或为病毒源头
: A编译到B，B编译到C
: 卧槽，难怪nature发文章道歉了，老酱喜讯啊
美帝只测去过武汉的人，当然就是得病的都是去过武汉的。
你们据此确定病毒来自武汉，
神一样的智商
采访原作者：
https://news.sina.com.cn/c/2020-04-11/doc-iirczymi5615400.shtml
【 在 shenjing (心灵捕手) 的大作中提到: 】
: 剑桥大学在PNAS发表论文。
: https://www.cam.ac.uk/research/news/covid-19-genetic-network-analysis-
: provides-snapshot-of-pandemic-origins?from=timeline&isappinstalled=0
: 武汉主要为B病毒，A病毒较少；
: 美国澳洲主要为A病毒；
: 欧洲主要为C病毒。
: 美国或为病毒源头
: A编译到B，B编译到C
: 卧槽，难怪nature发文章道歉了，老酱喜讯啊