Yu-Tzu Chiu Nature Medicine volume 9, page1335(2003)Cite this article
163 Accesses 3 Citations 2 Altmetric Metrics details A genetic variant in the immune system might render some groups of people more susceptible to severe acute respiratory syndrome (SARS) infection, Taiwanese researchers report.
Waiting to exhale: People in South China and Taiwan may be genetically susceptible to SARS. Credit: Richard Chung/Reuters Marie Lin, a hematologist at the Mackay Memorial Hospital in Taipei, says subtypes of human leukocyte antigen (HLA) class I are associated with severe SARS infection.
Lin and her team compared blood samples from 65 suspected SARS patients ( including 37 probable cases) with samples from 101 high-risk, uninfected health-care workers. The researchers used 190 healthy, unrelated Taiwanese individuals as controls.
People with the HLA-B*4601 allele are most likely to fall victim to SARS, the researchers reported (BMC Med. Genet. 4; 2003). Of the 37 probable cases, 15 had HLA-B*4601, and 5 severe cases had a significantly higher frequency of the allele when compared with controls. The HLA system is often used to search for the origins of infectious diseases and autoimmune disorders.
The HLA-B*4601 allele is found in about 10% of the Taiwanese population and among other southern Asians, including people from China's southern coast, Hong Kong, Singapore and part of Vietnam—areas hit hard by SARS. But it is seldom seen in the indigenous people of Taiwan—about 1.5% of the total Taiwanese population—in Caucasians or in people of African origin.
The results explain why south China was the epicenter of the SARS epidemic, the researchers suggest. The finding tallies with the scenario in Taiwan: no probable SARS cases were reported among indigenous people. It might also explain why the disease left Caucasian people largely unaffected—except in Toronto, which has a high Asian population.
Lin suggests screening health-care workers for HLA-B*4601 to prevent the spread of SARS. But other scientists are cautious about extrapolating results from a small study.
“It's too [early] to talk about mass screening now,” says Yuh-Shan Jou, a researcher in Taiwan's National Health Research Institutes. “The lack of data from other areas hit by SARS makes Lin's scientific evidence comparatively weak.”
Cuomo 在电视讲话中对全球透露，高层和情报人员普遍认为只有亚裔感染，依据是基于SARS1.0
我的最关键的预言被证实了
自然杂志宣布过，白人不感染 SARS1.0
Taiwanese scientists find genetic link to SARS
Yu-Tzu Chiu
Nature Medicine volume 9, page1335(2003)Cite this article
163 Accesses
3 Citations
2 Altmetric
Metrics details
A genetic variant in the immune system might render some groups of people
more susceptible to severe acute respiratory syndrome (SARS) infection,
Taiwanese researchers report.
Waiting to exhale: People in South China and Taiwan may be genetically
susceptible to SARS. Credit: Richard Chung/Reuters
Marie Lin, a hematologist at the Mackay Memorial Hospital in Taipei, says
subtypes of human leukocyte antigen (HLA) class I are associated with severe SARS infection.
Lin and her team compared blood samples from 65 suspected SARS patients (
including 37 probable cases) with samples from 101 high-risk, uninfected
health-care workers. The researchers used 190 healthy, unrelated Taiwanese
individuals as controls.
People with the HLA-B*4601 allele are most likely to fall victim to SARS,
the researchers reported (BMC Med. Genet. 4; 2003). Of the 37 probable cases, 15 had HLA-B*4601, and 5 severe cases had a significantly higher frequency of the allele when compared with controls. The HLA system is often used to search for the origins of infectious diseases and autoimmune disorders.
The HLA-B*4601 allele is found in about 10% of the Taiwanese population and among other southern Asians, including people from China's southern coast,
Hong Kong, Singapore and part of Vietnam—areas hit hard by SARS. But it is seldom seen in the indigenous people of Taiwan—about 1.5% of the total
Taiwanese population—in Caucasians or in people of African origin.
The results explain why south China was the epicenter of the SARS epidemic, the researchers suggest. The finding tallies with the scenario in Taiwan: no probable SARS cases were reported among indigenous people. It might also
explain why the disease left Caucasian people largely unaffected—except in Toronto, which has a high Asian population.
Lin suggests screening health-care workers for HLA-B*4601 to prevent the
spread of SARS. But other scientists are cautious about extrapolating
results from a small study.
“It's too [early] to talk about mass screening now,” says Yuh-Shan Jou, a researcher in Taiwan's National Health Research Institutes. “The lack of
data from other areas hit by SARS makes Lin's scientific evidence
comparatively weak.”
扯，当年SARS盖子捂不住的一个原因就是境外死了一个老外
【 在 Carraway (核弹共振掀翻美西板块原创者) 的大作中提到: 】
: Cuomo 在电视讲话中对全球透露，高层和情报人员普遍认为只有亚裔感染，依据是基于
: SARS1.0
: 我的最关键的预言被证实了
: 自然杂志宣布过，白人不感染 SARS1.0
: Taiwanese scientists find genetic link to SARS
: Yu-Tzu Chiu
: Nature Medicine volume 9, page1335(2003)Cite this article
: 163 Accesses
: 3 Citations
: 2 Altmetric
: ...................
不易感吧，不等于完全不感染。
有一两个不能说明啥
【 在 Inquiry(We will defeat SARS) 的大作中提到: 】
: 扯，当年SARS盖子捂不住的一个原因就是境外死了一个老外
命名SARS的欧洲医生就是传染死了，这个报告是专业造谣的啊。
我去。小黄人泪流下来吧？
【 在 Carraway (核弹共振掀翻美西板块原创者) 的大作中提到: 】
: Cuomo 在电视讲话中对全球透露，高层和情报人员普遍认为只有亚裔感染，依据是基于
: SARS1.0
: 我的最关键的预言被证实了
: 自然杂志宣布过，白人不感染 SARS1.0
: Taiwanese scientists find genetic link to SARS
: Yu-Tzu Chiu
: Nature Medicine volume 9, page1335(2003)Cite this article
: 163 Accesses
: 3 Citations
: 2 Altmetric
: ...................
这个弯弯医生被土共买通了。