More than 70% of Japan’s population has received the COVID-19 vaccines, and the government is moving ahead with a booster shot in December. But a conservative radio host in the U.S. falsely claimed, “Japan drops vax rollout, goes to Ivermectin.” Japan hasn’t stopped its vaccine program and hasn’t approved ivermectin as a COVID-19 treatment.
So, rather than ending its COVID-19 vaccination program, the Japanese government has said it plans to continue providing vaccines, including the booster shot as soon as December, according to NHK World Japan.
Ivermectin Never Approved for Treatment
Contrary to Turner’s claim, ivermectin is not on a list of pharmaceuticals approved to treat COVID-19 in Japan.
“Ivermectin is not endorsed by the Japanese government,” Kosuke Yasukawa, who is a physician at Medstar Washington Hospital Center and an assistant professor of clinical medicine at Georgetown University School of Medicine, told us in an email.
Haruo Ozaki, chairman of the Tokyo Medical Association, had recommended the use of ivermectin as a treatment for COVID-19 patients at Feb. 9 press conference, “which was criticized by many physicians in the U.S.,” said Yasukawa, an infectious disease specialist who received his medical degree at Keio University in Tokyo.
Ozaki is not a government official, and the Tokyo Medical Association is a professional organization that doesn’t make policy.
“I believe basic precautions like masks [and] social distancing, along with vaccination, helped reduce infections in Japan,” Yasukawa said.
【 在 cellcycle (vacoule) 的大作中提到: 】 : 非常希望是因为 IVM，看来官方说 不是。。 : ######## : More than 70% of Japan’s population has received the COVID-19 vaccines, and : the government is moving ahead with a booster shot in December. But a : conservative radio host in the U.S. falsely claimed, “Japan drops vax : rollout, goes to Ivermectin.” Japan hasn’t stopped its vaccine program and : hasn’t approved ivermectin as a COVID-19 treatment. : So, rather than ending its COVID-19 vaccination program, the Japanese : government has said it plans to continue providing vaccines, including the : booster shot as soon as December, according to NHK World Japan. : ...................
日本政府签了这个合同，所以不能公开使用ivermectin，但是私下里允许医生off- label use
【 在 cellcycle (vacoule) 的大作中提到: 】 : 非常希望是因为 IVM，看来官方说 不是。。 : ######## : More than 70% of Japan’s population has received the COVID-19 vaccines, and : the government is moving ahead with a booster shot in December. But a : conservative radio host in the U.S. falsely claimed, “Japan drops vax : rollout, goes to Ivermectin.” Japan hasn’t stopped its vaccine program and : hasn’t approved ivermectin as a COVID-19 treatment. : So, rather than ending its COVID-19 vaccination program, the Japanese : government has said it plans to continue providing vaccines, including the : booster shot as soon as December, according to NHK World Japan. : ...................
At least we need to see report from Japan's government saying that they have been using ivermectin to treat covid before we even consider giving it credit. People can post online saying that ETs from outer space are helping Japan, and Japan's cases did plummet, so it is true that ETs have helped Japan and Africa?
【 在 FortyNiner (Niner) 的大作中提到: 】 : At least we need to see report from Japan's government saying that they have : been using ivermectin to treat covid before we even consider giving it : credit. People can post online saying that ETs from outer space are helping : Japan, and Japan's cases did plummet, so it is true that ETs have helped : Japan and Africa?
Are you kidding me? Once Japan uses the vaccine, they cannot treat the breakthrough? What about those who are not vaxxed and get infected? Can they be treated? On 8/13, the date on your graph when ivermectin was recommended to be used to treat covid in Japen, only about 49.1% of Japan's population had been fully vaxxed. And the other 50.9% of Japanese cannot be treated for covid once they got it? Wow, Japanese government surely colludes with cdc. Do you believe that? You would rather believe some craps like that? Imagine that also applies to the US.
【 在 cellcycle (vacoule) 的大作中提到: 】 : 非常希望是因为 IVM，看来官方说 不是。。 : ######## : More than 70% of Japan’s population has received the COVID-19 vaccines, and : the government is moving ahead with a booster shot in December. But a : conservative radio host in the U.S. falsely claimed, “Japan drops vax : rollout, goes to Ivermectin.” Japan hasn’t stopped its vaccine program and : hasn’t approved ivermectin as a COVID-19 treatment. : So, rather than ending its COVID-19 vaccination program, the Japanese : government has said it plans to continue providing vaccines, including the : booster shot as soon as December, according to NHK World Japan. : ...................
【 在 cellcycle (vacoule) 的大作中提到: 】 : 非常希望是因为 IVM，看来官方说 不是。。 : ######## : More than 70% of Japan’s population has received the COVID-19 vaccines, and : the government is moving ahead with a booster shot in December. But a : conservative radio host in the U.S. falsely claimed, “Japan drops vax : rollout, goes to Ivermectin.” Japan hasn’t stopped its vaccine program and : hasn’t approved ivermectin as a COVID-19 treatment. : So, rather than ending its COVID-19 vaccination program, the Japanese : government has said it plans to continue providing vaccines, including the : booster shot as soon as December, according to NHK World Japan. : ...................
What's behind the rapid disappearance of the delta variant in Japan? It could be self-extinction. Osamu Tsukimori
Why did Japan’s fifth and biggest wave of the coronavirus pandemic, driven by the supercontagious delta variant, suddenly come to an abrupt end following a seemingly relentless rise in new infections? And what made Japan different from other developed countries that are now seeing a fresh surge in new cases?
According to one group of researchers, the surprising answer may be that the delta variant took care of itself in an act of “self-extinction.”
Three months after the delta variant spurred record daily nationwide caseloads of nearly 26,000, new COVID-19 infections in Japan have plummeted, dropping below 200 in recent weeks. Highlighting that drop was the fact that no deaths were reported on Nov. 7 — the first time that had happened in about 15 months.
Many scholars point to a variety of possibilities, which include one of the highest vaccination rates among advanced countries with 75.7% of residents fully vaccinated as of Wednesday. Other potential factors are the social distancing and mask-wearing measures that are now deeply embedded in Japanese society.
But the chief reason may be related to the genetic changes that the coronavirus undergoes during reproduction, at a pace of around two mutations per month. According to a potentially revolutionary theory proposed by Ituro Inoue, a professor at the National Institute of Genetics, the delta variant in Japan accumulated too many mutations to the virus’s error- correcting, non-structural protein called nsp14. As a result, the virus struggled to repair the errors in time, ultimately leading to “self- destruction.”
Studies have shown that more people in Asia have a defense enzyme called APOBEC3A that attacks RNA viruses, including the SARS-CoV-2 virus that causes COVID-19, when compared to people in Europe and Africa.
So the researchers from the National Institute of Genetics and Niigata University set out to discover how the APOBEC3A protein affects the nsp14 protein and whether it can inhibit the activity of the coronavirus. The team conducted an analysis of the genetic diversity data for the alpha and delta variants from infected clinical specimens in Japan from June to October.
They then visualized the relationships among the DNA sequences of the SARS- CoV-2 virus to show genetic diversity in a diagram called a haplotype network. In general, the bigger the network is, the more positive cases it represents. The Minami district of Osaka in Oct. 25. | KYODO The Minami district of Osaka in Oct. 25. | KYODO
The network of the alpha variant, which was the main driver for Japan’s fourth wave from March to June, had five major groups with many mutations branching out, confirming a high level of genetic diversity. The researchers thought the delta variant, which the U.S. Centers for Disease Control and Prevention says is more than twice as contagious as previous variants and might cause more severe illness in unvaccinated people, would have a far more vibrant genetic diversity.
Surprisingly, they found the opposite to be true. The haplotype network had only two major groups and the mutations seemed to come to a sudden stop in the middle of its evolutionary development process. When the researchers went on to examine the virus’s error-correcting enzyme nsp14, they discovered that the vast majority of nsp14 specimens in Japan seemed to have undergone many genetic changes in mutation sites called A394V.
“We were literally shocked to see the findings,” Inoue told The Japan Times. “The delta variant in Japan was highly transmissible and keeping other variants out. But as the mutations piled up, we believe it eventually became a faulty virus and it was unable to make copies of itself. Considering that the cases haven’t been increasing, we think that at some point during such mutations it headed straight toward its natural extinction.”
Inoue’s theory, while innovative, would lend support to the mysterious disappearance of the delta variant’s spread in Japan. While much of the rest of the world with similarly high vaccination rates, including South Korea and some Western countries, are suffering from record waves of new infections, Japan appears to be a peculiar case in that COVID-19 cases have remained subdued despite trains and restaurants filling up following the end of the most recent state of emergency.
“If the virus were alive and well, cases for sure would increase as masking and vaccination do not prevent breakthrough infections in some cases,” Inoue said. Ituro Inoue, a professor at the National Institute of Genetics | THE NATIONAL INSTITUTE OF GENETICS Ituro Inoue, a professor at the National Institute of Genetics | THE NATIONAL INSTITUTE OF GENETICS
Indeed, the unexpected plunge in new cases following the summer wave has been a hot topic of discussion among many experts, including those not conducting studies on the coronavirus, according to Takeshi Urano, a professor at Shimane University’s Faculty of Medicine who was not involved in the research led by Inoue.
“Nsp14 works with other virus proteins and has a critical function to protect the virus RNA from breaking apart,” he said when asked about Inoue ’s findings. “Studies have shown that a virus with a crippled nsp14 has a significantly reduced ability to replicate, so this can be one factor behind the rapid decline in new cases. The nsp14 is virus-derived, and the chemical agent to curb this protein could become a promising medicine, with development already underway.”
Japan seems to be an anomaly in that the delta variant was virtually shutting out alpha and other variants by late August. On the other hand, other countries — including India and Indonesia, both of which were hit particularly hard by the delta variant — have reported a mix of alpha and delta strains among cases.
A similar natural extinction of the coronavirus could possibly be observed overseas, Inoue says, adding that detecting that would be difficult as no other country seems to have accumulated as many mutations in the virus’s nsp14 as in Japan, though similar mutations at the A394V site have been discovered in at least 24 countries. Pedestrians pass bars on a street at night in the Shimbashi district of Tokyo on Oct. 29. | BLOOMBERG Pedestrians pass bars on a street at night in the Shimbashi district of Tokyo on Oct. 29. | BLOOMBERG
But Inoue’s theory may also help explain why the outbreak of severe acute respiratory syndrome (SARS) ended abruptly in 2003. An in vitro experiment in which the researchers caused mutations in nsp14 in the virus that causes SARS led to findings that the virus eventually could not replicate itself as mutations piled up.
“No genome data exists, so it’s just a hypothesis, but because it has disappeared, it will never see the light of day again,” he said.
So what are the chances that we could see a similar natural extinction overseas of the COVID-19-causing SARS-CoV-2 virus?
“The chances are not zero, but that seems too optimistic for now as we’re unable to get hold of any such evidence, though we have looked at various data of other countries,” he said.
Since peaking in mid-August, daily COVID-19 cases in Japan continued a downward slide to fall below 5,000 by mid-September and under 200 by late October. The country has been enjoying one of the lowest infection rates of any advanced country for some time, but it’s not immune to the next wave of the pandemic, Inoue says. A junior high school student is vaccinated in Saitama on Oct. 7. | KYODO A junior high school student is vaccinated in Saitama on Oct. 7. | KYODO
“There’s clearly a threat,” he said. “We have been all right because there was a delta variant. Other variants sneaked in little by little but Japan’s delta was keeping them away. But because there’s nothing now to keep them at bay, there’s room for new ones to enter as the vaccines alone would not solve the problem. In that sense, I think the quarantine measures for immigration control are very important because we never know what comes in from foreign countries.”
Some people may wonder if the self-extinction of the delta variant in Japan was caused by something special in the genetic make-up of Japanese people, but Inoue disagrees.
“I don’t think so,” he said. “People in East Asia, such as Koreans, are ethnically the same as Japanese. But I don’t know why this observation was made in Japan.”
Inoue said that the team of researchers at the National Institute of Genetics and Niigata University plan to compile a study on their findings by the end of November.
【 在 Carwash (for+free) 的大作中提到: 】 : What's behind the rapid disappearance of the delta variant in Japan? It : could be self-extinction. : Osamu Tsukimori : Why did Japan’s fifth and biggest wave of the coronavirus pandemic, driven : by the supercontagious delta variant, suddenly come to an abrupt end : following a seemingly relentless rise in new infections? And what made Japan : different from other developed countries that are now seeing a fresh surge : in new cases? : According to one group of researchers, the surprising answer may be that the : delta variant took care of itself in an act of “self-extinction.” : ...................
【 在 Carwash (for+free) 的大作中提到: 】 : What's behind the rapid disappearance of the delta variant in Japan? It : could be self-extinction. : Osamu Tsukimori : Why did Japan’s fifth and biggest wave of the coronavirus pandemic, driven : by the supercontagious delta variant, suddenly come to an abrupt end : following a seemingly relentless rise in new infections? And what made Japan : different from other developed countries that are now seeing a fresh surge : in new cases? : According to one group of researchers, the surprising answer may be that the : delta variant took care of itself in an act of “self-extinction.” : ...................
典型的断章取义。这个表明明是“Characteristics of Antiviral Agents That Are Approved or Under Evaluation for the Treatment of COVID-19”，也就是说有“ Approved”的和“Under Evaluation”两种。像Remdesivir，表中明确列出了医院的推荐使用方法，因为它是属于“Approved”。对于Ivermectin，写的是“Adults: The dose most commonly used in clinical trials is IVM 0.2–0.6 mg/kg PO given as a single dose or as a once-daily dose for up to 5 days.”，属于“Under Evaluation”，因为的确有不少clinical trials正在进行中。
非常希望是因为 IVM，看来官方说 不是。。
########
More than 70% of Japan’s population has received the COVID-19 vaccines, and the government is moving ahead with a booster shot in December. But a
conservative radio host in the U.S. falsely claimed, “Japan drops vax
rollout, goes to Ivermectin.” Japan hasn’t stopped its vaccine program and hasn’t approved ivermectin as a COVID-19 treatment.
So, rather than ending its COVID-19 vaccination program, the Japanese
government has said it plans to continue providing vaccines, including the
booster shot as soon as December, according to NHK World Japan.
Ivermectin Never Approved for Treatment
Contrary to Turner’s claim, ivermectin is not on a list of pharmaceuticals approved to treat COVID-19 in Japan.
“Ivermectin is not endorsed by the Japanese government,” Kosuke Yasukawa, who is a physician at Medstar Washington Hospital Center and an assistant
professor of clinical medicine at Georgetown University School of Medicine, told us in an email.
Haruo Ozaki, chairman of the Tokyo Medical Association, had recommended the use of ivermectin as a treatment for COVID-19 patients at Feb. 9 press
conference, “which was criticized by many physicians in the U.S.,” said
Yasukawa, an infectious disease specialist who received his medical degree
at Keio University in Tokyo.
Ozaki is not a government official, and the Tokyo Medical Association is a
professional organization that doesn’t make policy.
“I believe basic precautions like masks [and] social distancing, along with vaccination, helped reduce infections in Japan,” Yasukawa said.
早说了，小日本子处理这种事情阴奉阳违是一贯的态度。
它要是官宣了马药疗法马上会被踢出全球化阵营。
所以找了个医生组织，告诉大夫，你们可以用马药了。
【 在 cellcycle (vacoule) 的大作中提到: 】
: 非常希望是因为 IVM，看来官方说 不是。。
: ########
: More than 70% of Japan’s population has received the COVID-19 vaccines,
and
: the government is moving ahead with a booster shot in December. But a
: conservative radio host in the U.S. falsely claimed, “Japan drops vax
: rollout, goes to Ivermectin.” Japan hasn’t stopped its vaccine program
and
: hasn’t approved ivermectin as a COVID-19 treatment.
: So, rather than ending its COVID-19 vaccination program, the Japanese
: government has said it plans to continue providing vaccines, including the
: booster shot as soon as December, according to NHK World Japan.
: ...................
而且最近估计被盟友们指责不按规矩来了，
所以又炮制出一个病毒自杀论，却坚拒断马药。
【 在 RaoYing (老赵走好) 的大作中提到: 】
: 早说了，小日本子处理这种事情阴奉阳违是一贯的态度。
: 它要是官宣了马药疗法马上会被踢出全球化阵营。
: 所以找了个医生组织，告诉大夫，你们可以用马药了。
: and
: and
ok 这个报道哪里，日文也行，。。
而且我看的说 ，日本疫苗 ～70% 了，还要booster，
【 在 RaoYing (老赵走好) 的大作中提到: 】
: 早说了，小日本子处理这种事情阴奉阳违是一贯的态度。
: 它要是官宣了马药疗法马上会被踢出全球化阵营。
: 所以找了个医生组织，告诉大夫，你们可以用马药了。
: and
: and
【 在 cellcycle (vacoule) 的大作中提到: 】
: ok 这个报道哪里，日文也行，。。
Pfizer非常霸道，凡是购买Pfizer疫苗的国家，都必须签合同，不能允许使用治疗药物。
日本政府签了这个合同，所以不能公开使用ivermectin，但是私下里允许医生off-
label use
【 在 cellcycle (vacoule) 的大作中提到: 】
: 非常希望是因为 IVM，看来官方说 不是。。
: ########
: More than 70% of Japan’s population has received the COVID-19 vaccines,
and
: the government is moving ahead with a booster shot in December. But a
: conservative radio host in the U.S. falsely claimed, “Japan drops vax
: rollout, goes to Ivermectin.” Japan hasn’t stopped its vaccine program
and
: hasn’t approved ivermectin as a COVID-19 treatment.
: So, rather than ending its COVID-19 vaccination program, the Japanese
: government has said it plans to continue providing vaccines, including the
: booster shot as soon as December, according to NHK World Japan.
: ...................
好！ 谢谢，头一次算 credible 信息，。。
IVM 这事如属实，掩盖不了多长时间！ 西方整个世界要受到 审判！
【 在 RaoYing (老赵走好) 的大作中提到: 】
: http://www.newswars.com/now-is-the-time-to-use-ivermectin-tokyos-medical-assoc-chairman-recommends-ivermectin-to-all-doctors-to-treat-covid/
那视频我早在这里贴过吧. 就是日本医学会长说非洲国家用和不用马药的差别很大. 虽然还不知道具体原因, 但是应该有效, 所以他说允许医生用这个药.
【 在 cellcycle (vacoule) 的大作中提到: 】
: 好！ 谢谢，头一次算 credible 信息，。。
: IVM 这事如属实，掩盖不了多长时间！ 西方整个世界要受到 审判！
我觉得 中共中央 应该 带头了，他们也不是 西方阵营，日本有顾虑，中国没有，正好趁机 打掉西方的“虚伪！”
【 在 lczlcz (lcz) 的大作中提到: 】
: 那视频我早在这里贴过吧. 就是日本医学会长说非洲国家用和不用马药的差别很大. 虽
: 然还不知道具体原因, 但是应该有效, 所以他说允许医生用这个药.
非常同意, 这个是土工趁机打倒西方阵营的绝好时机啊.
【 在 cellcycle (vacoule) 的大作中提到: 】
: 我觉得 中共中央 应该 带头了，他们也不是 西方阵营，日本有顾虑，中国没有，正好
: 趁机 打掉西方的“虚伪！”
At least we need to see report from Japan's government saying that they have been using ivermectin to treat covid before we even consider giving it
credit. People can post online saying that ETs from outer space are helping Japan, and Japan's cases did plummet, so it is true that ETs have helped
Japan and Africa?
有人懂日语吗， 能确认一下视频的内容吗？
我前面不是已经说了吗，日本政府被迫跟Pfizer签了一个霸道的合同，使用Pfizer疫苗的国家，不能使用治疗药物。所以，日本政府不能公开使用ivermectin，只能私下里偷偷地让医生off-label use，然后发表science文章说，日本的病毒自杀了。
【 在 FortyNiner (Niner) 的大作中提到: 】
: At least we need to see report from Japan's government saying that they
have
: been using ivermectin to treat covid before we even consider giving it
: credit. People can post online saying that ETs from outer space are
helping
: Japan, and Japan's cases did plummet, so it is true that ETs have helped : Japan and Africa?
无视他就好了
【在Carwash（for+free）的大作中提到：】
：我前面不是已经说了吗，日本政府被迫跟Pfizer签了一个霸道的合同，使用Pfizer疫苗的国家，不能使用治疗药物。所以，日本政府不能公开使用ivermectin，只能私下里偷偷地让医生off-label use，然后发表science文章说，日本的病毒自杀了。
Are you kidding me? Once Japan uses the vaccine, they cannot treat the
breakthrough? What about those who are not vaxxed and get infected? Can
they be treated? On 8/13, the date on your graph when ivermectin was
recommended to be used to treat covid in Japen, only about 49.1% of Japan's population had been fully vaxxed. And the other 50.9% of Japanese cannot be treated for covid once they got it? Wow, Japanese government surely
colludes with cdc.
Do you believe that? You would rather believe some craps like that?
Imagine that also applies to the US.
【 在 Carwash (for+free) 的大作中提到: 】
: 我前面不是已经说了吗，日本政府被迫跟Pfizer签了一个霸道的合同，使用Pfizer疫苗
: 的国家，不能使用治疗药物。所以，日本政府不能公开使用ivermectin，只能私下里偷
: 偷地让医生off-label use，然后发表science文章说，日本的病毒自杀了。
: have
: helping
感染是外星人在日本测试新冠退出机制，省得未来新冠突然变弱让人觉得奇怪
不要做梦这个机制会马上实现
今年冬天大闹一场是无可避免的，革命成功才有几乎得到退出机制
在某些人看来，一个日本非官方机构主席推荐了IVM，既不需要知道日本到底有多少人
吃了IVM，也不需要将吃了IVM的日本人跟没吃IVM的日本人进行比较，就能断定日本的
疫情是由IVM控制住的，逻辑杠杠的。
【 在 cellcycle (vacoule) 的大作中提到: 】
: 非常希望是因为 IVM，看来官方说 不是。。
Do you have Japan friend ?
【 在 DreamTiger (祝你平安) 的大作中提到: 】
: 在某些人看来，一个日本非官方机构主席推荐了IVM，既不需要知道日本到底有多少人
: 吃了IVM，也不需要将吃了IVM的日本人跟没吃IVM的日本人进行比较，就能断定日本的
: 疫情是由IVM控制住的，逻辑杠杠的。
IVM即使能减少重症，也不能控制病毒传播，所以IVM导致疫情下降，只有大部分人都感染过，已经群免才可能
疫苗也没法控制病毒传播，当然日本疫苗打的晚，不过以色列打booster，也只能减到
几百人的水平，而日本人口比以色列还要多十几倍
病毒自杀是唯一解释，可是为啥其他地方病毒不自杀。显然这是在测试退出机制。日本不在这次的剧本里面，在日本测试对剧本没影响
可惜没有，如果有的话，真想让他们去街上采访采访。想去youtube找找有没有做过相
关调查，东京或者日本到底有没有人在吃IVM，也没找到。
不过呢，还是有不少在日本生活的人站出来反对这种IVM拯救了日本的论调，不妨看看
下面推特的comments，这些跟五毛无关，当然，也许会被冠上极左的帽子。
https://twitter.com/PierreKory/status/1462623647156289539
【 在 cellcycle (vacoule) 的大作中提到: 】
: Do you have Japan friend ?
东京医学会主席举行现场新闻发布会，向所有医生推荐伊维菌素，用于所有新冠病毒患者。https://twitter.com/busschool3/status/1431109401964781569
【 在 cellcycle (vacoule) 的大作中提到: 】
: 非常希望是因为 IVM，看来官方说 不是。。
: ########
: More than 70% of Japan’s population has received the COVID-19 vaccines,
and
: the government is moving ahead with a booster shot in December. But a
: conservative radio host in the U.S. falsely claimed, “Japan drops vax
: rollout, goes to Ivermectin.” Japan hasn’t stopped its vaccine program
and
: hasn’t approved ivermectin as a COVID-19 treatment.
: So, rather than ending its COVID-19 vaccination program, the Japanese
: government has said it plans to continue providing vaccines, including the
: booster shot as soon as December, according to NHK World Japan.
: ...................
总体统计没有
这个日本医生一个人用🐎药100%治好500人https://twitter.com/SabinehazanMD/status/1443589488869998593
【 在 DreamTiger (祝你平安) 的大作中提到: 】
: 在某些人看来，一个日本非官方机构主席推荐了IVM，既不需要知道日本到底有多少人
: 吃了IVM，也不需要将吃了IVM的日本人跟没吃IVM的日本人进行比较，就能断定日本的
: 疫情是由IVM控制住的，逻辑杠杠的。
辉瑞说疫苗对小孩100%重症保护，一堆人说造假，这个IVM的100%治愈，有没有人说造
假啊？
【 在 jkerry (Jake) 的大作中提到: 】
: 总体统计没有
: 这个日本医生一个人用🐎药100%治好500人
: https://twitter.com/SabinehazanMD/status/1443589488869998593
你在强国还是美国？这么关心日本？美国NIH已经把ivm列入covid的治疗名单了：https://www.covid19treatmentguidelines.nih.gov/tables/table-2e/
【 在 cellcycle (vacoule) 的大作中提到: 】
: 非常希望是因为 IVM，看来官方说 不是。。
: ########
: More than 70% of Japan’s population has received the COVID-19 vaccines,
and
: the government is moving ahead with a booster shot in December. But a
: conservative radio host in the U.S. falsely claimed, “Japan drops vax
: rollout, goes to Ivermectin.” Japan hasn’t stopped its vaccine program
and
: hasn’t approved ivermectin as a COVID-19 treatment.
: So, rather than ending its COVID-19 vaccination program, the Japanese
: government has said it plans to continue providing vaccines, including the
: booster shot as soon as December, according to NHK World Japan.
: ...................
可以分享一下日本那篇说病毒自杀的science paper链接吗？谢谢
【 在 Carwash (for+free) 的大作中提到: 】
: 我前面不是已经说了吗，日本政府被迫跟Pfizer签了一个霸道的合同，使用Pfizer疫苗
: 的国家，不能使用治疗药物。所以，日本政府不能公开使用ivermectin，只能私下里偷
: 偷地让医生off-label use，然后发表science文章说，日本的病毒自杀了。
: have
: helping
所有100%我都怀疑，但是辉瑞那个可不是只说100%防重症，人家还说100%不会被感染，这个很多家长都证明是假的了，因为他们的孩子打了疫苗之后感染了新冠。而且那么小的孩子身体健康的本就很难有重症，辉瑞的对照组里也没有，辉瑞如何得出100%防重症这个结论的？
【 在 DreamTiger (祝你平安) 的大作中提到: 】
: 辉瑞说疫苗对小孩100%重症保护，一堆人说造假，这个IVM的100%治愈，有没有人说造
: 假啊？
拍脑袋呗！fda也是拍脑袋让他们通过的啊！都拍的蜥蜴脑袋
【 在 CoolTeeth (小石头) 的大作中提到: 】
: 所有100%我都怀疑，但是辉瑞那个可不是只说100%防重症，人家还说100%不会被感染，
: 这个很多家长都证明是假的了，因为他们的孩子打了疫苗之后感染了新冠。而且那么小
: 的孩子身体健康的本就很难有重症，辉瑞的对照组里也没有，辉瑞如何得出100%防重症
: 这个结论的？
这真是对蜥蜴的侮辱啊。。。
【 在 zephyrkj (傻瓜西瓜) 的大作中提到: 】
: 拍脑袋呗！fda也是拍脑袋让他们通过的啊！都拍的蜥蜴脑袋
现在"science"这个词，已经成为一个贬义词，用来讽刺的意思。
下面是新闻来源，你自己去看吧。
https://www.japantimes.co.jp/news/2021/11/18/national/delta-variant-self-
destruction-theory/
【 在 CoolTeeth (小石头) 的大作中提到: 】
: 可以分享一下日本那篇说病毒自杀的science paper链接吗？谢谢
我去，看这家媒体的新闻还得注册账号
【 在 Carwash (for+free) 的大作中提到: 】
: 现在"science"这个词，已经成为一个贬义词，用来讽刺的意思。
: 下面是新闻来源，你自己去看吧。
: https://www.japantimes.co.jp/news/2021/11/18/national/delta-variant-self-
: destruction-theory/
What's behind the rapid disappearance of the delta variant in Japan? It
could be self-extinction.
Osamu Tsukimori
Why did Japan’s fifth and biggest wave of the coronavirus pandemic, driven by the supercontagious delta variant, suddenly come to an abrupt end
following a seemingly relentless rise in new infections? And what made Japan different from other developed countries that are now seeing a fresh surge in new cases?
According to one group of researchers, the surprising answer may be that the delta variant took care of itself in an act of “self-extinction.”
Three months after the delta variant spurred record daily nationwide
caseloads of nearly 26,000, new COVID-19 infections in Japan have plummeted, dropping below 200 in recent weeks. Highlighting that drop was the fact
that no deaths were reported on Nov. 7 — the first time that had happened
in about 15 months.
Many scholars point to a variety of possibilities, which include one of the highest vaccination rates among advanced countries with 75.7% of residents
fully vaccinated as of Wednesday. Other potential factors are the social
distancing and mask-wearing measures that are now deeply embedded in
Japanese society.
But the chief reason may be related to the genetic changes that the
coronavirus undergoes during reproduction, at a pace of around two mutations per month. According to a potentially revolutionary theory proposed by
Ituro Inoue, a professor at the National Institute of Genetics, the delta
variant in Japan accumulated too many mutations to the virus’s error-
correcting, non-structural protein called nsp14. As a result, the virus
struggled to repair the errors in time, ultimately leading to “self-
destruction.”
Studies have shown that more people in Asia have a defense enzyme called
APOBEC3A that attacks RNA viruses, including the SARS-CoV-2 virus that
causes COVID-19, when compared to people in Europe and Africa.
So the researchers from the National Institute of Genetics and Niigata
University set out to discover how the APOBEC3A protein affects the nsp14
protein and whether it can inhibit the activity of the coronavirus. The team conducted an analysis of the genetic diversity data for the alpha and delta variants from infected clinical specimens in Japan from June to October.
They then visualized the relationships among the DNA sequences of the SARS-
CoV-2 virus to show genetic diversity in a diagram called a haplotype
network. In general, the bigger the network is, the more positive cases it
represents.
The Minami district of Osaka in Oct. 25. | KYODO
The Minami district of Osaka in Oct. 25. | KYODO
The network of the alpha variant, which was the main driver for Japan’s
fourth wave from March to June, had five major groups with many mutations
branching out, confirming a high level of genetic diversity. The researchers thought the delta variant, which the U.S. Centers for Disease Control and
Prevention says is more than twice as contagious as previous variants and
might cause more severe illness in unvaccinated people, would have a far
more vibrant genetic diversity.
Surprisingly, they found the opposite to be true. The haplotype network had only two major groups and the mutations seemed to come to a sudden stop in
the middle of its evolutionary development process. When the researchers
went on to examine the virus’s error-correcting enzyme nsp14, they
discovered that the vast majority of nsp14 specimens in Japan seemed to have undergone many genetic changes in mutation sites called A394V.
“We were literally shocked to see the findings,” Inoue told The Japan
Times. “The delta variant in Japan was highly transmissible and keeping
other variants out. But as the mutations piled up, we believe it eventually became a faulty virus and it was unable to make copies of itself.
Considering that the cases haven’t been increasing, we think that at some
point during such mutations it headed straight toward its natural extinction.”
Inoue’s theory, while innovative, would lend support to the mysterious
disappearance of the delta variant’s spread in Japan. While much of the
rest of the world with similarly high vaccination rates, including South
Korea and some Western countries, are suffering from record waves of new
infections, Japan appears to be a peculiar case in that COVID-19 cases have remained subdued despite trains and restaurants filling up following the end of the most recent state of emergency.
“If the virus were alive and well, cases for sure would increase as masking and vaccination do not prevent breakthrough infections in some cases,”
Inoue said.
Ituro Inoue, a professor at the National Institute of Genetics | THE
NATIONAL INSTITUTE OF GENETICS
Ituro Inoue, a professor at the National Institute of Genetics | THE
NATIONAL INSTITUTE OF GENETICS
Indeed, the unexpected plunge in new cases following the summer wave has
been a hot topic of discussion among many experts, including those not
conducting studies on the coronavirus, according to Takeshi Urano, a
professor at Shimane University’s Faculty of Medicine who was not involved in the research led by Inoue.
“Nsp14 works with other virus proteins and has a critical function to
protect the virus RNA from breaking apart,” he said when asked about Inoue
’s findings. “Studies have shown that a virus with a crippled nsp14 has a significantly reduced ability to replicate, so this can be one factor behind the rapid decline in new cases. The nsp14 is virus-derived, and the
chemical agent to curb this protein could become a promising medicine, with development already underway.”
Japan seems to be an anomaly in that the delta variant was virtually
shutting out alpha and other variants by late August. On the other hand,
other countries — including India and Indonesia, both of which were hit
particularly hard by the delta variant — have reported a mix of alpha and
delta strains among cases.
A similar natural extinction of the coronavirus could possibly be observed
overseas, Inoue says, adding that detecting that would be difficult as no
other country seems to have accumulated as many mutations in the virus’s
nsp14 as in Japan, though similar mutations at the A394V site have been
discovered in at least 24 countries.
Pedestrians pass bars on a street at night in the Shimbashi district of
Tokyo on Oct. 29. | BLOOMBERG
Pedestrians pass bars on a street at night in the Shimbashi district of
Tokyo on Oct. 29. | BLOOMBERG
But Inoue’s theory may also help explain why the outbreak of severe acute
respiratory syndrome (SARS) ended abruptly in 2003. An in vitro experiment
in which the researchers caused mutations in nsp14 in the virus that causes SARS led to findings that the virus eventually could not replicate itself as mutations piled up.
“No genome data exists, so it’s just a hypothesis, but because it has
disappeared, it will never see the light of day again,” he said.
So what are the chances that we could see a similar natural extinction
overseas of the COVID-19-causing SARS-CoV-2 virus?
“The chances are not zero, but that seems too optimistic for now as we’re unable to get hold of any such evidence, though we have looked at various
data of other countries,” he said.
Since peaking in mid-August, daily COVID-19 cases in Japan continued a
downward slide to fall below 5,000 by mid-September and under 200 by late
October. The country has been enjoying one of the lowest infection rates of any advanced country for some time, but it’s not immune to the next wave of the pandemic, Inoue says.
A junior high school student is vaccinated in Saitama on Oct. 7. | KYODO
A junior high school student is vaccinated in Saitama on Oct. 7. | KYODO
“There’s clearly a threat,” he said. “We have been all right because
there was a delta variant. Other variants sneaked in little by little but
Japan’s delta was keeping them away. But because there’s nothing now to
keep them at bay, there’s room for new ones to enter as the vaccines alone would not solve the problem. In that sense, I think the quarantine measures for immigration control are very important because we never know what comes in from foreign countries.”
Some people may wonder if the self-extinction of the delta variant in Japan was caused by something special in the genetic make-up of Japanese people,
but Inoue disagrees.
“I don’t think so,” he said. “People in East Asia, such as Koreans, are ethnically the same as Japanese. But I don’t know why this observation was made in Japan.”
Inoue said that the team of researchers at the National Institute of
Genetics and Niigata University plan to compile a study on their findings by the end of November.
【 在 CoolTeeth (小石头) 的大作中提到: 】
: 我去，看这家媒体的新闻还得注册账号
谢谢
【 在 Carwash (for+free) 的大作中提到: 】
: What's behind the rapid disappearance of the delta variant in Japan? It
: could be self-extinction.
: Osamu Tsukimori
: Why did Japan’s fifth and biggest wave of the coronavirus pandemic,
driven
: by the supercontagious delta variant, suddenly come to an abrupt end
: following a seemingly relentless rise in new infections? And what made
Japan
: different from other developed countries that are now seeing a fresh
surge
: in new cases?
: According to one group of researchers, the surprising answer may be that
the
: delta variant took care of itself in an act of “self-extinction.”
: ...................
还是日本人比较牛逼, 能脑洞大开想出这个解释.
【 在 Carwash (for+free) 的大作中提到: 】
: What's behind the rapid disappearance of the delta variant in Japan? It
: could be self-extinction.
: Osamu Tsukimori
: Why did Japan’s fifth and biggest wave of the coronavirus pandemic,
driven
: by the supercontagious delta variant, suddenly come to an abrupt end
: following a seemingly relentless rise in new infections? And what made
Japan
: different from other developed countries that are now seeing a fresh
surge
: in new cases?
: According to one group of researchers, the surprising answer may be that
the
: delta variant took care of itself in an act of “self-extinction.”
: ...................
如果哪天美国用了马药疫情结束了我相信美国的主流媒体会更有创意的，哈哈
【 在 lczlcz (lcz) 的大作中提到: 】
: 还是日本人比较牛逼, 能脑洞大开想出这个解释.
: driven
: Japan
: surge
: the
如果美国用ivermectin控制了疫情，主流媒体肯定会发表100篇science文章，证明是
Joke Biden拉的屎，控制了疫情。最懂science的内科医生Fauxi，会亲自在电视机前示范怎么吃Joke Biden拉的屎，怎样吃最科学。
【 在 CoolTeeth (小石头) 的大作中提到: 】
: 如果哪天美国用了马药疫情结束了我相信美国的主流媒体会更有创意的，哈哈
https://covid.cdc.gov/covid-data-tracker/#covidnet-hospitalizations-
vaccination
大家都知道对于新冠，基本上是年龄越小，症状越轻，不管你是支持疫苗也好，反对疫苗也好，对这一点都没有啥争议。根据上面的数据，12-17岁，不打疫苗住院率最高也
就在十万分之四，打了疫苗基本在百万分之一左右了。相信5-11岁的情况不会比这个更糟糕。在这个情况下，指望几千人的疫苗实验能够有小孩重症，属于撞大运了。至于感染，在小样本情况下，轻症感染没法察觉，不代表没有感染，这当然是正确的。你当然可以说疫苗组有感染但没察觉罢了，但在实际操作中却无法区分。这结果也在意料之中。不过呢，clinical trial没有得到的数据，从现实中12-17岁的结果可以推测，重症
保护还是有的，只不过不是100%罢了。公司吹牛，不是只有辉瑞一家，自己有分辨能力就好了。
对于疫苗的保护作用，我是不怀疑的。无论是12-17岁的clinical trial，还是5-11岁
的clinical trial，我更关注的是疫苗是否产生了严重的副作用，或者说，是否会产生比得新冠更严重的副作用。
【 在 CoolTeeth (小石头) 的大作中提到: 】
: 所有100%我都怀疑，但是辉瑞那个可不是只说100%防重症，人家还说100%不会被感染，
: 这个很多家长都证明是假的了，因为他们的孩子打了疫苗之后感染了新冠。而且那么小
: 的孩子身体健康的本就很难有重症，辉瑞的对照组里也没有，辉瑞如何得出100%防重症
: 这个结论的？
哦，这样了！！
【 在 zephyrkj (傻瓜西瓜) 的大作中提到: 】
: 你在强国还是美国？这么关心日本？美国NIH已经把ivm列入covid的治疗名单了：
https
: ://www.covid19treatmentguidelines.nih.gov/tables/table-2e/
: and
: and
典型的断章取义。这个表明明是“Characteristics of Antiviral Agents That Are
Approved or Under Evaluation for the Treatment of COVID-19”，也就是说有“
Approved”的和“Under Evaluation”两种。像Remdesivir，表中明确列出了医院的推荐使用方法，因为它是属于“Approved”。对于Ivermectin，写的是“Adults: The
dose most commonly used in clinical trials is IVM 0.2–0.6 mg/kg PO given as a single dose or as a once-daily dose for up to 5 days.”，属于“Under
Evaluation”，因为的确有不少clinical trials正在进行中。
因为这个药物在clinical trials中，就说“美国NIH已经把ivm列入covid的治疗名单了”，属于明显的误导他人。
【 在 zephyrkj (傻瓜西瓜) 的大作中提到: 】
: 你在强国还是美国？这么关心日本？美国NIH已经把ivm列入covid的治疗名单了：
https
: ://www.covid19treatmentguidelines.nih.gov/tables/table-2e/