Biotech company Moderna Inc. dosed 45 patients between the ages of 18 and 55 with 25, 100 or 250 micrograms of its experimental drug. After receiving a second booster shot, those at the 25 and 100 dosage levels were found with antibody levels that were equal to or exceeded those found in patients who recovered from COVID-19, the company said in a press release.
Moderna CEO Stephane Bancel told Bloomberg that the results “ couldn’t have been better.”
“This is a very good sign that we make an antibody that can stop the virus from replicating,” he said.
【在 TravisBickle(Travis)的大作中提到：】 ：Biotech company Moderna Inc. dosed 45 patients between the ages of 18 and 55 with 25, 100 or 250 micrograms of its experimental drug. After receiving a second booster shot, those at the 25 and 100 dosage levels were found with ：antibody levels that were equal to or exceeded those found in patients who
The experimental vaccine, mRNA-1273, was found to be generally safe and well tolerated among patients, the company said. Further testing will begin in July.
【 在 cellcycle(vacoule) 的大作中提到: 】
: 不错，mRNA 疫苗吗？？
: ：Biotech company Moderna Inc. dosed 45 patients between the ages of 18 and
: 55 with 25, 100 or 250 micrograms of its experimental drug. After receiving
: a second booster shot, those at the 25 and 100 dosage levels were found with
: ：antibody levels that were equal to or exceeded those found in patients who
【 在 TravisBickle (Travis) 的大作中提到: 】 : Biotech company Moderna Inc. dosed 45 patients between the ages of 18 and 55 : with 25, 100 or 250 micrograms of its experimental drug. After receiving a : second booster shot, those at the 25 and 100 dosage levels were found with : antibody levels that were equal to or exceeded those found in patients who : recovered from COVID-19, the company said in a press release. : Moderna CEO Stephane Bancel told Bloomberg that the results “ : couldn’t have been better.” : “This is a very good sign that we make an antibody that can stop the virus : from replicating,” he said.
只测了八个人，都有抗体。 Moderna has vaccinated dozens of study participants and measured antibodies in eight of them. All eight developed neutralizing antibodies to the virus at levels reaching or exceeding the levels seen in people who've naturally recovered from Covid-19, according to the company.
"We've demonstrated that these antibodies, this immune response, can actually block the virus," Zaks said. "I think this is a very important first step in our journey towards having a vaccine."
【 在 TravisBickle (Travis) 的大作中提到: 】 : 只测了八个人，都有抗体。 : Moderna has vaccinated dozens of study participants and measured antibodies : in eight of them. All eight developed neutralizing antibodies to the virus : at levels reaching or exceeding the levels seen in people who've naturally : recovered from Covid-19, according to the company. : "We've demonstrated that these antibodies, this immune response, can : actually block the virus," Zaks said. "I think this is a very : important : first step in our journey towards having a vaccine." : : 只有20%的人产生了抗体。而且抗体的持续时间不知道。病人身上有抗体 : ...................
Immunogenicity data are currently available for the 25 μg and 100 μg dose level (ages 18-55) after two doses (day 43) and at the 250 μg level (ages 18-55) after one dose (day 29). Dose dependent increases in immunogenicity were seen across the three dose levels, and between prime and boost within the 25 μg and 100 μg dose levels. All participants ages 18-55 (n=15 per cohort) across all three dose levels seroconverted by day 15 after a single dose. At day 43, two weeks following the second dose, at the 25 μg dose level (n=15), levels of binding antibodies were at the levels seen in convalescent sera (blood samples from people who have recovered from COVID- 19) tested in the same assay. At day 43, at the 100 μg dose level (n=10), levels of binding antibodies significantly exceeded the levels seen in convalescent sera. Samples are not yet available for remaining participants.
At this time, neutralizing antibody data are available only for the first four participants in each of the 25 μg and 100 μg dose level cohorts. Consistent with the binding antibody data, mRNA-1273 vaccination elicited neutralizing antibodies in all eight of these participants, as measured by plaque reduction neutralization (PRNT) assays against live SARS-CoV-2. The levels of neutralizing antibodies at day 43 were at or above levels generally seen in convalescent sera.
这一段感觉有猫腻。大家分析分析？
公司今天就决定发行$1B的股票。我日，一个B，今天。
【 在 TravisBickle (Travis) 的大作中提到: 】 : 只测了八个人，都有抗体。 : Moderna has vaccinated dozens of study participants and measured antibodies : in eight of them. All eight developed neutralizing antibodies to the virus : at levels reaching or exceeding the levels seen in people who've naturally : recovered from Covid-19, according to the company. : "We've demonstrated that these antibodies, this immune response, can : actually block the virus," Zaks said. "I think this is a very : important : first step in our journey towards having a vaccine." : : 只有20%的人产生了抗体。而且抗体的持续时间不知道。病人身上有抗体 : ...................
【 在 TravisBickle (Travis) 的大作中提到: 】 : 啥问题? 除了数据还不全。加卖股票有点急啊。 : : Immunogenicity data are currently available for the 25 μg and 100 μg : dose : : level (ages 18-55) after two doses (day 43) and at the 250 μg level ( : ages : : 18-55) after one dose (day 29). Dose dependent increases in : immunogenicity : : were seen across the three dose levels, and between prime and boost : within : : the 25 μg and 100 μg dose levels. All participants ages 18-55 (n= 15 : ...................
【 在 TravisBickle (Travis) 的大作中提到: 】 : Biotech company Moderna Inc. dosed 45 patients between the ages of 18 and 55 : with 25, 100 or 250 micrograms of its experimental drug. After receiving a : second booster shot, those at the 25 and 100 dosage levels were found with : antibody levels that were equal to or exceeded those found in patients who : recovered from COVID-19, the company said in a press release. : Moderna CEO Stephane Bancel told Bloomberg that the results “ : couldn’t have been better.” : “This is a very good sign that we make an antibody that can stop the virus : from replicating,” he said.
中和试验是NIH做的，说是比较难做每组只搞了四个。抗体结合试验都做了。 Neutralizing antibody data are available only for the first four participants in each of the 25 and 100-microgram dose cohorts. Consistent with the binding antibody titers, mRNA-1273 vaccination elicited neutralizing titers in all age participants, as measured by plaque reduction neutralization assays against live SARS-CoV-2 virus. The levels of these neutralizing titers at day 43 were at or above levels generally seen in convalescent sera. Now, I should say, this is a difficult essay to perform for a live dangerous virus. And we’re really indebted to NIAID and its academic partners for setting these up and running them.
Oxford did a monkey test. (Adenovirus vector, I think, which should be more effective than mRNA albeit less safe) Anyone know why MRNA didn't do a monkey trial? Or, did they?
【 在 TravisBickle (Travis) 的大作中提到: 】 : 中和试验是NIH做的，说是比较难做每组只搞了四个。抗体结合试验都做了。 : Neutralizing antibody data are available only for the first four : participants in each of the 25 and 100-microgram dose cohorts. Consistent : with the binding antibody titers, mRNA-1273 vaccination elicited : neutralizing titers in all age participants, as measured by plaque reduction : neutralization assays against live SARS-CoV-2 virus. The levels of these : neutralizing titers at day 43 were at or above levels generally seen in : convalescent sera. Now, I should say, this is a difficult essay to perform : for a live dangerous virus. And we’re really indebted to NIAID and its : academic partners for setting these up and running them.
【 在 TeddyBear001 (TeddyBear001) 的大作中提到: 】 : Oxford did a monkey test. (Adenovirus vector, I think, which should be more : effective than mRNA albeit less safe) : Anyone know why MRNA didn't do a monkey trial? Or, did they? : reduction
【 在 TeddyBear001 (TeddyBear001) 的大作中提到: 】 : Oxford did a monkey test. (Adenovirus vector, I think, which should be more : effective than mRNA albeit less safe) : Anyone know why MRNA didn't do a monkey trial? Or, did they? : reduction
【 在 TeddyBear001 (TeddyBear001) 的大作中提到: 】 : Oxford did efficacy test in Rhesus monkey: vaccinated moneys exposed to : Covid-19. : Not sure if Moderna did monkey efficacy trial.
【 在 TeddyBear001 (TeddyBear001) 的大作中提到: 】 : My understanding is MRNA uses mRNA to generate virus spike protein in vivo : to induce immunity. : Essentially same 免疫路径, with different delivery vehicle.
Oxford Monkeys contracted Covid-19 after vaccination.
MRNA human trials did not and will not expose trial subjects to live virus. No direct efficacy data from clinical trials will be forth coming.. That is why I am surprised Not to see any primates efficacy data.
Biotech company Moderna Inc. dosed 45 patients between the ages of 18 and 55 with 25, 100 or 250 micrograms of its experimental drug. After receiving a second booster shot, those at the 25 and 100 dosage levels were found with
antibody levels that were equal to or exceeded those found in patients who
recovered from COVID-19, the company said in a press release.
Moderna CEO Stephane Bancel told Bloomberg that the results “
couldn’t have been better.”
“This is a very good sign that we make an antibody that can stop the virus from replicating,” he said.
不错，mRNA 疫苗吗？？
【在 TravisBickle(Travis)的大作中提到：】
：Biotech company Moderna Inc. dosed 45 patients between the ages of 18 and 55 with 25, 100 or 250 micrograms of its experimental drug. After receiving a second booster shot, those at the 25 and 100 dosage levels were found with
：antibody levels that were equal to or exceeded those found in patients who
The experimental vaccine, mRNA-1273, was found to be generally safe and well tolerated among patients, the company said. Further testing will begin in
July.
【 在 cellcycle(vacoule) 的大作中提到: 】
: 不错，mRNA 疫苗吗？？
: ：Biotech company Moderna Inc. dosed 45 patients between the ages of
18 and
: 55 with 25, 100 or 250 micrograms of its experimental drug. After
receiving
: a second booster shot, those at the 25 and 100 dosage levels were
found with
: ：antibody levels that were equal to or exceeded those found in
patients who
赞！
这个疫苗也是之前国内阴谋论的一个攻击的对象之一：完全没有去了解哪怕是从民科的角度，关于这个疫苗开发的技术，就直接喷：灭活病毒是怎么来的？美国是不是早就有这个毒株或病毒了？真是可悲啊
是的，要问一问合成抗原的这个序列是哪里来的。
【 在 easydude (easydude) 的大作中提到: 】
: 这个疫苗也是之前国内阴谋论的一个攻击的对象之一：完全没有去了解哪怕是从民科的
: 角度，关于这个疫苗开发的技术，就直接喷：灭活病毒是怎么来的？美国是不是早就有
: 这个毒株或病毒了？真是可悲啊
似乎是一月十一号，上海巴斯德实验室的测序结果公开了病毒的序列，但后来好像这个实验室被责令关停。但这个实验室关于病毒的序列其实早在一月五号就已经拿到了。
Tg一不注意让多个序列早早发表了，给了外国发展疫苗，检测和找源头的机会。后来发现改正了错误。
【 在 easydude(easydude) 的大作中提到: 】
: 似乎是一月十一号，上海巴斯德实验室的测序结果公开了病毒的序列，但后来好像这个
: 实验室被责令关停。但这个实验室关于病毒的序列其实早在一月五号就已经拿到了。
什么巴斯德，就是复旦。4/13还在招生，关个鸡巴。
[上海]上海市（复旦大学附属）公共卫生临床中心张永振教授研究团队
发布时间：2020-04-13工作地点：上海职位类型：全职来源：复旦大学附属中山医院南院职位：2020招聘
专业标签：生物科学 基础医学 计算机
职位详细
职位名称：
【科研岗】张永振教授团队科研人员
薪资：
面议
工作地点：
上海市-上海市-金山区
招聘人数：
6
工作性质：
全职
工作年限：
不限
学历：
硕士
发布时间：
刚刚
职位描述：
【 在 easydude (easydude) 的大作中提到: 】
: 似乎是一月十一号，上海巴斯德实验室的测序结果公开了病毒的序列，但后来好像这个
: 实验室被责令关停。但这个实验室关于病毒的序列其实早在一月五号就已经拿到了。
你这个消息是5月13号发表的，想说明什么？
【 在 comeandgo (春困秋乏夏打盹) 的大作中提到: 】
: 什么巴斯德，就是复旦。4/13还在招生，关个鸡巴。
: [上海]上海市（复旦大学附属）公共卫生临床中心张永振教授研究团队
: 发布时间：2020-04-13工作地点：上海职位类型：全职来源：复旦大学附属中山医院南
: 院职位：2020招聘
: 专业标签：生物科学 基础医学 计算机
: 职位详细
: 职位名称：
: 薪资：
:
: 面议
: ...................
【 在 easydude (easydude) 的大作中提到: 】
: http://www.shaphc.org/employ/146.html
: 你这个消息是5月13号发表的，想说明什么？
病毒起源可能永远无法搞清，何况tg还尼玛封锁研究。不管从哪出来，反正得有疫苗出来才能解决问题。
看胸，你这么舔共共匪知道么？还是你也有有些人士一样在国内有产业？
【 在 comeandgo (春困秋乏夏打盹) 的大作中提到: 】
: 什么巴斯德，就是复旦。4/13还在招生，关个鸡巴。
: [上海]上海市（复旦大学附属）公共卫生临床中心张永振教授研究团队
: 发布时间：2020-04-13工作地点：上海职位类型：全职来源：复旦大学附属中山医院南
: 院职位：2020招聘
: 专业标签：生物科学 基础医学 计算机
: 职位详细
: 职位名称：
: 薪资：
:
: 面议
: ...................
你去查查序列啥时候发表的..
【 在 comeandgo (春困秋乏夏打盹) 的大作中提到: 】
: 是的，要问一问合成抗原的这个序列是哪里来的。
一月初鳖的大腿张得太开了，让川肺彭嫖来了九浅一深，LOL
【 在 TravisBickle (Travis) 的大作中提到: 】
: 病毒起源可能永远无法搞清，何况tg还尼玛封锁研究。不管从哪出来，反正得有疫苗出
: 来才能解决问题。
是，应该对内隔离对外保密，把全世界都祸害了自己偷着乐才得tg精髓。
【 在 comeandgo(春困秋乏夏打盹) 的大作中提到: 】
: 一月初鳖的大腿张得太开了，让川肺彭嫖来了九浅一深，LOL
希望能成功。
不过比较悬，因为到目前为止我们还没有一个对RNA病毒有效的疫苗， 比如丙肝和HIV
研究了几十年也没有有效的疫苗。 何况冠状病毒还会很容易变异。
如果疫苗能成功的话，会创造两个奇迹，即人类历史上第一个针对RNA病毒的疫苗，并
且在这么短的时间就研制成功，拿诺贝尔奖是肯定的。
【 在 TravisBickle (Travis) 的大作中提到: 】
: Biotech company Moderna Inc. dosed 45 patients between the ages of 18 and 55
: with 25, 100 or 250 micrograms of its experimental drug. After receiving a
: second booster shot, those at the 25 and 100 dosage levels were found with
: antibody levels that were equal to or exceeded those found in patients who
: recovered from COVID-19, the company said in a press release.
: Moderna CEO Stephane Bancel told Bloomberg that the results “
: couldn’t have been better.”
: “This is a very good sign that we make an antibody that can stop the
virus
: from replicating,” he said.
乙肝疫苗早就出来几十年了
【 在 USMLESTEPS (USMLE123) 的大作中提到: 】
: 希望能成功。
: 不过比较悬，因为到目前为止我们还没有一个对RNA病毒有效的疫苗， 比如乙肝和
HIV
: 研究了几十年也没有有效的疫苗。 何况冠状病毒还会很容易变异。
: 如果疫苗能成功的话，会创造两个奇迹，即人类历史上第一个针对RNA病毒的疫苗，并
: 且在这么短的时间就研制成功，拿诺贝尔奖是肯定的。
: 55
: a
: virus
哈哈，笔误。 是丙肝，乙肝是DNA病毒。
只有20%的人产生了抗体。而且抗体的持续时间不知道。病人身上有抗体很快消失的情
况。
所以，难说。
【 在 USMLESTEPS (USMLE123) 的大作中提到: 】
: 希望能成功。
: 不过比较悬，因为到目前为止我们还没有一个对RNA病毒有效的疫苗， 比如丙肝和
HIV
: 研究了几十年也没有有效的疫苗。 何况冠状病毒还会很容易变异。
: 如果疫苗能成功的话，会创造两个奇迹，即人类历史上第一个针对RNA病毒的疫苗，并
: 且在这么短的时间就研制成功，拿诺贝尔奖是肯定的。
: 55
: a
: virus
只测了八个人，都有抗体。
Moderna has vaccinated dozens of study participants and measured antibodies in eight of them. All eight developed neutralizing antibodies to the virus
at levels reaching or exceeding the levels seen in people who've naturally
recovered from Covid-19, according to the company.
"We've demonstrated that these antibodies, this immune response, can
actually block the virus," Zaks said. "I think this is a very
important
first step in our journey towards having a vaccine."
【 在 iminosugar(伪糖) 的大作中提到: 】
<br>: 只有20%的人产生了抗体。而且抗体的持续时间不知道。病人身上有抗体
很快消
失的情
<br>: 况。
<br>: 所以，难说。
<br>: HIV
<br>
re
没有仔细看，但我理解是，都有抗体，深入测了八个，这八个都是中和抗体，中和抗体的体外实验是比较复杂的实验，
所以还要等一等，这些数据，支持进一步实验是 合理的 ！
【 在 TravisBickle (Travis) 的大作中提到: 】
: 只测了八个人，都有抗体。
: Moderna has vaccinated dozens of study participants and measured
antibodies
: in eight of them. All eight developed neutralizing antibodies to the virus
: at levels reaching or exceeding the levels seen in people who've naturally
: recovered from Covid-19, according to the company.
: "We've demonstrated that these antibodies, this immune response, can
: actually block the virus," Zaks said. "I think this is a very
: important
: first step in our journey towards having a vaccine."
:
: 只有20%的人产生了抗体。而且抗体的持续时间不知道。病人身上有抗体
: ...................
【 在 daemonself (mit行为艺术专业博士后导师) 的大作中提到: 】
: 看胸，你这么舔共共匪知道么？还是你也有有些人士一样在国内有产业？
只知道你们这些轮子老酱的名单
胆敢去中国就一个一个全请去廊坊喝茶
LOL
Immunogenicity data are currently available for the 25 μg and 100 μg dose level (ages 18-55) after two doses (day 43) and at the 250 μg level (ages
18-55) after one dose (day 29). Dose dependent increases in immunogenicity
were seen across the three dose levels, and between prime and boost within
the 25 μg and 100 μg dose levels. All participants ages 18-55 (n=15 per
cohort) across all three dose levels seroconverted by day 15 after a single dose. At day 43, two weeks following the second dose, at the 25 μg dose
level (n=15), levels of binding antibodies were at the levels seen in
convalescent sera (blood samples from people who have recovered from COVID-
19) tested in the same assay. At day 43, at the 100 μg dose level (n=10),
levels of binding antibodies significantly exceeded the levels seen in
convalescent sera. Samples are not yet available for remaining participants.
At this time, neutralizing antibody data are available only for the first
four participants in each of the 25 μg and 100 μg dose level cohorts.
Consistent with the binding antibody data, mRNA-1273 vaccination elicited
neutralizing antibodies in all eight of these participants, as measured by
plaque reduction neutralization (PRNT) assays against live SARS-CoV-2. The
levels of neutralizing antibodies at day 43 were at or above levels
generally seen in convalescent sera.
这一段感觉有猫腻。大家分析分析？
公司今天就决定发行$1B的股票。我日，一个B，今天。
【 在 TravisBickle (Travis) 的大作中提到: 】
: 只测了八个人，都有抗体。
: Moderna has vaccinated dozens of study participants and measured
antibodies
: in eight of them. All eight developed neutralizing antibodies to the virus
: at levels reaching or exceeding the levels seen in people who've naturally
: recovered from Covid-19, according to the company.
: "We've demonstrated that these antibodies, this immune response, can
: actually block the virus," Zaks said. "I think this is a very
: important
: first step in our journey towards having a vaccine."
:
: 只有20%的人产生了抗体。而且抗体的持续时间不知道。病人身上有抗体
: ...................
啥问题? 除了数据还不全。加卖股票有点急啊。
【 在 iminosugar(伪糖) 的大作中提到: 】
: Immunogenicity data are currently available for the 25 μg and 100 μg dose
: level (ages 18-55) after two doses (day 43) and at the 250 μg level (ages
: 18-55) after one dose (day 29). Dose dependent increases in
immunogenicity
: were seen across the three dose levels, and between prime and boost
within
: the 25 μg and 100 μg dose levels. All participants ages 18-55 (n=15 per
: cohort) across all three dose levels seroconverted by day 15 after a
single
: dose. At day 43, two weeks following the second dose, at the 25 μg
dose
: level (n=15), levels of binding antibodies were at the levels seen in
: convalescent sera (blood samples from people who have recovered from
COVID-
: 19) tested in the same assay. At day 43, at the 100 μg dose level (n=10),
: ...................
我估计就是按照抗体滴度的高低，每组滴度最高的4个（每组总共15）做中和试验，先
把结果发出来。滴度低的参与者就先不管了。可以说就是试验安排问题，以后效果不理想，也不能算欺诈。
也可能完全是我小人之心。但是，公司这么急一次性卖这么多的股票不是一个好兆头。
【 在 TravisBickle (Travis) 的大作中提到: 】
: 啥问题? 除了数据还不全。加卖股票有点急啊。
:
: Immunogenicity data are currently available for the 25 μg and 100
μg
: dose
:
: level (ages 18-55) after two doses (day 43) and at the 250 μg level (
: ages
:
: 18-55) after one dose (day 29). Dose dependent increases in
: immunogenicity
:
: were seen across the three dose levels, and between prime and boost : within
:
: the 25 μg and 100 μg dose levels. All participants ages 18-55 (n=
15
: ...................
忘了3个月前瑞德西韦神药的第一次亮相了吗？
都特么是金鱼
【 在 TravisBickle (Travis) 的大作中提到: 】
: Biotech company Moderna Inc. dosed 45 patients between the ages of 18 and 55
: with 25, 100 or 250 micrograms of its experimental drug. After receiving a
: second booster shot, those at the 25 and 100 dosage levels were found with
: antibody levels that were equal to or exceeded those found in patients who
: recovered from COVID-19, the company said in a press release.
: Moderna CEO Stephane Bancel told Bloomberg that the results “
: couldn’t have been better.”
: “This is a very good sign that we make an antibody that can stop the
virus
: from replicating,” he said.
没啥小人的，疫苗怎么都得 一年以上，
【 在 iminosugar (伪糖) 的大作中提到: 】
: 我估计就是按照抗体滴度的高低，每组滴度最高的4个（每组总共15）做中和试验，先
: 把结果发出来。滴度低的参与者就先不管了。可以说就是试验安排问题，以后效果不理
: 想，也不能算欺诈。
: 也可能完全是我小人之心。但是，公司这么急一次性卖这么多的股票不是一个好兆头。
: μg
: (
: 15
张文宏的意思是最乐观明年3-6月份才能出来而且还不一定能有效。
也许就要接着等到6-9月份甚至明年年底。
https://chinanews.sina.com/bg/chnmedia/chinanews/2020-05-16/doc-
ifzwkayy9548901.shtml
【 在 iminosugar (伪糖) 的大作中提到: 】
: 我估计就是按照抗体滴度的高低，每组滴度最高的4个（每组总共15）做中和试验，先
: 把结果发出来。滴度低的参与者就先不管了。可以说就是试验安排问题，以后效果不理
: 想，也不能算欺诈。
: 也可能完全是我小人之心。但是，公司这么急一次性卖这么多的股票不是一个好兆头。
中和试验是NIH做的，说是比较难做每组只搞了四个。抗体结合试验都做了。
Neutralizing antibody data are available only for the first four
participants in each of the 25 and 100-microgram dose cohorts. Consistent
with the binding antibody titers, mRNA-1273 vaccination elicited
neutralizing titers in all age participants, as measured by plaque reduction neutralization assays against live SARS-CoV-2 virus. The levels of these
neutralizing titers at day 43 were at or above levels generally seen in
convalescent sera. Now, I should say, this is a difficult essay to perform
for a live dangerous virus. And we’re really indebted to NIAID and its
academic partners for setting these up and running them.
中和实验当然难做，要能显示介导细胞毒反应
【在 TravisBickle(Travis)的大作中提到：】
：
：【 在 iminosugar (伪糖) 的大作中提到: 】
Oxford did a monkey test. (Adenovirus vector, I think, which should be more effective than mRNA albeit less safe)
Anyone know why MRNA didn't do a monkey trial? Or, did they?
【 在 TravisBickle (Travis) 的大作中提到: 】
: 中和试验是NIH做的，说是比较难做每组只搞了四个。抗体结合试验都做了。
: Neutralizing antibody data are available only for the first four
: participants in each of the 25 and 100-microgram dose cohorts. Consistent : with the binding antibody titers, mRNA-1273 vaccination elicited
: neutralizing titers in all age participants, as measured by plaque
reduction
: neutralization assays against live SARS-CoV-2 virus. The levels of these : neutralizing titers at day 43 were at or above levels generally seen in
: convalescent sera. Now, I should say, this is a difficult essay to perform
: for a live dangerous virus. And we’re really indebted to NIAID and its
: academic partners for setting these up and running them.
【 在 TeddyBear001 (TeddyBear001) 的大作中提到: 】
: Oxford did a monkey test. (Adenovirus vector, I think, which should be
more
: effective than mRNA albeit less safe)
: Anyone know why MRNA didn't do a monkey trial? Or, did they?
: reduction
不同免疫路径，adeno 应该是生产病毒蛋白激发免疫反应，这个病毒RNA作为抗原。看
起来moderna这个对人是有效的，几十个样本里反应率100%。下一步要看免疫能持续多
久，扩大到几百人怎么样。
冠状病毒的疫苗成功的几率太小了，而且mRNA疫苗效果从来就不如其他疫苗。这些都是写在教科书里的东西。我希望但是不相信Moderna就能够在这么短的时间里创造历史。
【 在 TravisBickle (Travis) 的大作中提到: 】
: more
: 不同免疫路径，adeno 应该是生产病毒蛋白激发免疫反应，这个病毒RNA作为抗原。看
: 起来moderna这个对人是有效的，几十个样本里反应率100%。下一步要看免疫能持续多
: 久，扩大到几百人怎么样。
因为 mRNA 本身就安全，几乎可以跳过 动物实验，
腺病毒的要是出事儿了，就是人出事儿，那就问题大了，
传统疫苗都要走动物，mRNA（估计 DNA) 疫苗可以跳过去。。
【 在 TeddyBear001 (TeddyBear001) 的大作中提到: 】
: Oxford did a monkey test. (Adenovirus vector, I think, which should be
more
: effective than mRNA albeit less safe)
: Anyone know why MRNA didn't do a monkey trial? Or, did they?
: reduction
Oxford did efficacy test in Rhesus monkey: vaccinated moneys exposed to
Covid-19.
Not sure if Moderna did monkey efficacy trial.
【 在 cellcycle (vacoule) 的大作中提到: 】
: 因为 mRNA 本身就安全，几乎可以跳过 动物实验，
: 腺病毒的要是出事儿了，就是人出事儿，那就问题大了，
: 传统疫苗都要走动物，mRNA（估计 DNA) 疫苗可以跳过去。。
: more
My understanding is MRNA uses mRNA to generate virus spike protein in vivo
to induce immunity.
Essentially same 免疫路径, with different delivery vehicle.
【 在 TravisBickle (Travis) 的大作中提到: 】
: more
: 不同免疫路径，adeno 应该是生产病毒蛋白激发免疫反应，这个病毒RNA作为抗原。看
: 起来moderna这个对人是有效的，几十个样本里反应率100%。下一步要看免疫能持续多
: 久，扩大到几百人怎么样。
做了猴，人也得做，
mRNA 跳过动物，直接上人，就因为安全。。
他们三个 dose 也证明了，基本没有副作用，受试者，只有高剂量有皮疹，但都没有发烧的，不过一期吗数据量小。。
【 在 TeddyBear001 (TeddyBear001) 的大作中提到: 】
: Oxford did efficacy test in Rhesus monkey: vaccinated moneys exposed to
: Covid-19.
: Not sure if Moderna did monkey efficacy trial.
【 在 TeddyBear001 (TeddyBear001) 的大作中提到: 】
: My understanding is MRNA uses mRNA to generate virus spike protein in vivo
: to induce immunity.
: Essentially same 免疫路径, with different delivery vehicle.
看了下，是这样。mRNA主要问题是如何有效进入细胞。
Oxford Monkeys contracted Covid-19 after vaccination.
MRNA human trials did not and will not expose trial subjects to live virus. No direct efficacy data from clinical trials will be forth coming.. That is why I am surprised Not to see any primates efficacy data.
【 在 cellcycle (vacoule) 的大作中提到: 】
: 做了猴，人也得做，
: mRNA 跳过动物，直接上人，就因为安全。。
: 他们三个 dose 也证明了，基本没有副作用，受试者，只有高剂量有皮疹，但都没有发
: 烧的，不过一期吗数据量小。。
就几乎是 被动扩散，
不过分裂细胞容易进。。
【 在 TravisBickle (Travis) 的大作中提到: 】
: 看了下，是这样。mRNA主要问题是如何有效进入细胞。
That is why adenovirus usually is more effective. More risk though.
【 在 TravisBickle (Travis) 的大作中提到: 】
: 看了下，是这样。mRNA主要问题是如何有效进入细胞。
【 在 TeddyBear001 (TeddyBear001) 的大作中提到: 】
: That is why adenovirus usually is more effective. More risk though.
adenovirus二十年前吧，james wilson做基因疗法出过人命。现在应该技术改进了。
20多年前，还搞过 构建基因治疗 腺病毒载体。。。。
【 在 TravisBickle (Travis) 的大作中提到: 】
: adenovirus二十年前吧，james wilson做基因疗法出过人命。现在应该技术改进了。
【 在 cellcycle (vacoule) 的大作中提到: 】
: 20多年前，还搞过 构建基因治疗 腺病毒载体。。。。
那时候基因疗法大跃进，wilson给治死一个消停了，后来搞AAV又满血复活。
原来不懂， 现在看基因治疗根本不靠谱，干细胞有一定的希望，
再一个，人的现代病几乎都是 因为 寿命延长来的。。
改变生活方式，预防医学对大部分人更有效。。
病能不能治好基本取决于 病本身，治疗手段都是 secondary ！
【 在 TravisBickle (Travis) 的大作中提到: 】
: 那时候基因疗法大跃进，wilson给治死一个消停了，后来搞AAV又满血复活。
【 在 cellcycle (vacoule) 的大作中提到: 】
: 原来不懂， 现在看基因治疗根本不靠谱，干细胞有一定的希望，
: 再一个，人的现代病几乎都是 因为 寿命延长来的。。
: 改变生活方式，预防医学对大部分人更有效。。
: 病能不能治好基本取决于 病本身，治疗手段都是 secondary ！
这几年基因疗法也成功了不少。每种疗法都有弱点，干细胞有给种出肿瘤的。