To my knowledge, Ying and Austin Smith defined the ground/naive pluripotent state(2008 Nature). His lab made the first rat ES cell lines (2018 Cell) and the first KO rat (2011 Nature). Due to these outbreak discoveries, he won the 2016 McEwen Award for Innovation, the highest honor bestowed by the International Society for Stem Cell Research (ISSCR).
He also made other milestone findings: 1. The first ES cell fusion-induced reprogramming (2002 Nature)---a different route to get pluripotent cells, 4 years earlier than Yamanaka's iPSC 2. The role of BMP4 signaling in the selfrenewal of mouse ES cells (2003 Cell). 3. Monolayer neural differentiation (2003 Nature Biot) ...
Of course, Yu made great contribution to human iPS. However, as mentioned by gene8, the first iPS was made by Yamanaka lab. So, ...
【 在 LargeT (SmallT) 的大作中提到: 】 : To my knowledge, Ying and Austin Smith defined the ground/naive pluripotent : state(2008 Nature). His lab made the first rat ES cell lines (2018 Cell) and : the first KO rat (2011 Nature). Due to these outbreak discoveries, he won : the 2016 McEwen Award for Innovation, the highest honor bestowed by the : International Society for Stem Cell Research (ISSCR). : He also made other milestone findings: : 1. The first ES cell fusion-induced reprogramming (2002 Nature)---a : different route to get pluripotent cells, 4 years earlier than Yamanaka's : iPSC : 2. The role of BMP4 signaling in the selfrenewal of mouse ES cells (2003 : ...................
Qi-Long Ying wins 2016 McEwen Award for Innovation The International Society for Stem Cell Research (ISSCR) has named Qi-Long Ying, MD, PhD, as one of the winners of the 2016 McEwen Award for Innovation, the highest honor bestowed for stem cell research. Supported by the McEwen Centre for Regenerative Medicine, the award recognizes groundbreaking stem cell discoveries that open new avenues to explore or treat human disease.
Ying, an associate professor of Stem Cell & Regenerative Medicine at the Keck School of Medicine of USC, was named in the award with Austin Smith, PhD, from the University of Cambridge. The researchers accepted the award and shared the $100,000 prize at ISSCR’s annual meeting this June in San Francisco.
Ying originally joined Smith’s laboratory as someone who knew next to nothing about stem cells. The third child of a farmer and a factory worker, he grew up in Yongkang, a small city in China’s Zhejiang province, during the Cultural Revolution.
Despite his natural curiosity, Ying had had little chance of obtaining a higher education. Chinese universities admitted students based on political and family connections, not academics, throughout most of his childhood. This changed with the death of Chairman Mao in 1976, and the subsequent reinstatement of China’s merit-based college entrance exam. Ying earned a top score.
Although he originally dreamed of becoming a detective or a civil engineer, charismatic recruiters from the First Military Medical University persuaded him to choose a different path. What he didn’t fully appreciate at the time was that attending one of China’s military medical universities carried an obligation of 25 years of army service.
After Ying graduated, the army decided that he would treat minor ailments at a remote missile base near the Chinese border with North Korea — a three- day train ride from his hometown, his parents and his three sisters.
“We were in the mountains,” he said. “It was very, very cold — minus 30 degrees Celsius in the winter. And there were no women, and there was no hope, and life was very boring. We had no future.”
But Ying was determined to elude his fate. He spent two years studying for the highly competitive exam to attend graduate school in China and earned admission to Shanghai Medical University, where he pursued his master’s and PhD degrees and postdoctoral training.
Then the army noticed his nine-year absence and summoned him back to his missile troop — now relocated to the country’s remote central region. He realized that to get out of the army, he had to get out of China.
Ying applied to at least 50 jobs all over the world and landed a postdoctoral position in Smith’s laboratory, then at the University of Edinburgh in Scotland.
New to both stem cells and the English language, Ying began trying to “ rewind” mouse neural stem cells into embryonic stem (ES) cells — and thought he had succeeded. Months later, he realized that that the neural stem cells had spontaneously fused with ES cells in the same petri dish, producing abnormally large ES cells. It was the first proof of spontaneous fusion, and it earned him and Smith a publication in the journal Nature in 2002.
Still under Smith’s mentorship, he found a more efficient way to turn ES cells into neurons, published in Nature Biotechnology in 2003.
Next, he and Smith made the landmark breakthrough that would eventually earn the 2016 McEwen Award for Innovation. They discovered that they could inhibit ES cells from differentiating into specialized cells by exposing them to two proteins — called leukemia inhibitory factor (LIF) and bone morphogenic protein (BMP) — and published the results in Cell in 2003. Subsequently, in a 2008 paper in Nature, they used two inhibitory molecules — dubbed 2i — to mimic this effect.
“We can use embryonic stem cells to generate different cell types,” Ying said. “And these cell types can be used for cell replacement therapy, for drug screening and for many other purposes.”
After seven years, Ying left the Smith Lab to accept a faculty position at the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, where he also serves as the director of the Chang Stem Cell Engineering Facility. Ying’s team made one of Science magazine’s “Top 10 Breakthroughs of 2010” by using ES cell-based gene targeting to produce the world’s first knockout rats, modified to lack one or more genes.
“To be successful in this very competitive scientific career,” Ying said, “you have to have confidence that you can achieve something.”
最近我系统的回顾了干细胞研究的发展历程，并通过对大量干细胞的研究成果汇总，当我特别对华人科学家的研究成果仔细研究后，我得出一下结论：
当今在干细胞，胚胎发育及动物模型研究领域，最具有原创性、最突出的华人科学家只有
应其龙 一人也
其他有华人科学家尽管cns灌水不少，但不是跟风，就是利用动物资源优势做一些重复
性工作，或者结果不可靠，根本没有原创性。
让人意外的是，应其龙还是土鳖博士一枚。在土鳖博士中能够出来如此具有创造力的科学家，真的太难得太难得了！
赞赏应其龙，真科学家！
你倒是说说你的研究成果啊，哪些原创性工作。
你知道俞君英吗？她甩应其龙十条街
同意！他也是首位获得干细胞领域最高奖“麦克尤思创新奖”的华人科学家。
【 在 gene8 (haha) 的大作中提到: 】
: 通过对大量干细胞领域的华人科学家的研究成果仔细研究发现：
: 当今在干细胞，胚胎发育及动物模型研究领域，最具有原创性，最突出的华人科学家只有
: 应其龙 一人也
: 其他有华人科学家尽管cns灌水不少，但不是跟风，就是利用动物资源优势做一些重复
: 性工作，根本没有原创性。还让人意外的是，应其龙还是土鳖博士一枚。在土鳖博士中
: 能够出来如此具有创造力的科学家，真的太难得太难得了！
: 赞赏应其龙，真科学家！
放屁！明明是季博士，季博士都用干细胞直接让新冠ICU插管病人一星期直接拔管出院
了。
【 在 gene8 (haha) 的大作中提到: 】
: 通过对大量干细胞领域的华人科学家的研究成果仔细研究发现：
: 当今在干细胞，胚胎发育及动物模型研究领域，最具有原创性，最突出的华人科学家只有
: 应其龙 一人也
: 其他有华人科学家尽管cns灌水不少，但不是跟风，就是利用动物资源优势做一些重复
: 性工作，根本没有原创性。还让人意外的是，应其龙还是土鳖博士一枚。在土鳖博士中
: 能够出来如此具有创造力的科学家，真的太难得太难得了！
: 赞赏应其龙，真科学家！
【 在 howardx (howard) 的大作中提到: 】
: 你知道俞君英吗？她甩应其龙十条街
Rebuttal：
尽管Yu在Thomson实验室做博后的时候和Yamanaka同时做出来的人的iPSCs，但是那不是第一个iPSCs，小鼠的Yamanaka早一年就做出来了，就是换了个物种，所以2012年的NB
奖Thomas没有入列。
其次最重要的是，Yu单飞出来再也没有大的成果，所以只能说她获得人iPSCs的思路几
乎是Thomas的，她就是个动手的博后罢了。
【 在 LargeT (SmallT) 的大作中提到: 】
: 同意！他也是首位获得干细胞领域最高奖“麦克尤思创新奖”的华人科学家。
: 只有
谢谢，看来你懂干细胞。
【 在 stk110 () 的大作中提到: 】
: 你倒是说说你的研究成果啊，哪些原创性工作。
我能猜到你是谁
我的原创性研究成果就是：我发现zhong 国人是最gossip的物种
当年那篇文章俞是共同通讯作者，这种分量的工作让博后做通讯作者说明她并不仅仅是老板idea的执行者，当年他和山中，Thomson一起评为年度科学人物，也是对她的认可
。后来她就离开学术界去开公司了，难道你还要用学术成果来要求她？既然你在评论原创性，又不是终身成就。你觉得应的哪项成果原创性超过俞？
【 在 gene8(haha) 的大作中提到: 】
: Rebuttal：
: 尽管Yu在Thomson实验室做博后的时候和Yamanaka同时做出来的人的iPSCs，但是那不是
: 第一个iPSCs，小鼠的Yamanaka早一年就做出来了，就是换了个物种，所以2012
年的NB
: 奖Thomas没有入列。
: 其次最重要的是，Yu单飞出来再也没有大的成果，所以只能说她获得人iPSCs的
思路几
: 乎是Thomas的，她就是个动手的博后罢了。
【 在 howardx (howard) 的大作中提到: 】
: 当年那篇文章俞是共同通讯作者，这种分量的工作让博后做通讯作者说明她并不仅仅是
: 老板idea的执行者，当年他和山中，Thomson一起评为年度科学人物，也是对她的认可
: 。后来她就离开学术界去开公司了，难道你还要用学术成果来要求她？既然你在评论原
: 创性，又不是终身成就。你觉得应的哪项成果原创性超过俞？
:
: Rebuttal：
:
: 尽管Yu在Thomson实验室做博后的时候和Yamanaka同时做出来的人的iPSCs，但是
: 那不是
:
: 第一个iPSCs，小鼠的Yamanaka早一年就做出来了，就是换了个物种，所以
2012
: 年的NB
:
: 奖Thomas没有入列。
: ...................
如果没有自己独立的实验室做出来的成果，其根本都是老板的，老板的资源，老板的思路，老板的管理，老板的经费，这是毋庸置疑的事实。
Yamanaka 2006 和2007年从小鼠到人ips的2篇cell文章的第一作者Kazutoshi
Takahashi 有谁知道他？
【 在 howardx (howard) 的大作中提到: 】
: 当年那篇文章俞是共同通讯作者，这种分量的工作让博后做通讯作者说明她并不仅仅是
: 老板idea的执行者，当年他和山中，Thomson一起评为年度科学人物，也是对她的认可
: 。后来她就离开学术界去开公司了，难道你还要用学术成果来要求她？既然你在评论原
: 创性，又不是终身成就。你觉得应的哪项成果原创性超过俞？
:
: Rebuttal：
:
: 尽管Yu在Thomson实验室做博后的时候和Yamanaka同时做出来的人的iPSCs，但是
: 那不是
:
: 第一个iPSCs，小鼠的Yamanaka早一年就做出来了，就是换了个物种，所以
2012
: 年的NB
:
: 奖Thomas没有入列。
: ...................
如果就在phd或者博后期间第一作发个好文章好研究结果，还不能真正意义上的科学家
，只不过碰到了好老板，运气好罢了。
有自己独立的实验室自己的经费管理体系做出来的成果那才是自己的。
算不算科学家不是你说了算，有些时候博后靠老板吃饭，有时候好博后成就老板。当年的年度科学人物有俞君英没有takahashi你怎么看？扯了半天你也没能说出来应的原创
性工作有什么资格在华人中排第一
【 在 gene8(haha) 的大作中提到: 】
: 2012
: 如果就在phd或者博后期间第一作发个好文章好研究结果，还不能真正意义上的
科学家
: ，只不过碰到了好老板，运气好罢了。
: 有自己独立的实验室自己的经费管理体系做出来的成果那才是自己的。
To my knowledge, Ying and Austin Smith defined the ground/naive pluripotent state(2008 Nature). His lab made the first rat ES cell lines (2018 Cell) and the first KO rat (2011 Nature). Due to these outbreak discoveries, he won
the 2016 McEwen Award for Innovation, the highest honor bestowed by the
International Society for Stem Cell Research (ISSCR).
He also made other milestone findings:
1. The first ES cell fusion-induced reprogramming (2002 Nature)---a
different route to get pluripotent cells, 4 years earlier than Yamanaka's
iPSC
2. The role of BMP4 signaling in the selfrenewal of mouse ES cells (2003
Cell).
3. Monolayer neural differentiation (2003 Nature Biot)
...
Of course, Yu made great contribution to human iPS. However, as mentioned by gene8, the first iPS was made by Yamanaka lab. So, ...
【 在 howardx (howard) 的大作中提到: 】
: 算不算科学家不是你说了算，有些时候博后靠老板吃饭，有时候好博后成就老板。当年
: 的年度科学人物有俞君英没有takahashi你怎么看？扯了半天你也没能说出来应的原创
: 性工作有什么资格在华人中排第一
:
: 2012
:
: 如果就在phd或者博后期间第一作发个好文章好研究结果，还不能真正意义上的
: 科学家
:
: ，只不过碰到了好老板，运气好罢了。
:
: 有自己独立的实验室自己的经费管理体系做出来的成果那才是自己的。
:
俞还没独立？老板不支持她独立吗？
【 在 howardx (howard) 的大作中提到: 】
: 算不算科学家不是你说了算，有些时候博后靠老板吃饭，有时候好博后成就老板。当年
: 的年度科学人物有俞君英没有takahashi你怎么看？扯了半天你也没能说出来应的原创
: 性工作有什么资格在华人中排第一
:
: 2012
:
: 如果就在phd或者博后期间第一作发个好文章好研究结果，还不能真正意义上的
: 科学家
:
: ，只不过碰到了好老板，运气好罢了。
:
: 有自己独立的实验室自己的经费管理体系做出来的成果那才是自己的。
:
【 在 LargeT (SmallT) 的大作中提到: 】
: To my knowledge, Ying and Austin Smith defined the ground/naive
pluripotent
: state(2008 Nature). His lab made the first rat ES cell lines (2018 Cell)
and
: the first KO rat (2011 Nature). Due to these outbreak discoveries, he won
: the 2016 McEwen Award for Innovation, the highest honor bestowed by the
: International Society for Stem Cell Research (ISSCR).
: He also made other milestone findings:
: 1. The first ES cell fusion-induced reprogramming (2002 Nature)---a
: different route to get pluripotent cells, 4 years earlier than Yamanaka's : iPSC
: 2. The role of BMP4 signaling in the selfrenewal of mouse ES cells (2003
: ...................
谢谢帮我罗列，看来你真的非常懂干细胞。
Thanks!
Correct a typo: the first rat ES cell line should be 2008 Cell.
【 在 gene8 (haha) 的大作中提到: 】
: pluripotent
: and
: 谢谢帮我罗列，看来你真的非常懂干细胞。
【 在 howardx (howard) 的大作中提到: 】
: 算不算科学家不是你说了算，有些时候博后靠老板吃饭，有时候好博后成就老板。当年
: 的年度科学人物有俞君英没有takahashi你怎么看？扯了半天你也没能说出来应的原创
: 性工作有什么资格在华人中排第一
:
: 2012
:
: 如果就在phd或者博后期间第一作发个好文章好研究结果，还不能真正意义上的
: 科学家
:
: ，只不过碰到了好老板，运气好罢了。
:
: 有自己独立的实验室自己的经费管理体系做出来的成果那才是自己的。
:
你看我题目，我说的是干细胞领域，不是整个华人。
至于ying的真正贡献，你自己去查了才能真正理解，别人说了也没用
Qi-Long Ying wins 2016 McEwen Award for Innovation
The International Society for Stem Cell Research (ISSCR) has named Qi-Long
Ying, MD, PhD, as one of the winners of the 2016 McEwen Award for Innovation, the highest honor bestowed for stem cell research. Supported by the McEwen Centre for Regenerative Medicine, the award recognizes groundbreaking stem cell discoveries that open new avenues to explore or treat human disease.
Ying, an associate professor of Stem Cell & Regenerative Medicine at the
Keck School of Medicine of USC, was named in the award with Austin Smith,
PhD, from the University of Cambridge. The researchers accepted the award
and shared the $100,000 prize at ISSCR’s annual meeting this June in San
Francisco.
Ying originally joined Smith’s laboratory as someone who knew next to
nothing about stem cells. The third child of a farmer and a factory worker, he grew up in Yongkang, a small city in China’s Zhejiang province, during
the Cultural Revolution.
Despite his natural curiosity, Ying had had little chance of obtaining a
higher education. Chinese universities admitted students based on political and family connections, not academics, throughout most of his childhood.
This changed with the death of Chairman Mao in 1976, and the subsequent
reinstatement of China’s merit-based college entrance exam. Ying earned a
top score.
Although he originally dreamed of becoming a detective or a civil engineer, charismatic recruiters from the First Military Medical University persuaded him to choose a different path. What he didn’t fully appreciate at the time was that attending one of China’s military medical universities carried an obligation of 25 years of army service.
After Ying graduated, the army decided that he would treat minor ailments at a remote missile base near the Chinese border with North Korea — a three-
day train ride from his hometown, his parents and his three sisters.
“We were in the mountains,” he said. “It was very, very cold — minus 30 degrees Celsius in the winter. And there were no women, and there was no
hope, and life was very boring. We had no future.”
But Ying was determined to elude his fate. He spent two years studying for
the highly competitive exam to attend graduate school in China and earned
admission to Shanghai Medical University, where he pursued his master’s and PhD degrees and postdoctoral training.
Then the army noticed his nine-year absence and summoned him back to his
missile troop — now relocated to the country’s remote central region. He
realized that to get out of the army, he had to get out of China.
Ying applied to at least 50 jobs all over the world and landed a
postdoctoral position in Smith’s laboratory, then at the University of
Edinburgh in Scotland.
New to both stem cells and the English language, Ying began trying to “
rewind” mouse neural stem cells into embryonic stem (ES) cells — and
thought he had succeeded. Months later, he realized that that the neural
stem cells had spontaneously fused with ES cells in the same petri dish,
producing abnormally large ES cells. It was the first proof of spontaneous
fusion, and it earned him and Smith a publication in the journal Nature in
2002.
Still under Smith’s mentorship, he found a more efficient way to turn ES
cells into neurons, published in Nature Biotechnology in 2003.
Next, he and Smith made the landmark breakthrough that would eventually earn the 2016 McEwen Award for Innovation. They discovered that they could
inhibit ES cells from differentiating into specialized cells by exposing
them to two proteins — called leukemia inhibitory factor (LIF) and bone
morphogenic protein (BMP) — and published the results in Cell in 2003.
Subsequently, in a 2008 paper in Nature, they used two inhibitory molecules — dubbed 2i — to mimic this effect.
“We can use embryonic stem cells to generate different cell types,” Ying
said. “And these cell types can be used for cell replacement therapy, for
drug screening and for many other purposes.”
After seven years, Ying left the Smith Lab to accept a faculty position at
the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell
Research at USC, where he also serves as the director of the Chang Stem Cell Engineering Facility. Ying’s team made one of Science magazine’s “Top 10 Breakthroughs of 2010” by using ES cell-based gene targeting to produce
the world’s first knockout rats, modified to lack one or more genes.
“To be successful in this very competitive scientific career,” Ying said, “you have to have confidence that you can achieve something.”
— Cristy Lytal