Selected Publications: Wang S, Zheng Y, Li J, Yu Y, Zhang W, Song M, Liu Z, Min Z, Hu H, Jing Y, He X, Sun L, Esteban C, Chan P, Qiao J, Zhou Q, Belmonte JC*, Jing Qu*, Tang F*, Liu GH*. Single-Cell Transcriptomic Atlas of Primate Ovarian Aging. Cell. 2020. 180(3):585-600 (Cover story) Ma S, Sun S, Geng L, Song M, Wang W, Ye Y, Ji Q, Zou Z, Wang S, He X, Li W, Rodriguez Esteban C, Long X, Guo G, Chan P, Zhou Q, Belmonte JC*, Zhang W*, Qu J*, Liu GH*. Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging. Cell. 2020. 180(5):984-1001. Liang C, Liu Z, Song M, Li W, Wu Z, Wang Z, Wang Q, Wang S, Yan K, Sun L, Hishida T, Cai Y, Izpisua Belmonte JC, Guillen P, Chan P, Zhou Q, Zhang W*, Qu J*, Liu GH*. Stabilization of Heterochromatin by CLOCK Promotes Stem Cell Rejuvenation and Cartilage Regeneration. Cell Research. 2020. DOI:10.1038/ s41422-020-0385-7. Ma S, Sun S, Li J, Fan Y, Qu J, Sun L, Wang S, Zhang Y, Yang S, Liu Z, Wu Z, Zhang S, Wang Q, Zheng A, Duo S, Yu Y, Belmonte JCI, Chan P, Zhou Q, Song M*, Zhang W*, Liu GH*. Single-Cell Transcriptomic Atlas of Primate Cardiopulmonary Aging. Cell Research. 2020. doi: 10.1038/s41422-020-00412-6.Li J, Zheng Y, Yan P, Song M, Wang S, Sun L, Liu Z, Ma S, Chan P, Zhou Q, Belmonte JC, Zhang W*, Liu GH*, Tang F*, Qu J*. A Single-cell Transcriptomic Atlas of Primate Pancreatic Islet Aging. National Science Review. 2020. DOI: 10.1093/nsr/nwaa127 Zhang W, Zhang S, Yan P, Ren J, Song M, Li J, Lei J, Pan H, Wang S, Ma X, Ma S, Li H, Sun F, Wan H, Li W, Chan P, Zhou Q, Liu GH*, Tang F*, Qu J*. A Single-Cell Transcriptomic landscape of Primate Arterial Aging. Nature Communications. 2020. 11(1):2202. Yan P, Liu Z, Song M, Wu Z, Xu W, Li K, Ji Q, Wang S, Liu X, Yan K, Esteban CR, Ci W, Izpisua Belmonte JC, Xie W, Ren J, Zhang W*, Sun Q*, Qu J*, Liu GH*. Genome-wide R-loop landscapes during cell differentiation and reprogramming. Cell Reports. 2020. 32(1):107870 Wang F, Zhang W, Yang Q, Kang Y, Fan Y, Wei J, Liu Z, Dai S, Li H, Li Z, Xu L, Chu C, Qu J, Si C, Ji W*, Liu GH*, Long C*, Niu Y*. Generation of a Hutchinson-Gilford progeria syndrome monkey model by base editing. Protein Cell. 2020. DOI: 10.1007/s13238-020-00740-8 Zheng Y, Liu X, Le W, Xie L, Li H, Wen W, Wang S, Ma S, Huang Z, Ye J, Shi W, Ye Y, Liu Z, Song M, Zhang W, Belmonte JCI, Xiao C, Qu J*, Wang H*, Liu GH*, Su W*. A human circulating immune cell landscape in aging and COVID-19. Protein Cell. 2020. DOI: 10.1007/s13238-020-00762-2 Li H, Wei X, Zhou L, Zhang W, Wang C, Guo Y, Li D, Chen J, Liu T, Zhang Y, Ma S, Wang C, Tan F, Xu J, Liu Y, Yuan Y, Chen L, Wang Q, Qu J, Shen Y, Liu S, Fan G, Liu L, Liu X, Hou Y, Liu GH*, Gu Y*, Xu X*. Dynamic cell transition and immune response landscapes of axolotl limb regeneration revealed by single-cell analysis. Protein Cell. 2020. DOI: 10.1007/s13238- 020-00763-1 Wang S, Min Z, Ji Q, Geng L, Su Y, Liu Z, Hu H, Wang L, Zhang W, Suzuiki K, Huang Y，Zhang P, Tang T, Qu J*, Yu Y*, Liu GH*, Qiao J*. Rescue of Premature Aging Defects in Cockayne Syndrome Stem Cells by CRISPR/Cas9- mediated Gene Correction. Protein Cell. 2020. 11(1):1-22. Yan P, Li Q, Wang L, Lu P, Suzuki K, Liu Z, Lei J, Li W, Ren R, He X, Wang S, Ding J, Chan P, Zhang W, Song M, Belmonte JC, Qu J*, Tang F*, Liu GH*. FOXO3-engineered human ESC-derived vascular cells promote vascular protection and regeneration. Cell Stem Cell. 2019. 24(3), 447-461 (cover story) Deng L, Ren R, Liu Z, Song M, Li J, Wu Z, Ren X, Fu L, Li W, Zhang W, P, Belmonte J, Chan P, Qu J*, Liu GH*. Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis. Nature Communications. 2019.10(1):3329. Fu L, Hu Y, Song M, Liu Z, Zhang W, Yu FX, Wu J, Wang S, Belmonte JC, Chan P, Qu J*, Tang F*, Liu GH*. Upregulation of FOXD1 by YAP alleviates senescence and osteoarthritis. PLoS Biology. 2019. 17(4):e3000201 Ren X, Hu B, Song M, Ding Z, Dang Y, Liu Z, Zhang W, Ji Q, Ren R, Ding J, Chan P, Jiang C, Ye K, Qu J*, Tang F*, Liu GH*. Maintenance of nucleolar homeostasis by CBX4 alleviates senescence and osteoarthritis. Cell Reports. 2019. 26(13):3643-3656. Ling C, Liu Z, Song M, Zhang W, Wang S, Liu X, Ma S, Sun S, Fu L, Chu Q, Belmonte JC, Wang Z, Qu J*, Yuan Y*, Liu GH*. Modeling CADASIL vascular pathologies with patient-derived induced pluripotent stem cells. Protein Cell. 2019. 10(4):249-271 Cheng F, Wang S, Song M, Liu Z, Liu P, Wang L, Wang Y, Zhao Q, Yan K, Chan P, Zhang W*, Qu, J*, Liu GH*. DJ-1 is dispensable for human stem cell homeostasis. Protein Cell. 2019. 10(11):846-853 Geng L, Liu Z, Zhang W*, Li W, Wu Z, Wang W, Ren R, Su Y, Wang P, Ju Z, Chan P, Song M*, Qu J*, Liu GH*. Chemical Screen Identifies a Geroprotective Role of Quercetin in Premature Aging. Protein Cell. 2019. 10(6):417-435 Zhang W, Wan H, Feng G, Qu J, Wang J, Jing Y, Ren R, Liu Z, Zhang L, Chen Z, Wang S, Zhao Y, Wang Z, Yuan Y, Zhou Q, Li W*, Liu GH*, Hu B*. SIRT6 deficiency results in developmental retardation in cynomolgus monkeys. Nature. 2018. 560(7720):661-665. Wang S, Hu B, Ding Z, Dang Y, Wu J, Li D, Liu X, Xiao B, Zhang W, Ren R, Lei J, Hu H, Chen C, Chan P, Li D, Qu J*, Tang F*, Liu GH*. ATF6 safeguards organelle homeostasis and cellular aging in human mesenchymal stem cells. Cell Discovery. 2018. Jan 5;4:2. Differential stem cell aging kinetics in Hutchinson–Gilford progeria syndrome and Werner syndrome. Protein Cell. 2018. 9(4):333-350. (cover story) Fang J, Yang J, Wu X, Zhang G, Li T, Zhang H, Wang CC, Liu GH*, Wang L*. Metformin alleviates human cellular aging by upregulating the ER peroxidase GPx7. Aging Cell. 2018.17(4):e12765. Ren R, Deng L, Xue Y, Suzuki K, Zhang W, Yu Y, Wu J, Sun L, Gong X, Luan H, Yang F, Ju Z, Ren X, Wang S, Tang H, Geng L, Zhang W, Li J, Qiao J, Xu T*, Qu J*, Liu GH*. Visualization of aging-associated chromatin alterations with an engineered TALE system. Cell Research. 2017. 27(4):483-504. (cover story) Yang J, Li J, Suzuki K, Liu X, Wu J, Zhang W, Ren R, Zhang W, Chan P, Belmonte JC, Qu J*, Tang F*, Liu GH*. Genetic enhancement in cultured human adult stem cells conferred by a single nucleotide recoding. Cell Research. 2017. 27(9):1178-1181 Wang L, Yi F, Fu L, Yang J, Wang S, Wang Z, Suzuki K, Sun L, Xu X, Yu Y, Qiao J, Belmonte JC, Yang Z, Yuan Y*, Qu J*, Liu GH*. CRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral sclerosis patient iPSCs. Protein Cell. 2017. 8(5):365-378. (cover story) Kubben N, Zhang W, Wang L, Voss T, Yang J, Qu J, Liu GH*, Misteli T*, Repression of the antioxidant NRF2 pathway in premature aging. Cell. 2016. 165(6):1361-74 Pan H, Guan D, Liu X, Li J, Wang L, Wu J, Zhou J, Zhang W, Ren R, Zhang W, Li Y, Yang J, Hao Y, Yuan T, Yuan G, Wang H, Ju Z, Mao Z, Li J, Qu J*, Tang F*, Liu GH*. SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2. Cell Research. 2016. 26(2):190-205. Suzuki K, Tsunekawa Y, Hernandez-Benitez R, Wu J, Zhu J, Kim EJ, Hatanaka F, Yamamoto M, Araoka T, Li Z, Kurita M, Hishida T, Li M, Aizawa E, Guo S, Chen S, Goebl A, Soligalla RD, Qu J, Jiang T, Fu X, Jafari M, Esteban CR, Berggren WT, Lajara J, Nunez-Delicado E, Guillen P, Campistol JM, Matsuzaki F, Liu GH, Magistretti P, Zhang K, Callaway EM, Zhang K, Belmonte JC. In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration. Nature. 2016. 540(7631):144-149. Wang H, Diao D, Shi Z, Zhu X, Gao Y, Gao S, Liu X, Wu Y, Rudolph KL, Liu GH, Li T, Ju Z. SIRT6 Controls Hematopoietic Stem Cell Homeostasis through Epigenetic Regulation of Wnt Signaling. Cell Stem Cell. 2016. 7;18(4):495- 507. Fu L, XX, Ren R, Wu J, Zhang W, Yang J, Ren X, Wang S, Zhao Y, Sun L, Yu Y, Wang Z, Yang Z, Yuan Y, Qiao J, Belmonte JC*, Qu J*, Liu GH*. Modeling Xeroderma Pigmentosum associated neurological pathologies with patients- derived iPSCs. Protein Cell. 2016.7(3):210-21. Li Y, Zhang W, Chang L, Han Y, Sun L, Guo X, Tang H, Liu Z, Deng H, Ye Y, Ren R, Wang Y, Li J, Qiao J, Qu J*, Zhang W*, Liu GH*. Vitamin C alleviates aging defects in a stem cell model for Werner syndrome. Protein Cell. 2016. 7(7):478-88. (cover story) Zhang W, Li J, Suzuki K, Qu J, Wang P, Zhou J, Liu X, Ren R, Xu X, Ocampo A, Yuan T, Yang J, Li Y, Shi L, Guan D, Pan H, Duan S, Ding Z, Li M, Yi F, Bai R, Wang Y, Chen C, Yang F, Li X, Wang Z, Aizawa E, Goebl A, Soligalla RD, Reddy P, Esteban CR, Tang F*, Liu GH*, Belmonte JC*. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging. Science. 2015; 348(6239):1160-3. Reddy P, Ocampo A, Suzuki K, Luo J, Bacman SR, Williams SL, Sugawara A, Okamura D, Tsunekawa Y, Wu J, Lam D, Xiong X, Montserrat N, Esteban CR, Liu GH, Sancho-Martinez I, Manau D, Civico S, Cardellach F, Del Mar O'Callaghan M, Campistol J, Zhao H, Campistol JM, Moraes CT, Izpisua Belmonte JC. Selective Elimination of Mitochondrial Mutations in the Germline by Genome Editing. Cell. 2015; 161(3):459-469. Duan S, Yuan G, Liu X, Ren R, Li J, Zhang W, Wu J, Xu X, Fu L, Li Y, Yang J, Zhang W, Bai R, Yi F, Suzuki K, Gao H, Esteban CR, Zhang C, Belmonte JC, Chen Z, Wang X, Jiang T, Qu J*, Tang F*, Liu GH*. PTEN deficiency reprograms human neural stem cells towards a glioblastoma stem cell-like phenotype. Nat Commun.2015. 6:10068. Reviews： The Aging Epigenome and its Rejuvenation. Nature Review Molecular Cell Biology. 2020. 21(3):137-150. Engineering Tissues and Organs: The Road to the Clinic. Cell. 2020. 181(1): 22-23. DOI: 10.1016/j.cell.2020.03.026. (Voices) Single-Cell “OMICS” in Aging: A Young Growing Field. Nature Metabolism. 2020. 2: 293-302. A Beta-Galactosidase Kiss of Death for Senescent Cells. Cell Research. 2020. DOI:10.1038/s41422-020-0325-6. Treating Osteoarthritis via Gene Therapy with Rejuvenation Factors. Gene Therapy. 2020. DOI: 10.1038/s41434-020-0149-5. Age-Related Cardiopathies Gene Editing. Aging. 2019. 11(5):1327-1328. Epigenetic Modifications in Cardiovascular Aging and Diseases. Circulation Research. 2018. 123(7):773-786. Regulation of Stem Cell Aging by Metabolism and Epigenetic Factors. Cell Metabolism. 2017. 26(3):460-474.
Selected Publications:
Wang S, Zheng Y, Li J, Yu Y, Zhang W, Song M, Liu Z, Min Z, Hu H, Jing Y, He X, Sun L, Esteban C, Chan P, Qiao J, Zhou Q, Belmonte JC*, Jing Qu*, Tang F*, Liu GH*. Single-Cell Transcriptomic Atlas of Primate Ovarian Aging. Cell. 2020. 180(3):585-600 (Cover story)
Ma S, Sun S, Geng L, Song M, Wang W, Ye Y, Ji Q, Zou Z, Wang S, He X, Li W, Rodriguez Esteban C, Long X, Guo G, Chan P, Zhou Q, Belmonte JC*, Zhang W*, Qu J*, Liu GH*. Caloric Restriction Reprograms the Single-Cell
Transcriptional Landscape of Rattus Norvegicus Aging. Cell. 2020. 180(5):984-1001.
Liang C, Liu Z, Song M, Li W, Wu Z, Wang Z, Wang Q, Wang S, Yan K, Sun L,
Hishida T, Cai Y, Izpisua Belmonte JC, Guillen P, Chan P, Zhou Q, Zhang W*, Qu J*, Liu GH*. Stabilization of Heterochromatin by CLOCK Promotes Stem Cell Rejuvenation and Cartilage Regeneration. Cell Research. 2020. DOI:10.1038/
s41422-020-0385-7.
Ma S, Sun S, Li J, Fan Y, Qu J, Sun L, Wang S, Zhang Y, Yang S, Liu Z, Wu Z, Zhang S, Wang Q, Zheng A, Duo S, Yu Y, Belmonte JCI, Chan P, Zhou Q, Song M*, Zhang W*, Liu GH*. Single-Cell Transcriptomic Atlas of Primate
Cardiopulmonary Aging. Cell Research. 2020. doi: 10.1038/s41422-020-00412-6.Li J, Zheng Y, Yan P, Song M, Wang S, Sun L, Liu Z, Ma S, Chan P, Zhou Q,
Belmonte JC, Zhang W*, Liu GH*, Tang F*, Qu J*. A Single-cell Transcriptomic Atlas of Primate Pancreatic Islet Aging. National Science Review. 2020. DOI: 10.1093/nsr/nwaa127
Zhang W, Zhang S, Yan P, Ren J, Song M, Li J, Lei J, Pan H, Wang S, Ma X, Ma S, Li H, Sun F, Wan H, Li W, Chan P, Zhou Q, Liu GH*, Tang F*, Qu J*. A
Single-Cell Transcriptomic landscape of Primate Arterial Aging. Nature
Communications. 2020. 11(1):2202.
Yan P, Liu Z, Song M, Wu Z, Xu W, Li K, Ji Q, Wang S, Liu X, Yan K, Esteban CR, Ci W, Izpisua Belmonte JC, Xie W, Ren J, Zhang W*, Sun Q*, Qu J*, Liu GH*. Genome-wide R-loop landscapes during cell differentiation and
reprogramming. Cell Reports. 2020. 32(1):107870
Wang F, Zhang W, Yang Q, Kang Y, Fan Y, Wei J, Liu Z, Dai S, Li H, Li Z, Xu L, Chu C, Qu J, Si C, Ji W*, Liu GH*, Long C*, Niu Y*. Generation of a
Hutchinson-Gilford progeria syndrome monkey model by base editing. Protein
Cell. 2020. DOI: 10.1007/s13238-020-00740-8
Zheng Y, Liu X, Le W, Xie L, Li H, Wen W, Wang S, Ma S, Huang Z, Ye J, Shi W, Ye Y, Liu Z, Song M, Zhang W, Belmonte JCI, Xiao C, Qu J*, Wang H*, Liu GH*, Su W*. A human circulating immune cell landscape in aging and COVID-19.
Protein Cell. 2020. DOI: 10.1007/s13238-020-00762-2
Li H, Wei X, Zhou L, Zhang W, Wang C, Guo Y, Li D, Chen J, Liu T, Zhang Y,
Ma S, Wang C, Tan F, Xu J, Liu Y, Yuan Y, Chen L, Wang Q, Qu J, Shen Y, Liu S, Fan G, Liu L, Liu X, Hou Y, Liu GH*, Gu Y*, Xu X*. Dynamic cell
transition and immune response landscapes of axolotl limb regeneration
revealed by single-cell analysis. Protein Cell. 2020. DOI: 10.1007/s13238-
020-00763-1
Wang S, Min Z, Ji Q, Geng L, Su Y, Liu Z, Hu H, Wang L, Zhang W, Suzuiki K, Huang Y，Zhang P, Tang T, Qu J*, Yu Y*, Liu GH*, Qiao J*. Rescue of
Premature Aging Defects in Cockayne Syndrome Stem Cells by CRISPR/Cas9-
mediated Gene Correction. Protein Cell. 2020. 11(1):1-22.
Yan P, Li Q, Wang L, Lu P, Suzuki K, Liu Z, Lei J, Li W, Ren R, He X, Wang S, Ding J, Chan P, Zhang W, Song M, Belmonte JC, Qu J*, Tang F*, Liu GH*.
FOXO3-engineered human ESC-derived vascular cells promote vascular
protection and regeneration. Cell Stem Cell. 2019. 24(3), 447-461 (cover
story)
Deng L, Ren R, Liu Z, Song M, Li J, Wu Z, Ren X, Fu L, Li W, Zhang W, P,
Belmonte J, Chan P, Qu J*, Liu GH*. Stabilizing heterochromatin by DGCR8
alleviates senescence and osteoarthritis. Nature Communications. 2019.10(1):3329.
Fu L, Hu Y, Song M, Liu Z, Zhang W, Yu FX, Wu J, Wang S, Belmonte JC, Chan P, Qu J*, Tang F*, Liu GH*. Upregulation of FOXD1 by YAP alleviates
senescence and osteoarthritis. PLoS Biology. 2019. 17(4):e3000201
Ren X, Hu B, Song M, Ding Z, Dang Y, Liu Z, Zhang W, Ji Q, Ren R, Ding J,
Chan P, Jiang C, Ye K, Qu J*, Tang F*, Liu GH*. Maintenance of nucleolar
homeostasis by CBX4 alleviates senescence and osteoarthritis. Cell Reports. 2019. 26(13):3643-3656.
Ling C, Liu Z, Song M, Zhang W, Wang S, Liu X, Ma S, Sun S, Fu L, Chu Q,
Belmonte JC, Wang Z, Qu J*, Yuan Y*, Liu GH*. Modeling CADASIL vascular
pathologies with patient-derived induced pluripotent stem cells. Protein
Cell. 2019. 10(4):249-271
Cheng F, Wang S, Song M, Liu Z, Liu P, Wang L, Wang Y, Zhao Q, Yan K, Chan P, Zhang W*, Qu, J*, Liu GH*. DJ-1 is dispensable for human stem cell
homeostasis. Protein Cell. 2019. 10(11):846-853
Geng L, Liu Z, Zhang W*, Li W, Wu Z, Wang W, Ren R, Su Y, Wang P, Ju Z, Chan P, Song M*, Qu J*, Liu GH*. Chemical Screen Identifies a Geroprotective
Role of Quercetin in Premature Aging. Protein Cell. 2019. 10(6):417-435
Zhang W, Wan H, Feng G, Qu J, Wang J, Jing Y, Ren R, Liu Z, Zhang L, Chen Z, Wang S, Zhao Y, Wang Z, Yuan Y, Zhou Q, Li W*, Liu GH*, Hu B*. SIRT6
deficiency results in developmental retardation in cynomolgus monkeys.
Nature. 2018. 560(7720):661-665.
Wang S, Hu B, Ding Z, Dang Y, Wu J, Li D, Liu X, Xiao B, Zhang W, Ren R, Lei J, Hu H, Chen C, Chan P, Li D, Qu J*, Tang F*, Liu GH*. ATF6 safeguards
organelle homeostasis and cellular aging in human mesenchymal stem cells.
Cell Discovery. 2018. Jan 5;4:2.
Differential stem cell aging kinetics in Hutchinson–Gilford progeria
syndrome and Werner syndrome. Protein Cell. 2018. 9(4):333-350. (cover story)
Fang J, Yang J, Wu X, Zhang G, Li T, Zhang H, Wang CC, Liu GH*, Wang L*.
Metformin alleviates human cellular aging by upregulating the ER peroxidase GPx7. Aging Cell. 2018.17(4):e12765.
Ren R, Deng L, Xue Y, Suzuki K, Zhang W, Yu Y, Wu J, Sun L, Gong X, Luan H, Yang F, Ju Z, Ren X, Wang S, Tang H, Geng L, Zhang W, Li J, Qiao J, Xu T*,
Qu J*, Liu GH*. Visualization of aging-associated chromatin alterations with an engineered TALE system. Cell Research. 2017. 27(4):483-504. (cover story)
Yang J, Li J, Suzuki K, Liu X, Wu J, Zhang W, Ren R, Zhang W, Chan P,
Belmonte JC, Qu J*, Tang F*, Liu GH*. Genetic enhancement in cultured human adult stem cells conferred by a single nucleotide recoding. Cell Research.
2017. 27(9):1178-1181
Wang L, Yi F, Fu L, Yang J, Wang S, Wang Z, Suzuki K, Sun L, Xu X, Yu Y,
Qiao J, Belmonte JC, Yang Z, Yuan Y*, Qu J*, Liu GH*. CRISPR/Cas9-mediated
targeted gene correction in amyotrophic lateral sclerosis patient iPSCs.
Protein Cell. 2017. 8(5):365-378. (cover story)
Kubben N, Zhang W, Wang L, Voss T, Yang J, Qu J, Liu GH*, Misteli T*,
Repression of the antioxidant NRF2 pathway in premature aging. Cell. 2016.
165(6):1361-74
Pan H, Guan D, Liu X, Li J, Wang L, Wu J, Zhou J, Zhang W, Ren R, Zhang W,
Li Y, Yang J, Hao Y, Yuan T, Yuan G, Wang H, Ju Z, Mao Z, Li J, Qu J*, Tang F*, Liu GH*. SIRT6 safeguards human mesenchymal stem cells from oxidative
stress by coactivating NRF2. Cell Research. 2016. 26(2):190-205.
Suzuki K, Tsunekawa Y, Hernandez-Benitez R, Wu J, Zhu J, Kim EJ, Hatanaka F, Yamamoto M, Araoka T, Li Z, Kurita M, Hishida T, Li M, Aizawa E, Guo S,
Chen S, Goebl A, Soligalla RD, Qu J, Jiang T, Fu X, Jafari M, Esteban CR,
Berggren WT, Lajara J, Nunez-Delicado E, Guillen P, Campistol JM, Matsuzaki F, Liu GH, Magistretti P, Zhang K, Callaway EM, Zhang K, Belmonte JC. In
vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted
integration. Nature. 2016. 540(7631):144-149.
Wang H, Diao D, Shi Z, Zhu X, Gao Y, Gao S, Liu X, Wu Y, Rudolph KL, Liu GH, Li T, Ju Z. SIRT6 Controls Hematopoietic Stem Cell Homeostasis through
Epigenetic Regulation of Wnt Signaling. Cell Stem Cell. 2016. 7;18(4):495-
507.
Fu L, XX, Ren R, Wu J, Zhang W, Yang J, Ren X, Wang S, Zhao Y, Sun L, Yu Y, Wang Z, Yang Z, Yuan Y, Qiao J, Belmonte JC*, Qu J*, Liu GH*. Modeling
Xeroderma Pigmentosum associated neurological pathologies with patients-
derived iPSCs. Protein Cell. 2016.7(3):210-21.
Li Y, Zhang W, Chang L, Han Y, Sun L, Guo X, Tang H, Liu Z, Deng H, Ye Y,
Ren R, Wang Y, Li J, Qiao J, Qu J*, Zhang W*, Liu GH*. Vitamin C alleviates aging defects in a stem cell model for Werner syndrome. Protein Cell. 2016. 7(7):478-88. (cover story)
Zhang W, Li J, Suzuki K, Qu J, Wang P, Zhou J, Liu X, Ren R, Xu X, Ocampo A, Yuan T, Yang J, Li Y, Shi L, Guan D, Pan H, Duan S, Ding Z, Li M, Yi F, Bai R, Wang Y, Chen C, Yang F, Li X, Wang Z, Aizawa E, Goebl A, Soligalla RD,
Reddy P, Esteban CR, Tang F*, Liu GH*, Belmonte JC*. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging.
Science. 2015; 348(6239):1160-3.
Reddy P, Ocampo A, Suzuki K, Luo J, Bacman SR, Williams SL, Sugawara A,
Okamura D, Tsunekawa Y, Wu J, Lam D, Xiong X, Montserrat N, Esteban CR, Liu GH, Sancho-Martinez I, Manau D, Civico S, Cardellach F, Del Mar O'Callaghan M, Campistol J, Zhao H, Campistol JM, Moraes CT, Izpisua Belmonte JC.
Selective Elimination of Mitochondrial Mutations in the Germline by Genome
Editing. Cell. 2015; 161(3):459-469.
Duan S, Yuan G, Liu X, Ren R, Li J, Zhang W, Wu J, Xu X, Fu L, Li Y, Yang J, Zhang W, Bai R, Yi F, Suzuki K, Gao H, Esteban CR, Zhang C, Belmonte JC,
Chen Z, Wang X, Jiang T, Qu J*, Tang F*, Liu GH*. PTEN deficiency reprograms human neural stem cells towards a glioblastoma stem cell-like phenotype.
Nat Commun.2015. 6:10068.
Reviews：
The Aging Epigenome and its Rejuvenation. Nature Review Molecular Cell
Biology. 2020. 21(3):137-150.
Engineering Tissues and Organs: The Road to the Clinic. Cell. 2020. 181(1):
22-23. DOI: 10.1016/j.cell.2020.03.026. (Voices)
Single-Cell “OMICS” in Aging: A Young Growing Field. Nature Metabolism.
2020. 2: 293-302.
A Beta-Galactosidase Kiss of Death for Senescent Cells. Cell Research. 2020. DOI:10.1038/s41422-020-0325-6.
Treating Osteoarthritis via Gene Therapy with Rejuvenation Factors. Gene
Therapy. 2020. DOI: 10.1038/s41434-020-0149-5.
Age-Related Cardiopathies Gene Editing. Aging. 2019. 11(5):1327-1328.
Epigenetic Modifications in Cardiovascular Aging and Diseases. Circulation
Research. 2018. 123(7):773-786.
Regulation of Stem Cell Aging by Metabolism and Epigenetic Factors. Cell
Metabolism. 2017. 26(3):460-474.
杂志这个cell， 那个cell。 Cell 算个球？
你是黑光慧专业户……
刘光慧可以说是中国造假最厉害的人,比曹雪涛还厉害.
这个我不认同，我认为曹将军还是带头大哥，刘光慧已经可以给曹将军提鞋了。
老曹的地位不容撼动,世界级的,历史级的
【 在 forjoy (三分华盖) 的大作中提到: 】
: 这个我不认同，我认为曹将军还是带头大哥，刘光慧已经可以给曹将军提鞋了。
他干啥了？
有空我去看看。。
【在 crispr2016()的大作中提到：】
：刘光慧可以说是中国造假最厉害的人,比曹雪涛还厉害.