Chimeric antigen receptor (CAR) T-cell therapy is becoming more common in the treatment of both hematological and solid tumors. Prior to infusion, lymphodepletion is frequently performed, however, no standardized protocol exists for this procedure. During the eighth annual meeting of the Society of Hematologic Oncology (SOHO), Elizabeth Budde presented how this process can be optimized to aid persistence and efficacy of infused CAR T cells.1
Why use lymphodepletion? Lymphodepletion leads to lymphopenia, affecting T, B, and NK cells, and it has multiple positive effects prior to CAR T-cell therapy:
Debulking of the tumor Alteration of tumor phenotype Decreased production of certain metabolites Change in expression of costimulatory molecules
https://multiplemyelomahub.com/medical-information/lymphodepletion-
optimization-for-car-t-cell-therapy
Chimeric antigen receptor (CAR) T-cell therapy is becoming more common in
the treatment of both hematological and solid tumors. Prior to infusion,
lymphodepletion is frequently performed, however, no standardized protocol
exists for this procedure. During the eighth annual meeting of the Society
of Hematologic Oncology (SOHO), Elizabeth Budde presented how this process
can be optimized to aid persistence and efficacy of infused CAR T cells.1
Why use lymphodepletion?
Lymphodepletion leads to lymphopenia, affecting T, B, and NK cells, and it
has multiple positive effects prior to CAR T-cell therapy:
Debulking of the tumor
Alteration of tumor phenotype
Decreased production of certain metabolites
Change in expression of costimulatory molecules
该篇重要论文共享了32例患者的临床试验结果。在开展探索CAR-T细胞剂量的临床试验
之前，这些患者接受了化疗，该程序被称为“ lymphodepletion（淋巴细胞清除）”，目的是在患者体内构建一个更有利于CAR-T细胞生长的免疫环境。该研究的主要结果证
明了如何选择lymphodepletion方案以及不同剂量CAR-T细胞作用的重要性。
https://med.sina.com/article_detail_103_2_57690.html#:~:text=CAR%2DT%EF%BC%
88Chimeric%20antigen%20receptor,%E9%87%8A%E6%94%BE%E7%BB%86%E8%83%9E%E5%9B%
A0%E5%AD%90%E5%8B%9F%E9%9B%86%E4%BA%BA
Target selection for CAR-T therapy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587237/