The analysis revealed consistent nonlinear patterns in molecular markers of aging, with substantial dysregulation occurring at two major periods occurring at approximately 44 years and 60 years of chronological age. https://www.nature.com/articles/s43587-024-00692-2
首先，女性更年期是45到55岁，不是44岁。 其次，根据作者说的，女性更年期不能解释所有现象，而是男女在这个年龄都有巨变。 Although confounders, including sex, were corrected before analysis (Methods), we acknowledge that the age range for menopause in females is typically between 45 years and 55 years of age20, which is very close to the major transition points in all three clusters (Fig. 2c). Therefore, we conducted further investigation into whether the menopausal status of females in the dataset contributed to the observed transition point at approximately 55 years of age (Fig. 2c) by performing separate clustering analyses on the male and female datasets. Surprisingly, both the male and female datasets exhibited similar clusters, as illustrated in Extended Data Fig. 4a. This suggests that the transition point observed at approximately 55 years of age is not solely attributed to female menopause but, rather, represents a common phenomenon in the aging process of both sexes.
首先，女性更年期是45到55岁，不是44岁。 其次，根据作者说的，女性更年期不能解释所有现象，而是男女在这个年龄都有巨变。 Although confounders, including sex, were corrected before analysis (Methods), we acknowledge that the age range for menopause in females is typically between 45 years and 55 years of age20, which is very close to the major transition points in all three clusters (Fig. 2c). Therefore, we conducted further investigation into whether the menopausal status of females in the dataset contributed to the observed transition point at approximately 55 years of age (Fig. 2c) by performing separate clustering analyses on the male and female datasets. Surprisingly, both the male and female datasets exhibited similar clusters, as illustrated in Extended Data Fig. 4a. This suggests that the transition point observed at approximately 55 years of age is not solely attributed to female menopause but, rather, represents a common phenomenon in the aging process of both sexes. gigivivi 发表于 2024-08-15 11:50
https://www.nature.com/articles/s43587-024-00692-2
配图
参加研究的对象总共有108个 （108好汉
不符合，研究对象年龄上限是75岁，这个研究不支持73岁巨变的说法。当然也有可能是因为这个年龄组参与研究的人不够多，所以结果不显著。但是这篇论文不支持这个说法。
首先，女性更年期是45到55岁，不是44岁。 其次，根据作者说的，女性更年期不能解释所有现象，而是男女在这个年龄都有巨变。
Although confounders, including sex, were corrected before analysis (Methods), we acknowledge that the age range for menopause in females is typically between 45 years and 55 years of age20, which is very close to the major transition points in all three clusters (Fig. 2c). Therefore, we conducted further investigation into whether the menopausal status of females in the dataset contributed to the observed transition point at approximately 55 years of age (Fig. 2c) by performing separate clustering analyses on the male and female datasets. Surprisingly, both the male and female datasets exhibited similar clusters, as illustrated in Extended Data Fig. 4a. This suggests that the transition point observed at approximately 55 years of age is not solely attributed to female menopause but, rather, represents a common phenomenon in the aging process of both sexes.
这篇文章没有足够多的参与人数来研究人种的影响。具体参与研究人种的分布请看我5楼贴的图。
不是说70岁断崖式衰老吗？
我是不信的，代入感最重要
忘记年龄吧？
不躺，做做体操，几个后空翻，体能断崖式上升
还有吃的，中午如果吃水饺馄饨的话，下午大概率跑不动，就是跑步的意愿消失，估计同血糖有关系
差不多！
75岁了，还波动啥啊，
医疗条件比较好的国家平均寿命在85岁左右，75之后还可以活10年呢。 别人不知道，我要努力活到至少90岁
mid-40断崖，完全有可能的
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https://www.youtube.com/embed/nx4aogA8ago
这次参加奥运马拉松的杭州95后银行客户经理，就是为了抗衰老，每天早上5点多起床，6点出去跑步一个小时
整个人看上去非常酷
我自己的体会，多年跑步跑出了翘臀，其实没有什么翘臀，只是腰和屁股长一起了
腰和屁股长一起了，就非常经得起摔，起夜也不在话下
所以我经常说，我现在替人做月子保姆，没有一丝一毫的问题，保证称职
普通人没有翘臀，是绝对经不起夜里折腾的
至于为什么不用说了吧。
是生理还是家庭？
擦，精准推送啊
就是所有分子层面能反应出的变化，可以是DNA，RNA，蛋白质，化学分子等等。
肯定的，貌似白人44没错，中国姐姐们好多60看着也还不错的
作为动物，刚吃饱饱谁愿意跑啊
47岁以后吧，看着渐渐老去，40还能看着貌美如花呢。
更前？睡眠开始有问题了。。。。开始别的问题了。。。
另，之前骶髂关节那里总疼，或称之为腰痛。最近经常拉伸那里，舒服多了。
生理，家庭，心理。。。
更年期之后。
“女子七岁，肾气盛，齿更发长；二七而天癸至，任脉通，太冲脉盛，月事以时下，故有子；三七，肾气平均，故真牙生而长极；四七，筋骨坚，发长极，身体盛壮；五七，阳明脉衰，面始焦，发始堕；六七，三阳脉衰于上，面皆焦，发始白；七七，任脉衰，太冲脉衰少，天癸竭，地道不通，故形坏而无子也。
“丈夫八岁，肾气实，发长齿更；二八，肾气盛，天癸至，精气溢写（同泻），阴阳和，故能有子；三八，肾气平均，筋骨劲强，故真牙生而长极；四八，筋骨隆盛，肌肉满壮；五八，肾气衰，发堕齿槁；六八，阳气衰竭于上，面焦，发鬓颁白；七八，肝气衰，筋不能动，天癸竭，精少，肾藏衰，形体皆极；八八，则齿发去......天癸尽矣。故发鬓白，身体重，行步不正，而无子耳。”
推荐这个视频
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https://www.youtube.com/embed/Cgo2mD4Pc54
这个73 84 是因为孔子73 孟子84 去世，圣人都如此 所以对普通人就更是坎儿。不是从科学上讲的
我41岁开始老花
我一离开杭州，杭州就没人管了
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https://www.youtube.com/embed/JIUjl44Wr7k?si=FvNrBlaa0sA5YITj
感觉这个研究挺靠谱，感觉也是这样40多以后皮肤暗沉松弛…体能下降，加强运动精力提升一些
谢谢分享。brain在更年期前期就开始变化了，也就是40中开始了。看完这个video就得变老是一个必然的过程，各个器官之间都相互影响。也没有太多的办法和药物能改变，好好享受每一天吧。
哈哈哈，我知道会有搞笑回复出现的
而且还有空巢的缘故。娃是非常耗人的，家里少了娃会轻松很多。
这么点研究对象，也好意思写这么大的题目