12周自然流产了，心里很难过，把胚胎送去做染色体筛查，结果发现罗氏易位 15，22，15三体。请问大家这种情况需要夫妻双方去做carrier screening吗？以后能不能自然怀孕必须做试管吗？ RESULT: ABNORMAL MALE KARYOTYPE WITH TRISOMY 15 SECONDARY TO AN UNBALANCED ROBERTSONIAN TRANSLOCATION INTERPRETATION: Metaphase cells show an abnormal male karyotype with an unbalanced Robertsonian translocation, der(15;22)(q10;q10),+15, resulting in trisomy for chromosome 15. This individual or her partner may be a balanced carrier of a der(15;22)(q10;q10) translocation that predisposed to the imbalance detected here. Carriers of Robertsonian translocations generally do not exhibit phenotypic or developmental abnormalities; however, the rearrangement may lead to decreased fertility, repeated pregnancy loss, chromosomally abnormal offspring, or (rarely) UPD. RECOMMENDATIONS: Genetic counseling is recommended. It is recommended that karyotype analyses be performed on this individu al and her partner. If either carries a related balanced rearrangement, other relatives may also be at risk. Regardless of carrier status, genetic counseling with respect to prenatal diagnosis in subsequent pregnancies is generally considered warranted for a couple who have had a pregnancy loss secondary to a structurally unbalanced chromosome rearrangement. NOMENCLATURE: 46,XY,+15,der(15;22)(q10;q10) ASSAY INFORMATION: Method: G-Band (Digital Analysis: MetaSystems/Ikaros) Cells Counted: 20 Band Level: 450 Cells Analyzed: 5 Cells Karyotyped: 5 This test does not address genetic disorders that cannot be detected by standard cytogenetic methods or rare events such as low level mosaicism or subtle rearrangements. A portion of the testing was performed at AMD11.
RESULT: ABNORMAL MALE KARYOTYPE WITH TRISOMY 15 SECONDARY TO AN UNBALANCED ROBERTSONIAN TRANSLOCATION INTERPRETATION: Metaphase cells show an abnormal male karyotype with an unbalanced Robertsonian translocation, der(15;22)(q10;q10),+15, resulting in trisomy for chromosome 15. This individual or her partner may be a balanced carrier of a der(15;22)(q10;q10) translocation that predisposed to the imbalance detected here. Carriers of Robertsonian translocations generally do not exhibit phenotypic or developmental abnormalities; however, the rearrangement may lead to decreased fertility, repeated pregnancy loss, chromosomally abnormal offspring, or (rarely) UPD. RECOMMENDATIONS: Genetic counseling is recommended. It is recommended that karyotype analyses be performed on this individu al and her partner. If either carries a related balanced rearrangement, other relatives may also be at risk. Regardless of carrier status, genetic counseling with respect to prenatal diagnosis in subsequent pregnancies is generally considered warranted for a couple who have had a pregnancy loss secondary to a structurally unbalanced chromosome rearrangement. NOMENCLATURE: 46,XY,+15,der(15;22)(q10;q10) ASSAY INFORMATION: Method: G-Band (Digital Analysis: MetaSystems/Ikaros) Cells Counted: 20 Band Level: 450 Cells Analyzed: 5 Cells Karyotyped: 5 This test does not address genetic disorders that cannot be detected by standard cytogenetic methods or rare events such as low level mosaicism or subtle rearrangements. A portion of the testing was performed at AMD11.
Unfortunately, 我们的保险不包，于是我们每人自掏了$350的样子，还算可以接受的。这事，一辈子也就做一次了。
多谢，怎么知道是老公的问题呀
"Metaphase cells show an abnormal male karyotype with an unbalanced Robertsonian translocation"
这个报告上写了是男方
我感觉这个写的是胚胎的异常 胚胎是男性，不然的话没必要后面写的 This individual or her partner may be a balanced carrier
你这个推断也有道理。报告感觉不太清楚。为啥医生不给好好解释一下呀
看起来不能确定
没有携带任何致病基因 减数分裂也会出现这种问题的 而且年龄越大 三体风险越高
真的会基因突变吗