All types of hormonal birth control may increase breast cancer risk, study finds Share on Pinterest Progestin-only birth control pills are a common form of hormonal contraceptive, yet knowledge on their association with breast cancer risk was limited. In a new study, researchers investigated the link between hormonal contraceptive use and breast cancer risk.They found that progestin-only contraceptive use increases breast cancer risk similarly to combined contraceptive use.They say that physicians should weigh the benefits and risks to patients of hormonal contraceptive use. Experts say the findings are broadly in line with known risks, which overall are small. Between 2017 and 2019, around 65% of womenTrusted Source aged 15- 49 used some sort of contraception, and 14% of them used the pill. Contraceptive pills come in two forms: the progestin-only pill and the combined pill containing both progestin and estrogen-based ingredients. Progestin, or progestogen, is a synthetic version of progesterone, a naturally occurring hormone. A meta-analysis from 1996 found that people taking combined contraceptives have a slightly increased risk for breast cancer within 10 years of usage. In recent years, progestin-only methods of contraception — including pills, injectables, implants, and intrauterine devices (IUDs) — have become more popular. In England, drug prescriptions increased from 1.9 million in 2010 to 3.3 million in 2020. Until now, however, there has been limited research on the impact of progestin-only contraceptives on breast cancer risk. Recently, researchers investigated the link between hormonal contraceptive use and break cancer risk. Like combined pills, they found that progestin-only contraceptives slightly increase breast cancer risk. The study was published in PLOS Medicine. Breast cancer and hormonal contraceptives For the study, the researchers analyzed health records from a UK primary care database. They included data from 9,498 women aged under 50 years old with breast cancer and 18,171 women without. Altogether, 44% of women with breast cancer and 39% of those without had a prescription for hormonal contraceptives. About half of these were for progestin-only preparations. Ultimately, the researchers found that combined contraceptive pill use increased breast cancer risk by 23%. They also found that oral progestin-only contraceptive pills increased breast cancer risk by 29%. Was this helpful? Other progestin-only formulations, including injectables, implants, and intrauterine devices (IUDs), increased breast cancer risk by 18%, 28%, and 21%, respectively. The researchers added that five years of oral contraceptive use was linked to breast cancer incidence in 8 per 100,000 users aged 16 to 20 years old and an incidence of 265 per 100,000 users aged 35- 39 years old. Increased cancer risk is relatively small Dr. Irene M. Kang, medical director of women’s health medical oncology at City of Hope Orange County, not involved in the study, told Medical News Today: “All medications have risks and benefits, which is why discussing concerns with your provider is essential. Negative effects of oral contraceptives include strokes, heart attacks and blood clots. Research has shown that oral contraceptives can impact an individual’s risk of certain types of cancer – in some cases upwards, and in some cases, such as ovarian and endometrial cancers, downwards – through changing the levels of estrogen and progesterone. Additional benefits are family planning and more regulated menstrual cycles.” Dr. Lilian Harris, a medical oncologist at Novant Health Cancer Institute, not involved in the study, agreed that hormonal contraceptives have risks and benefits: “For example, they can protect against pelvic inflammatory disease and help with menstrual pain, […] fibroids, endometriosis and acne. They have also been shown to decrease the risk of […] uterine cancers. Conversely, there are also potential risks with any medication. For oral contraceptives, these risks can range from nausea, headaches, and breast tenderness to […] increased risk for breast cancer.” The researchers concluded that current or recent progestin-only contraceptives are linked to a slight increase in breast cancer risk. They say that such risks must be balanced against the benefits of contraceptives in childbearing years. Was this helpful? Study limitations When asked about the study’s limitations, Dr. Kang noted that due to the study design, it only explains short-term risk associations as opposed to long-term risk. Dr. Kristina Shaffer, breast surgical oncologist at Novant Health Cancer Institute, not involved in the study, also told MNT: “In addition, the study included premenopausal women, an age group where breast cancer incidence is lower, meaning that other factors may have been driving the slightly higher risk demonstrated in the study. For example, while the study did account for some of the factors known to be related to breast cancer risk, it did not account for family history, genetic predisposition, or history of atypical breast cells which are well-established to impact breast cancer risk.” Implications for contraceptives use MNT also spoke with Dr. Parvin Peddi, board certified medical oncologist and director of Breast Medical Oncology for the Margie Petersen Breast Center at Providence Saint John’s Health Center and Associate Professor of Medical Oncology at Saint John’s Cancer Institute in Santa Monica, CA, not involved in the study.
“[The] main take home message is that this study finds that women do not need to choose a progesterone only containing birth control medication because of perceived lower risk of birth cancer.”
– Dr. Peddie
“On the other hand, it’s important to note that the absolute increased risk of breast cancer from any of these medications is quite low and this study should not dissuade women from using hormone-containing birth controls,” Dr. Peddie explained. “Risk of breast cancer was seen in less than 0.5% of women age 35-39 years old due to use of these medications and in even fewer women who used these medications at a younger age.” Dr. Schaffer agreed that while the increase in risk may sound high at 20-30%, it is relatively small. “For instance, if the risk of a 30-year-old female developing breast cancer is 5%, then a relative increase of 20% would bring her risk to 6%. And this is why the study concludes that there is a slight increase in breast cancer risk,” she explained. Dr. Kang also noted: “As with all cancers, your breast cancer risk increases with age, and in this case, also with the length of time that hormonal contraceptives are used. If you are at a higher risk for breast cancer, switching to a hormone-free birth control may be a more beneficial option for you. If you are diagnosed with breast cancer, seek care from an expert who specializes in your type of cancer.” “Finding breast cancer early is one of the most important factors in successful treatment of this disease — and that’s why self-exams and screenings are so vital,” Dr. Kang concluded.
“Research has shown that oral contraceptives can impact an individual’s risk of certain types of cancer – in some cases upwards, and in some cases, such as ovarian and endometrial cancers, downwards ”
All types of hormonal birth control may increase breast cancer risk, study finds Share on Pinterest Progestin-only birth control pills are a common form of hormonal contraceptive, yet knowledge on their association with breast cancer risk was limited. In a new study, researchers investigated the link between hormonal contraceptive use and breast cancer risk.They found that progestin-only contraceptive use increases breast cancer risk similarly to combined contraceptive use.They say that physicians should weigh the benefits and risks to patients of hormonal contraceptive use. Experts say the findings are broadly in line with known risks, which overall are small. Between 2017 and 2019, around 65% of womenTrusted Source aged 15- 49 used some sort of contraception, and 14% of them used the pill. Contraceptive pills come in two forms: the progestin-only pill and the combined pill containing both progestin and estrogen-based ingredients. Progestin, or progestogen, is a synthetic version of progesterone, a naturally occurring hormone. A meta-analysis from 1996 found that people taking combined contraceptives have a slightly increased risk for breast cancer within 10 years of usage. In recent years, progestin-only methods of contraception — including pills, injectables, implants, and intrauterine devices (IUDs) — have become more popular. In England, drug prescriptions increased from 1.9 million in 2010 to 3.3 million in 2020. Until now, however, there has been limited research on the impact of progestin-only contraceptives on breast cancer risk. Recently, researchers investigated the link between hormonal contraceptive use and break cancer risk. Like combined pills, they found that progestin-only contraceptives slightly increase breast cancer risk. The study was published in PLOS Medicine. Breast cancer and hormonal contraceptives For the study, the researchers analyzed health records from a UK primary care database. They included data from 9,498 women aged under 50 years old with breast cancer and 18,171 women without. Altogether, 44% of women with breast cancer and 39% of those without had a prescription for hormonal contraceptives. About half of these were for progestin-only preparations. Ultimately, the researchers found that combined contraceptive pill use increased breast cancer risk by 23%. They also found that oral progestin-only contraceptive pills increased breast cancer risk by 29%. Was this helpful? Other progestin-only formulations, including injectables, implants, and intrauterine devices (IUDs), increased breast cancer risk by 18%, 28%, and 21%, respectively. The researchers added that five years of oral contraceptive use was linked to breast cancer incidence in 8 per 100,000 users aged 16 to 20 years old and an incidence of 265 per 100,000 users aged 35- 39 years old. Increased cancer risk is relatively small Dr. Irene M. Kang, medical director of women’s health medical oncology at City of Hope Orange County, not involved in the study, told Medical News Today: “All medications have risks and benefits, which is why discussing concerns with your provider is essential. Negative effects of oral contraceptives include strokes, heart attacks and blood clots. Research has shown that oral contraceptives can impact an individual’s risk of certain types of cancer – in some cases upwards, and in some cases, such as ovarian and endometrial cancers, downwards – through changing the levels of estrogen and progesterone. Additional benefits are family planning and more regulated menstrual cycles.” Dr. Lilian Harris, a medical oncologist at Novant Health Cancer Institute, not involved in the study, agreed that hormonal contraceptives have risks and benefits: “For example, they can protect against pelvic inflammatory disease and help with menstrual pain, […] fibroids, endometriosis and acne. They have also been shown to decrease the risk of […] uterine cancers. Conversely, there are also potential risks with any medication. For oral contraceptives, these risks can range from nausea, headaches, and breast tenderness to […] increased risk for breast cancer.” The researchers concluded that current or recent progestin-only contraceptives are linked to a slight increase in breast cancer risk. They say that such risks must be balanced against the benefits of contraceptives in childbearing years. Was this helpful? Study limitations When asked about the study’s limitations, Dr. Kang noted that due to the study design, it only explains short-term risk associations as opposed to long-term risk. Dr. Kristina Shaffer, breast surgical oncologist at Novant Health Cancer Institute, not involved in the study, also told MNT: “In addition, the study included premenopausal women, an age group where breast cancer incidence is lower, meaning that other factors may have been driving the slightly higher risk demonstrated in the study. For example, while the study did account for some of the factors known to be related to breast cancer risk, it did not account for family history, genetic predisposition, or history of atypical breast cells which are well-established to impact breast cancer risk.” Implications for contraceptives use MNT also spoke with Dr. Parvin Peddi, board certified medical oncologist and director of Breast Medical Oncology for the Margie Petersen Breast Center at Providence Saint John’s Health Center and Associate Professor of Medical Oncology at Saint John’s Cancer Institute in Santa Monica, CA, not involved in the study.
“[The] main take home message is that this study finds that women do not need to choose a progesterone only containing birth control medication because of perceived lower risk of birth cancer.”
– Dr. Peddie
“On the other hand, it’s important to note that the absolute increased risk of breast cancer from any of these medications is quite low and this study should not dissuade women from using hormone-containing birth controls,” Dr. Peddie explained. “Risk of breast cancer was seen in less than 0.5% of women age 35-39 years old due to use of these medications and in even fewer women who used these medications at a younger age.” Dr. Schaffer agreed that while the increase in risk may sound high at 20-30%, it is relatively small. “For instance, if the risk of a 30-year-old female developing breast cancer is 5%, then a relative increase of 20% would bring her risk to 6%. And this is why the study concludes that there is a slight increase in breast cancer risk,” she explained. Dr. Kang also noted: “As with all cancers, your breast cancer risk increases with age, and in this case, also with the length of time that hormonal contraceptives are used. If you are at a higher risk for breast cancer, switching to a hormone-free birth control may be a more beneficial option for you. If you are diagnosed with breast cancer, seek care from an expert who specializes in your type of cancer.” “Finding breast cancer early is one of the most important factors in successful treatment of this disease — and that’s why self-exams and screenings are so vital,” Dr. Kang concluded. wielkacytryna 发表于 2023-11-26 05:26
Cervical cancer: Women who have used oral contraceptives for 5 or more years have a higher risk of cervical cancer than women who have never used oral contraceptives. The longer a woman uses oral contraceptives, the greater the increase in her risk of cervical cancer. One study found a 10% increased risk for less than 5 years of use, a 60% increased risk with 5–9 years of use, and a doubling of the risk with 10 or more years of use (9). https://www.cancer.gov/about-cancer/causes-prevention/risk/hormones/oral-contraceptives-fact-sheet#:~:text=The%20longer%20a%20woman%20uses,years%20of%20use%20(9). In the CPRD data, there was a significant increase in risk of breast cancer associated with hormonal contraceptive use, regardless of whether the contraceptive last prescribed was a combined (oestrogen and progestogen) oral preparation (23%), a progestogen-only oral preparation (26%), an injected progestogen (25%), or a progestogen-releasing intra-uterine device (32%); https://www.ceu.ox.ac.uk/news/any-type-of-hormonal-contraceptive-may-increase-risk-of-breast-cancer
根据我妈妈主治医生分析,我妈妈乳瘤的成因:
1)只生了一个娃,乳汁未能充分释放,所以导致乳腺导管瘤。
2)长期口服避孕药。
所以古时候乳瘤发病率应该低很多。
是的,说是可以降低卵巢癌和另外一个癌症 但是女性现在最高的两个癌症是乳腺癌和宫颈癌啊? 所以我们应该预防的不是这两个癌症吗?
而这两个癌症恰恰又是避孕药可以增加机率的,这么巧的吗? 对science不是很懂 但我觉得社会有一点抑制避孕药危害的信息了吧?
女人不避孕就得男人避孕,男人当然想解放自己。
哪里有文献得出这个结论?我的医生说避孕药不会增加癌症风险,该信谁?
你说的男人避孕的方法是带套? 所以大部分女生吃避孕药都是因为男的不愿意带套? 但我以为带套不保险,就是会不会流出来之类的
好像是最近的reaearch,我吃完夜宵一会儿贴上来 之前看breast cancer risk factor我以为是饮食、作息、基因、抽烟喝酒,所以也不知道是我对science理解不好,还是说社会不想让女性知道hormone based 避孕药的危害
大脑部位的垂体,下丘脑,松果体, 脖子部位的甲状腺,甲状旁腺,胸腺, 胸腹部位的消化腺,性腺
越往上越等级越高,即便最低级的激素也有拮抗作用,而且都是非常少的量就足以牵一发而动全身的,为什么非要从分子级化学生物的角度死磕呢?而且一时半会儿都看不到尽头,就这样的半拉子研究结果,都用在了当下的小白鼠身上。就像一百年前肾上腺激素包治百病一样,这个路子,再来一百年,还是原地打转。
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Progestin-only birth control pills are a common form of hormonal contraceptive, yet knowledge on their association with breast cancer risk was limited. In a new study, researchers investigated the link between hormonal contraceptive use and breast cancer risk. They found that progestin-only contraceptive use increases breast cancer risk similarly to combined contraceptive use. They say that physicians should weigh the benefits and risks to patients of hormonal contraceptive use. Experts say the findings are broadly in line with known risks, which overall are small. Between 2017 and 2019, around 65% of womenTrusted Source aged 15- 49 used some sort of contraception, and 14% of them used the pill. Contraceptive pills come in two forms: the progestin-only pill and the combined pill containing both progestin and estrogen-based ingredients. Progestin, or progestogen, is a synthetic version of progesterone, a naturally occurring hormone. A meta-analysis from 1996 found that people taking combined contraceptives have a slightly increased risk for breast cancer within 10 years of usage. In recent years, progestin-only methods of contraception — including pills, injectables, implants, and intrauterine devices (IUDs) — have become more popular. In England, drug prescriptions increased from 1.9 million in 2010 to 3.3 million in 2020. Until now, however, there has been limited research on the impact of progestin-only contraceptives on breast cancer risk. Recently, researchers investigated the link between hormonal contraceptive use and break cancer risk. Like combined pills, they found that progestin-only contraceptives slightly increase breast cancer risk. The study was published in PLOS Medicine.
Breast cancer and hormonal contraceptives For the study, the researchers analyzed health records from a UK primary care database. They included data from 9,498 women aged under 50 years old with breast cancer and 18,171 women without. Altogether, 44% of women with breast cancer and 39% of those without had a prescription for hormonal contraceptives. About half of these were for progestin-only preparations. Ultimately, the researchers found that combined contraceptive pill use increased breast cancer risk by 23%. They also found that oral progestin-only contraceptive pills increased breast cancer risk by 29%. Was this helpful? Other progestin-only formulations, including injectables, implants, and intrauterine devices (IUDs), increased breast cancer risk by 18%, 28%, and 21%, respectively. The researchers added that five years of oral contraceptive use was linked to breast cancer incidence in 8 per 100,000 users aged 16 to 20 years old and an incidence of 265 per 100,000 users aged 35- 39 years old.
Increased cancer risk is relatively small Dr. Irene M. Kang, medical director of women’s health medical oncology at City of Hope Orange County, not involved in the study, told Medical News Today: “All medications have risks and benefits, which is why discussing concerns with your provider is essential. Negative effects of oral contraceptives include strokes, heart attacks and blood clots. Research has shown that oral contraceptives can impact an individual’s risk of certain types of cancer – in some cases upwards, and in some cases, such as ovarian and endometrial cancers, downwards – through changing the levels of estrogen and progesterone. Additional benefits are family planning and more regulated menstrual cycles.” Dr. Lilian Harris, a medical oncologist at Novant Health Cancer Institute, not involved in the study, agreed that hormonal contraceptives have risks and benefits: “For example, they can protect against pelvic inflammatory disease and help with menstrual pain, […] fibroids, endometriosis and acne. They have also been shown to decrease the risk of […] uterine cancers. Conversely, there are also potential risks with any medication. For oral contraceptives, these risks can range from nausea, headaches, and breast tenderness to […] increased risk for breast cancer.” The researchers concluded that current or recent progestin-only contraceptives are linked to a slight increase in breast cancer risk. They say that such risks must be balanced against the benefits of contraceptives in childbearing years. Was this helpful?
Study limitations When asked about the study’s limitations, Dr. Kang noted that due to the study design, it only explains short-term risk associations as opposed to long-term risk. Dr. Kristina Shaffer, breast surgical oncologist at Novant Health Cancer Institute, not involved in the study, also told MNT: “In addition, the study included premenopausal women, an age group where breast cancer incidence is lower, meaning that other factors may have been driving the slightly higher risk demonstrated in the study. For example, while the study did account for some of the factors known to be related to breast cancer risk, it did not account for family history, genetic predisposition, or history of atypical breast cells which are well-established to impact breast cancer risk.” Implications for contraceptives use MNT also spoke with Dr. Parvin Peddi, board certified medical oncologist and director of Breast Medical Oncology for the Margie Petersen Breast Center at Providence Saint John’s Health Center and Associate Professor of Medical Oncology at Saint John’s Cancer Institute in Santa Monica, CA, not involved in the study. “On the other hand, it’s important to note that the absolute increased risk of breast cancer from any of these medications is quite low and this study should not dissuade women from using hormone-containing birth controls,” Dr. Peddie explained. “Risk of breast cancer was seen in less than 0.5% of women age 35-39 years old due to use of these medications and in even fewer women who used these medications at a younger age.” Dr. Schaffer agreed that while the increase in risk may sound high at 20-30%, it is relatively small. “For instance, if the risk of a 30-year-old female developing breast cancer is 5%, then a relative increase of 20% would bring her risk to 6%. And this is why the study concludes that there is a slight increase in breast cancer risk,” she explained. Dr. Kang also noted: “As with all cancers, your breast cancer risk increases with age, and in this case, also with the length of time that hormonal contraceptives are used. If you are at a higher risk for breast cancer, switching to a hormone-free birth control may be a more beneficial option for you. If you are diagnosed with breast cancer, seek care from an expert who specializes in your type of cancer.” “Finding breast cancer early is one of the most important factors in successful treatment of this disease — and that’s why self-exams and screenings are so vital,” Dr. Kang concluded.
有去德州治疗乳腺癌的人说那里的医生说很多病人都是用长期避孕药的,但避孕药厂砸了大钱游说,医生们也只是自己的临床观察私下跟病人说说
我信这个。 所以从来没吃过避孕药。 这个世界,资本家都把百姓当蝼蚁,但自己要长脑子
但是乳腺癌的预后比较好 卵巢癌差很多 以我有限的知识宫颈癌跟避孕药没关系 宫颈癌绝大多数是hpv感染引起的 当然我觉得所有药应该认真disclose所有的副作用
另一个是降低子宫内膜癌
乳腺癌无论是死亡还是发病率都是全球第一,之后我有空再来贴数据
因为雌激素皮肤会变好吧,还可以治疗子宫内膜异位,子宫腺肌症
痤疮一般是雄激素过剩
发病率是最高,但死亡率的计算分母是全体人群,发病率高了死亡率不可能低。看预后应该看五年生存率。 乳癌五年生存率有80%多 卵巢癌只有40%
说这些不是说避孕药的副作用就该被无视 也不是说得了乳腺癌就没事
男的可以结扎还是啥的,可逆的一个小手术
记得有mm说医生给开避孕药治痘痘。
每当我听到这样两性对立的言论我就觉得很无语,男人想解放自己在乎什么避孕,打完炮就走不是更好?女人用避孕药难道不是为了保护自己?就好像你跟防弹衣有仇觉得是那些持枪的想解放自己,问题是你指望别人不乱放枪,你对自己负责吗?
啥意思,避孕药增加乳腺癌几率不是很well published fact吗?
哦懂了 但是发病率高的话还是应该预防乳腺癌>卵巢癌?因为得的机率更高?
男的愿意结扎的太少了吧
学习了
乳腺癌5年存活率高于卵巢癌,我认为主要差异在乳腺癌早期筛查容易,发现得早,5年治愈率当然高。
你这说的是约炮,我说的是夫妻。 约炮当然互相不用负责,夫妻丈夫可以打完炮就走吗?孩子生下来了养育可是夫妻共同的责任,版上男人有几个完全不避孕,希望老婆一辈子生孩子的?
这么狠
对自己更负责的方法难道不是挑选合适的男人吗?男人不愿意戴套你就让他滚,凭什么你不愿意戴套我就得吃药?只要女人把好关,不跟不靠谱的男人上床,他再自私再垃圾跟女人有什么关系?
长知识了
那出家的人癌症概率最高了
Cervical cancer: Women who have used oral contraceptives for 5 or more years have a higher risk of cervical cancer than women who have never used oral contraceptives. The longer a woman uses oral contraceptives, the greater the increase in her risk of cervical cancer. One study found a 10% increased risk for less than 5 years of use, a 60% increased risk with 5–9 years of use, and a doubling of the risk with 10 or more years of use (9). https://www.cancer.gov/about-cancer/causes-prevention/risk/hormones/oral-contraceptives-fact-sheet#:~:text=The%20longer%20a%20woman%20uses,years%20of%20use%20(9). In the CPRD data, there was a significant increase in risk of breast cancer associated with hormonal contraceptive use, regardless of whether the contraceptive last prescribed was a combined (oestrogen and progestogen) oral preparation (23%), a progestogen-only oral preparation (26%), an injected progestogen (25%), or a progestogen-releasing intra-uterine device (32%); https://www.ceu.ox.ac.uk/news/any-type-of-hormonal-contraceptive-may-increase-risk-of-breast-cancer
我医生说吃避孕药可以防止更年期的骨质疏松,能吃吗?
古时候任何肿瘤发病率都低
当然是啊。但是不要上升到男女对立
您说得对,那个时候普通人吃的食品都是有机的。
您的切入点总是这么独特
今天很多病都是病从口入。
因为古代死得早吧
其实我不相信古时候人死得早。
不可否认,清朝后期和民国时期因为战乱贫困,人均寿命很低。
但是中国三皇五帝时代还有中东圣经时代,普通人活200岁轻轻松松。
高中毕业了吗?
我上个世纪80年代就高中毕业了。
所以彭祖活800岁也没啥稀奇的?
那为啥养宠物都是绝育的寿命更长呢?
这是神话吧? 有没有彭祖都不一定呢
寿命都到不了得癌症
有这说法?
我也以为呢,改变激素的,想想也不会完全无害
太频繁生育也不好啊,以前生10个8个孩子的年代,很多孩子都活不到成年,妈妈身体也不好
因为古人很多40人就没了,现代人活得长
版上讨论是停药后会得病。应该还是激素问题吧。这药一吃就不能停的感觉。
你怎么跟金星一个调调?
有。绝育的狗要长寿。
但是宠物绝育了就是完全没有任何荷尔蒙分泌了。人类不可能愿意放弃这些吧。我感觉就是这些荷尔蒙起伏如果不能完全消除,那么不得到释放反而更不好。
生孩子时候荷尔蒙起伏更大。见过好几个生娃后一两年乳腺癌的
去跟前面那个古人都活200岁的说
除了乳腺癌还有啥
应该是有影响的。看网上说胸部如果有结节要慎吃避孕药。 不过我不知道胸部结节和乳腺癌的区别是什么,看网上说没啥关联?
避孕药治青春痘有奇效。我用任何中西药、护肤品、调整作息饮食都治不了青春痘,吃避孕药马上见效。
No wonder. 已经老糊涂啦
荷尔蒙based的避孕药是会增加乳腺癌几率的。 药盒上写的都是。 但是你去问医生,医生会告诉你那是小概率事件。 这后面谁给了钱lobby, 谁拿了钱回扣。谁知道。
大好年华(15-45岁)的健康女性服用药物干扰自然的激素分泌,我觉得想想就是不自然的事情
是的。我自己和有认识的人都是这样。小概率事件 发生在自己身上就是灾难