https://www.science.org/content/blog-post/paxlovid-resistance-it-just-matter-time-now With their vast numbers, fast generation time, and number of mutations, resistance to a given small molecule is generally just a matter of “when”, not “if”. The usual way around this problem is to try to use a drug cocktail, hitting the pathogen simultaneously with compounds that target more than one mechanism.
新的延长到18个月了 lots of Paxlovid with dates of expiry from July 2022 to May 2023 may be stored for an additional six months from the labeled date of expiry https://aspr.hhs.gov/COVID-19/Therapeutics/updates/Pages/important-update-06September2022.aspx
你没看清楚，我说的是培养出来耐药株导致这个药没用了。
看正文的意思，楼主可能是指耐药性，但她说成了“失效”，所以从外面看标题，我也以为她说的是Paxlovid 的保质期有多久呢
好像不会，这个药是蛋白酶拟肽抑制剂， 如果新冠进化出不同的蛋白酶， 那可能就失效了
https://www.science.org/content/blog-post/paxlovid-resistance-it-just-matter-time-now
With their vast numbers, fast generation time, and number of mutations, resistance to a given small molecule is generally just a matter of “when”, not “if”. The usual way around this problem is to try to use a drug cocktail, hitting the pathogen simultaneously with compounds that target more than one mechanism.
美国就有不少人，吃了以后明显好转， 但一周以后复阳，而且症状更严重
新的延长到18个月了
lots of Paxlovid with dates of expiry from July 2022 to May 2023 may be stored for an additional six months from the labeled date of expiry
https://aspr.hhs.gov/COVID-19/Therapeutics/updates/Pages/important-update-06September2022.aspx