Same imprinting concern: "Our findings suggest that immune imprinting by prior antigenic exposure may pose a greater challenge than currently appreciated for inducing robust immunity to covid variants."
2nd study of bivalent BA.5 booster replicates the 1st (Ho Lab, yesterday) No significant difference (~1.3x) in BA.5 neutralizing antibodies compared with the original ancestral (monovalent) booster, by @BarouchLabhttps://t.co/wG1xcooVCzpic.twitter.com/spsmuY05VG — Eric Topol (@EricTopol) October 25, 2022
plain English please?what is immune imprinting 就看懂了新的二介疫苗不比前面那个更有效。。。 huaren_ID 发表于 2022-10-25 21:30
https://en.wikipedia.org/wiki/Original_antigenic_sin Original antigenic sin, also known as antigenic imprinting, the Hoskins effect,[1] or immunological imprinting[2] is the propensity of the immune system to preferentially use immunological memory based on a previous infection when a second slightly different version of that foreign pathogen (e.g. a virus or bacterium) is encountered. This leaves the immune system "trapped" by the first response it has made to each antigen, and unable to mount potentially more effective responses during subsequent infections. Antibodies or T-cells induced during infections with the first variant of the pathogen are subject to repertoire freeze, a form of original antigenic sin. The phenomenon has been described in relation to influenza virus, SARS-CoV-2,[2] dengue fever, human immunodeficiency virus (HIV) [3] and to several other viruses. 流感也有这个问题。所以flu shot也没用，而且越打越没用。
那为啥从去年下半年到今年上半年一直都有什么研究说两针疫苗加感染当前病株会产生更强的保护？从Delta到omicron的一系列变种。。。第一次这么说的时候觉得还能接受，后来每一波变种都走同样的what doesn't kill you makes you stronger套路就有点让人不得不起疑了。这也太巧了吧？每次疫苗不好用马上就有研究结果恭喜你，得了不要紧，只要你有两针以上，下次你就无敌了。。。感觉这疫苗自己逢凶化吉的能力也太强了
2021年“阴谋论”就说过这个抗原原罪的问题。
就看懂了新的二介疫苗不比前面那个更有效。。。
CDC director打了二价疫苗二三周后就确诊covid，就说明二价疫苗的效果差强人意。
https://en.wikipedia.org/wiki/Original_antigenic_sin
Original antigenic sin, also known as antigenic imprinting, the Hoskins effect,[1] or immunological imprinting[2] is the propensity of the immune system to preferentially use immunological memory based on a previous infection when a second slightly different version of that foreign pathogen (e.g. a virus or bacterium) is encountered. This leaves the immune system "trapped" by the first response it has made to each antigen, and unable to mount potentially more effective responses during subsequent infections. Antibodies or T-cells induced during infections with the first variant of the pathogen are subject to repertoire freeze, a form of original antigenic sin.
The phenomenon has been described in relation to influenza virus, SARS-CoV-2,[2] dengue fever, human immunodeficiency virus (HIV) [3] and to several other viruses.
流感也有这个问题。所以flu shot也没用，而且越打越没用。
善意提醒：差强人意的意思是勉强令人满意；你可能想用的是：不尽如人意