google了一下，If you test positive for Lynch syndrome, meaning that genetic mutations were found in your blood, this does not necessarily mean that you will get cancer. It means that your lifetime risk of developing colon cancer is between 60 to 80 percent. lz如果现在发现有 Lynch syndrome，可以定期体检，希望一切顺利，big bless!
HNPCC is also classically divided into two subgroups on clinical grounds 1. Hereditary site specific colon cancer (Lynch syndrome I) 2. Cancer family syndrome or (Lynch syndrome II) - Lynch syndrome II is distinctly associated with a high risk of extracolonic tumors, the most common of which is endometrial carcinoma, which develops in up to 43% of females in affected families. Also associated with ovarian and skin cancers. Endometrial cancer screening withannual endometrial biopsy should beginat age 30-35.Ovarian cancer risk is also increased andmay present at a relatively younger age.Therefore, prophylactic hysterectomyand bilateral oophorectomy isrecommended at age 40 or earlier ifchildbearing is complete. 我从网上抄的。mm还是咨询一下医生吧！多做癌症筛查。big bless! Google了一下这个基因的突变 Variants in the MSH6 gene have been reported in about 13 percent of families with Lynch syndrome that have an identified gene variant. Lynch syndrome increases the risk of many types of cancer, particularly colorectal cancer. People with Lynch syndrome also have an increased risk of cancers of the endometrium (lining of the uterus), ovaries, stomach, small intestine, gallbladder ducts, upper urinary tract, and brain. By age 75, the risk of developing one of these cancers is 60 percent for women and 40 percent for men with an MSH6 gene variant. Endometrial cancer is especially common in women with Lynch syndrome caused by MSH6 gene variants.
求祝福，也祝大家一切安好！
--------------------------- 谢谢楼里所有的祝福，和很多有效的信息，从昨天刚得知这个消息的手足无措、沮丧，到今天逐渐平复，接受现实，开始进行心态调整了。我会乐观起来的。在这个版上’，我获益良多！ 也祝愿所有的朋友们一切顺利！
🔥 最新回帖
谢谢您的鼓励和安慰，很让人安心！是的，这也是给我敲响警钟，需要改变之前不良的生活方式。也祝您及楼里所有的朋友生活如意！
🛋️ 沙发板凳
lz如果现在发现有 Lynch syndrome，可以定期体检，希望一切顺利，big bless!
饮食营养均衡，定期做肠镜检查。 聂卫平肠癌手术很多年了，照样活的好好的，前2天还去参加围棋比赛的揭幕式了
Endometrial cancer screening with annual endometrial biopsy should begin at age 30-35. Ovarian cancer risk is also increased and may present at a relatively younger age. Therefore, prophylactic hysterectomy and bilateral oophorectomy is recommended at age 40 or earlier if childbearing is complete. 我从网上抄的。mm还是咨询一下医生吧！多做癌症筛查。big bless!
Google了一下这个基因的突变 Variants in the MSH6 gene have been reported in about 13 percent of families with Lynch syndrome that have an identified gene variant. Lynch syndrome increases the risk of many types of cancer, particularly colorectal cancer. People with Lynch syndrome also have an increased risk of cancers of the endometrium (lining of the uterus), ovaries, stomach, small intestine, gallbladder ducts, upper urinary tract, and brain. By age 75, the risk of developing one of these cancers is 60 percent for women and 40 percent for men with an MSH6 gene variant. Endometrial cancer is especially common in women with Lynch syndrome caused by MSH6 gene variants.
Big big bless
同样很难的一年，希望明年我们都能好起来
以前在一片文章中看过，女主林奇综合症，肠癌，除手术外，可用沙默东的PD-1抑制剂keytruda治疗
mm您好，没太看懂您写的，“除手术外，可用”是什么意思呢？多谢回复！
就是这个基因变异引起的癌症除了传统的手术切除、化疗这些方案外，有这个药可以对症治疗的
建议把直肠切掉，可以在肚子上挂个袋子接屎，跟正常人生活差不多
楼主祝好，Lynch syndrome要多做screen检查。肠镜好像是每年都要做吧。20-80%的概率会得colon cancer，10-60%会得endometrial cancer，还有其他的肿瘤。找妇产科和消化科定期做检查。 你孩子50%会遗传lynch基因，他们有检查吗？
bless
谢谢提醒，我医生已经refer了，说可能排队时间估计挺长，要等一阵子才能见到专门筛查的医生。几个月倒是不急。只怕之后一直活在恐惧中了。
不过也不要怕，现在的免疫治疗对这种MSI的癌症效果比其他癌症要好很多。兵来将挡，水来土掩吧。 不过你的小孩最好也去做一下genetic test。还有你国内其他亲人（看你的描述有点像你妈那边的，还有表兄妹啥的，都去查查吧）。知道总比不知道好。
谢谢您的解释。应该是我妈妈那边的。我外婆是65岁之后（可能是66、67）查出肠癌，由于当地的医院手术出现严重事故，引发了肠漏，68岁左右走的；我舅舅是61岁左右查出来的时候已经是晚期了，治疗了两年多离世了。也许他们都是50多岁的时候得了，但没有去做肠镜筛查。 我问了医生小孩是否需要筛查，医生建议是成年之后25岁左右筛查。 再次感谢所有的回复和祝福，祝大家一切顺顺顺！
转到脑子和肝上才麻烦
知道了其实是好消息
请问“专业人士的帮助”，是指医院专门的program长期帮助来监测/早筛吗？还是自己联系什么机构呢？感谢回复！