小孩还是等一等好 novavax 12月31号向 FDA提交了数据， 按规定会在30天后提交紧急使用申请 “first time in history that the ineffectiveness of a medicine is being blamed on those who haven't taken it” --- Robert Wallace Malone
Robert Wallace Malone is an American virologist and immunologist. His work has focused on mRNA technology, pharmaceuticals, and drug repurposing research. During the COVID-19 pandemic, he has been criticized for promoting misinformation about the safety and efficacy of COVID-19 vaccines.[1][2][3][4] In the late 1980s, while a graduate student researcher at the Salk Institute for Biological Studies in San Diego, California, Malone conducted studies on messenger ribonucleic acid (mRNA) technology, discovering that it was possible to transfer mRNA protected by a liposome into cultured cells to signal the information needed for the production of proteins.[8][2] In 1987, Malone performed a landmark experiment on transfection of RNA into human, rat, mouse, Xenopus, and Drosophila cells, published in 1989.[9][10] A follow-up study also published in 1989 found that frog embryos absorbed such mRNA. A 1990 paper, in collaboration with Jon A. Wolff, Dennis A. Carson, and others, first suggested the possibility of synthesizing mRNA in a laboratory to trigger the production of a desired protein.[11] These studies are recognized as among the earliest steps towards mRNA vaccine development.[12][9][1][13][14] Malone claims to be the inventor of mRNA vaccines, and while Stan Gromkowski, an early mRNA vaccine researcher and cellular immunologist, views Malone as "an underappreciated pioneer" who could be in contention to win a Nobel Prize for his work,[1] credit for the distinction is more often given to later advancements by Katalin Karikó or Derrick Rossi,[8][15][16] and was ultimately the result of the contributions of hundreds of researchers, including Malone.[17]
小孩还是等一等好 novavax 12月31号向 FDA提交了数据， 按规定会在30天后提交紧急使用申请 “first time in history that the ineffectiveness of a medicine is being blamed on those who haven't taken it” --- Robert Wallace Malone
Robert Wallace Malone is an American virologist and immunologist. His work has focused on mRNA technology, pharmaceuticals, and drug repurposing research. During the COVID-19 pandemic, he has been criticized for promoting misinformation about the safety and efficacy of COVID-19 vaccines.[1][2][3][4] In the late 1980s, while a graduate student researcher at the Salk Institute for Biological Studies in San Diego, California, Malone conducted studies on messenger ribonucleic acid (mRNA) technology, discovering that it was possible to transfer mRNA protected by a liposome into cultured cells to signal the information needed for the production of proteins.[8][2] In 1987, Malone performed a landmark experiment on transfection of RNA into human, rat, mouse, Xenopus, and Drosophila cells, published in 1989.[9][10] A follow-up study also published in 1989 found that frog embryos absorbed such mRNA. A 1990 paper, in collaboration with Jon A. Wolff, Dennis A. Carson, and others, first suggested the possibility of synthesizing mRNA in a laboratory to trigger the production of a desired protein.[11] These studies are recognized as among the earliest steps towards mRNA vaccine development.[12][9][1][13][14] Malone claims to be the inventor of mRNA vaccines, and while Stan Gromkowski, an early mRNA vaccine researcher and cellular immunologist, views Malone as "an underappreciated pioneer" who could be in contention to win a Nobel Prize for his work,[1] credit for the distinction is more often given to later advancements by Katalin Karikó or Derrick Rossi,[8][15][16] and was ultimately the result of the contributions of hundreds of researchers, including Malone.[17]
关于是不是给孩子打，可以参考一下这个新闻文章，和里面提起的两篇research 文章 https://www.nature.com/articles/d41586-021-02423-8 https://www.science.org/doi/10.1126/scitranslmed.abd5487 https://www.nature.com/articles/s41467-021-24938-4 现在观察到的是小孩子的innate response很好，能够比成人反应快1-2天，而小孩子的adaptive response， specifically the production of t-cell, 相对较弱，但是这不影响儿童对covid的抵抗力，”Herold suspected that the children mounted a less robust adaptive immune response because their innate response was more efficient at eliminating the threat. An overactive adaptive response in adults, she says, could be causing some of the complications in COVID-19.“ 某种程度上过于active的adaptive response反而有害 ”Children with disorders affecting their adaptive immune response — those who don’t produce antibodies or have faulty B-cell and T-cell production, for example — did not encounter problems when infected with SARS-CoV-2. Among those that became severely ill were children with shortcomings in their innate immune response, she says. “It’s not really the adaptive immune system that is helping you to beat this virus.” 而且小朋友自身产生的antibody更broad She and her colleagues found that adults had more cross-reactive antibodies targeted at parts of SARS-CoV-2 that were similar to bits of other coronaviruses, whereas children tended to produce a broader range of antibodies against all sections of the virus.
总之，儿童先天的免疫力还是很强的。 最后，文章中的一组数据：a total of 3,649 children were hospitalized between March 2020 and late August 2021, and more than 420 have died. 这个数据是在delta surge之前，当然也是omicron之前。
我家打过疫苗，并且大人都已经得过新冠。去年得新冠的时候孩子嘛事都没有。所以真不想冒险给孩子打疫苗。毕竟这疫苗是新产品，万一有害呢？
求拍醒。
可是孩子不能去游泳啊。
同意，除了最后一项。希望美国不会堕落到不打疫苗不让上学
我家里是大人都打了booster，大娃寄宿私校要求疫苗，打了两针。他们学校还每天检测。不过他身高体重都是成年人的size，我们觉得还好。 小娃一直还没打。照常上学，除了上学基本不去任何室内，出门只去户外山上或者海边。
北半球国家一半的州现在冰天雪地
novavax怎么还没批 太慢了
novavax 12月31号向 FDA提交了数据， 按规定会在30天后提交紧急使用申请
“first time in history that the ineffectiveness of a medicine is being blamed on those who haven't taken it” --- Robert Wallace Malone
Robert Wallace Malone is an American virologist and immunologist. His work has focused on mRNA technology, pharmaceuticals, and drug repurposing research. During the COVID-19 pandemic, he has been criticized for promoting misinformation about the safety and efficacy of COVID-19 vaccines.[1][2][3][4]
In the late 1980s, while a graduate student researcher at the Salk Institute for Biological Studies in San Diego, California, Malone conducted studies on messenger ribonucleic acid (mRNA) technology, discovering that it was possible to transfer mRNA protected by a liposome into cultured cells to signal the information needed for the production of proteins.[8][2] In 1987, Malone performed a landmark experiment on transfection of RNA into human, rat, mouse, Xenopus, and Drosophila cells, published in 1989.[9][10] A follow-up study also published in 1989 found that frog embryos absorbed such mRNA. A 1990 paper, in collaboration with Jon A. Wolff, Dennis A. Carson, and others, first suggested the possibility of synthesizing mRNA in a laboratory to trigger the production of a desired protein.[11] These studies are recognized as among the earliest steps towards mRNA vaccine development.[12][9][1][13][14] Malone claims to be the inventor of mRNA vaccines, and while Stan Gromkowski, an early mRNA vaccine researcher and cellular immunologist, views Malone as "an underappreciated pioneer" who could be in contention to win a Nobel Prize for his work,[1] credit for the distinction is more often given to later advancements by Katalin Karikó or Derrick Rossi,[8][15][16] and was ultimately the result of the contributions of hundreds of researchers, including Malone.[17]
我们去年得过有经验了，那时候孩子天天和我们一起，应该也是得过了。真是担心疫苗的risk，反而不是很怕新冠了。
纽约小孩的新冠住院率最近飙升。我专门治疗新冠的医生朋友强烈建议小孩要打。这一轮感觉很难躲开。
我有朋友小孩没打疫苗，得了和流感症状差不多，打过疫苗的小孩最近也确诊的，都是无症状和轻症。
小孩没有基础病，感觉大都能抗过去。不过还是看人，纽约现在住院的小孩没啥基础病的也一把一把的。
我看到的是纽约住院小孩很多是因为其他的病才住院的，顺便查出来covid阳性.
这个具体我不了解。不过这两种情况并不是彼此矛盾，互不兼容的。
这个也难讲，Pfizer毕竟打了上亿人的，副作用研究肯定更清楚点。这个新产品sample size还小啊。
https://nypost.com/2021/12/30/most-kids-in-icu-with-covid-19-had-underlying-conditions/
只是想知道5-6岁小孩打疫苗到底值不值得冒这个未知的风险
这个只能爹妈自己决定啊。。。孩子岁数小，有concern太正常不过了啊。
和你想法类似，唯独现在我感觉这一波即使防护得当也不太“可能躲过去”，只要一回学校我觉得就很难防了。。。希望我是错的。。。
我对于现在政府不顾一切推疫苗的态度很不满意。我觉得但凡疫苗有效率高或者副作用小我也就认了，但是效果又差副作用又不小还对数据遮遮掩掩的，我真的很难相信里面没有利益勾兑。
好多大学都是强制打的。不然就上网课。
这个即使批了，我也不会马上给孩子打，很多副作用是大量数据和长期观测才看得出来的，比如JJ疫苗... 我跟LZ一样，大人打了两针，没有打 booster，也没有给孩子打, so far so good
我朋友的姐姐就是儿童ICU护士，她看到好多是心脏病进来的，所以她们全家没给男孩子打，女孩子倒是都打了。
因为小孩出生就打的hepatitis B疫苗也是recombinant nanoparticle. 在临床已经很多年应用了。Novavax covid vaccine作为同一类技术的疫苗，believed to be safer
我娃有两个男同学，家长一个是心脏科医生，一个免疫科的director ，两个男孩全部第一时间都打了。
我也希望novavax 快出来，但是他们大人的疫苗都还没申请，小娃在美的trial 还未开始
我家女孩我无所谓，你们爱干嘛就干嘛。😄
https://www.nature.com/articles/d41586-021-02423-8
https://www.science.org/doi/10.1126/scitranslmed.abd5487
https://www.nature.com/articles/s41467-021-24938-4
现在观察到的是小孩子的innate response很好，能够比成人反应快1-2天，而小孩子的adaptive response， specifically the production of t-cell, 相对较弱，但是这不影响儿童对covid的抵抗力，”Herold suspected that the children mounted a less robust adaptive immune response because their innate response was more efficient at eliminating the threat. An overactive adaptive response in adults, she says, could be causing some of the complications in COVID-19.“
某种程度上过于active的adaptive response反而有害 ”Children with disorders affecting their adaptive immune response — those who don’t produce antibodies or have faulty B-cell and T-cell production, for example — did not encounter problems when infected with SARS-CoV-2. Among those that became severely ill were children with shortcomings in their innate immune response, she says. “It’s not really the adaptive immune system that is helping you to beat this virus.”
而且小朋友自身产生的antibody更broad
She and her colleagues found that adults had more cross-reactive antibodies targeted at parts of SARS-CoV-2 that were similar to bits of other coronaviruses, whereas children tended to produce a broader range of antibodies against all sections of the virus.
总之，儿童先天的免疫力还是很强的。
最后，文章中的一组数据：a total of 3,649 children were hospitalized between March 2020 and late August 2021, and more than 420 have died. 这个数据是在delta surge之前，当然也是omicron之前。
支持你的想法，能不打就不打，毕竟副作用还不知道。
除了novavax自身原因，我怀疑也有大药厂lobbyists的因素在里面。美国市场的羹已经分差不多了，现在又出了booster shot这杯羹，凭啥要多分一杯出去。
是啊，感觉把全世界人民当傻子。
你这不是很正常吗？这个病对小孩伤害很小。大人值得打不等于小孩值得打。多想想没什么错。
re 还一个劲的宣传无症状和轻症都会有后遗症，virus长久在体内存在，long covid什么的 问题是打了疫苗也不防感染呀。打了疫苗再感染（即使轻症）就没有后遗症了吗？ 逻辑和智商真是欠费