The US Food and Drug Administration has authorized Pfizer''s antiviral pill, Paxlovid, to treat Covid-19 in high-risk individuals age 12 and older who weigh at least 88 pounds 加上新闻link
The US Food and Drug Administration has authorized Pfizer's antiviral pill, Paxlovid, to treat Covid-19 in high-risk individuals age 12 and older who weigh at least 88 pounds 溜溜哒哒 发表于 2021-12-22 14:13
好啊，这下high risk不死了，估计他们很快就能开到了 Paxlovid is available by prescription only and should be initiated as soon as possible after diagnosis of COVID-19 and within five days of symptom onset. Paxlovid is administered as three tablets (two tablets of nirmatrelvir and one tablet of ritonavir) taken together orally twice daily for five days, for a total of 30 tablets. Possible side effects of Paxlovid include impaired sense of taste, diarrhea, high blood pressure and muscle aches. Using Paxlovid at the same time as certain other drugs may result in potentially significant drug interactions. Using Paxlovid in people with uncontrolled or undiagnosed HIV-1 infection may lead to HIV-1 drug resistance. Ritonavir may cause liver damage, so caution should be exercised when giving Paxlovid to patients with preexisting liver diseases, liver enzyme abnormalities or liver inflammation. https://www.fda.gov/media/155052/download 这个是high risk定义： https://www.cdc.gov/coronavirus/2019-ncov/need-extra-precautions/people-with-medical-conditions.html
不可以。是药， 不是维生素😂 一共吃5天，确诊之后吃 Final data from the EPIC-HR study confirmed that Paxlovid reduced risk of hospitalization or death by 89% (within three days of symptom onset) and 88% (within five days of symptom onset) compared to placebo.
https://www.sciencenews.org/article/covid-antidepressant-fluvoxamine-drug-hospital-death/amp In newly infected COVID-19 patients at high risk of complications, a 10-day course of the antidepressant fluvoxamine cut hospitalizations by two-thirds and reduced deaths by 91 percentin patients who tolerated the medicine, researchers report October 27 in the Lancet Global Health. 现存的药，10天药费$20。效果基本一样。 辉瑞这个要多少钱？
https://www.sciencenews.org/article/covid-antidepressant-fluvoxamine-drug-hospital-death/amp In newly infected COVID-19 patients at high risk of complications, a 10-day course of the antidepressant fluvoxamine cut hospitalizations by two-thirds and reduced deaths by 91 percentin patients who tolerated the medicine, researchers report October 27 in the Lancet Global Health. 现存的药，10天药费$20。效果基本一样。 辉瑞这个要多少钱？ Dohremi 发表于 2021-12-22 14:58
这个临床试验结果比Pfizer的paxlovid差太远了。 Lancet paper: Efficacy of fluvoxamine: We found a clinically important absolute risk reduction of 5% and 32% RR reduction on the primary outcome of hospitalization. There were 17 deaths in the fluvoxamine group and 25 deaths in the placebo group in the primary intention-to-treat analysis (odds ratio [OR] 0·68, 95% CI: 0·36–1·27). There was one death in the fluvoxamine group and 12 in the placebo group for the per-protocol population (OR 0·09; 95% CI 0·01–0·47). https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(21)00448-4/fulltext
https://www.sciencenews.org/article/covid-antidepressant-fluvoxamine-drug-hospital-death/amp In newly infected COVID-19 patients at high risk of complications, a 10-day course of the antidepressant fluvoxamine cut hospitalizations by two-thirds and reduced deaths by 91 percentin patients who tolerated the medicine, researchers report October 27 in the Lancet Global Health. 现存的药，10天药费$20。效果基本一样。 辉瑞这个要多少钱？ Dohremi 发表于 2021-12-22 14:58
The US Food and Drug Administration has authorized Pfizer''s antiviral pill, Paxlovid, to treat Covid-19 in high-risk individuals age 12 and older who weigh at least 88 pounds 加上新闻link
刚刚FDA也批了Merck的molnupiravir给高风险的成年人。虽然只有30%住院风险减少，也是给那些没有别的治疗手段情况下的一种选择吧。 The agency authorized the oral drug for the treatment of mild-to-moderate COVID-19 in adults who are at risk for severe disease, and for whom alternative COVID-19 treatments are not accessible or clinically appropriate.
刚刚FDA也批了Merck的molnupiravir给高风险的成年人。虽然只有30%住院风险减少，也是给那些没有别的治疗手段情况下的一种选择吧。 The agency authorized the oral drug for the treatment of mild-to-moderate COVID-19 in adults who are at risk for severe disease, and for whom alternative COVID-19 treatments are not accessible or clinically appropriate. Rutang48 发表于 2021-12-23 09:58
加上新闻link
懂的人来说说这个药啊？
Paxlovid is available by prescription only and should be initiated as soon as possible after diagnosis of COVID-19 and within five days of symptom onset.
Paxlovid is administered as three tablets (two tablets of nirmatrelvir and one tablet of ritonavir) taken together orally twice daily for five days, for a total of 30 tablets.
Possible side effects of Paxlovid include impaired sense of taste, diarrhea, high blood pressure and muscle aches. Using Paxlovid at the same time as certain other drugs may result in potentially significant drug interactions. Using Paxlovid in people with uncontrolled or undiagnosed HIV-1 infection may lead to HIV-1 drug resistance. Ritonavir may cause liver damage, so caution should be exercised when giving Paxlovid to patients with preexisting liver diseases, liver enzyme abnormalities or liver inflammation.
https://www.fda.gov/media/155052/download
这个是high risk定义： https://www.cdc.gov/coronavirus/2019-ncov/need-extra-precautions/people-with-medical-conditions.html
相当于tamiflu 对付流感
有效率89%
神药
不可以。是药， 不是维生素😂 一共吃5天，确诊之后吃
Final data from the EPIC-HR study confirmed that Paxlovid reduced risk of hospitalization or death by 89% (within three days of symptom onset) and 88% (within five days of symptom onset) compared to placebo.
跟另一家那个让病毒突变的原理一样吗？
有的人喜欢吃药 有的人不喜欢吃药 你喜欢 就多吃啊
生病了要吃药。尤其是high risk的病。和没病乱打针是一回事吗？脑子被驴踢了吧。
脑子进水了吧？我哪里说了喜欢这药了？
好意提醒而已，真是狗咬吕洞宾
药是每天要吃的吗？药和疫苗最大的不同是，药生了病才吃，疫苗是有没有病都要打。
In newly infected COVID-19 patients at high risk of complications, a 10-day course of the antidepressant fluvoxamine cut hospitalizations by two-thirds and reduced deaths by 91 percentin patients who tolerated the medicine, researchers report October 27 in the Lancet Global Health.
现存的药，10天药费$20。效果基本一样。
辉瑞这个要多少钱？
不是一个原理 这个理论上应该更安全一点 希望快批给普通人
这个药的原理和 Ivermectin 一致，但结构不一样。很多人对 Ivermectin 寄予很大希望，但三期效果就是做不出来。Pfizer的Paxlovid在美国和以色列的三期效果现在出来了，所以就成功了。
俺这是听管上的人说的。
这个临床试验结果比Pfizer的paxlovid差太远了。 Lancet paper: Efficacy of fluvoxamine: We found a clinically important absolute risk reduction of 5% and 32% RR reduction on the primary outcome of hospitalization.
There were 17 deaths in the fluvoxamine group and 25 deaths in the placebo group in the primary intention-to-treat analysis (odds ratio [OR] 0·68, 95% CI: 0·36–1·27). There was one death in the fluvoxamine group and 12 in the placebo group for the per-protocol population (OR 0·09; 95% CI 0·01–0·47). https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(21)00448-4/fulltext
这个怎么可能？辉瑞再砸几百亿塞给各国政府也会全力挡住，不然现在这药怎么推销。
没你吹的那么神吧，大概减少三分之一的住院
不过呢，这个药好歹是真刀真枪的做出结果来了，同一个实验里面兽药IVM没看出有什么效果来。这么久过去了，也没见几个川粉去屯这个fluvoxamine，什么前线医生也没见鼓吹吃fluvoxamine，照样一窝蜂地把兽药吃到断货
为什么？不打疫苗的人命不是命？
得找网上医生开，不然估计开不到的
你的行为表现类似叛逆期青少年。把标新立异特当做成熟已经长大，实现上幼稚可笑。
量产很快，大家用不上主要是还没批给普通人
家里有胖子的可以去碰碰运气
好像这个必须尽早吃。 有症状就要马上测，开药。 超过5天，就没什么用了。 那么配合这个药， testing也很重要。 大多数人吃个泰诺就好了。 这个一个疗程530 （Merck 的更贵），不知道自负多少。
对的 这个药早吃才有用 测出来马上吃 可很多人测出来就已经过去至少3天了 所以不能等到严重要去医院 那时候吃这个药就太晚了
真的得尽快吃 不早点吃就好了
可是很多感染了早期测不出来吧。 我们这里学区都是建议密接后第五天到第七天去测。
这个效果比tamiflu还好，记得tami的efficacy 还没有那么好
没打过疫苗不是更加需要这个药吗？
不应该是，药都有了，大部分又不是severe case，更不用强制疫苗，才是有道理吗？
就事论事，不要人身攻击。 还是除了人身攻击就不会说话了？
tamiflu小孩都可以吃的，这个药只能12岁以上。失望
这个药应该会广泛推广吧，不会只用在高危人群中。 看新闻报道，像是重大突破，曙光出现。 但如果Omicron大多数是轻症，也许这药的意义也就没有这么大了。
啧啧，真是没骨气。邪恶的big pharma逼大家打疫苗赚黑心钱，他家出药必须要抵制呀。
这不已经年底了吗
Paxlovid是3C like protease inhibitor。 这个3C蛋白酶是冠状病毒里的（eg. SARS和COVID). 不明白你说会抑制人体的正常复制。 临床试验先从high risk病人做起，现在在做Standard risk病人。结果好的话自然会让普通新冠病人使用。
只批了high risk的。 普通人还要再等等
脑子被驴踢了的表现是一边宣传Pfizer的新冠疫苗是阴谋，一边哭着喊着要用Pfizer的新冠药
人民的希望刚出现也是这么说的，结果过了没几个月就没有动静了。
唉，这年头扯大旗唬大皮的人太多。
Tamiflu 要吃Brand的， 印度产的Generic Tamiflu效果大打折扣
这药能快速生产吗？
手动赞一个，有些人打了三针jabs给打傻了
打了疫苗的有反应不给治疗可不可以？
被🦌踢了就你这样。我们说的不是反疫苗，是反强制疫苗。
我完全支持你们传粉统统不打疫苗，你们都死了才好咧
有些人傻乎乎苦口婆心劝你们打疫苗，才是真的傻
COVID一直是大多数轻症，折腾到现在就是为了挽救少数不是轻症甚至会死亡的人。这个药得早期吃才有效，所以只能预估一个人会不会发展成重症，也就是high risk的人群。现在是给high risk的人使用，如果效果良好副作用低广泛应用才有意义吧，如果副作用太大，就没有广泛应用的意义了。其实疫苗既然不妨传染，也给high risk的人群用就好了，没必要全民打。
正是。医生有权开出自己觉得合适的处方，现在却是政府说了算，还打压。
估计这个药不好卖了，连批都批的晚一天
可能看到抑制剂就以为是抑制核酸复制的。不知道其实大部分药物是蛋白酶抑制剂😺
我骂的是反疫苗宣传阴谋论的。你如果不反疫苗，为什么要跑来对号入座讨骂？是猪脑子吗？还是说你确实是反疫苗，又没脸承认，所以暗戳戳地偷换概念来达到替反疫苗阴谋论出头的目的？