好像来不及跟merck一起赚钱了。原来可能过于自信，phase 2 只招100个人，其中2/3都是年轻（平均37岁）无基础病的轻症。结果在无基础病的人中治不治无区别，剩余一小组有基础病的中有些用。所以他们又得去修改他们的phase 3, 春天等不到三期结果了 Oct. 19, 2021 (GLOBE NEWSWIRE) -- Atea Pharmaceuticals, Inc. (Nasdaq: AVIR) (“Atea”), a clinical-stage biopharmaceutical company, today reported that the global Phase 2 MOONSONG trial evaluating AT-527 in the outpatient setting did not meet the primary endpoint of reduction from baseline in the amount of SARS-CoV-2 virus in patients with mild or moderate COVID-19 compared to placebo in the overall study population, of which approximately two thirds of patients were low-risk with mild symptoms. However, in high-risk patients with underlying health conditions, a reduction of viral load of approximately 0.5 log10 at Day 7 was observed at 550 mg (prespecified subgroup analysis) and 1,100 mg BID (exploratory subgroup analysis) compared with placebo. Based on the MOONSONG topline and additional recent results for AT-527 as well as the evolving COVID-19 environment, Atea, together with Roche, are assessing potential modifications to the global Phase 3 MORNINGSKY trial including the trial’s primary endpoint and patient population. As a result, we now anticipate Phase 3 MORNINGSKY data in the second half of 2022. The news is a bitter disappointment for Atea, which has spent the past 18 months touting the potential of AT-527, developed as a treatment for hepatitis C, to change the course of the Covid-19 pandemic. The company, which commanded a market value of about $3.4 billion as of Monday, fell 70% in premarket trading on Tuesday. https://finance.yahoo.com/news/atea-pharmaceuticals-provides-topline-results-110000980.html
Oct. 19, 2021 (GLOBE NEWSWIRE) -- Atea Pharmaceuticals, Inc. (Nasdaq: AVIR) (“Atea”), a clinical-stage biopharmaceutical company, today reported that the global Phase 2 MOONSONG trial evaluating AT-527 in the outpatient setting did not meet the primary endpoint of reduction from baseline in the amount of SARS-CoV-2 virus in patients with mild or moderate COVID-19 compared to placebo in the overall study population, of which approximately two thirds of patients were low-risk with mild symptoms. However, in high-risk patients with underlying health conditions, a reduction of viral load of approximately 0.5 log10 at Day 7 was observed at 550 mg (prespecified subgroup analysis) and 1,100 mg BID (exploratory subgroup analysis) compared with placebo.
Based on the MOONSONG topline and additional recent results for AT-527 as well as the evolving COVID-19 environment, Atea, together with Roche, are assessing potential modifications to the global Phase 3 MORNINGSKY trial including the trial’s primary endpoint and patient population. As a result, we now anticipate Phase 3 MORNINGSKY data in the second half of 2022.
The news is a bitter disappointment for Atea, which has spent the past 18 months touting the potential of AT-527, developed as a treatment for hepatitis C, to change the course of the Covid-19 pandemic. The company, which commanded a market value of about $3.4 billion as of Monday, fell 70% in premarket trading on Tuesday.
https://finance.yahoo.com/news/atea-pharmaceuticals-provides-topline-results-110000980.html
下跌的曲线非常感人啊