我们在湾区,我家男娃刚三岁,9月初送到这家华人开的family day care, 是一家经营多年口碑很不错的幼儿园。11个小娃,两位英文老师,另外一个生活阿姨是中国人。孩子去幼儿园的第一周,其中一位英文老师也是他们幼儿园工作了12年的最优秀的老师每天与我联络,有时发孩子相片给我,有时告诉我孩子的一些情况,我感觉她非常有爱心。9月11日周六晚上我主动给她发短信,感谢她们这一周的照顾,特别是周五孩子带回来的手印(脚印👣画)让我非常impressed,孩子也很喜欢这种活动。这位老师礼貌地回复了我,顺便和我介绍了一下她的家庭成员和工作经历。怎么都没有想到,这竟然是我们最后一次联系。 9月13日我送孩子去学校,就发现这位老师没有来,接下来几周她都没有来,学校找了临时的老师顶替。9月22日我们家长收到园长的邮件,告知近期学校有位员工在9月21日做了检测,9月22收到结果确诊了Covid-19, 她咨询了Licensing Department和Public Health Department, 因为这位老师在9月13到18号之前做过一次测试,结果是negative,认为她是在家里休息的那一周被家人传染,并没有将病毒带到学校,所以我们幼儿园不用关闭。 10月5号再次收到邮件,通知这位老师在10月4日已经过世。家长群里一片震惊和难过。现在我们幼儿园照常开着,小朋友都还是照常去,到目前没有听说其他感染情况。这位老师大概4,50岁,听说她平时身体就很不好,免疫力很低。难过了好几天,觉得一下子接受不了,打算为她做一点捐款。手机里还保留着她的短信,哎! 更新:园长说所有的老师职员都打过疫苗了,这位老师平时身体就很差免疫力很低。每周都要请1-2天假在家休息的。我们幼儿园孩子老师都是戴口罩的。
我们在湾区,我家男娃刚三岁,9月初送到这家华人开的family day care, 是一家经营多年口碑很不错的幼儿园。11个小娃,两位英文老师,另外一个生活阿姨是中国人。孩子去幼儿园的第一周,其中一位英文老师也是他们幼儿园工作了12年的最优秀的老师每天与我联络,有时发孩子相片给我,有时告诉我孩子的一些情况,我感觉她非常有爱心。9月11日周六晚上我主动给她发短信,感谢她们这一周的照顾,特别是周五孩子带回来的手印(脚印👣画)让我非常impressed,孩子也很喜欢这种活动。这位老师礼貌地回复了我,顺便和我介绍了一下她的家庭成员和工作经历。怎么都没有想到,这竟然是我们最后一次联系。 9月13日我送孩子去学校,就发现这位老师没有来,接下来几周她都没有来,学校找了临时的老师顶替。9月22日我们家长收到园长的邮件,告知近期学校有位员工在9月21日做了检测,9月22收到结果确诊了Covid-19, 她咨询了Licensing Department和Public Health Department, 因为这位老师在9月13到18号之前做过一次测试,结果是negative,认为她是在家里休息的那一周被家人传染,并没有将病毒带到学校,所以我们幼儿园不用关闭。 10月5号再次收到邮件,通知这位老师在10月4日已经过世。家长群里一片震惊和难过。现在我们幼儿园照常开着,小朋友都还是照常去,到目前没有听说其他感染情况。这位老师大概4,50岁,听说她平时身体就很不好,免疫力很低。难过了好几天,觉得一下子接受不了,打算为她做一点捐款。手机里还保留着她的短信,哎! Yujia666 发表于 2021-10-08 14:17
Pfizer vaccine is formally coded as "state of the art US weapon system" Check the definition of the redaction codes used https://www.archives.gov/declassification/iscap/redaction-codes.htmlhttps://www.acus.gov/recommendation/exemption-b4-freedom-information-act 3.3 (b) (4) Reveal information that would impair the application of state-of-the-art technology within a U.S. weapon system https://www.fda.gov/media/151733/download On page 6 of 30, redaction code (b) (4) refers to a weapon technology 3. Chemistry, Manufacturing and Controls (CMC) a. Product Quality COMIRNATY Manufacturing Overview COMIRNATY contains a nucleoside-modified messenger RNA (mRNA) encoding the viral spike glycoprotein (S) of SARS-CoV-2 that is formulated in lipids including ((4- hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2- hexyldecanoate), 2-(polyethylene glycol 2000)-N,N-ditetradecylacetamide, 1,2-distearoyl-sn-glycero-3-phosphocholine, and cholesterol. COMIRNATY is supplied as a frozen suspension to be diluted with a diluent, 0.9% Sodium Chloride Injection, USP, that is supplied separately or can be acquired elsewhere, if necessary. Manufacture of the mRNA drug substance will take place in Andover, MA, USA. The final formulated drug product will be manufactured, filled, finished, labeled and packaged in Puurs, Belgium or in Kalamazoo, MI, USA. The 0.9% Sodium Chloride Injection, USP diluent will be manufactured by Fresenius-Kabi USA, LLC (b) (4) ) and Hospira, Inc. (b) (4) The mRNA in COMIRNATY is a single-stranded, 5’-capped mRNA encoding the full- length SARS-CoV-2 spike glycoprotein derived from the Wuhan-Hu-1 isolate (GenBank MN908947.3 and GenBank QHD43416.1). The antigen-coding RNA sequence is codon- optimized and contains two proline mutations ( (b) (4)), which ensures an antigenically optimal trimerized pre-fusion confirmation (S-2P). The RNA also contains common structural elements, including 5’-cap, 5’-UTR, 3’-UTR, and poly(A) tail, all of which are designed for mediating high RNA stability and translation efficiency. During RNA transcription, (b) (4) is replaced with the (b) (4) . This nucleoside substitution has been demonstrated to enhance translation of in vitro transcribed mRNA while reducing its reactogenicity.
9月13日我送孩子去学校,就发现这位老师没有来,接下来几周她都没有来,学校找了临时的老师顶替。9月22日我们家长收到园长的邮件,告知近期学校有位员工在9月21日做了检测,9月22收到结果确诊了Covid-19, 她咨询了Licensing Department和Public Health Department, 因为这位老师在9月13到18号之前做过一次测试,结果是negative,认为她是在家里休息的那一周被家人传染,并没有将病毒带到学校,所以我们幼儿园不用关闭。
10月5号再次收到邮件,通知这位老师在10月4日已经过世。家长群里一片震惊和难过。现在我们幼儿园照常开着,小朋友都还是照常去,到目前没有听说其他感染情况。这位老师大概4,50岁,听说她平时身体就很不好,免疫力很低。难过了好几天,觉得一下子接受不了,打算为她做一点捐款。手机里还保留着她的短信,哎!
更新:园长说所有的老师职员都打过疫苗了,这位老师平时身体就很差免疫力很低。每周都要请1-2天假在家休息的。我们幼儿园孩子老师都是戴口罩的。
🔥 最新回帖
感冒每年也对免疫力差的人可能有致命危害。周边就曾有这样的数个例子。可惜从来没机会上任何新闻。
注册新ID是因为不想让别人认出来,湾区华人圈子小,发这个帖子只是想找个树洞倾诉一下。老师去世一周了,也没有很多人知道这件事情,我认识她所以感叹难过。 不明白这又有什么引导性了??
这帖子有明显的引导性,注册一个新ID来发很让人怀疑真实性。你也知道不然也不会注册一个新ID来发。
这跟有没有共情毫无关系。上来就用这种抹黑不让人说话还真是有意思。
🛋️ 沙发板凳
老师应该都打过了吧
rip
哎
有新闻链接吗?
未必
打过了。
我们这里有位年纪大的老师 一直战战兢兢 买菜都是instacart 和我说她挣的那点工资都花在买菜上了
我的天啊,这太令人伤心了
还好还好万幸没有传染给幼儿园其他人
这位死了老师的有什么基础病吗?
新闻链接???
嗯 是的 不过这位老师大概是家里过到的 这个真的很惨
現在COVID每死掉一人,都上個新聞?
免疫力很低的话疫苗其实打了也是白打
daycare 老师是 community service,local news 多数会报道。
这位老师体型较胖,具体什么基础疾病我也不清楚。但外表看着非常和蔼健康。
真的假的 我从没见过
可惜了, RIP. 我们学校有个体育老师也重症了,是个胖子,好在抢救过来了
你们幼儿园带口罩吗
我们幼儿园孩子老师都要求戴口罩,每天进门测体温。
想问他们都打疫苗了吗?
故事还可以这样写:因为是不打疫苗的传染给她的。
两个未知,其他的确实没打疫苗
你想多了。我认识的一个服务业的也covid去世了,没打疫苗,也没上新闻。家人和顾客募捐。
那需要70万条新闻,如果每条来个notification,手机估计挂了
每天都死惹人,死人不是新闻。中国人被撞被杀也只是在自己华人圈子里
你是从我们中国人客气那种说体型较胖吗,还是真的就是大胖子
肥胖是真的非常容易被COVID搞倒得,去年COVID刚开始的时候,那时候媒体还报道每一个死亡案例的时候,就有不少是胖子
每天要死1400多人
幼稚的问题
免疫力低的是不是应该一查出阳性就去搞单抗治疗?感觉疫苗对高风险也不特别有用。这种打了疫苗得COVID死的,在现在力推疫苗的大环境下估计不会多少媒体跟进
应该可以先去查抗体 如果抗体低 感染了就第一时间单抗
不是说建议免疫力低的,年龄大的都要去打疫苗吗?
嗯
尼玛都是命。
不一定. 我工作这个agency是最受impacted的政府部门之一, 去年去世的有个别报道, 这两个月几个covid去世都没报道.
歪楼,10米身价现在成了“也就”?贫困线10米了!?
理解。身体不行,多少钱都没用
坑爹啊 不过有单抗大概率死不了
没有选择。能选择呆家里的是少部分。底层人民普遍身体更差
免疫差一般是免疫类疾病,糖尿病之类的。没有基础病,肥胖,和老的话,不属于免疫差
人家老师打过了呀,没啥服不服的。
免疫力低打了也是白打-确实之前看到研究说免疫力低下的不容易产生抗体 所以疫苗对他们意义不大
然而 免疫力强的不打估计得了问题也不大 那这么强迫大家打是为哪般?
无奈的现实是:越需要保护的群体,efficay越小。越不需要的群体,efficacy越大。
这真的是
现代医学发展遇到了瓶颈
她当family care的英文老师,接触的人应该还算比较少的,职业门槛也低,也不用面对恶劣天气,其实很适合身体不好的人 不然去当收银员之类的更危险了
没打疫苗的人COVID死了才会上新闻
这都有10m了,别让女儿回家啦,年轻人整天外面浪,回家没好事。扔点钱给女 儿,让她外面租房子住
可是加强针是免疫力低才有资格打呀,要是打了也白打,干嘛还去冒那个(副作用的)险
老板这麽优秀,为什麽女儿大学退学?
请问什么是单抗治疗?
RIP. sigh
Volleyball player collapses during game, dies https://www.thehindu.com/news/cities/Mangalore/volleyball-player-collapses-during-game-dies/article34185430.ece
Christian Eriksen Collapses at Euros due to heart issue
Indonesian doubles star Kido dies of heart attack at 36
Britain's Jack Draper collapses at Miami Open
Ghanaian referee collapses during AFCON Match
Two West Indies Players – Chinelle Henry, Chedean Nation Collapse on Field: https://www.india.com/sports/cricket-two-west-indies-players-chinelle-henry-chedean-nation-collapse-on-field-during-2nd-t20i-against-pakistan-women-watch-video-4785827/
Brazilian soccer player Alex Apolinario dies after collapsing on pitch during match in Portugal https://www.cbssports.com/soccer/news/brazilian-soccer-player-alex-apolinario-dies-after-collapsing-on-pitch-during-match-in-portugal/
Josh Downie: Cricketer, 24, dies after heart attack at practice https://www.bbc.co.uk/news/uk-england-nottinghamshire-57058626
Atletico Madrid striker collapses in training and requires medical attention
Referee Bert Smith collapses on court, taken off on stretcher during first half of Gonzaga-USC men's Elite Eight game
Raymond van Barneveld collapses and receives paramedic attention during PDC Players Championship https://www.dailystar.co.uk/sport/darts/pdc-players-championship-8-suspended-23759939
Ex-Parma footballer Giuseppe Perrino dies aged 29 at brother’s memorial match after collapsing while playing
Ethan Jovani Trejo, a 16-year-old soccer player, collapsed on the field during conditioning https://eu.cincinnati.com/story/news/2021/06/25/teen-dies-after-medical-incident-princeton-high-school-field/5344293001/
Vinny Curry, 33, out for season due to blood clots: https://nypost.com/2021/08/25/jets-vinny-curry-out-after-rare-blood-disorder-diagnosis/
Samuel Kalu, 24, collapses minutes into football game: https://www.bbc.com/sport/football/58228778
Francis Perron, 25, dies after football game - https://www.cbc.ca/news/canada/ottawa/usports-ottawa-gee-gees-francis-perron-dies-1.6182332
Bollywood’s star, 40, dies following heart attack https://www.dailymail.co.uk/news/article-9950385/Indian-TV-film-star-Siddharth-Shukla-40-dies-heart-attack.html#reader-comments
Tom Felton, 34, collapses during golf game: https://bbc.in/3i4YpI5?fbclid=IwAR0aZBaXpiX9ky34g3eLiG3pcMs5r2udih4kRGUIi7GOBK3iciefX1-qoXkThe Frenchman, 20, suddenly fell unconscious in worrying and distressing scenes, he had a tachycardia attack, an abnormal electrical impulse in his heart, causing him to lose consciousness. https://www.thesun.co.uk/sport/football/13901939/goalkeepers-rushed-hospital-collapsing/
FA Youth Cup - player suffered sudden cardiac arrest on the field : https://www.mirror.co.uk/sport/football/news/breaking-fa-youth-cup-match-24898627
Roy Butler, 23, Irish footballer Watford FC dies after Jansen: https://twitter.com/NewsForAllIre/status/1428301909715296263?s=20
Two young Columbia High school footballers die: https://www.wistv.com/2021/09/04/he-would-love-it-donadrian-robinsons-family-reacts-tribute-wj-keenan-high-school/?outputType=apps
Australian sailor Cameron Dale, 29, dies after catastrophic stroke: https://7news.com.au/sport/sailing/australian-sailor-jessica-watson-reveals-sudden-death-of-partner-cameron-dale-c-3845979
Yusuke Kinoshita, 27, baseball pro dies 7 weeks post vaccine: https://thecovidworld.com/yusuke-kinoshita-27-year-old-japanese-professional-baseball-player-dies-7-weeks-after-covid-19-vaccine/
Jeremy Chardy, 34, tennis pro cannot train or play after vaccine: https://www.tennisworldusa.org/tennis/news/Tennis_Interviews/102836/jeremy-chardy-i-regret-getting-vaccinated-i-have-series-of-problems-now/
Jimmy Hayes, 31, former Bruins player unexpectedly dies: https://www.bostonglobe.com/2021/08/23/sports/jimmy-hayes-former-bruin-boston-college-hockey-champ-dies-31/ Parys Haralson, 37, former Saints line backer dies https://www.usatoday.com/story/sports/nfl/2021/09/13/parys-haralson-former-49-ers-and-saints-lb-dies-37/8328669002/
Kjeld Nuis, 31, Dutch professional skater admitted to hospital with inflamed heart: https://www.rtlboulevard.nl/entertainment/news/artikel/5243606/kjeld-nuis-vaccinatie-ziek-update
Francesca Marcon, 38, volleybal professional can’t play, has pericarditis post vaccine: https://www.lapressa.it/notiziario/sport/la-campionessa-di-volley-ho-una-pericardite-post-vaccino
John Stokes, 21, athlete at Tennessee Uni hospitalized with heart inflammation: https://www.yahoo.com/lifestyle/student-athlete-john-stokes-myocarditis-covid-vaccine-002451374.html?guccounter=1
Jake Ehlinger, 20, found dead - cause unknown: https://usdaynews.com/celebrities/celebrity-death/sam-ehlinger-brother-death-cause/
Shocking ,但意料之中。我这样的人打了疫苗尚且心脏一直不行,平时只能散步不敢跑了。运动员更是心脏负担比一般人大很多,很容易heart attack 。不过他们有些打没打疫苗不清楚。
打疫苗还不一定能保护这些人
然而我们也没有办法知道了
感觉就是美国大多数都感染过了
76% of September Covid-19 deaths are vax breakthroughs
防重症快骗不下去了吧
怪就怪在 既然没啥大用 还副作用一堆 那各种强制 大家不觉得奇怪吗?想想历史上那么多疫苗 有哪个把人逼的工作都丢了?关键这所谓的疫苗效果嘛要啥没啥 副作用吗倒是各种你想到想不到的都出来了 这个病毒死亡率嘛保守都是99%能活 小孩那就更是跟流感差不多了 那这么十八般武器软硬皆施的非要人人打 到底是为了啥 越想越不对劲啊 大家不觉得吗?
疫苗致死致残的也是real啊
对啊,人家打了疫苗,而且在自食其力辛勤工作,怎么叫专治不服?
我也不懂这个case里面大家到底要服啥
不知道,可能觉得这个老师应该老老实实蹲家里躺平了领钱抗疫?
就是如此。 從小到大打過的疫苗,都是能幾乎百分百防止得病,才要求接種。這個疫苗不防感染,也不防重症,還強迫大眾打?
現在不僅不防重症,連死亡也不防。這種明目張膽的謊言居然現在還能騙過很多人。
Christian Eriksen Collapses at Euros due to heart issue
Two West Indies Players – Chinelle Henry, Chedean Nation Collapse on Field: https://www.india.com/sports/cricket-two-west-indies-players-chinelle-henry-chedean-nation-collapse-on-field-during-2nd-t20i-against-pakistan-women-watch-video-4785827/
Atletico Madrid striker collapses in training and requires medical attention
Brazilian soccer player Alex Apolinario dies after collapsing on pitch during match in Portugal https://www.cbssports.com/soccer/news/brazilian-soccer-player-alex-apolinario-dies-after-collapsing-on-pitch-during-match-in-portugal/
Britain's Jack Draper collapses at Miami Open
Indonesian doubles star Kido dies of heart attack at 36
Ghanaian referee collapses during AFCON Match
Referee Bert Smith collapses on court, taken off on stretcher during first half of Gonzaga-USC men's Elite Eight game
Josh Downie: Cricketer, 24, dies after heart attack at practice https://www.bbc.co.uk/news/uk-england-nottinghamshire-57058626
Ex-Parma footballer Giuseppe Perrino dies aged 29 at brother’s memorial match after collapsing while playing https://www.thesun.co.uk/sport/football/15151824/giuseppe-perrino-dead-29-parma-brother/
Raymond van Barneveld collapses and receives paramedic attention during PDC Players Championship https://www.dailystar.co.uk/sport/darts/pdc-players-championship-8-suspended-23759939
Volleyball player collapses during game, dies https://www.thehindu.com/news/cities/Mangalore/volleyball-player-collapses-during-game-dies/article34185430.ece
The Frenchman, 20, suddenly fell unconscious in worrying and distressing scenes, he had a tachycardia attack, an abnormal electrical impulse in his heart, causing him to lose consciousness. https://www.thesun.co.uk/sport/football/13901939/goalkeepers-rushed-hospital-collapsing/
Ethan Jovani Trejo, a 16-year-old soccer player, collapsed on the field during conditioning https://eu.cincinnati.com/story/news/2021/06/25/teen-dies-after-medical-incident-princeton-high-school-field/5344293001/
Samuel Kalu, 24, collapses minutes into football game: https://www.bbc.com/sport/football/58228778
Roy Butler, 23, Irish footballer Watford FC dies after Jansen: https://twitter.com/NewsForAllIre/status/1428301909715296263?s=20
FA Youth Cup - player suffered sudden cardiac arrest on the field : https://www.mirror.co.uk/sport/football/news/breaking-fa-youth-cup-match-24898627
Vinny Curry, 33, out for season due to blood clots: https://nypost.com/2021/08/25/jets-vinny-curry-out-after-rare-blood-disorder-diagnosis/
Australian sailor Cameron Dale, 29, dies after catastrophic stroke: https://7news.com.au/sport/sailing/australian-sailor-jessica-watson-reveals-sudden-death-of-partner-cameron-dale-c-3845979
Two young Columbia High school footballers die: https://www.wistv.com/2021/09/04/he-would-love-it-donadrian-robinsons-family-reacts-tribute-wj-keenan-high-school/?outputType=apps
Bollywood’s star, 40, dies following heart attack https://www.dailymail.co.uk/news/article-9950385/Indian-TV-film-star-Siddharth-Shukla-40-dies-heart-attack.html#reader-comments
Tom Felton, 34, collapses during golf game: https://bbc.in/3i4YpI5?fbclid=IwAR0aZBaXpiX9ky34g3eLiG3pcMs5r2udih4kRGUIi7GOBK3iciefX1-qoXk
Francis Perron, 25, dies after football game - https://www.cbc.ca/news/canada/ottawa/usports-ottawa-gee-gees-francis-perron-dies-1.6182332
Parys Haralson, 37, former Saints line backer dies https://www.usatoday.com/story/sports/nfl/2021/09/13/parys-haralson-former-49-ers-and-saints-lb-dies-37/8328669002/
Jimmy Hayes, 31, former Bruins player unexpectedly dies: https://www.bostonglobe.com/2021/08/23/sports/jimmy-hayes-former-bruin-boston-college-hockey-champ-dies-31/
Kjeld Nuis, 31, Dutch professional skater admitted to hospital with inflamed heart: https://www.rtlboulevard.nl/entertainment/news/artikel/5243606/kjeld-nuis-vaccinatie-ziek-update
John Stokes, 21, athlete at Tennessee Uni hospitalized with heart inflammation: https://www.yahoo.com/lifestyle/student-athlete-john-stokes-myocarditis-covid-vaccine-002451374.html?guccounter=1
Jake Ehlinger, 20, found dead - cause unknown: https://usdaynews.com/celebrities/celebrity-death/sam-ehlinger-brother-death-cause/
Jeremy Chardy, 34, tennis pro cannot train or play after vaccine: https://www.tennisworldusa.org/tennis/news/Tennis_Interviews/102836/jeremy-chardy-i-regret-getting-vaccinated-i-have-series-of-problems-now/
Francesca Marcon, 38, volleybal professional can’t play, has pericarditis post vaccine: https://www.lapressa.it/notiziario/sport/la-campionessa-di-volley-ho-una-pericardite-post-vaccino
Yusuke Kinoshita, 27, baseball pro dies 7 weeks post vaccine: https://thecovidworld.com/yusuke-kinoshita-27-year-old-japanese-professional-baseball-player-dies-7-weeks-after-covid-19-vaccine/
Check the definition of the redaction codes used https://www.archives.gov/declassification/iscap/redaction-codes.html https://www.acus.gov/recommendation/exemption-b4-freedom-information-act 3.3 (b) (4) Reveal information that would impair the application of state-of-the-art technology within a U.S. weapon system
https://www.fda.gov/media/151733/download On page 6 of 30, redaction code (b) (4) refers to a weapon technology
3. Chemistry, Manufacturing and Controls (CMC) a. Product Quality
COMIRNATY Manufacturing Overview COMIRNATY contains a nucleoside-modified messenger RNA (mRNA) encoding the viral spike glycoprotein (S) of SARS-CoV-2 that is formulated in lipids including ((4- hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2- hexyldecanoate), 2-(polyethylene glycol 2000)-N,N-ditetradecylacetamide, 1,2-distearoyl-sn-glycero-3-phosphocholine, and cholesterol. COMIRNATY is supplied as a frozen suspension to be diluted with a diluent, 0.9% Sodium Chloride Injection, USP, that is supplied separately or can be acquired elsewhere, if necessary. Manufacture of the mRNA drug substance will take place in Andover, MA, USA. The final formulated drug product will be manufactured, filled, finished, labeled and packaged in Puurs, Belgium or in Kalamazoo, MI, USA. The 0.9% Sodium Chloride Injection, USP diluent will be manufactured by Fresenius-Kabi USA, LLC (b) (4) ) and Hospira, Inc. (b) (4)
The mRNA in COMIRNATY is a single-stranded, 5’-capped mRNA encoding the full- length SARS-CoV-2 spike glycoprotein derived from the Wuhan-Hu-1 isolate (GenBank MN908947.3 and GenBank QHD43416.1). The antigen-coding RNA sequence is codon- optimized and contains two proline mutations ( (b) (4)), which ensures an antigenically optimal trimerized pre-fusion confirmation (S-2P). The RNA also contains common structural elements, including 5’-cap, 5’-UTR, 3’-UTR, and poly(A) tail, all of which are designed for mediating high RNA stability and translation efficiency. During RNA transcription, (b) (4) is replaced with the (b) (4) . This nucleoside substitution has been demonstrated to enhance translation of in vitro transcribed mRNA while reducing its reactogenicity.