第一个 COVID-19 - Blood IgG Antibody COVID-19 Total Antibody 结果是 Non-Reactive A Non-Reactive test result does not rule out the possibility of an infection with SARS-CoV-2. Serum or plasma samples from the early (pre-seroconversion) phase of illness can yield negative findings. Therefore, this test cannot be used to diagnose an acute infection. Testing with molecular diagnostic should be performed to evaluate for active infection in symptomatic individuals. It is not known at this time if the presence of antibodies to SARS-CoV-2 confers immunity to reinfection. False positive (Reactive) results for the test may occur due to cross-reactivity. The Roche Covid-19 Total Antibody test was developed, and its performance characteristics determined by Roche for the COBAS e411. The FDA has authorized this test for EUA.
第二个 COVID-19 - Blood Spike Protein Ab value reference range COVID-19 Spike Total Ab 899.40H <0.80 (U/mL) Anti SARS CoV-2S is for qualitative and semi-quantitative detection of antibodies to "SARS-CoV-2 spike (S) protein receptor-binding domain (RBD)" in human serum and plasma. The platform used is an electrochemiluminescence immunoassay performed on the Roche COBAS e analyzer. This assay is intended to identify individuals with an adaptive immune response to SARS CoV-2, indicating recent or prior infection. The Elecsys Anti SARS CoV-2 assay should not be used to diagnose acute SARS CoV-2 infection. It is yet undetermined what antibody level to SARS CoV-2 spike protein correlates to immunity against developing symptomatic SARS -CoV-2 disease. Studies are underway to measure the quantitative levels of specific SARS CoV-2 antibodies following vaccination. Such studies will provide valuable insights into the correlation between protection from vaccination and antibody levels. Interpretation: Negative: Less Than 0.80 U/mL Positive: Greater Than or Equal to 0.80 U/mL This test has not been F.D.A. cleared or approved. F.D.A. has authorized this test under an Emergency Use Authorization (E.U.A.). This test is only authorized for the duration of the declaration that circumstances exist justifying the authorization of emergency use of in vitro diagnostics for detection and/ or diagnosis of COVID-19 under Section 564 (b) (1) of the Act, 21 U.S.C. 360bbb-3 (b) (1), unless the authorization is terminated or revoked sooner. This test has been authorized only for detecting the presence of antibodies against SARS-CoV-2, not for any other viruses or pathogens. This test was performed at Summit Medical Group, PA. CLIA # 31D0116144. Dir: G. Katava, DO
有长期保护作用的是IgG，楼主可能是打了疫苗但是时间比较短，所以没有测出IgG。 打了疫苗和感染获得的IgG的不同是，感染会同时有N protein IgG, and S protein IgG，而疫苗只能测出S protein IgG.
lingling7 发表于 2021-08-30 12:20
刚才又ｇｏｏｇｌｅ了以下，觉得您说得可能不对。 Positive: You produced the COVID-19 IgG antibody and have a high likelihood of prior infection. Some patients with past infections may not have experienced any symptoms. It is unclear at this time if a positive IgG infers immunity against future COVID-19 infection. Please continue with universal precautions: social distancing, hand washing and when applicable PPE such as masks or gloves. Negative: You tested negative for COVID-19 IgG antibody. This means you have not been infected with COVID-19. Please note, it may take 14-21 days to produce detectable levels of IgG following infection. If you had symptoms consistent with COVID-19 within the past 3 weeks and tested negative, repeat testing in 1-2 weeks may yield a positive result.
根据google来的结果， 第一项lgN，是测以前是否感染过。（只是不能完全排除最近期的感染，因为需要时间让病毒表达出来）。 - IgG COVID-19 Antibody (Blood Test): - This was the first antibody test developed for COVID-19 – it potentially identifies antibodies created by you in response to an infection in order to fight the COVID-19 virus. It does NOT test for antibodies made in response to COVID-19 vaccination. https://www.citymd.com/spike-protein-antibody-blood-test-faq
根据google来的结果， 第一项lgN，是测以前是否感染过。（只是不能完全排除最近期的感染，因为需要时间让病毒表达出来）。 - IgG COVID-19 Antibody (Blood Test): - This was the first antibody test developed for COVID-19 – it potentially identifies antibodies created by you in response to an infection in order to fight the COVID-19 virus. It does NOT test for antibodies made in response to COVID-19 vaccination. https://www.citymd.com/spike-protein-antibody-blood-test-faq Grace302 发表于 2021-08-30 17:23
感染和疫苗都会产生covid病毒蛋白IgG阳性。covid的病毒有两种蛋白，一种是N protein，另一种是spike protein。如果是疫苗产生的IgG阳性，那么因为疫苗只含有spike protein，所以只有可能是spike protine specific IgG test 阳性，N protein specific IgG test阴性。你的IgG 结果如果包含这两种protein，就说明疫苗没有给你长期的antibody 保护。 还有你的检测结果比较奇怪的是，照理来说，过了3个月，IgM早就应该检测不到了，但是你这个lgM level还是很高的。
- IgG COVID-19 Antibody (Blood Test): - This was the first antibody test developed for COVID-19 – it potentially identifies antibodies created by you in response to an infection in order to fight the COVID-19 virus. It does NOT test for antibodies made in response to COVID-19 vaccination.
- IgG COVID-19 Antibody (Blood Test): - This was the first antibody test developed for COVID-19 – it potentially identifies antibodies created by you in response to an infection in order to fight the COVID-19 virus. It does NOT test for antibodies made in response to COVID-19 vaccination. Grace302 发表于 2021-08-30 22:08
https://www.cdc.gov/coronavirus/2019-ncov/lab/resources/antibody-tests-guidelines.html The results of available anti-SARS-CoV-2 IgG serologic tests may be interpreted in the following way: In a person never vaccinated: testing positive for antibody against either N, S, or RBD indicates prior natural infection In a vaccinated person: testing positive for antibody against the vaccine antigen target, such as the S protein, and negative for other antigens suggests that they have produced vaccine-induced antibody and that they were never infected with SARS-CoV-2 testing positive for any antibody other than the vaccine-induced antibody, such as the N protein, indicates resolving or resolved SARS-CoV-2 infection that could have occurred before or after vaccination. 至于你的推论有部分道理但也不完全一定。因为有些人感染很轻或者无症状，也有很多人感染以后很长时间，IgG也会转阴，说明长期抗体会减弱甚至消失。这也是为什么现在一直要打booster，因为有人打完疫苗也未必产生IgG，或者强度不够，比如你就是。这么说吧，如果打完疫苗后IgG阳性，并不能区分到底是曾经感染还是疫苗产生的抗体。但你是打完疫苗后IgG阴性，也只能说明疫苗或者曾经感染没产生长期抗体，至于到底是哪种情况，仅靠IgG一项指标无法区分。而你现在IgM阳性，也不能区分到底是疫苗导致的阳性，还是近期感染导致的，所以才需要测N蛋白来区分。
------------------------------------------------------------------------------------------------------------------------ 更新： 我的理解，第一个lgG测试，排除了曾经感染的可能性（只是不能完全排除最近的感染，因为需要时间让病毒表达出来）。不需要测什么N PROTEIN. 第二个测试，疫苗产生了抗体。 所以，结论是：疫苗产生了抗体，并且以往未曾感染。
但是有人认为，我的理解是错误的。 按照他的说法：有抗体，但因为打了疫苗，所以不能确定之前是否感染过。 必须再去测N PROTEIN才能知道是否感染过。
请继续讨论，期待高人指点。
参考： https://www.citymd.com/spike-protein-antibody-blood-test-faq https://www.labcorp.com/coronavirus-disease-covid-19/providers/antibody-test
第一个 COVID-19 - Blood IgG Antibody
COVID-19 Total Antibody 结果是 Non-Reactive A Non-Reactive test result does not rule out the possibility of an infection with SARS-CoV-2. Serum or plasma samples from the early (pre-seroconversion) phase of illness can yield negative findings. Therefore, this test cannot be used to diagnose an acute infection. Testing with molecular diagnostic should be performed to evaluate for active infection in symptomatic individuals. It is not known at this time if the presence of antibodies to SARS-CoV-2 confers immunity to reinfection. False positive (Reactive) results for the test may occur due to cross-reactivity. The Roche Covid-19 Total Antibody test was developed, and its performance characteristics determined by Roche for the COBAS e411. The FDA has authorized this test for EUA.
第二个 COVID-19 - Blood Spike Protein Ab
value reference range COVID-19 Spike Total Ab 899.40 H <0.80 (U/mL)
Anti SARS CoV-2S is for qualitative and semi-quantitative detection of antibodies to "SARS-CoV-2 spike (S) protein receptor-binding domain (RBD)" in human serum and plasma. The platform used is an electrochemiluminescence immunoassay performed on the Roche COBAS e analyzer. This assay is intended to identify individuals with an adaptive immune response to SARS CoV-2, indicating recent or prior infection. The Elecsys Anti SARS CoV-2 assay should not be used to diagnose acute SARS CoV-2 infection. It is yet undetermined what antibody level to SARS CoV-2 spike protein correlates to immunity against developing symptomatic SARS -CoV-2 disease. Studies are underway to measure the quantitative levels of specific SARS CoV-2 antibodies following vaccination. Such studies will provide valuable insights into the correlation between protection from vaccination and antibody levels. Interpretation: Negative: Less Than 0.80 U/mL Positive: Greater Than or Equal to 0.80 U/mL This test has not been F.D.A. cleared or approved. F.D.A. has authorized this test under an Emergency Use Authorization (E.U.A.). This test is only authorized for the duration of the declaration that circumstances exist justifying the authorization of emergency use of in vitro diagnostics for detection and/ or diagnosis of COVID-19 under Section 564 (b) (1) of the Act, 21 U.S.C. 360bbb-3 (b) (1), unless the authorization is terminated or revoked sooner. This test has been authorized only for detecting the presence of antibodies against SARS-CoV-2, not for any other viruses or pathogens. This test was performed at Summit Medical Group, PA. CLIA # 31D0116144. Dir: G. Katava, DO
谢谢回复，我是医学盲，只能从字面理解。 不知道理解得对不对。
你这人也是，楼主要是看懂了还发帖问什么？像你一样多此一举吗？ 你要明白就给人家解释解释，不明白就闭嘴，没必要显示优越感。
谢谢回复。
我觉得第二个检测是说明疫苗起作用了，对吧？ 谢谢指教。
今年五月底打第二针。
谢谢顶贴。
你这又是 哪个 举 ？
你理解完全 正确！
疫苗一定是起作用了，只是不太懂900大概是什么range？因为疫苗作用会waning，不知道多少算高，多少算低？
打了疫苗和感染获得的IgG的不同是，感染会同时有N protein IgG, and S protein IgG，而疫苗只能测出S protein IgG.
你有这怂人的功夫好好给别人解释一下。
莫德纳还是辉瑞啊？三个月了还有这么高的抗体浓度
我是专门去的，保险付。
谢谢回复。 我是五月底打完的ｐｆｉｚｅｒ第二针。 现在三个月了，如果还没测出来ｌｇｎ，是不是也不会再有了？
ｃｉｔｙｍｄ，保险付，不知道多少。
ｐｆｉｚｅｒ。
刚才又ｇｏｏｇｌｅ了以下，觉得您说得可能不对。
Positive: You produced the COVID-19 IgG antibody and have a high likelihood of prior infection. Some patients with past infections may not have experienced any symptoms. It is unclear at this time if a positive IgG infers immunity against future COVID-19 infection. Please continue with universal precautions: social distancing, hand washing and when applicable PPE such as masks or gloves. Negative: You tested negative for COVID-19 IgG antibody. This means you have not been infected with COVID-19. Please note, it may take 14-21 days to produce detectable levels of IgG following infection. If you had symptoms consistent with COVID-19 within the past 3 weeks and tested negative, repeat testing in 1-2 weeks may yield a positive result.
疫苗接种的原理其实就是利用比原本致病病毒更安全的抗原成分，让人体模拟自然感染病毒而产生免疫反应的过程，所以在接种后，身体会如自然感染病毒一样，在短期内先产生IgM抗体，IgM抗体水平会逐渐降低，在稍后时间还会产生持续时间更长的IgG抗体。
谢谢回复。 这个和我的理解符合。 ｓｐｉｋｅ ｐｒｏｔｅｉｎ检测结果，说明我或者打了疫苗，或者感染过。
ｌｇｎ检测结果，说明我没有得过ｃｏｖｉｄ。
两者综合，就是说，打过疫苗，但是没有实际感染过。
华人上象你这种反问的风气特别不好 人家诚心诚意上来问问题 知道就回答不知道就算了 没必要既不帮助人还要显得你比人家聪明
在打过疫苗的情况下，Igm和Igg都看不出来，因为感染和疫苗都会导致这俩阳性，要查N蛋白才能确定是否有曾经感染过，不过你如果不需要回国的话，也没必要专门去测一下吧
恕我愚昧，ｌｇｎ不是查Ｎ蛋白的吗？
你好像没查ign吧，报告结果是igg和s蛋白而已，而且就没有ign这个说法呢
谢谢指点。 那就是说，我之前的理解是错误的。 彻底糊涂了，之前有人说我的理解是正确的呀。
按照你的说法，我检测的结果是，有抗体，但搞不清是疫苗接种产生的，还是以前感染过。
恕我言辞不严谨，医学盲一个，呵呵。
但是根据citymd的说法，lgG测试，已经排除了曾经感染的可能性，只是不能完全排除最近的感染，因为需要时间让它表现出来。 所以查lgN没有必要了呀。
第一项是总抗体，第二项针对S蛋白的抗体也应该在第一项中体现出来呀。为什么第一项没有呢？
根据google来的结果， 第一项lgN，是测以前是否感染过。（只是不能完全排除最近期的感染，因为需要时间让病毒表达出来）。
- IgG COVID-19 Antibody (Blood Test): - This was the first antibody test developed for COVID-19 – it potentially identifies antibodies created by you in response to an infection in order to fight the COVID-19 virus. It does NOT test for antibodies made in response to COVID-19 vaccination.
https://www.citymd.com/spike-protein-antibody-blood-test-faq
感染和疫苗都会产生covid病毒蛋白IgG阳性。covid的病毒有两种蛋白，一种是N protein，另一种是spike protein。如果是疫苗产生的IgG阳性，那么因为疫苗只含有spike protein，所以只有可能是spike protine specific IgG test 阳性，N protein specific IgG test阴性。你的IgG 结果如果包含这两种protein，就说明疫苗没有给你长期的antibody 保护。
还有你的检测结果比较奇怪的是，照理来说，过了3个月，IgM早就应该检测不到了，但是你这个lgM level还是很高的。
谢谢回复。 说实话，没看懂，不明觉厉，呵呵。
能不能用简单语言科普下，就说，我的理解对不对吧？如果错了，错在哪里？
lz你的概念真的很混乱，首先没有IgN这个东西，我不知道你把哪个当成IgN了自己在这瞎命名。
IgM是病毒感染早期产生的抗体，因为mRNA也是类似病毒感染的模式，所以无论你是近期感染，还是近期打了疫苗，都可能产生IgM。
IgG是晚期抗体，就是你过了刚感染/接种之后，康复了，体内保留的抗体。但也有很多人康复和打疫苗以后自体并不产生抗体，所以IgG同样不能区分你是否感染过。
针对美国疫苗，目前唯一能确认是否有感染过的办法就是测N蛋白，大使馆已经说的很清楚了，光测S蛋白也不能区分。目前只知道mRNA对N蛋白没有刺激反应，但感染和灭活蛋白都会导致N蛋白也阳性。你也没打过灭活疫苗，所以只要测一下N蛋白，就能清楚是否曾经感染了，但我觉得如果你不回国的话，并没有多大意义。因为无论你是否曾经感染，还是疫苗起效，最终的目的都是希望产生IgG长期抗体，你又非不去测N蛋白，想用其他的有限数据推导一个结论，这根本站不住脚。
S蛋白，N蛋白是作为抗原检测IgM和IgG抗体的，不同的概念不能混为一谈。隔壁文学城也有类似的讨论，你去看看别人说的吧，别老纠结自己的结论到底是对还是错，不看别人给你的解释。 https://bbs.wenxuecity.com/health/966075.html
你错在一直把IgG当成IgN，然后以为它是N蛋白！
这个我认识到了，见笑。 但是，我还是认为，lgG测试可以查出来之前是否感染过，不用专门查N PROTEIN.
- IgG COVID-19 Antibody (Blood Test): - This was the first antibody test developed for COVID-19 – it potentially identifies antibodies created by you in response to an infection in order to fight the COVID-19 virus. It does NOT test for antibodies made in response to COVID-19 vaccination.
well，你引用的这个解释肯定是不完全对的，写的人大概并不了解现在的研究。
https://www.nature.com/articles/s41564-021-00947-3
据权威学术期刊《自然》（Nature）的调查结果： 打完第二剂辉瑞、莫德纳等mRNA疫苗的8周后，接种者的IgM、IgG抗体水平仍然非常高。
https://www.cdc.gov/coronavirus/2019-ncov/lab/resources/antibody-tests-guidelines.html The results of available anti-SARS-CoV-2 IgG serologic tests may be interpreted in the following way: In a person never vaccinated: testing positive for antibody against either N, S, or RBD indicates prior natural infection In a vaccinated person: testing positive for antibody against the vaccine antigen target, such as the S protein, and negative for other antigens suggests that they have produced vaccine-induced antibody and that they were never infected with SARS-CoV-2 testing positive for any antibody other than the vaccine-induced antibody, such as the N protein, indicates resolving or resolved SARS-CoV-2 infection that could have occurred before or after vaccination.
至于你的推论有部分道理但也不完全一定。因为有些人感染很轻或者无症状，也有很多人感染以后很长时间，IgG也会转阴，说明长期抗体会减弱甚至消失。这也是为什么现在一直要打booster，因为有人打完疫苗也未必产生IgG，或者强度不够，比如你就是。这么说吧，如果打完疫苗后IgG阳性，并不能区分到底是曾经感染还是疫苗产生的抗体。但你是打完疫苗后IgG阴性，也只能说明疫苗或者曾经感染没产生长期抗体，至于到底是哪种情况，仅靠IgG一项指标无法区分。而你现在IgM阳性，也不能区分到底是疫苗导致的阳性，还是近期感染导致的，所以才需要测N蛋白来区分。
同意以上回复的说法