Little_Racoon 想问妳: Novavax 疫苗能否刺激 T 细胞免疫?

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JamesPotter
楼主 (北美华人网)
像mRNA疫苗或是AstraZeneca疫苗会在细胞表现S蛋白所以一定会有T-cell的反应
这是不是意味着Novavax疫苗不会刺激T-cell反应呢?
Little_Raccon妳有这方面的资讯吗?
J
JamesPotter
自己顶
x
xinfoall
坐等小浣熊。 按照下面链接,Novavax 也产生 T-cells (see the section for Novavax). https://www.yalemedicine.org/news/covid-19-vaccine-comparison
How it works: Unlike the mRNA and vector vaccines, this is a protein adjuvant (an adjuvant is an ingredient used to strengthen the immune response). While other vaccines trick the body’s cells into creating parts of the virus that can trigger the immune system, the Novavax vaccine takes a different approach. It contains the spike protein of the coronavirus itself, but formulated as a nanoparticle, which cannot cause disease. When the vaccine is injected, this stimulates the immune system to produce antibodies and T-cell immune responses.

南京菜农
我可以1小时内随手召唤10个美国 biomed 博士回答这个问题,也可以从哈尔滨兽医所到中国 CDC 召唤10个土博士回答这个问题,不过没有意义啊。~~
J
JamesPotter
坐等小浣熊。 按照下面链接,Novavax 也产生 T-cells (see the section for Novavax). https://www.yalemedicine.org/news/covid-19-vaccine-comparison
How it works: Unlike the mRNA and vector vaccines, this is a protein adjuvant (an adjuvant is an ingredient used to strengthen the immune response). While other vaccines trick the body’s cells into creating parts of the virus that can trigger the immune system, the Novavax vaccine takes a different approach. It contains the spike protein of the coronavirus itself, but formulated as a nanoparticle, which cannot cause disease. When the vaccine is injected, this stimulates the immune system to produce antibodies and T-cell immune responses.


xinfoall 发表于 2021-07-14 04:38

https://www.nytimes.com/interactive/2020/health/novavax-covid-19-vaccine.html
我也看到这个
理论上Antigen presenting cells可以把 S 蛋白吞噬了以後用 MHC 把抗原表现给 T-cell 看,所以应该也有 T-cell 免疫。
不过还是希望 Little_Racoon 解释一下是不是 mRNA & 腺病毒疫苗刺激 T-cell 效果更好。
感谢!