原论文是这么说的，没看懂： Results: A total of 9 retrospective cohort studies with 1,270,179 patients were included. A meta-analysis revealed that metformin intake was associated with an increased recurrence-free survival (HR = 0.55, 95% confidence interval [CI] = 0.35–0.88; P = .01; I2 = 64%), improved progression-free survival (HR = 0.70, 95% CI = 0.51–0.96; P = .03; I2 = 33%), and prolonged cancer-specific survival (HR = 0.57, 95% CI = 0.40–0.81; P = .002; I2 = 0%). However, results demonstrated that metformin intake was not associated with a decreased incidence of bladder cancer (HR = 0.82, 95% CI = 0.61–1.09; P = .17; I2 = 85%) or an increased overall survival in bladder cancer patients (HR = 0.83, 95% CI = 0.47–1.44; P = .50; I2 = 64%). Conclusion: The present meta-analysis indicated that metformin intake could improve the prognosis of bladder cancer patients. Further prospective cohort studies and mechanistic studies are still required to determine the precise role of metformin in the initiation and progression of bladder cancer.
回复 38楼kekkai的帖子 Metformin, the well-known drug often prescribed for Type 2 diabetes, was recalled by the US Food and Drug Administration (FDA) on May 28, after testing found high levels of the carcinogen N-nitrosodimethylamine (NDMA). https://www.mayoclinic.org/drugs-supplements/pioglitazone-and-metformin-oral-route/precautions/drg-20063126 This medicine may increase the risk for bone fractures in women. Ask your doctor about ways to keep your bones strong to help prevent fractures. This medicine may increase your risk for bladder cancer if you take it for more than 12 months. Tell your doctor right away if you have blood in the urine, a frequent, strong, or increased urge to urinate, painful urination, or pain in the back, lower abdomen, or stomach.
All of them agree that metformin’s effects have been under-studied, in part because there isn’t much of a financial incentive for the pharmaceutical industry to research the impact of an extremely cheap, generic drug. That could explain why doctors don’t routinely recommend it to people without diabetes, and why metformin hasn’t made it into the mainstream.
回复 38楼kekkai的帖子 Metformin, the well-known drug often prescribed for Type 2 diabetes, was recalled by the US Food and Drug Administration (FDA) on May 28, after testing found high levels of the carcinogen N-nitrosodimethylamine (NDMA). https://www.mayoclinic.org/drugs-supplements/pioglitazone-and-metformin-oral-route/precautions/drg-20063126 This medicine may increase the risk for bone fractures in women. Ask your doctor about ways to keep your bones strong to help prevent fractures. This medicine may increase your risk for bladder cancer if you take it for more than 12 months. Tell your doctor right away if you have blood in the urine, a frequent, strong, or increased urge to urinate, painful urination, or pain in the back, lower abdomen, or stomach. springbee 发表于 2021-07-06 21:21
"Tell your doctor right away if you have blood in the urine, a frequent, strong, or increased urge to urinate, painful urination, or pain in the back, lower abdomen, or stomach."
回复 54楼springbee的帖子 这个链接里是没有recall。 recall这段话是Google直接显示的。google keyword metaformin bladder cancer 会搜出很多文章。比如：Why the FDA Recalled Metformin Over a Cancer-Causing Agent (verywellhealth.com) 我知道这个药也是因为我妈以前一直在吃。吃了有几年。然后从去年底开始每天定点腹痛一个小时左右。痛的全身出汗的那种。后来各种检查，医生怀疑是膀胱癌。我们家从没有人得过膀胱癌。我就开始怀疑是不是吃的药引发的。随手Google了一下。发现metaformin可以增加的膀胱癌的机率。后来药停了。她的腹痛也好了很多。现在也确诊下来不是膀胱癌。算是松了一口气。但是药是不敢继续吃了。她现在还是时不时的会有腹痛，但是比起以前是好太多了。
能不能具体说说什么方面
Walking aggressively 20 min after meal can have similar effect on insulin resistance
wow
能不能具体讲讲细节，那岂不是普通人更应该吃了？
这个药不是处方药吗？怎么可能amazon有卖？
吃完饭多久去走呢？吃完就出去走对胃不好
amazon上有卖书，讲怎么用自然方法reverse diabetes, 下面不少留言说，吃metformin, 吃久了觉得有stomach upset, 然后用书中的办法，控制好了血糖。
普通人中为啥不推广呢
求个书名
不会
mm, 能说一下书名嘛？给老人看看
是药三分毒，特别是西药，没有副作用的药只有可能是安慰剂。
Thanks for sharing
我爸也是吃了两三年的样子，一直说吃了肠胃不舒服，每天在厕所里待很久，今年换了胰岛素就好了
对，我也听过，感觉说的神乎其神，神药一样。
对啊，为什么
原论文是这么说的，没看懂： Results: A total of 9 retrospective cohort studies with 1,270,179 patients were included. A meta-analysis revealed that metformin intake was associated with an increased recurrence-free survival (HR = 0.55, 95% confidence interval [CI] = 0.35–0.88; P = .01; I2 = 64%), improved progression-free survival (HR = 0.70, 95% CI = 0.51–0.96; P = .03; I2 = 33%), and prolonged cancer-specific survival (HR = 0.57, 95% CI = 0.40–0.81; P = .002; I2 = 0%). However, results demonstrated that metformin intake was not associated with a decreased incidence of bladder cancer (HR = 0.82, 95% CI = 0.61–1.09; P = .17; I2 = 85%) or an increased overall survival in bladder cancer patients (HR = 0.83, 95% CI = 0.47–1.44; P = .50; I2 = 64%).
Conclusion: The present meta-analysis indicated that metformin intake could improve the prognosis of bladder cancer patients. Further prospective cohort studies and mechanistic studies are still required to determine the precise role of metformin in the initiation and progression of bladder cancer.
正常人血糖没问题的话，医生也不会给你开这个药啊。
对的。要开的话，只有找那种冷门的nutrition doc或者longevity specialist，这种医生你说他forward thinking也好，说为了挣钱没规范也可以。：））
前几年对metformin最大的研究不仅仅是抗衰老，更重要的是有些医生觉得使用metformin的人得肿瘤的概率降低或者得了肿瘤后治疗效果更好些。这也是metaformin-hype的一部分，而且很多临床数据的分析也支持这个结论。就如同你这个文章就是分析metformin和膀胱癌的关系，结论就是metformin对于治疗膀胱癌有一定帮助，但是它不会降低膀胱癌的发生率。所以之前那个人说的增加膀胱癌的几率，我也是一脸黑人问号？
这个药算是副作用非常小，效果好，价格低的治疗糖尿病的药，几乎没有副作用。当然有人爱说是药三分毒，尤其是西药这种话，首先中药肝毒是导致中国很多肝癌发生率高的一个原因，雷公藤类的药物滥用，所以药物毒性不分东西，只是中药缺乏系统的分析手段而已，所以显得没有毒性了。其次每个人对药物的耐受性不同，药物的剂量只能保证绝大部分人得到比较好的药效和比较低的毒性反应，但是每个人的体质不同，反应也不一样，不要因为一两个人的反应盲目地去否定一个药。举个不恰当的例子，有人喝一升水就肚涨想吐，有的人什么事都没有，你不能说这水有问题。
这药是唯一进入临床实验的抗衰老药
妹妹的回帖真专业，可惜只能赞一次！ 感谢！
看来一定要去读paper具体说了什么，而不是人云亦云的看个标题
临床试验有结果了吗
知道一个吃了几十年的，身体超级好，老了没一处有毛病。
吃药当然是要权衡利弊的。中药更毒，你还不知道怎么个毒法
同求
英语是什么
sustained release缓释
https://www.amazon.com/Diabetes-Code-Prevent-Reverse-Naturally/dp/1771642653/ref=tmm_pap_swatch_0?_encoding=UTF8&qid=1625617320&sr=1-3
https://www.amazon.com/Dr-Bernsteins-Diabetes-Solution-Achieving/dp/0316182699/ref=tmm_hrd_swatch_0?_encoding=UTF8&qid=1625617429&sr=8-17
Metformin Extended Release 简称 metformin ER
Metformin, the well-known drug often prescribed for Type 2 diabetes, was recalled by the US Food and Drug Administration (FDA) on May 28, after testing found high levels of the carcinogen N-nitrosodimethylamine (NDMA).
https://www.mayoclinic.org/drugs-supplements/pioglitazone-and-metformin-oral-route/precautions/drg-20063126
This medicine may increase the risk for bone fractures in women. Ask your doctor about ways to keep your bones strong to help prevent fractures. This medicine may increase your risk for bladder cancer if you take it for more than 12 months. Tell your doctor right away if you have blood in the urine, a frequent, strong, or increased urge to urinate, painful urination, or pain in the back, lower abdomen, or stomach.
你吃多久了？看到一篇文章说很多有钱人在吃这个药：https://www.cnbc.com/2019/03/23/metformin-for-cancer-prevention-longevity-popular-in-silicon-valley.html 里面有一个观点很有意思，说药厂没有动力研究这个药的长寿作用的实验，因为这个药已经太便宜了，没有financial return。即使这样也还是有很多正面结果，就说明这个药很可能是有效的
All of them agree that metformin’s effects have been under-studied, in part because there isn’t much of a financial incentive for the pharmaceutical industry to research the impact of an extremely cheap, generic drug. That could explain why doctors don’t routinely recommend it to people without diabetes, and why metformin hasn’t made it into the mainstream.
你给的链接里没有说到recall的事？
这些副作用是针对pioglitazone的，你给的link是combo drug
我的医生曾经给我开过低剂量的，因为我那段时间压力肥+血糖接近pre-d, 基因测试还有type 2 diabetic risk，最后还是没敢吃，靠着好好睡觉+锻炼减下来了。
这个链接里是没有recall。 recall这段话是Google直接显示的。google keyword metaformin bladder cancer 会搜出很多文章。比如：Why the FDA Recalled Metformin Over a Cancer-Causing Agent (verywellhealth.com)
我知道这个药也是因为我妈以前一直在吃。吃了有几年。然后从去年底开始每天定点腹痛一个小时左右。痛的全身出汗的那种。后来各种检查，医生怀疑是膀胱癌。我们家从没有人得过膀胱癌。我就开始怀疑是不是吃的药引发的。随手Google了一下。发现metaformin可以增加的膀胱癌的机率。后来药停了。她的腹痛也好了很多。现在也确诊下来不是膀胱癌。算是松了一口气。但是药是不敢继续吃了。她现在还是时不时的会有腹痛，但是比起以前是好太多了。
动心了怎么办。。。想减肥的话，吃什么剂量的呢？
这么说是又安全又能有效减肥。。。动心了
家里老人吃这个药胃不舒服。另一位老人得糖尿病比较早，45周岁开始得的，吃这个药（国内好像也叫消渴丸，都是二甲双胍的成分），60来岁的时候就不怎么好用了，即使计量很大也不管用。
没病别乱吃药
这是什么原理
有1年多了。 目前没有感到任何问题。 当然体重没啥改变
我也是。 握爪
。
正常人吃会对肾脏造成什么长期影响
在肾功能还好的情况下是治疗type 2 diabetes 最好的药。最常见的副作用是拉肚子，一般会建议刚开始一天服用500mg 两次, 如果没什么肠胃反应，可以一天服用1000mg 两次。 如果肾功能比较差，就不能服用这个药， 可能会引起lactate acidosis, 不过这个极少见到，一般是在教科书上看到。前几天一个墨西哥大妈就因为服用这个药引起了非常严重的 lactate acidosis （估计不经常follow up，肾功能有问题自己不知道还继续服用） , 在急诊市的时候身体ph 6.9, 我昨天离开医院的时候还插着管，血压很低，不知道挺不挺得过来。