这里还有一个新鲜出炉的关于来源的报道 from🇹🇼媒体 https://www.taiwannews.com.tw/en/news/4104828 WHO inspector caught on camera revealing coronavirus manipulation in Wuhan before pandemic Video shows scientist mention coronavirus experimentation in Wuhan lab weeks before pandemic 115722 Tweet By , Taiwan News, Staff Writer 2021/01/18 00:31 In a video that was originally taken on Dec. 9, 2019, three weeks before the Wuhan Municipal Health Commission announced an outbreak of a new form of pneumonia, virologist Vincent Racaniello interviewed British zoologist and president of EcoHealth Alliance Peter Daszak about his work at the nonprofit to protect the world from the emergence of new diseases and predict pandemics. Since 2014, Daszak''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''s organization has received millions of dollars of funding from the U.S. National Institutes of Health (NIH), which it has funneled to the WIV to carry out research on bat coronaviruses. In the first phase of research, which took place from 2014 to 2019, Daszak coordinated with Shi Zhengli, (石正麗), also known as "Bat Woman," at the WIV on investigating and cataloging bat coronaviruses across China. EcoHealth Alliance received US$3.7 million in funding from the NIH for this research and 10 percent was channeled to the WIV, reported . The second, more dangerous phase, which started in 2019, involved gain-of-function (GoF) research on coronaviruses and chimeras in humanized mice from the lab of Ralph S. Baric of the University of North Carolina. Funding for the program was withdrawn by the NIH under the Trump administration on April 27 amid the pandemic. At the 28:10 mark of the podcast interview, Daszak states that researchers found that SARS likely originated from bats and then set out to find more SARS-related coronaviruses, eventually finding over 100. He observed that some coronaviruses can "get into human cells in the lab," and others can cause SARS disease in "humanized mouse models." He ominously warned that such coronaviruses are "untreatable with therapeutic monoclonals [antibodies] and you can’t vaccinate against them with a vaccine." Ironically, he claims that his team''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''s goal was trying to find the next "spillover event" that could cause the next pandemic, mere weeks before cases of COVID-19 were beginning to be reported in Wuhan.
这里还有一个新鲜出炉的关于来源的报道 from🇹🇼媒体 https://www.taiwannews.com.tw/en/news/4104828 WHO inspector caught on camera revealing coronavirus manipulation in Wuhan before pandemic Video shows scientist mention coronavirus experimentation in Wuhan lab weeks before pandemic 115722 Tweet By , Taiwan News, Staff Writer 2021/01/18 00:31 In a video that was originally taken on Dec. 9, 2019, three weeks before the Wuhan Municipal Health Commission announced an outbreak of a new form of pneumonia, virologist Vincent Racaniello interviewed British zoologist and president of EcoHealth Alliance Peter Daszak about his work at the nonprofit to protect the world from the emergence of new diseases and predict pandemics. Since 2014, Daszak''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''s organization has received millions of dollars of funding from the U.S. National Institutes of Health (NIH), which it has funneled to the WIV to carry out research on bat coronaviruses. In the first phase of research, which took place from 2014 to 2019, Daszak coordinated with Shi Zhengli, (石正麗), also known as "Bat Woman," at the WIV on investigating and cataloging bat coronaviruses across China. EcoHealth Alliance received US$3.7 million in funding from the NIH for this research and 10 percent was channeled to the WIV, reported . The second, more dangerous phase, which started in 2019, involved gain-of-function (GoF) research on coronaviruses and chimeras in humanized mice from the lab of Ralph S. Baric of the University of North Carolina. Funding for the program was withdrawn by the NIH under the Trump administration on April 27 amid the pandemic. At the 28:10 mark of the podcast interview, Daszak states that researchers found that SARS likely originated from bats and then set out to find more SARS-related coronaviruses, eventually finding over 100. He observed that some coronaviruses can "get into human cells in the lab," and others can cause SARS disease in "humanized mouse models." He ominously warned that such coronaviruses are "untreatable with therapeutic monoclonals [antibodies] and you can’t vaccinate against them with a vaccine." Ironically, he claims that his team''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''s goal was trying to find the next "spillover event" that could cause the next pandemic, mere weeks before cases of COVID-19 were beginning to be reported in Wuhan.
这里还有一个新鲜出炉的关于来源的报道 from🇹🇼媒体 https://www.taiwannews.com.tw/en/news/4104828 WHO inspector caught on camera revealing coronavirus manipulation in Wuhan before pandemic Video shows scientist mention coronavirus experimentation in Wuhan lab weeks before pandemic 115722 Tweet By , Taiwan News, Staff Writer 2021/01/18 00:31 In a video that was originally taken on Dec. 9, 2019, three weeks before the Wuhan Municipal Health Commission announced an outbreak of a new form of pneumonia, virologist Vincent Racaniello interviewed British zoologist and president of EcoHealth Alliance Peter Daszak about his work at the nonprofit to protect the world from the emergence of new diseases and predict pandemics. Since 2014, Daszak''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''s organization has received millions of dollars of funding from the U.S. National Institutes of Health (NIH), which it has funneled to the WIV to carry out research on bat coronaviruses. In the first phase of research, which took place from 2014 to 2019, Daszak coordinated with Shi Zhengli, (石正麗), also known as "Bat Woman," at the WIV on investigating and cataloging bat coronaviruses across China. EcoHealth Alliance received US$3.7 million in funding from the NIH for this research and 10 percent was channeled to the WIV, reported . The second, more dangerous phase, which started in 2019, involved gain-of-function (GoF) research on coronaviruses and chimeras in humanized mice from the lab of Ralph S. Baric of the University of North Carolina. Funding for the program was withdrawn by the NIH under the Trump administration on April 27 amid the pandemic. At the 28:10 mark of the podcast interview, Daszak states that researchers found that SARS likely originated from bats and then set out to find more SARS-related coronaviruses, eventually finding over 100. He observed that some coronaviruses can "get into human cells in the lab," and others can cause SARS disease in "humanized mouse models." He ominously warned that such coronaviruses are "untreatable with therapeutic monoclonals [antibodies] and you can’t vaccinate against them with a vaccine." Ironically, he claims that his team''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''s goal was trying to find the next "spillover event" that could cause the next pandemic, mere weeks before cases of COVID-19 were beginning to be reported in Wuhan.
今天有两项十分重要的新型冠状病毒SARS-CoV-2两种关键突变株（英国/南非）的研究原始数据被公布：1. 剑桥大学Gupta实验室在推特展示了接种辉瑞/BioNTech的COVID-19疫苗BNT162b2对英国突变株B.1.1.7保护力变化的原始数据；2. 南非突变株的501.V2科学会议视频被上传到了YouTube，链接可见评论。
根据最新数据（图1），全球已有57个国家发现了英国B.1.1.7突变株；13个国家发现了南非501Y.V2突变株（即B.1.351株）。这两种突变株的输入性传播均在中国被检出。但从今天公布的数据看来，南非的501.V2毒株十分值得警惕。而我之前总结过的包括B.1.1.7和501.V2等含N501Y突变的毒株的一些体外实验原始数据可见以前的微博（O子陵在听歌）。
1. 截止到目前，Fred Hutch研究所的Bedford分析的6089个丹麦SARS-CoV-2病毒基因组序列中，3%为英国B.1.1.7突变株；3093个美国病毒基因组序列中，1%为B.1.1.7突变株。B.1.1.7所占比例增长十分迅速。今天剑桥大学教授、传染病医生及HIV耐药突变专家Ravindra Gupta在推特上传了他一个重要的实验结果。
Gutpa这项研究构建了B.1.1.7的假病毒，这个假病毒含有del69/70，del144/145，N501Y，A570D，P681H，T716I，S982A，D1118H突变。该研究选取了15名接受BNT162b2首次接种后21天的接种者血清，发现相比野生型毒株，这些接种者的血清对B.1.1.7的中和活性（ID50）显著下降，下降中位数为3.85倍（IQR 2.68-5.28）。虽然接种者血清对B.1.1.7中和活性下降，但接种者血清依然对该毒株具有中和活性（图2）。Gutpa认为del144/145突变可能对中和活性影响较大。之前强调过的，相比PRNT50/80，假病毒中和试验具有一定缺陷，因此现在还需要大样本量的疫苗加强接种7天以后的金标准中和试验进行进一步验证。
2. B.1.1.7虽然棘手，但从目前证据来看，南非毒突变株501Y.V2的E484（位于RBD内）突变对于既往感染和疫苗诱导的中和抗体的抵抗性更显著（O子陵在听歌）。华盛顿大学Bloom实验室之前上传的数据证明3/8的COVID-19康复者血清对E484K突变株的结合（或中和）活性降低10倍或以上（O子陵在听歌）。
Bloom组在今天南非突变株的501.V2的科学会议上进一步报道了随访研究，发现11个COVID-19康复患者中9个的血清样品对含E484突变的毒株的中和活性显著下降（82%），其中部分样本下降10倍以上。而来自南非国家传染病研究所（NICD）的研究结果更让人忧虑，该研究发现44个COVID-19康复患者中的21个的血清（48%）对501.V2突变株的完全失去了结合能力，即病毒表位发生了完全逃逸（图3）。这符合我们之前预测的病毒发生了抗原漂移（O子陵在听歌）。但幸运的是，T细胞对501.V2突变株的免疫反应依然保存，这可能在一定程度可以帮助宿主预防重复感染。
这两项研究结果分别提示，虽然COVID-19疫苗接种者血清对B.1.1.7假病毒中和活性下降，但依然对其具有一定中和活性；而COVID-19康复者血清对501.V2中和活性显著下降，在小型研究中48%的康复者血清对501.V2完全失去结合能力（病毒完全逃逸），因此501.V2可能发生了较完整的抗原漂移，这为全球抗疫带来了更大的挑战：追加疫苗接种有可能会成为现实，因此疫苗生产企业需要及早筹备针对新突变株疫苗的生产和投放。
44个康复患者血清是来自南非的"first wave”，所以时间大概是去年夏天，6个月以前。之前Bloom lab的结果是E484K变异能够降低很多康复患者血清的中和效果，现在直接用南非突变毒株做出来的结果更惊人，这个毒株已经能够让一小半6个月前得过新冠的人康复血清完全失效！这是个非常严重的信号。（E484K只是南非毒株上面的一个突变）
我个人的观点是这项研究进一步说明疫苗诱导的T细胞免疫至关重要，只有抗体没有T细胞免疫的疫苗碰到突变毒株以后有效率会大打折扣。另外很可能明年的这个时候疫苗需要重新设计，每年秋冬季节打一针covid shot将会成为新常态。
如果研究定论了，感觉这个南非病毒可能会诱发ADE吧。
谢谢科普。那以后就跟流感一样每年都打了
我记得Pfizer的疫苗是有T Cell response的，而Moderna的不是很明显，对吧？
打可能也没用，传染过程中再变异，人体产生的抗体不对版无作用不说，而且会导致ADE.
我以后可能流感疫苗也不会打了
这真是个产业
那怎么办。。。。。太绝望了。。。人类还有救么
这个文章说的是要指望T细胞
这个因人而异，但流感疫苗没有必要年年打，年年打也未必有效。
哦，学习了
话说，E484K在我们这里有了
https://www.seattletimes.com/seattle-news/health/a-worrying-coronavirus-mutation-is-discovered-in-washington-state-but-hasnt-spread/
https://www.taiwannews.com.tw/en/news/4104828
WHO inspector caught on camera revealing coronavirus manipulation in Wuhan before pandemic Video shows scientist mention coronavirus experimentation in Wuhan lab weeks before pandemic 115722 Tweet By , Taiwan News, Staff Writer 2021/01/18 00:31
In a video that was originally taken on Dec. 9, 2019, three weeks before the Wuhan Municipal Health Commission announced an outbreak of a new form of pneumonia, virologist Vincent Racaniello interviewed British zoologist and president of EcoHealth Alliance Peter Daszak about his work at the nonprofit to protect the world from the emergence of new diseases and predict pandemics. Since 2014, Daszak''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''s organization has received millions of dollars of funding from the U.S. National Institutes of Health (NIH), which it has funneled to the WIV to carry out research on bat coronaviruses.
In the first phase of research, which took place from 2014 to 2019, Daszak coordinated with Shi Zhengli, (石正麗), also known as "Bat Woman," at the WIV on investigating and cataloging bat coronaviruses across China. EcoHealth Alliance received US$3.7 million in funding from the NIH for this research and 10 percent was channeled to the WIV, reported .
The second, more dangerous phase, which started in 2019, involved gain-of-function (GoF) research on coronaviruses and chimeras in humanized mice from the lab of Ralph S. Baric of the University of North Carolina. Funding for the program was withdrawn by the NIH under the Trump administration on April 27 amid the pandemic.
At the 28:10 mark of the podcast interview, Daszak states that researchers found that SARS likely originated from bats and then set out to find more SARS-related coronaviruses, eventually finding over 100. He observed that some coronaviruses can "get into human cells in the lab," and others can cause SARS disease in "humanized mouse models."
He ominously warned that such coronaviruses are "untreatable with therapeutic monoclonals [antibodies] and you can’t vaccinate against them with a vaccine." Ironically, he claims that his team''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''s goal was trying to find the next "spillover event" that could cause the next pandemic, mere weeks before cases of COVID-19 were beginning to be reported in Wuhan.
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https://www.youtube.com/embed/IdYDL_RK--w
我脑海里飘过两个字：完蛋
这个Peter Daszak 很可疑，他一会说不知道RaTG13, 一会说放冰箱里就给忘了7年，直到去年疫情爆发才想起来，结果又被人挖出来他们早就拿蝙蝠病毒做gain-of-function实验。他还是中国坚持的世卫专家组成员调查病毒起源 (可想而知病毒起源能调查出什么结果了)。
CD8 最好的是AZ的，然后是Pfizer, moderna差不多是pfizer的一半 不过应该也够了 不过这不是一个月以前的旧闻嘛。
why ?
ic
谢谢科普