新冠疫苗有效期

MiMi777
楼主 (北美华人网)
打了疫苗以后管多久啊?
炫彩衣飞舞
确切时间还还不清楚,不过modern前几天说预计几年,因为至今4个月了中和抗体减弱极慢极慢
MiMi777
如果真的能够几年那真是太好了
平明寻白羽
有可能很长。前两天看到过一篇paper, SARS 患者,17年后依然记忆T细胞。
Article Published: 15 July 2020 SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls Nina Le Bert, Anthony T. Tan, Kamini Kunasegaran, Christine Y. L. Tham, Morteza Hafezi, Adeline Chia, Melissa Hui Yen Chng, Meiyin Lin, Nicole Tan, Martin Linster, Wan Ni Chia, Mark I-Cheng Chen, Lin-Fa Wang, Eng Eong Ooi, Shirin Kalimuddin, Paul Anantharajah Tambyah, Jenny Guek-Hong Low, Yee-Joo Tan & Antonio Bertoletti  Nature volume 584, pages457–462(2020)Cite this article 516k Accesses 144 Citations 9004 Altmetric Metrics details Abstract Memory T cells induced by previous pathogens can shape susceptibility to, and the clinical severity of, subsequent infections1. Little is known about the presence in humans of pre-existing memory T cells that have the potential to recognize severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here we studied T cell responses against the structural (nucleocapsid (N) protein) and non-structural (NSP7 and NSP13 of ORF1) regions of SARS-CoV-2 in individuals convalescing from coronavirus disease 2019 (COVID-19) (n = 36). In all of these individuals, we found CD4 and CD8 T cells that recognized multiple regions of the N protein. Next, we showed that patients (n = 23) who recovered from SARS (the disease associated with SARS-CoV infection) possess long-lasting memory T cells that are reactive to the N protein of SARS-CoV 17 years after the outbreak of SARS in 2003; these T cells displayed robust cross-reactivity to the N protein of SARS-CoV-2. We also detected SARS-CoV-2-specific T cells in individuals with no history of SARS, COVID-19 or contact with individuals who had SARS and/or COVID-19 (n = 37). SARS-CoV-2-specific T cells in uninfected donors exhibited a different pattern of immunodominance, and frequently targeted NSP7 and NSP13 as well as the N protein. Epitope characterization of NSP7-specific T cells showed the recognition of protein fragments that are conserved among animal betacoronaviruses but have low homology to ‘common cold’ human-associated coronaviruses. Thus, infection with betacoronaviruses induces multi-specific and long-lasting T cell immunity against the structural N protein. Understanding how pre-existing N- and ORF1-specific T cells that are present in the general population affect the susceptibility to and pathogenesis of SARS-CoV-2 infection is important for the management of the current COVID-19 pandemic.


These findings demonstrate that virus-specific T cells induced by infection with betacoronaviruses are long-lasting, supporting the notion that patients with COVID-19 will develop long-term T cell immunity. Our findings also raise the possibility that long-lasting T cells generated after infection with related viruses may be able to protect against, or modify the pathology caused by, infection with SARS-CoV-2.

平明寻白羽
这篇文章也支持有机会打灭活疫苗一定不要错过,有可能提供长期pan coronavirus protection.
Athen2015
业内估计是至少九个月 从一期试验者体内抗体浓度的数据来看
l
lunchmm
那灭活疫苗看来是有效期更长啊
缺德舅舅
预期几年没问题,具体多久,包括药厂在内没人知道。因为哪怕是第一个做实验的人,到现在也才几个月。
平明寻白羽
业内估计是至少九个月 从一期试验者体内抗体浓度的数据来看
Athen2015 发表于 2021-01-09 17:20

抗体没有了不可怕,细胞免疫记忆会保持很久。
csliz
回复 1楼MiMi777的帖子
有说一年的,估计应该有半年!
csliz
回复 7楼lunchmm的帖子
看不出来为啥?
MiMi777
家里有人坚决反对打任何疫苗,这样的人怎么说服呢?我自己还是想打
AppleLee45
可是covid 患者的抗体也没有几年啊!二次感染的陆陆续续地来
CleverBeaver
可是covid 患者的抗体也没有几年啊!二次感染的陆陆续续地来
AppleLee45 发表于 2021-01-09 19:22

这个一方面是由于变异

Athen2015
回复 13楼AppleLee45的帖子
COVID 康复后抗体维持四个月 疫苗要强很多。摩德纳的结果 一期的试验者九个月后抗体浓度还是维持得还不错
炫彩衣飞舞
回复 13楼AppleLee45的帖子

有研究证明mrna疫苗的保护率比得病后康复的效果好。
不过灭活的疫苗,应该没有得病后康复的保护率高
francesjj
要真能管几年就太好了,世界就太平多了。看起来反应挺大,受一次罪管几年。