BREAKING: Pfizer/BioNTech疫苗appears对英国/南非变种有效 study find

梅干茶泡饭
楼主 (北美华人网)
https://news.trust.org/item/20210108022715-m5obt Pfizer/BioNTech vaccine appears effective against mutation in new coronavirus variants -study
NEW YORK, Jan 7 (Reuters) - Pfizer Inc and BioNTech''s COVID-19 vaccine appeared to work against a key mutation in the highly transmissible new variants of the coronavirus discovered in the UK and South Africa, according to a laboratory study conducted by the U.S. drugmaker. The not-yet peer reviewed study by Pfizer and scientists from the University of Texas Medical Branch indicated the vaccine was effective in neutralizing virus with the so-called N501Y mutation of the spike protein.
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meetmylove2015
好消息
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ellecindy
Moderna的呢?对变异株有效吗?
梅干茶泡饭
Moderna的呢?对变异株有效吗?
ellecindy 发表于 2021-01-07 23:10

这要问Moderna啊
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hemonc
N501Y本来就不是最concerning的,E484K才是
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coalpilerd
太好了
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doorsopen
https://news.trust.org/item/20210108022715-m5obt Pfizer/BioNTech vaccine appears effective against mutation in new coronavirus variants -study
NEW YORK, Jan 7 (Reuters) - Pfizer Inc and BioNTech''s COVID-19 vaccine appeared to work against a key mutation in the highly transmissible new variants of the coronavirus discovered in the UK and South Africa, according to a laboratory study conducted by the U.S. drugmaker. The not-yet peer reviewed study by Pfizer and scientists from the University of Texas Medical Branch indicated the vaccine was effective in neutralizing virus with the so-called N501Y mutation of the spike protein.
梅干茶泡饭 发表于 2021-01-07 23:05

你没有贴完.测了的部分有效.但是还有一些变种没有测.
The researchers plan to run similar tests to see if the vaccine is effective against other mutations found in the UK and South African variants and hope to have more data within weeks.
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csliz
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csliz
回复 3楼ellecindy的帖子
MOSTLY THEY ARE VERY SIMILAR, mRNA BASED, SO LIKELY EFFECTIVE TOO
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mylittle9
敲木头。
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ellecindy
回复 9楼csliz的帖子
谢谢!
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andyconnor
太好了
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ellecindy
问Moderna的主要原因就是目前新的一批打得好像都是Moderna的。希望能对南非/英国变异株有效
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drugdealer
这结果是在预料之中的。 病毒需要保持spike protein适合人类的ACE受体,更重要的是receptor binding domain(RBD)受体适合。 如果是个大量改变这些部分的mutation,能突变能逃避针对spike protein和RBD的疫苗那么也就难以容易感染人类了。
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andyconnor
那就不出门了,专心在家等疫苗
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Viviennedd
好事啊!
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VozProgresiva
很可惜, 美国最大量的是astraZeneca
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Abbots
不知道国产的灭活疫苗对变异有效吗
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isabel
这结果是在预料之中的。 病毒需要保持spike protein适合人类的ACE受体,更重要的是receptor binding domain(RBD)受体适合。 如果是个大量改变这些部分的mutation,能突变能逃避针对spike protein和RBD的疫苗那么也就难以容易感染人类了。
drugdealer 发表于 2021-01-07 23:30

道理是没错,就是怕病毒进化出利用其他受体的RBD. 记得还有另外一个受体可以用的,但是表达那个受体的细胞没有表达Ace2的多
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Darkangle008
希望有效!这几天天天bad news完全没出门,凌晨才睡着,郁闷的不得了
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CleverBeaver
https://news.trust.org/item/20210108022715-m5obt Pfizer/BioNTech vaccine appears effective against mutation in new coronavirus variants -study
NEW YORK, Jan 7 (Reuters) - Pfizer Inc and BioNTech''''''''''''''''s COVID-19 vaccine appeared to work against a key mutation in the highly transmissible new variants of the coronavirus discovered in the UK and South Africa, according to a laboratory study conducted by the U.S. drugmaker. The not-yet peer reviewed study by Pfizer and scientists from the University of Texas Medical Branch indicated the vaccine was effective in neutralizing virus with the so-called N501Y mutation of the spike protein.
梅干茶泡饭 发表于 2021-01-07 23:05

lz是说uk变异和南非变异共有的那个吗?这个好像是预知会work的
hemonc同学讲的对,南非变异里有但uk变异里没有的那个才是有问题的
这里有一个在巴西的二次感染,第二次的strain测序就含有E484K Spike Mutation

https://www.preprints.org/manuscript/202101.0132/v1
We report the first case of reinfection from genetically distinct SARS-CoV-2 lineage presenting the E484K spike mutation in Brazil, a variant associated with escape from neutralizing antibodies.
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CleverBeaver
N501Y本来就不是最concerning的,E484K才是
hemonc 发表于 2021-01-07 23:14

+1
查了一下 大多数同一时间刊登了这篇新闻稿的媒体都还挺正直的 很清晰的说了仅包含british variant
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CleverBeaver
lz没贴全
The not-yet peer reviewed study by Pfizer and scientists from the University of Texas Medical Branch indicated the vaccine was effective in neutralizing virus with the so-called N501Y mutation of the spike protein.
The mutation could be responsible for greater transmissibility and there had been concern it could also make the virus escape antibody neutralization elicited by the vaccine, said Phil Dormitzer, one of Pfizer's top viral vaccine scientists.
The study was conducted on blood taken from people who had been given the vaccine. Its findings are limited, because it does not look at the full set of mutations found in either of the new variants of the rapidly spreading virus. Dormitzer said it was encouraging that the vaccine appears effective against the mutation, as well as 15 other mutations the company has previously tested against.
"So we've now tested 16 different mutations, and none of them have really had any significant impact. That's the good news," he said. "That doesn't mean that the 17th won't."
Dormitzer noted another mutation found in the South African variant, called the E484K mutation, is also concerning.
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Bmhr01233210
意料之中的
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chenshuise
好!求快打疫苗 再快点
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playagame
管用不管用都快点打好吗 时间就是生命 没变的病毒也还在
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Temporarilycalm
而且就算现在的疫苗对新的变异无效,mRNA疫苗是可以编辑的啊,并不需要从头开始搞个新疫苗,不理解都在担心啥
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CleverBeaver
而且就算现在的疫苗对新的变异无效,mRNA疫苗是可以编辑的啊,并不需要从头开始搞个新疫苗,不理解都在担心啥
Temporarilycalm 发表于 2021-01-08 00:37

你要想变异是怎么来的 又是怎么会有选择优势的
昨天看推特上说疫苗不改变fatality rate 我还没去查过
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somuch
天天盼着快轮上打疫苗呢
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somuch
而且就算现在的疫苗对新的变异无效,mRNA疫苗是可以编辑的啊,并不需要从头开始搞个新疫苗,不理解都在担心啥
Temporarilycalm 发表于 2021-01-08 00:37

我们都不担心。就是WM带节奏啊。
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doorsopen
而且就算现在的疫苗对新的变异无效,mRNA疫苗是可以编辑的啊,并不需要从头开始搞个新疫苗,不理解都在担心啥
Temporarilycalm 发表于 2021-01-08 00:37

新的疫苗发展测试审批和发放都需要时间,人力和物力...有些传染疾病到现在也没有疫苗...
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francesjj
看了这么多天,感觉轮上去打疫苗,但要拜拜希望没有大的副作用;然后还得继续尽量家蹲,出门戴口罩,因为好多不确定因素啊。Lower expectation for 2021。。。