https://www.wired.com/story/heres-a-plan-to-stop-the-coronavirus-from-mutating/ 最近看到很多科普文章说新冠在免疫力有缺陷的病人体内可以快速变异 （HIV infections allow other viruses in the individual to last longer and morph. Herpes simplex virus can evolve unusual drug-resistance in AIDS patients, for example） 于是我又想到了最初排除武汉p4有问题的关键点在于石发表的冠状毒序列和新冠病毒的序列差异有点大，光靠自然进化的速度不够 （我也一直没想明白什么样的环境可以提供足够强大的selective pressure） 现在uk和南非变异的出现及其原因的解释等于是补充了这一个missing link…… hiv和蝙蝠都是用来帮助制造一个immunodeficienct的环境，进而加速冠状毒的变异 这也很好的解释了为何hiv研究出身的Fauci会说新冠是一个big flu，因为在免疫力缺失的环境下新冠病毒会高速变异，疫苗也只能专攻部分序列，永远跟不上新序列的产生 当然 谜团并未完全解开 比如疫情初期为何美帝也帮着圆 说没人工修改的痕迹？ 我仍然倾向p4也好美帝也罢，很可能原来只是想借冠状毒搞一种新型疫苗，不用打针，靠人群自然传播即可。可能中间发生了什么意想不到的变故，比如和其它什么病毒混了一下，致病性大大的增强了，还由舌吻传播变成了空气传播，才导致了今天的结果
I don’t think I have made any conclusions... only observations also, from BBC https://www.bbc.com/news/health-55388846 about the uk mutation Where has it come from? The variant is unusually highly mutated. The most likely explanation is the variant has emerged in a patient with a weakened immune system that was unable to beat the virus. Instead their body became a breeding ground for the virus to mutate.
Will the vaccines work against the new variant? Almost certainly yes, or at least for now. All three leading vaccines develop an immune response against the existing spike, which is why the question comes up. Vaccines train the immune system to attack several different parts of the virus, so even though part of the spike has mutated, the vaccines should still work. "But if we let it add more mutations, then you start worrying," said Prof Gupta. "This virus is potentially on a pathway for vaccine escape, it has taken the first couple of steps towards that." Vaccine escape happens when the virus changes so it dodges the full effect of the vaccine and continues to infect people. This may be the most concerning element of what is happening with the virus. This variant is just the latest to show the virus is continuing to adapt as it infects more and more of us. A presentation by Prof David Robertson, from the University of Glasgow on Friday, concluded: "
The virus will probably be able to generate vaccine escape mutants
在主流媒体里 bbc算是有脊梁的 没有避重就轻 对比一下 我们的媒体是这么写的 https://www.sfgate.com/coronavirus/article/mutant-COVID-strain-California-UK-Newsom-Fauci-15836808.php Fauci urges calm as mutated COVID-19 strain from UK found in California Eric Ting | on December 30, 2020 Photo: Jae Hong / Associated Press California Gov. Gavin Newsom holds up a vial of the Pfizer-BioNTech COVID-19 vaccine at Kaiser Permanente Los Angeles Medical Center in Los Angeles, Monday, Dec. 14, 2020. California became the second state to report a case of the mutated COVID-19 strain from the United Kingdom when Gov. Gavin Newsom announced its presence during a Facebook Live conversation with Dr. Anthony Fauci on Wednesday afternoon. Newsom announced the strain — which U.K. scientists estimate spreads 70% more easily than the main strain in the United States — has been detected in Southern California. Fauci said it''s not a surprise the strain is in the state and urged residents to remain calm. "I don''t think Californians should feel this is something odd; this is something expected," he said. Colorado became the first state to report the new strain on Tuesday, but health experts have stated that newly approved vaccines should still work against the variant, and being infected by a prior strain should also confer immunity against this strain. "There''s no indication at all that it increases the virulence, and by virulence I mean the ability to make you sick or kill you," Fauci told Newsom. "It doesn''t seem to make it more strong in that regard. In addition, it doesn''t seem to evade the protection from the antibodies induced by vaccines. The other thing they''ve noted in the U.K. is people who have been infected don''t seem to be reinfected by this." Fauci told Newsom to expect more cases going forward and said federal officials continue to study the strain. 真的没有对比就没有伤害 从一开始的cdc完全不设防，到现在完全淡化uk变异的重要性，我对美帝的防疫抗议工作实在是服气的
https://www.wired.com/story/heres-a-plan-to-stop-the-coronavirus-from-mutating/ 最近看到很多科普文章说新冠在免疫力有缺陷的病人体内可以快速变异 （HIV infections allow other viruses in the individual to last longer and morph. Herpes simplex virus can evolve unusual drug-resistance in AIDS patients, for example） 于是我又想到了最初排除武汉p4有问题的关键点在于石发表的冠状毒序列和新冠病毒的序列差异有点大，光靠自然进化的速度不够 （我也一直没想明白什么样的环境可以提供足够强大的selective pressure） 现在uk和南非变异的出现及其原因的解释等于是补充了这一个missing link…… hiv和蝙蝠都是用来帮助制造一个immunodeficienct的环境，进而加速冠状毒的变异 这也很好的解释了为何hiv研究出身的Fauci会说新冠是一个big flu，因为在免疫力缺失的环境下新冠病毒会高速变异，疫苗也只能专攻部分序列，永远跟不上新序列的产生 当然 谜团并未完全解开 比如疫情初期为何美帝也帮着圆 说没人工修改的痕迹？ 我仍然倾向p4也好美帝也罢，很可能原来只是想借冠状毒搞一种新型疫苗，不用打针，靠人群自然传播即可。可能中间发生了什么意想不到的变故，比如和其它什么病毒混了一下，致病性大大的增强了，还由舌吻传播变成了空气传播，才导致了今天的结果 CleverBeaver 发表于 2021-01-02 03:23
最近看到很多科普文章说新冠在免疫力有缺陷的病人体内可以快速变异 （HIV infections allow other viruses in the individual to last longer and morph. Herpes simplex virus can evolve unusual drug-resistance in AIDS patients, for example）
于是我又想到了最初排除武汉p4有问题的关键点在于石发表的冠状毒序列和新冠病毒的序列差异有点大，光靠自然进化的速度不够 （我也一直没想明白什么样的环境可以提供足够强大的selective pressure）
现在uk和南非变异的出现及其原因的解释等于是补充了这一个missing link…… hiv和蝙蝠都是用来帮助制造一个immunodeficienct的环境，进而加速冠状毒的变异
这也很好的解释了为何hiv研究出身的Fauci会说新冠是一个big flu，因为在免疫力缺失的环境下新冠病毒会高速变异，疫苗也只能专攻部分序列，永远跟不上新序列的产生
当然 谜团并未完全解开 比如疫情初期为何美帝也帮着圆 说没人工修改的痕迹？
我仍然倾向p4也好美帝也罢，很可能原来只是想借冠状毒搞一种新型疫苗，不用打针，靠人群自然传播即可。可能中间发生了什么意想不到的变故，比如和其它什么病毒混了一下，致病性大大的增强了，还由舌吻传播变成了空气传播，才导致了今天的结果
有这个可能，但为什么欧美这么处理啊，是不是国内更清楚漏了什么
好早的时候就有美国人传美国军方参与了
疫苗已经很多了，有些根本不必要。 有人为了赚钱也是丧心病狂了。
话说某巨富巨量投资的疫苗是谋划者吗？
被siwang? 这么恐怖
I don’t think I have made any conclusions... only observations
also, from BBC https://www.bbc.com/news/health-55388846 about the uk mutation
Where has it come from? The variant is unusually highly mutated.
The most likely explanation is the variant has emerged in a patient with a weakened immune system that was unable to beat the virus.
Instead their body became a breeding ground for the virus to mutate.
Will the vaccines work against the new variant? Almost certainly yes, or at least for now.
All three leading vaccines develop an immune response against the existing spike, which is why the question comes up.
Vaccines train the immune system to attack several different parts of the virus, so even though part of the spike has mutated, the vaccines should still work. "But if we let it add more mutations, then you start worrying," said Prof Gupta.
"This virus is potentially on a pathway for vaccine escape, it has taken the first couple of steps towards that." Vaccine escape happens when the virus changes so it dodges the full effect of the vaccine and continues to infect people.
This may be the most concerning element of what is happening with the virus.
This variant is just the latest to show the virus is continuing to adapt as it infects more and more of us. A presentation by Prof David Robertson, from the University of Glasgow on Friday, concluded: "
对比一下 我们的媒体是这么写的
https://www.sfgate.com/coronavirus/article/mutant-COVID-strain-California-UK-Newsom-Fauci-15836808.php
Fauci urges calm as mutated COVID-19 strain from UK found in California Eric Ting | on December 30, 2020
California Gov. Gavin Newsom holds up a vial of the Pfizer-BioNTech COVID-19 vaccine at Kaiser Permanente Los Angeles Medical Center in Los Angeles, Monday, Dec. 14, 2020.
California became the second state to report a case of the mutated COVID-19 strain from the United Kingdom when Gov. Gavin Newsom announced its presence during a Facebook Live conversation with Dr. Anthony Fauci on Wednesday afternoon.
Newsom announced the strain — which U.K. scientists estimate spreads 70% more easily than the main strain in the United States — has been detected in Southern California. Fauci said it''s not a surprise the strain is in the state and urged residents to remain calm.
"I don''t think Californians should feel this is something odd; this is something expected," he said.
Colorado became the first state to report the new strain on Tuesday, but health experts have stated that newly approved vaccines should still work against the variant, and being infected by a prior strain should also confer immunity against this strain.
"There''s no indication at all that it increases the virulence, and by virulence I mean the ability to make you sick or kill you," Fauci told Newsom. "It doesn''t seem to make it more strong in that regard. In addition, it doesn''t seem to evade the protection from the antibodies induced by vaccines. The other thing they''ve noted in the U.K. is people who have been infected don''t seem to be reinfected by this."
Fauci told Newsom to expect more cases going forward and said federal officials continue to study the strain.
真的没有对比就没有伤害
从一开始的cdc完全不设防，到现在完全淡化uk变异的重要性，我对美帝的防疫抗议工作实在是服气的
要是真的咋办啊？
我也想知道啊
人类难道要都进化成避世的？
金三胖那里貌似问题不大？
新加坡好像也没有各种乌龙
Mm你是相关专业的嘛
本科的时候念完所有premed需要的课程的
之后对evolution有一点浅浅的认知；mRNA的protection和degradation是研究了有一段时间的
个人觉得 新冠真的是研究bioinformatics的人的天堂
哈哈，你们都好牛
不光是这个P4主任，还有好几个相关领域的人突然死亡
美帝完全就是故意造病毒的，还派了军人投毒，没想到搬起石头砸了自己的脚
活捉五毛一只，回去问你们领导，现在早不说投毒论了好么？
你如果在美国的大学，去问问生物系抓蝙蝠养蝙蝠的，问问他们谁提供的经费去抓蝙蝠，就知道美国自己也脱不了干系。这个事儿美国自己也不想深究（某种程度上）
美帝倒是不至于投毒，应该是研究的时候不小心泄露了。
哈哈，这个有道理
骂中国是因为选举。上次骂墨西哥人WIN了，这次改中国人而已。