回复 1楼whisperer的帖子 Hereditary angioedema and acquired angioedema (acquired C1 inhibitor deficiency) are caused by deficiency or dysfunction of complement 1 (C1) inhibitor, a protein involved in the regulation of the classical and lectin complement activation pathways, and also of the kinin, clotting, and fibrinolytic pathways. C1 Esterase Inhibitor Deficiency By Kathy Li | Pearl of the Day | Comments are Closed | 16 March, 2018 | 0 A 67 year-old man presents with lower lip swelling for the past two hours, and tells you he was recently diagnosed with acquired C1 esterase inhibitor deficiency. He has normal vitals, is speaking in full sentences, and denies any sensation of tongue or airway swelling. What do you do next? Easy, right? In addition to closely monitoring the patient for developing airway compromise, you need to replace their C1 esterase inhibitor! But how exactly does that work? C1 esterase inhibitor can be replaced a number of ways (a refresher on the bradykinin/complement pathway can be found here): human plasma-derived C1INH concentrate (pdC1INH), brand name Berinert, administered as 20mg/kg IV recombinant C1INH (rC1INH), brand name Ruconest, administered as 50mg/kg IV FFP (which contains C1 esterase inhibitor and also contains ACE, which degrades bradykinin) bradykinin 2 -receptor inhibitor, brand name Icatibant, administered as a fixed 30mg subcutaneous injection kallikrein inhibitor, brand name Ecallantide, administered as three 10mg subcutaneous injections After administration of one of the above, the patient should be observed until there is definite improvement, generally a few hours. Those with severe angioedema or frequent recurrent episodes of unclear etiology should be admitted. However, patients who have established C1 esterase inhibitor deficiency may know their disease and their symptoms better, and Berinert has been approved for self-administration, so certain patients may not need to be watched for as long. At Sinai, we have Ruconest available, though this patient was actually given Berinert due to a pharmacy/quality issue with mixing the Ruconest. This patient noted significant improvement within several minutes of receiving the injection, and was discharged with close allergy follow up. Special thanks to Dr. Moira Carroll for inspiring this pearl, and to patient JM, who generously consented for these photos to be taken and published. References: Hereditary Angioedema, NEJMAngioedema, Life in the Fast Lane
医生回电了 说吃抗过敏药 还要吃抗生素😓 但是药店都关了 抗生素只能明天了
医生说如果情况严重了就去ER
不知道呢 晚上也没吃啥 吃的韭菜盒子😭
医生说是什么？为什么吃抗生素？
他说有可能是infection，我也不知道他为何这样认为
没有呢 唉
都没有 所以感觉很奇怪 也很害怕
过敏，可能是荨麻疹，吃抗过敏药，药到病除 Loratadine 吃一粒就可以了，非处方药，超市开架处有卖 不是吃抗生素。
Hereditary angioedema and acquired angioedema (acquired C1 inhibitor deficiency) are caused by deficiency or dysfunction of complement 1 (C1) inhibitor, a protein involved in the regulation of the classical and lectin complement activation pathways, and also of the kinin, clotting, and fibrinolytic pathways.