I think it is fine to be conservative on this one 这个mRNA疫苗很早就开始研发了，但是一直没有一个可适用的经典案例，其实mRNA疫苗的目标才不是什么新冠这种小case，它是要被拿来治疗癌症的 但是这中间有很多uncharted territory，ls说的auto- immune disease就是一个可能，所以需要大规模的接种，来验证 我不认为feeling conservative about mRNA-based vaccines in general就是反疫苗，美国的民调显示三四月的时候，有2/3的民众愿意接种新冠疫苗，现在跌到1/2了，就是因为这个急促的研发过程，安全隐患还是令人担心的 自愿参加比较好，想打的就打，不想打的等等
I think it is fine to be conservative on this one 这个mRNA疫苗很早就开始研发了，但是一直没有一个可适用的经典案例，其实mRNA疫苗的目标才不是什么新冠这种小case，它是要被拿来治疗癌症的 但是这中间有很多uncharted territory，ls说的auto- immune disease就是一个可能，所以需要大规模的接种，来验证 我不认为feeling conservative about mRNA-based vaccines in general就是反疫苗，美国的民调显示三四月的时候，有2/3的民众愿意接种新冠疫苗，现在跌到1/2了，就是因为这个急促的研发过程，安全隐患还是令人担心的 自愿参加比较好，想打的就打，不想打的等等 CleverBeaver 发表于 2020-11-19 11:45
Link plz? this is what I saw from https://www.phgfoundation.org/briefing/rna-vaccines Benefits Benefits of mRNA vaccines over conventional approaches are1: Safety: RNA vaccines are not made with pathogen particles or inactivated pathogen, so are non-infectious. RNA does not integrate itself into the host genome and the RNA strand in the vaccine is degraded once the protein is made. Efficacy: early clinical trial results indicate that these vaccines generate a reliable immune response and are well-tolerated by healthy individuals, with few side effects. Production: vaccines can be produced more rapidly in the laboratory in a process that can be standardised, which improves responsiveness to emerging outbreaks. Important challenges The methods to make mRNA vaccines can be very effective. However, there are technical challenges to overcome to ensure these vaccines work appropriately: Unintended effects: the mRNA strand in the vaccine may elicit an unintended immune reaction. To minimise this the mRNA vaccine sequences are designed to mimic those produced by mammalian cells. Delivery: delivering the vaccine effectively to cells is challenging since free RNA in the body is quickly broken down. To help achieve delivery, the RNA strand is incorporated into a larger molecule to help stabilise it and/or packaged into particles or liposomes. Storage: many RNA vaccines, like conventional vaccines, need to be frozen or refrigerated. Work is ongoing to reliably produce vaccines that can be stored outside the cold chain, since these will be much more suitable for use in countries with limited or no refrigeration facilities.
No
you can google it
auto-immune is a legit concern
这个mRNA疫苗很早就开始研发了，但是一直没有一个可适用的经典案例，其实mRNA疫苗的目标才不是什么新冠这种小case，它是要被拿来治疗癌症的
但是这中间有很多uncharted territory，ls说的auto- immune disease就是一个可能，所以需要大规模的接种，来验证
我不认为feeling conservative about mRNA-based vaccines in general就是反疫苗，美国的民调显示三四月的时候，有2/3的民众愿意接种新冠疫苗，现在跌到1/2了，就是因为这个急促的研发过程，安全隐患还是令人担心的
自愿参加比较好，想打的就打，不想打的等等
因为他们重仓复工股
所以都和trump一个路子
只看钱包
auto-immune的风险所有疫苗都有， 没理由mRNA疫苗高。 灭活疫苗auto-immune的风险更高。
我是很期待mRNA疫苗或者说治疗方法能够早日普惠大众。这次新冠，把进度加快了很多，不过在没有经过验证的前提下，还是谨慎点儿好。 好在美国小白鼠多，拭目以待。
不需要。目前还没有给小孩的疫苗。只有12岁以上的临床实验数据。以后有没有不知道。小孩新冠风险比成人低
Link plz?
this is what I saw from https://www.phgfoundation.org/briefing/rna-vaccines
Benefits Benefits of mRNA vaccines over conventional approaches are1:
Safety: RNA vaccines are not made with pathogen particles or inactivated pathogen, so are non-infectious. RNA does not integrate itself into the host genome and the RNA strand in the vaccine is degraded once the protein is made.
Efficacy: early clinical trial results indicate that these vaccines generate a reliable immune response and are well-tolerated by healthy individuals, with few side effects.
Production: vaccines can be produced more rapidly in the laboratory in a process that can be standardised, which improves responsiveness to emerging outbreaks.
Important challenges The methods to make mRNA vaccines can be very effective. However, there are technical challenges to overcome to ensure these vaccines work appropriately:
Unintended effects: the mRNA strand in the vaccine may elicit an unintended immune reaction. To minimise this the mRNA vaccine sequences are designed to mimic those produced by mammalian cells.
Delivery: delivering the vaccine effectively to cells is challenging since free RNA in the body is quickly broken down. To help achieve delivery, the RNA strand is incorporated into a larger molecule to help stabilise it and/or packaged into particles or liposomes.
Storage: many RNA vaccines, like conventional vaccines, need to be frozen or refrigerated. Work is ongoing to reliably produce vaccines that can be stored outside the cold chain, since these will be much more suitable for use in countries with limited or no refrigeration facilities.
谢谢层主科普
因为做疫苗不赚钱呀，你以为呢？ 还什么“mRNA疫苗发明几十年了” -- 这么不严谨的表述又是哪个中文媒体给灌输的？
Last time I checked mRNA-based vaccines against MERS were also in moderna’s pipeline
not sure what happened to them
每个人都有自己选择的权力，你不打是你的自由，别人也有选择打的权力，同样受尊重。没有牺牲自己勇做人肉小白鼠的志愿者们，医药水平还停留在中世纪，我们应该致敬这些人。