这个本来就是针对 mild/moderate disease, 治疗轻症的目的是为了预防重症，重症的时候必须住院治疗，会加重医疗系统负担，病人prognosis也会变差。疫苗之外, the most valuable therapeutics are those targeting mild/moderate disease.
这个本来就是针对 mild/moderate disease, 治疗轻症的目的是为了预防重症，重症的时候必须住院治疗，会加重医疗系统负担，病人prognosis也会变差。疫苗之外, the most valuable therapeutics are those targeting mild/moderate disease. qinqinmiao 发表于 2020-10-08 13:08
川普的鸡尾酒独门用药哪来？原来是这层特殊关系！ Dr. Leonard Schleifer is a member at Trump''''s golf club in Westchester, New York, and his company also received $450 million in government funding in July. https://t.co/mX5hCucrxU
Angiotensin-converting enzyme 2 (ACE2) is an enzyme attached to the cell membranes of cells located in the lungs, arteries, heart, kidney, and intestines. ACE2 lowers blood pressure by catalyzing the hydrolysis of angiotensin II (a vasoconstrictor peptide) into angiotensin (1–7) (a vasodilator).
Angiotensin-converting enzyme 2 (ACE2) is an enzyme attached to the cell membranes of cells located in the lungs, arteries, heart, kidney, and intestines. ACE2 lowers blood pressure by catalyzing the hydrolysis of angiotensin II (a vasoconstrictor peptide) into angiotensin (1–7) (a vasodilator). PT8964 发表于 2020-10-08 17:07
”突刺蛋白和ACE2结合+抗体和突刺蛋白结合”并不能直接说明抗体和ACE2有竞争关系。有没有文章研究抗体和ACE2的直接竞争关系的？你列的文章也有下面一段： "Patients who received convalescent plasma from recovered SARS patients had shorter hospital stays and lower mortality rates without evident adverse effects (45–47). These results might reflect a different quality of antibodies in recovered patients from deceased patients during early infection. ... ... Further studies that will attempt to identify antibodies and epitopes that mediate prevention or enhancement of ALI might be needed for future vaccine design and immunotherapy."
REGN10933 and REGN10987是中和新冠突刺蛋白的抗体, 突刺蛋白通过ACE2侵袭人体. 人类面临的困境是ACE2具有修复上皮细胞损伤,尤其肺细胞的重要功能,抗体抑制了新冠病毒的同时,也抑制了ACE2的修复功能,这恐怕就是抗体浓度越高病情越重的原因.人体和新冠病毒的斗争犹如饮鸩止渴的绝望. 或许,UBC用直接注射ACE2的办法要比注射抗体更有效. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167588/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347488/
用抗体药必须住院，因为发生注射反应的几率很大，8克抗体至少要100毫升，甚至1000毫升都有可能，就这一点就注定了它不可能大规模给轻症患者使用。医院没那么多床位和护士。
从我的分析看，这个药只能用在肺损伤之前，而大部分人根本就不会有肺损伤，这就是个死循环。
我也不喜欢他带货，但他说的的确是 实话，个人经历，所以到时候 还是听医生的吧。。。
你·真的明白抗体的作用机理吗？
因为党争已经不讲理智了
来，我给你讲讲。 ACE2结合S蛋白，这个抗体也结合病毒的S蛋白， 这样ACE2就可以正常其作用了。 抗体有可能比ACE2对病毒的结合能力强，有竞争优势
ace2要和这个抗体竞争修复点位，导致ace2无法修复损伤的细胞，这就是抗体浓度越高病情越重的原因。
错误百出，吐槽无力。 你看起来不是行内人，既然不懂，最好不要误导别人。
对老年人， 即使是轻症， 也是很有用得。
还有双黄连，莲花清瘟。。
民主党最擅长是不让大众服药，自己偷偷的服用大统领推荐的药。那个Chris Cumuo得病的时候偷偷吃HCQ，他哥还不准医生开处方。
是不是莲花清瘟效果最好？
川普的鸡尾酒独门用药哪来？原来是这层特殊关系！
Dr. Leonard Schleifer is a member at Trump''''s golf club in Westchester, New York, and his company also received $450 million in government funding in July.
https://t.co/mX5hCucrxU
今天巨巨恐怕也意识到这个药根本无法大规模全面铺开，开始暗示只给老人用了。注射抗体本身就是高风险操作，一般要先上苯海拉明，再缓慢滴注，这种异源蛋白,每分钟也就敢注入100毫克量级,打完了还要密切观察，前后几个小时，美国哪里有那么多资源。
你内行就多说说？
能够针对刺蛋白的IgG又不是只有一种，拿来做单抗之前当然是要认真筛选的，有可能引起细胞因子风暴的不能要。参加Regeneron和Lilly临床实验的都有上千人了，真要是有IgG抗体引起的细胞因子风暴，实验早就被叫停了。
你这就是纯粹是胡搅蛮缠了吧？我啥时候说过抗体引起细胞因子风暴？
你提到的文章里面说的啊！！！还是那句话，大外行一个上一边凉快去
抗体当然会选专一性比较强的，不结合angiotensin II 的抗体。
Angiotensin-converting enzyme 2 (ACE2) is an enzyme attached to the cell membranes of cells located in the lungs, arteries, heart, kidney, and intestines. ACE2 lowers blood pressure by catalyzing the hydrolysis of angiotensin II (a vasoconstrictor peptide) into angiotensin (1–7) (a vasodilator).
抗体和突刺蛋白结合，和ace2是竞争关系，高浓度抗体会抑制ace2的功能。
这里的火药味真浓，咋就不能就事论事了？
奇了怪，你们大统领这次怎么不用自己推荐的神药？
”突刺蛋白和ACE2结合+抗体和突刺蛋白结合”并不能直接说明抗体和ACE2有竞争关系。有没有文章研究抗体和ACE2的直接竞争关系的？你列的文章也有下面一段：
"Patients who received convalescent plasma from recovered SARS patients had shorter hospital stays and lower mortality rates without evident adverse effects (45–47). These results might reflect a different quality of antibodies in recovered patients from deceased patients during early infection. ... ... Further studies that will attempt to identify antibodies and epitopes that mediate prevention or enhancement of ALI might be needed for future vaccine design and immunotherapy."
这个和ACE2没有关系。你的链接文章是关于抗体对炎症的修复的影响。没有炎症，就不需要修复。 用激素也可以抗炎
左x徹底瘋了。還要再弄死多少人
总统说的不一定是好货。 总统治病吃的肯定是好货。