英国要开展健康志愿者新冠疫苗攻毒试验

平明寻白羽
楼主 (北美华人网)
Financial Times报道,英国决定开展健康志愿者疫苗接种后新冠攻毒试验,以加速筛选有效疫苗。
志愿者接种疫苗以后一个月接受病毒挑战试验。他们会集中隔离在伦敦某处。
https://www.ft.com/content/b782f666-6847-4487-986c-56d3f5e46c0b
UK to test vaccines on volunteers deliberately infected with Covid-19 ‘Human challenge trials’ intended to accelerate vaccine development programmes A clinic run by hVivo has been earmarked for the initial challenge trials © Chris Dawes/hVIVO Clive Cookson in London 6 hours ago
London is to host the world’s first Covid-19 human challenge trials — in which healthy volunteers are deliberately infected with coronavirus to assess the effectiveness of experimental vaccines. The UK government-funded studies are expected to begin in January at a secure quarantine facility in east London, according to several people involved in the project, which will be announced next week. The researchers, who did not want to comment publicly ahead of the launch, said the trials would play a vital role in narrowing the large field of promising Covid-19 vaccines likely to move into clinical testing early next year. Volunteers will be inoculated with a vaccine and a month or so later receive a “challenge” dose of Sars-Cov-2, the virus that causes Covid-19, under controlled conditions. About 2,000 potential volunteers have signed up for challenge studies in the UK through the US-based advocacy group 1Day Sooner, which campaigns for Covid-19 infection trials and has enlisted 37,000 people worldwide. Traditional clinical trials need tens of thousands of participants and researchers would struggle to attract enough for multiple vaccine studies.
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gzhsyw
是随机对照双盲的吗?
little_racoon
回复 2楼gzhsyw的帖子
这个不用对照,谁都知道打了病毒会感染,就像验证降落伞的安全性不需要双盲对照一样。
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zhegufei
是随机对照双盲的吗?
gzhsyw 发表于 2020-09-23 16:39

这个直接是当小白鼠了。这会极大的加快疫苗开发进程。
目前三期效率太低了。设置的目标是实验人群感染超过100(200)个人之后揭盲,然后比较效率。



cinderedna
我昨天还听广播说这么做有ethical issue,想不到英国人真敢为天下先。
梅干茶泡饭
我昨天还听广播说这么做有ethical issue,想不到英国人真敢为天下先。
cinderedna 发表于 2020-09-23 17:05

达尔文 John Snow的故乡 公共卫生学发源地... 看看昨天的address the nation

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gzhsyw
回复 3楼little_racoon的帖子
我觉得对新冠不好说。新冠本来90%以上是轻症,如果做出来不能避免感染只是减轻症状,那没有对照的话很难衡量有没有效 效果多大。我觉得跟三期一样 对照组是必要的。