概括回答就是：When a virus infects human cells, the body reacts by turning on what are essentially antivirus alarm systems. These alarms identify viral invaders and tell the immune system to send cytotoxic T cells — a type of white blood cell — to destroy the infected cells and hopefully slow the infection. But not all alarm systems are created equal. People have different versions of the same genes — called alleles — and some of these alleles are more sensitive to certain viruses or pathogens than others. The part of the alarm system that we tested is called the human leukocyte antigen system, or HLA. Each person has multiple alleles of the genes that make up their HLA type. Each allele codes for a different HLA protein. The results of our modeling predict that some HLA types bind to a large number of the SARS-CoV-2 peptides while others bind to very few. That is to say, some sensors may be better tailored to SARS-CoV-2 than others. If true, the specific HLA alleles a person has would likely be a factor in how effective their immune response is to COVID-19.
Your genes could determine whether coronavirus puts you in the hospital — and we’re starting to unravel which ones matter
虽然是个model simulation study, 但是做的挺靠谱的。之后又拿SARS验证了一下。
问：为啥有些人感染了是重症，有些人轻症甚至无症状就过去了？
概括回答就是：When a virus infects human cells, the body reacts by turning on what are essentially antivirus alarm systems. These alarms identify viral invaders and tell the immune system to send cytotoxic T cells — a type of white blood cell — to destroy the infected cells and hopefully slow the infection.
But not all alarm systems are created equal. People have different versions of the same genes — called alleles — and some of these alleles are more sensitive to certain viruses or pathogens than others. The part of the alarm system that we tested is called the human leukocyte antigen system, or HLA. Each person has multiple alleles of the genes that make up their HLA type. Each allele codes for a different HLA protein. The results of our modeling predict that some HLA types bind to a large number of the SARS-CoV-2 peptides while others bind to very few. That is to say, some sensors may be better tailored to SARS-CoV-2 than others. If true, the specific HLA alleles a person has would likely be a factor in how effective their immune response is to COVID-19.
这是基因歧视啊。。。。
赞思路！别搞全民病毒检测了，直接大规模地搞基因测试，告知每个人的HLA类型和大概率的感染几率，然后自己考虑要不要出门浪。
是的。12月1月那时候的结论是白人免疫, 不知道最近这个话题为啥消失了，呵呵。
肾病尿毒症也是。这种基因易感的疾病，很多发病年龄和先辈一样，死亡年龄都差不多
这是老天的歧视。
是的，完全正确。但其他病，比如HIV, 你不跟别人乱，一般不会得。即使你同一基因，同一FAMILY的其他人得了，你仍然不会。
纯不可能假设。这个病毒，由于传染性极强，只要你得了，那么，由于人人暴露在病毒中，跟你同一基因的其他人，必然会得，跟人一样的症状，或轻或重，早晚的事情，而不是得不得的问题，而且如果在同一FAMILY时，加快传染。
都含有同一类基因。夫妻常常是老乡，同学，同事，性格什么的有相近相似的，一些基因有大概率相同
你自己去查没事，强制查基因美国人不得跟你拼命……
这个人得100多岁了吧