Max Crispin 发现，新冠状病毒不同于HIV等其他病毒，它的保护病毒蛋白的外层糖衣密度低比较薄弱，容易被免疫抗体攻破。这对疫苗开发是喜讯。
the lower glycan density means there are fewer obstacles for the immune system to neutralise the virus with antibodies. So this is a very encouraging message for vaccine development.”
The institute last week began a Phase I clinical trial involving 1,100 people. Crucially, next month it will begin a combined Phase II and Phase III trial involving another 5,000. Unlike any other vaccine project now underway, that trial is designed to prove effectiveness as well as safety.
The scientists would declare victory if as many as a dozen participants who are given a placebo become sick with Covid-19 compared with only one or two who receive the inoculation. “Then we have a party and tell the world,” Professor Hill said. Everyone who had received only the placebo would also be vaccinated immediately.
Most other teams have had to start with small clinical trials of a few hundred participants to demonstrate safety. But scientists at the university’s Jenner Institute had a head start on a vaccine, having proved in previous trials that similar inoculations — including one last year against an earlier coronavirus — were harmless to humans. That has enabled them to leap ahead and schedule tests of their new coronavirus vaccine involving more than 6,000 people by the end of next month, hoping to show not only that it is safe, but also that it works.
一个月后应该有一些初步结果 The scientists would declare victory if as many as a dozen participants who are given a placebo become sick with Covid-19 compared with only one or two who receive the inoculation. “Then we have a party and tell the world,” Professor Hill said. Everyone who had received only the placebo would also be vaccinated immediately.
在先前的试验中牛津大学已经证明接种（包括去年针对较早的其它冠状病毒的接种）对人类无害。这样一来，他们就可以突飞猛进，计划在下个月底之前对涉及的新型冠状病毒疫苗进行测试，希望不仅证明它安全而且有效。如果证明有效，他们的疫苗可以在九月份上市。
早前，美国国立卫生研究院的科学家也已试验了牛津疫苗，上个月在蒙大拿州的六只恒河猴上作了接种该疫苗的单剂量， 然后，使恒河猴暴露于巨量新冠病毒中，超过28天后，猴子们都是健康的，而对照组的猴子全部生病。
https://www.barrons.com/articles/good-news-on-oxford-vaccine-is-bright-spot-in-somber-covid-19-landscape-51588084298?mod=RTA
https://www.nytimes.com/2020/04/27/world/europe/coronavirus-vaccine-update-oxford.html?mod=article_inline
对猴子有用对人没用甚至有危险的药多了去了。新冠病毒有抗体增强效应，疫苗做不好的话反而打过疫苗的人会快速转成重症，哪有那么好做。
该疫苗已经通过人体安全性试验，与你这样笼统地归结一大堆不安全和危险的药完全不同。
猴子这个真是好消息了。
疫苗没有这么快的, 除非跳过常规步骤.
可笑，谁告诉你新冠有抗体增强效应？网上看了几个烂帖子就现学现卖了
中国疫苗二期临床已经开始了。前段时候不是也在猴子身上做了实验么。
你反对人民的希望，反对疫苗，但又替五毒所说话，为什么
就是制造恐慌
要过几天，等冰箱里不新鲜的菜卖完再去
nyc15这个ID很有问题，他也成功地引起了我的注意
可能是病毒本人…
这不用担心，非常时期fda 会放行的
什么时候替五毒所说过话了？厉害国现在在试验的几个疫苗比牛津这个还没前途好不好？
这个病毒的疫苗不会比HIV和登革热容易，不信算了。
已经证实这个病毒比HIV容易攻破：
Max Crispin 发现，新冠状病毒不同于HIV等其他病毒，它的保护病毒蛋白的外层糖衣密度低比较薄弱，容易被免疫抗体攻破。这对疫苗开发是喜讯。
the lower glycan density means there are fewer obstacles for the immune system to neutralise the virus with antibodies. So this is a very encouraging message for vaccine development.”
https://forums.huaren.us/showtopic.aspx?topicid=2535930
挺有希望的，有效性肯定比Moderna的mRNA疫苗强（mRNA或者DNA虽然制作简单，但是进入人体细胞刺激抗体产生的能力弱很多）
希望各国疫苗都早点上市啊！！！
牛津詹纳研究所（Jenner Institute）开发的黑猩猩腺病毒疫苗载体（ChAdOx1）被选为SARS-CoV-2疫苗的最合适疫苗技术，因为它可以从一剂产生强烈的免疫反应，并且不是复制型病毒， 因此它不会导致接种疫苗的人持续感染。 这也使给儿童，老人和任何已患有糖尿病等疾病的人更安全。 黑猩猩腺病毒载体是一种经过深入研究的疫苗类型，从1周到90岁，已在成千上万名受试者中安全使用，靶向10多种不同疾病的疫苗。
这个在欧美是最快的，见下。
中国的大规模试验，没有病毒流行，现在进展较难吧。
The institute last week began a Phase I clinical trial involving 1,100 people. Crucially, next month it will begin a combined Phase II and Phase III trial involving another 5,000. Unlike any other vaccine project now underway, that trial is designed to prove effectiveness as well as safety.
The scientists would declare victory if as many as a dozen participants who are given a placebo become sick with Covid-19 compared with only one or two who receive the inoculation. “Then we have a party and tell the world,” Professor Hill said. Everyone who had received only the placebo would also be vaccinated immediately.
https://www.nytimes.com/2020/04/27/world/europe/coronavirus-vaccine-update-oxford.html?mod=article_inline
这个病毒你研发的？这么知根知底
Lol
美国这么强的医药研究没抢着这个先机啊
你每个贴都像在吵架，多列理由少发泄吧。
因为这个nyc15是wm啊。
对啊，只要有效安全，保险不cover自费打我也愿意啊
可能就是前几天说的无毒所叛逃的？
文中说道：“该疫苗有领先优势：因为在先前的试验中已经证明类似的接种（包括去年针对较早的冠状病毒的接种）对人类无害”， 现在开始的平行试验是证实有效性。
关于这个病毒不容易出疫苗的报道早就有了，我看过好几个了，不知道真假，持保留态度。但是这个病致死率不像埃博拉病毒那么高，但是比流感略高，有了疫苗后人们打不打还真不一定下的了决心。
嗯，我也是这么想的，现在就期待各国的临床传来好消息
哈哈，共产专制正是人类文明社会中的病毒
反正第一批也轮不到你啊。。。现在的基本级别是医护优先，然后是老人儿童，成年人最末
那你说咋办？
5月底有初步结果后， 印度血清研究所就可開始生產這款疫苗。他们希望牛津大學9月對疫苗的人體試驗結束後，印度血清研究所立刻就有上亿支疫苗，成本大約是每支13美元。