High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa by Hao Xu et. al. It has been reported that ACE2 is the main host cell receptor of 2019-nCoV and plays a crucial role in the entry of virus into the cell to cause the final infection. To investigate the potential route of 2019-nCov infection on the mucosa of oral cavity, bulk RNA-seq profiles from two public databases including The Cancer Genome Atlas (TCGA) and Functional Annotation of The Mammalian Genome Cap Analysis of Gene Expression (FANTOM5 CAGE) dataset were collected. RNA-seq profiling data of 13 organ types with para-carcinoma normal tissues from TCGA and 14 organ types with normal tissues from FANTOM5 CAGE were analyzed in order to explore and validate the expression of ACE2 on the mucosa of oral cavity. Further, single-cell transcriptomes from an independent data generated in-house were used to identify and confirm the ACE2-expressing cell composition and proportion in oral cavity. The results demonstrated that the ACE2 expressed on the mucosa of oral cavity. Interestingly, this receptor was highly enriched in epithelial cells of tongue. Preliminarily, those findings have explained the basic mechanism that the oral cavity is a potentially high risk for 2019-nCoV infectious susceptibility and provided a piece of evidence for the future prevention strategy in dental clinical practice as well as daily life.
It has been reported that ACE2 is the main host cell receptor of 2019-nCoV and plays a crucial role in the entry of virus into the cell to cause the final infection. To investigate the potential route of 2019-nCov infection on the mucosa of oral cavity, bulk RNA-seq profiles from two public databases including The Cancer Genome Atlas (TCGA) and Functional Annotation of The Mammalian Genome Cap Analysis of Gene Expression (FANTOM5 CAGE) dataset were collected. RNA-seq profiling data of 13 organ types with para-carcinoma normal tissues from TCGA and 14 organ types with normal tissues from FANTOM5 CAGE were analyzed in order to explore and validate the expression of ACE2 on the mucosa of oral cavity. Further, single-cell transcriptomes from an independent data generated in-house were used to identify and confirm the ACE2-expressing cell composition and proportion in oral cavity. The results demonstrated that the ACE2 expressed on the mucosa of oral cavity. Interestingly, this receptor was highly enriched in epithelial cells of tongue. Preliminarily, those findings have explained the basic mechanism that the oral cavity is a potentially high risk for 2019-nCoV infectious susceptibility and provided a piece of evidence for the future prevention strategy in dental clinical practice as well as daily life. Skipper 发表于 2020-04-19 21:15
我的意思是冰淇淋制作源头污染了，就像最近猪肉厂员工被感染之类。。。。
既然不是吃出来的，那为啥很多科普要大家加热食物吃，或者水果要洗洁精洗了吃。。。
我的意思不是外包装问题，是制作工厂的源头如果污染了，就像最近猪肉厂有员工确诊之类。。。
怎么可能没事啊！体重啊！
仔细看，科普文章都有说是怕蔬菜外皮以及外卖食物的外包装有病毒被手碰到了啊，然后触碰口鼻之类。比如如果可以做到不碰外皮直接吃到水果里面，或者不碰外卖外包装悬空吃到里面的食物，那不加热也可以。。。如果不考虑外包装污染，冰淇淋你用勺子直接吃了就进嘴里肚子里了，即使有污染病毒也无法感染你了。肉的潜在危险是你还要用手/戴着手套处理生肉。但我觉得危险还是很小：你会用抓过肉不洗的手直接触摸脸吗？照你食品加工厂污染会感染新冠理论，那不是吃啥都不安全，当一个只喝露水的小仙女最安全？(可是巴黎非饮用水还查出了新冠病毒呢🤣)
想想我们之前那么糙地生活在满是各种细菌病毒的世界，也没有中各种病啊。小心谨慎是好的，应该在非常时期做好基本消毒工作。但感觉板上有些人防病毒已经过分魔障了。。。(顶锅盖跑)
没事，就是讨论一下。。。不用顶锅盖哈。。。主要是看之前帖子说病毒在冰柜里存活时间长，且生菜最好别吃，寿司也是，就想到了这个。。。
那冰淇淋店里的能吃吗？
这个主意甚好
想多了，想吃就吃。
我还有个疑问，如果吃东西没事，为啥碰了病毒的手不能摸嘴，摸嘴感染是什么原理呢
不吃这俩又不会饿死。。。真是笑话了。。。。
摸嘴如果只是吃进去了就没事
但是你摸了嘴，那病毒可能爬进鼻孔里，立刻破功了
懂了吧
这样看来我也啥必要对外包装消毒了，反正我拿了冰箱里的东西从来都会洗手，不会碰脸。
神回复！！！
冰淇凌店里得。。。。。。
一杯三色冰淇淋，加半杯杏仁牛奶，半杯irish cream，
调匀后涂一层巧克力syrup，顶上喷一层奶油，
讲究点的再上面撒些巧克力颗粒或者杏仁颗粒，
再插顶小花伞～搞定。
喜欢吃又遇上源头污染那就只能怪命了。
冰激凌没吃，酸奶基本每天吃
我觉得比较需要处理一下的是外壳
冷冻的时候，一定浓度的高糖是能够起到保护细胞的作用的。。。covid19也有膜结构一定程度上应该也是保护作用。。。
实话说，如果是生肉制品，那还可以烧一烧吃，酸奶冰淇淋的车间真的应该要监管一下
🤝，看看回复都是些什么人类，不是咒人死就是上纲上线。。。正常讨论一下有何不可？cdc之前还说口罩没用呢。。。
刚刚和lg也讨论了一下。他表示一直以为食品车间里面的工人常规操作是戴口罩的。不过我也就是看了几个视频，建议大家针对自己喜欢的牌子都去考察一下。我们家暂时没有新买酸奶和冰淇淋。
超市买的冰淇淋好像就哈根达斯里面还有一层密封塑料膜，其他都是随便可以打开的纸盖子，去年夏天不是有人恶作剧打开盖子舔里面的冰淇淋然后盖回去
哈哈哈哈哈哈。太有才
这图片配合你的头像 绝了
被你笑死了
这个表达了成为病毒的攻击对象，但是不是帮助病毒进一步繁殖传播呢？当然这不代表我不赞成吃到嘴里没有危险。。。另外如果有胃溃疡什么的就应该更加小心了。我们冰淇淋还是在吃的。我觉得这个工艺上为了避免沙门菌之类污染应该灭菌做得很仔细了。但是这个病毒有太多未知，会给未来生活带来很多改变，很多事情也不要想当然
好办法
看一下YouTube冰激凌工厂车间操作视频。低温杀不死病毒，冰激凌成型入包装时很多人在那操作，且没带口罩。不过之前大家回复说是吃东西不传染，希望如此吧。
我这一问感觉触动了甜食爱好者的神经…既然都认为食物不会传染，那之前消毒啊，肉厂感染的帖子也都没啥意义，反正吃啥都不会是用鼻子吃。😄
嘿嘿，厉害👍。我也不是非吃不可，就是之前看大家对猪肉厂感染的讨论，想到这俩产品。
不可能好几个月，好几个月的话好多食品都要过期了
除了体重，不觉得有啥好担心的
什么牌子的？
哈哈哈