回复 1楼绮雨的帖子 研究冠状病毒MERS and SARS 的疫苗七年了，也没出来，这次怎么会突然看好？但愿不是先声夺人夺经费 Asked why her team is moving faster than others, Corbett said, “It is based on several of our previous projects where we were investigating vaccines for MERS and SARS – coronaviruses which are very closely related to the virus that causes COVID-19. ... We've researched coronavirus vaccine development for the last seven years [and] particularly under my direction the team has researched this coronavirus development for five years.
回复1楼绮雨的帖子 研究冠状病毒MERS and SARS 的疫苗七年了，也没出来，这次怎么会突然看好？但愿不是先声夺人夺经费 Asked why her team is moving faster than others, Corbett said, “It is based on several of our previous projects where we were investigating vaccines for MERS and SARS – coronaviruses which are very closely related to the virus that causes COVID-19. ... We've researched coronavirus vaccine development for the last seven years [and] particularly under my direction the team has researched this coronavirus development for five years. minren 发表于 4/15/2020 5:07:00 PM
“We're targeting fall for emergency use,” she said. “That would be for health care workers and people who might be in constant contact and [at] risk of being exposed. … And then for the general population our target goal is for next spring. And that is if all things go well – if these phase one, phase two and phase three clinical trials work simultaneously for the good. Our plan is to have people vaccinated all over the world by next spring.”
研究冠状病毒MERS and SARS 的疫苗七年了，也没出来，这次怎么会突然看好？但愿不是先声夺人夺经费
Asked why her team is moving faster than others, Corbett said, “It is based on several of our previous projects where we were investigating vaccines for MERS and SARS – coronaviruses which are very closely related to the virus that causes COVID-19. ... We've researched coronavirus vaccine development for the last seven years [and] particularly under my direction the team has researched this coronavirus development for five years. minren 发表于 4/15/2020 5:07:36 PM [/url]
看了一下，旧金山这个所谓追踪计划，San Francisco’s new program will engage with individuals who test positive for COVID-19 to identify whom they have had contact with in recent days. 纯粹就是问卷调查，让确诊者自己回忆/提供密切接触者的信息？
回复1楼绮雨的帖子 研究冠状病毒MERS and SARS 的疫苗七年了，也没出来，这次怎么会突然看好？但愿不是先声夺人夺经费 Asked why her team is moving faster than others, Corbett said, “It is based on several of our previous projects where we were investigating vaccines for MERS and SARS – coronaviruses which are very closely related to the virus that causes COVID-19. ... We've researched coronavirus vaccine development for the last seven years [and] particularly under my direction the team has researched this coronavirus development for five years. minren 发表于 4/15/2020 5:07:00 PM
看了一下，旧金山这个所谓追踪计划，San Francisco’s new program will engage with individuals who test positive for COVID-19 to identify whom they have had contact with in recent days. 纯粹就是问卷调查，让确诊者自己回忆/提供密切接触者的信息？ 这种程度不够吧？ Namama 发表于 4/15/2020 6:31:00 PM
https://www.christianheadlines.com/contributors/michael-foust/nih-is-on-track-for-emergency-use-coronavirus-vaccine-by-fall-scientist-says.html
（1） 纽约州已开发了自己的冠状病毒抗体测试
开始时每天2,000测试，主要用于医务人员和其他重要行业。FDA批准后，可增加到每天100,000个。
https://fortune.com/2020/04/15/coronavirus-antibody-tests-essential-workers-covid-19-new-york-cuomo/
（2） 旧金山开启接触人追踪计划
https://sfmayor.org/article/san-francisco-launches-innovative-contact-tracing-program-strengthen-coronavirus-response
要是每天真的可以查10万人那就太好了。
谢谢发链接， 赞负责任的楼主。
希望这个不是政府over-promising.
要是这些种子选手出来报告进展我比较新，nih的。。。
这篇文章有解释：
There was no vaccine for Sars or Mers. Will there be one for the new coronavirus?
https://www.scmp.com/news/china/science/article/3051853/there-was-no-vaccine-sars-or-mers-will-there-be-one-new
今天发表的这篇“Coronavirus Vaccine Prospects”也应该有帮助：
https://blogs.sciencemag.org/pipeline/archives/2020/04/15/coronavirus-vaccine-prospects
现在是全球一起推进，也不是只有美国在研发。。所以我觉得按照头号种子选手的进程计算，应该问题不是很大？
看了一下，旧金山这个所谓追踪计划，San Francisco’s new program will engage with individuals who test positive for COVID-19 to identify whom they have had contact with in recent days.
纯粹就是问卷调查，让确诊者自己回忆/提供密切接触者的信息？
这种程度不够吧？
有些新疫苗方法可以直接跳过动物实验。
CLINICAL TRIALS - Coronavirus Vaccine Prospects
https://blogs.sciencemag.org/pipeline/archives/2020/04/15/coronavirus-vaccine-prospects
要维持隐私，不通过手机定位，那么这感染率就下不来，无法全面复工。。。
这是整个社会需要做的选择。。
设计疫苗的时候可以消除可能的ADE效应，把标靶设定在一个特定的范围就行。
DNA和RNA疫苗的问题是稳定性比较差，要大规模生产、运输、储存和接种比较难。但是研发速度快，倒是确实适合先给医护用。不过J&J的是传统疫苗，也是target FIH在九月。当然这些时间线都是建立在各个研究机构和公司的头号种子选手（best candidate)上的。一旦在安全性或者有效性或者其他环节fail掉了，那如果是小问题，可以delay一下，让二号candidate上。如果是大问题，那就不知道要到什么时候才行了。但是这个是个新病毒，没人知道会有什么难点。时间线就是按这个candidate一切顺利来计算的。就好像瑞德西韦，按一切顺利应该双盲试验四月应该揭盲了，同情用药也该出结果了，药该上上市了。但实际上呢？
疫苗如何能使人成为无症状传染者？
可能楼上的认为疫苗是活病毒。