结果还是不错的，病情加重率4.3%，死亡率0.47%，而且这些人病情的恶化和“use of selective beta-blocking agents and angiotensin II receptor blockers”有关，以后搞清楚了结果应该会更好。他们的建议是尽早用这两种药物治疗：
“The HCQ-AZ combination, when started immediately after diagnosis, is a safe and efficient treatment for COVID-19, with a mortality rate of 0.5%, in elderly patients. It avoids worsening and clears virus persistence and contagiosity in most cases.”
结果还是不错的，病情加重率4.3%，死亡率0.47%，而且这些人病情的恶化和“use of selective beta-blocking agents and angiotensin II receptor blockers”有关，以后搞清楚了结果应该会更好。他们的建议是尽早用这两种药物治疗：
“The HCQ-AZ combination, when started immediately after diagnosis, is a safe and efficient treatment for COVID-19, with a mortality rate of 0.5%, in elderly patients. It avoids worsening and clears virus persistence and contagiosity in most cases.”
结果还是不错的，病情加重率4.3%，死亡率0.47%，而且这些人病情的恶化和“use of selective beta-blocking agents and angiotensin II receptor blockers”有关，以后搞清楚了结果应该会更好。他们的建议是尽早用这两种药物治疗：
“The HCQ-AZ combination, when started immediately after diagnosis, is a safe and efficient treatment for COVID-19, with a mortality rate of 0.5%, in elderly patients. It avoids worsening and clears virus persistence and contagiosity in most cases.”
做实验的研究人员的结论很积极 The HCQ-AZ combination, when started immediately after diagnosis, is a safe and efficient treatment for COVID-19, with a mortality rate of 0.5%,in elderlypatients. It avoidsworsening and clearsvirus persistence and contagiosity in most cases
为啥只有abstract？全文呢？在哪里能找到？ yanhren 发表于 4/10/2020 8:07:17 AM
这个可能就是这篇文章里提到的那个没有control group peer review的preprint, The popular faith in hydroxychloroquine stands in stark contrast to the weakness of the data. Several studies of its efficacy against COVID-19 have delivered an equivocal or negative verdict, and it can have significant side effects, including heart arrhythmias. Raoult’s positive studies have been widely criticized for their limitations and methodological issues. The first included only 42 patients, and Raoult chose who received the drug or a placebo, a no-no in clinical research; the International Society of Antimicrobial Chemotherapy has distanced itself from the paper, published in the society’s International Journal of Antimicrobial Agents. The second study, published as a preprint without peer review, didn’t have a control group at all.
FDA就是这么批的,”hospitalized” This EUA is for the unapproved use of hydroxychloroquine sulfate supplied from the Strategic National Stockpile (SNS) to treat adults and adolescents who weigh 50 kg or more and are hospitalized with COVID-19 for whom a clinical trial is not available, or participation is not feasible. Hydroxychloroquine sulfate must be administered orally
4月7日的文章 提到纽约，麻省，俄州，华州，加州 “ Doctors and pharmacists from more than half a dozen large healthcare systems in New York, Louisiana, Massachusetts, Ohio, Washington and California told Reuters they are routinely using hydroxychloroquine on patients hospitalized with COVID-19. ” https://mobile.reuters.com/article/amp/idUSKBN21O2VO?__twitter_impression=true
http://www.mediterranee-infection.com/wp-content/uploads/2020/04/Abstract_Raoult_EarlyTrtCovid19_09042020_vD1v.pdf
结果还是不错的，病情加重率4.3%，死亡率0.47%，而且这些人病情的恶化和“use of selective beta-blocking agents and angiotensin II receptor blockers”有关，以后搞清楚了结果应该会更好。他们的建议是尽早用这两种药物治疗：
“The HCQ-AZ combination, when started immediately after diagnosis, is a safe and efficient treatment for COVID-19, with a mortality rate of 0.5%, in elderly patients. It avoids worsening and clears virus persistence and contagiosity in most cases.”
🔥 最新回帖
为了党争让人命去填选票吗
是标准治疗啊，不是安慰剂，别误导人了。张文宏给美国医生讲认为所有试验的这些药都没啥奇效。最重要的就是呼吸支持。氯喹这东西万一吃多了有毒一个月才能排出体内，标准支持治疗治愈率也很高，为啥不愿意去标准治疗组呢？
就是有一种design是没有control的啊，但是需要size很大我记得。好像是大到这个sample足以代表所有感染者的程度。
🛋️ 沙发板凳
意思就是轻症的时候管用，可以避免重症，还可以降低病毒传染是吗老年组死亡率0.5% 确实不错了
文件里没看到剂量，是我哪里看漏了吗？
做实验的研究人员的结论很积极
The HCQ-AZ combination, when started immediately after diagnosis, is a safe and efficient treatment for COVID-19, with a mortality rate of 0.5%,in elderlypatients. It avoidsworsening and clearsvirus persistence and contagiosity in most cases
Exactly说的就是cuomo吧，联邦给了纽约百万doses硫酸羟氯喹，他一个州长行政命令只给住院的人用。
轻症可以发药回家吃，就像流感四十八小时内吃tamiflu一样
貌似是有的，说死亡率比用其他方式治疗的significantly低，但abstract里没有具体的数据，所以我问有没有原文。这个abstract标题都没有，不好搜。
哭魔是故意的，想让死亡率上去给川普难堪，他又不是医生凭什么决定什么时候给病人吃什么药！
是的 所以很多医生不同意 因为这些人很有可能就是轻症自愈的那些
那些人当初还信誓旦旦的说川普当选后要移民外国呢。
纽约医生听州长的。密歇根有一拼：不是白痴不去政府部门啊。
正是如此。又蠢又坏。
老年人组，全世界都知道重症率死亡率很高的吧，还要对照组么？
话不是这么说的，用的时间久不代表毒性不大，这样毒性大但已经用了几十年的药不要太多，说明没有更好的药代替而已，至少在某些人群里。
要的，这是科学研究的根本，没有对照组的话，你可以说也许是那医院的空气有治疗作用。
总算看到一个讲道理的
这楼里好多人都觉得自己是医生似的
结果都连基础的科学知识都匮乏
总是看到层主这样的，略感安慰
国内有的实验组有效，有的实验组无效。说明其实还是靠人品。
Michigan Nevada的州长也是不许医生用。
确实
这个可能就是这篇文章里提到的那个没有control group peer review的preprint,
The popular faith in hydroxychloroquine stands in stark contrast to the weakness of the data. Several studies of its efficacy against COVID-19 have delivered an equivocal or negative verdict, and it can have significant side effects, including heart arrhythmias. Raoult’s positive studies have been widely criticized for their limitations and methodological issues. The first included only 42 patients, and Raoult chose who received the drug or a placebo, a no-no in clinical research; the International Society of Antimicrobial Chemotherapy has distanced itself from the paper, published in the society’s International Journal of Antimicrobial Agents. The second study, published as a preprint without peer review, didn’t have a control group at all.
https://www.sciencemag.org/news/2020/04/france-s-president-fueling-hype-over-unproven-coronavirus-treatment
对，这两种药的combination国内压根没用过，我向国内的一线医生咨询的时候他们还很奇怪为什么会有阿奇霉素，国内用的都是氯喹，后来看到huaren上说有美国医生尝试两种药+锌的效果更好。
FDA就是这么批的,”hospitalized”
This EUA is for the unapproved use of hydroxychloroquine sulfate supplied from the Strategic National Stockpile (SNS) to treat adults and adolescents who weigh 50 kg or more and are hospitalized with COVID-19 for whom a clinical trial is not available, or participation is not feasible.
Hydroxychloroquine sulfate must be administered orally
https://www.fda.gov/media/136537/download
Page 5
https://www.fda.gov/media/136534/download
indeed
感觉科普的任务任重而道远
不少人盲信盲从 不但没有用 还给防疫增加了负担
你去看看做这个人的实验的采访，他还特意提到，他目前的实验是根据中国的资料做的。 中国还有更详细血浆实验。
可能他家人病情不严重，觉得可以manage，也自信不会发展为重症；病人到了重症的时候，为了救命什么都想试的。
昨天查新闻，看到德州休斯顿地区的死亡率只有0.7%，里面采访了0号病人，他现在回家了，进去已经是重症了，给的药就是氯喹，维生素C和锌的组合，有点滴给药的
据说上海的医生用过
据说上海的医生用过，效果不知和人种是否有关
发重了
https://www.wlox.com/2020/04/08/bay-doctor-prescribing-anti-malarial-drug-with-success-against-covid-/这个医生用了，所有病人都好转，只有一个咳嗽不能根除，睁大眼睛看清了
FDA不批，只能同情用药。
平均43.6岁就算老年组？
比啥比，没有control。
什么时候给撤的？我只听说CDC修改了它自己的网页，我还没有去核实
同情用药的是remdesivir，氯喹羟氯喹都是已经批了的药，FDA4/3批了EUA
专门为这事注册个号，发贴吗？
那个Fauci也不是好鸟。他自己不是呼吸传染病专家，但好歹做过艾滋病防治，这么一个已经广泛使用几十年只有长期服用才有副作用的便宜药，他老在唠叨实验数据不够，面对这种排山倒海的传染病明知道几个月几年那种传统实验对现状毫无助益，简直就是跟Cuomo一样草菅人命。
你引用的分享经历是纽约州长发禁令之前的。
现在不也可以用轻症吗？前面有人贴了FDA的file，自己去看一下就知道了。氯喹羟氯喹一度限制进口的，大概两周前已经放开了，供应问题已经在好转中。另外美国的测试量已经很大了。
Ohio也是有限制，不过州长是共和党，所以这板上只骂Cuomo https://twitter.com/DougGT500/status/1248631609785487361?s=20
4月7日的文章 提到纽约，麻省，俄州，华州，加州
“ Doctors and pharmacists from more than half a dozen large healthcare systems in New York, Louisiana, Massachusetts, Ohio, Washington and California told Reuters they are routinely using hydroxychloroquine on patients hospitalized with COVID-19. ”
https://mobile.reuters.com/article/amp/idUSKBN21O2VO?__twitter_impression=true
就是有一种design是没有control的啊，但是需要size很大我记得。好像是大到这个sample足以代表所有感染者的程度。
是标准治疗啊，不是安慰剂，别误导人了。张文宏给美国医生讲认为所有试验的这些药都没啥奇效。最重要的就是呼吸支持。氯喹这东西万一吃多了有毒一个月才能排出体内，标准支持治疗治愈率也很高，为啥不愿意去标准治疗组呢？