又发现新神药了 --- leronlimab

g
genechn
楼主 (北美华人网)
可以阻止细胞因子风暴,这一点和托珠单抗类似,同时还可以增强免疫系统反应。

https://apnews.com/Globe%20Newswire/5f340ac37ee044e098fd1a843cb46b08
The treatment with leronlimab is targeted as a therapy for patients who experience respiratory complications as a result of contracting SARS-CoV-2 causing the Coronavirus Disease 2019 (COVID-19). Leronlimab is believed to provide therapeutic benefit by enhancing the immune response while mitigating the “cytokine storm” that leads to morbidity and mortality in these patients. The laboratory evaluation of the first four patients treated with leronlimab revealed that the immune profile in these patients approached normal levels and the levels of cytokines involved in the cytokine storm (including IL-6 and TNF alpha) were much improved. The results of the three additional patients are expected this week.

现在正在做两个trial,包括轻症和危重症:

https://www.drugs.com/medical-answers/leronlimab-pro-140-treat-covid-19-coronavirus-3535182/

Leronlimab (PRO 140) has been used in a number of patients with COVID-19 (coronavirus) as part of two clinical trials applications that have been fast tracked by the FDA.
The first trial being applied for is to study the leronlimab in patients with mild to moderate COVID-19 respiratory symptoms.
The second trial that is being applied for will study leronlimab in patients with severe COVID-19 respiratory symptoms.
m
mouton
静待结果
x
xinfoall
Great news!
q
qxixi77
我是医药生物小白。这个跟其他的抗艾滋的药是一样原理吗?
g
genechn
我是医药生物小白。这个跟其他的抗艾滋的药是一样原理吗?
qxixi77 发表于 3/31/2020 3:08:53 AM

不知道其它抗艾滋的药是怎么起作用的,Leronlimab是一种靶向CCR5的人源化IgG4单抗,用途很广泛。如

https://med.sina.com/article_detail_100_2_65739.html
g
genechn
托珠单抗在伴随有细菌感染时是不能用的,这个看起来似乎可以。
B
BayArea999
好消息
呼啦圈
感觉都人民希望好多轮了,不知道最后哪个能真的力挽狂澜
芥小末
有希望总是好的!Bless!!!
C
Cinderella_smile
希望一定是个好消息!
V
Vlj
看来只要有合适的药,轻症还是容易对付的
d
drchao
有希望是好的!
c
cheeryinmay
我是医药生物小白。这个跟其他的抗艾滋的药是一样原理吗?
qxixi77 发表于 3/31/2020 3:08:53 AM


如果指克立芝的话,完全不一样
焱焱
希望听到越来越多的可能的治疗手段
b
bonton
我是医药生物小白。这个跟其他的抗艾滋的药是一样原理吗?
qxixi77 发表于 3/31/2020 3:08:53 AM

不是吧?我也是小白,但是听说抗艾滋的药是抗病毒复制,艾滋病毒并不会引起免疫风暴,会摧毁免疫系统。
b
bonton
多一个希望,best wishes!
A
Augustines
回复 1楼genechn的帖子 希望天天有好消息,一天比一天好
好消息!轻症靠增强免疫力,重症靠阻止细胞因子风暴,二合一,是这个意思吗?
k
kinston
完全不看好这个抗CCR5 receptor的单抗,开发用来治疗HIV感染,可能抑制T细胞的CCR5信号通路对缓解某些重症患者的细胞因子风暴有效,但肯定不会是治愈covid-19感染的药。
可以阻止细胞因子风暴,这一点和托珠单抗类似,同时还可以增强免疫系统反应。 https://apnews.com/Globe%20Newswire/5f340ac37ee044e098fd1a843cb46b08 The treatment with leronlimab is targeted as a therapy for patients who experience respiratory complications as a result of contracting SARS-CoV-2 causing the Coronavirus Disease 2019 (COVID-19). Leronlimab is believed to provide therapeutic benefit byenhancing the immune response while mitigating the “cytokine storm”that leads to morbidity and mortality in these patients. The laboratory evaluation of the first four patients treated with leronlimab revealed that the immune profile in these patients approached normal levels and the levels of cytokines involved in the cytokine storm (including IL-6 and TNF alpha) were much improved. The results of the three additional patients are expected this week. 现在正在做两个trial,包括轻症和危重症: https://www.drugs.com/medical-answers/leronlimab-pro-140-treat-covid-19-coronavirus-3535182/ Leronlimab (PRO 140) has been used in a number of patients with COVID-19 (coronavirus) as part of two clinical trials applications that have been fast tracked by the FDA. The first trial being applied for is to study the leronlimab in patients with mild to moderate COVID-19  respiratory symptoms. The second trial that is being applied for will study leronlimab in patients with severe COVID-19 respiratory symptoms. genechn 发表于 3/31/2020 2:17:00 AM
s
sophia002
好消息啊.......