https://www.kron4.com/news/national/us-fda-issues-limited-emergency-use-authorization-for-two-drugs-usually-used-to-treat-malaria/?from=timeline&isappinstalled=0 (CNN) — The US Food and Drug Administration (FDA) has issued an emergency use authorization for chloroquine and hydroxychloroquine to treat patients hospitalized with COVID-19. The drugs — which are used to treat malaria and other conditions — have been called game changers by President Donald Trump. But thus far, there is little scientific evidence that chloroquine, or its closely-related analogue hydroxychloroquine, are effective in treating Covid-19. What happened? The authorization came in a letter dated Saturday, but the US Department of Health and Human Services (HHS) acknowledged the FDA’s action in a Sunday news release. The FDA limited the scope of its authorization to drugs supplied from the Strategic National Stockpile. The HHS announced that two pharmaceutical companies — Bayer and a division of Novartis — had donated the drugs to the stockpile. Do the drugs work? In its statement, HHS said:
“Anecdotal reports suggest that these drugs may offer some benefit in the treatment of hospitalized COVID-19 patients. “The safety profile of these drugs has only been studied for FDA approved indications, not COVID-19.”
While there’s limited evidence on the efficacy of chloroquine, or hydroxychloroquine, the FDA said the drugs’ benefits outweighed their risk. In its letter, the FDA encouraged randomized clinical trials that could assess the effectiveness of the drugs. It also noted that the known and potential benefits outweigh the risks. Who can the drugs be used to treat? The authorization is limited to patients who are currently hospitalized and weigh at least 50kg, or about 110 pounds. Under the emergency use authorization, health care providers must contact their local or state health department to access the drugs.
But thus far, there is little scientific evidence that chloroquine, or its closely-related analogue hydroxychloroquine, are effective in treating Covid-19.
“ Wow. Just, wow. No credible medical expert is saying this. Either the former governor of Kansas is a genius ahead of his time or he's a politician peddling snake oil.” — wsj comments
“ This is how it will go: If the treatment is effective - Trump will claim to have been decisive is pushing the treatment, even though it originated overseas and would have proceeded under the current course without his commentary. If the treatment is ineffective - Trump will claim he didn’t say “that,“ or he really said “this.” If the treatment proves ineffective and harmful, especially if it is widely misused in a way that undermines science - Trump will “take no responsibility at all” and blame his own administration or a previous administration. This is playing disgusting politics with science and lives.” 基本就是这样，一会儿说要么剂量不够要么用的太晚时间不对，根本不符合特效药的标准啊
I think the production is scaled for on-label use originally, and there is a legit concern for patients who needed them for survival unrelated to Covid 19
Who can the drugs be used to treat? The authorization is limited to patients who are currently hospitalized and weigh at least 50kg, or about 110 pounds ——————————- 体重不够的怎么办？
(CNN) — The US Food and Drug Administration (FDA) has issued an emergency use authorization for chloroquine and hydroxychloroquine to treat patients hospitalized with COVID-19. The drugs — which are used to treat malaria and other conditions — have been called game changers by President Donald Trump. But thus far, there is little scientific evidence that chloroquine, or its closely-related analogue hydroxychloroquine, are effective in treating Covid-19. What happened? The authorization came in a letter dated Saturday, but the US Department of Health and Human Services (HHS) acknowledged the FDA’s action in a Sunday news release. The FDA limited the scope of its authorization to drugs supplied from the Strategic National Stockpile. The HHS announced that two pharmaceutical companies — Bayer and a division of Novartis — had donated the drugs to the stockpile. Do the drugs work? In its statement, HHS said: While there’s limited evidence on the efficacy of chloroquine, or hydroxychloroquine, the FDA said the drugs’ benefits outweighed their risk. In its letter, the FDA encouraged randomized clinical trials that could assess the effectiveness of the drugs. It also noted that the known and potential benefits outweigh the risks. Who can the drugs be used to treat? The authorization is limited to patients who are currently hospitalized and weigh at least 50kg, or about 110 pounds. Under the emergency use authorization, health care providers must contact their local or state health department to access the drugs.
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按照外宣的解释，全世界都把中共当敌人，敌人的话不可信。
能说说对视力会有什么影响吗？谢谢！
🛋️ 沙发板凳
CNN还要脸么？前几天骂的太狠现在要收回来很难受把呵呵
显然没关系。。。
昨天人民的希望也重开access program，我觉得这个作用更大
受迫害妄想症真是没得治
左霉和猪党都完全疯了，反川反的什么都不管了
受迫害妄想症真是没得治
全世界都在抢呢，印度还禁了出口
怎么可能没有药，还没下放下去可能。之前好几个制药公司已经说有几千万片。
硫酸氯喹主要给红斑狼疮患者用 储量小
氯喹是抗疟疾必备的储备药 任何国家的公共卫生部门都应该有大量储备 肯定拿得出来
这东西流水线一开成千上万 一声令下可以产生无数
千万不要告诉我这个药以前也都是从中国进口的。
不要老把自己想成受害者，没有任何人看中国的笑话。1，2月份时的话题是如何买口罩和往中国邮寄口罩。
全世界都不知道这个病毒的危害。所以才有现在全世界200个国家（包括美国在内）全部沦陷。为什么全世界200个国家的领导都不知道这个病毒这么厉害，谁来解释？？？
非常赞同，的确如此。有些人有受害妄想症！！
不知道美国的货源 我在欧洲买的反正都是当地产的 这东西没啥必要依赖中国吧。。。
等药厂的MM上来说
本来就是，她凭什么指导医生用药。上周五我认识的医生就全都不敢开了，因为州长下令，只要开的医生就“sanction". 密州这么多病人，她没本事搞来ppe， test和呼吸机，就只会下令轻症都不让测了，药也不让开了。光会骂trump. 她比他也好不了多少。
意大利一开始爆发就上了克力芝鸡尾酒给中度到重症的 效果是不错的。
然而这个还是不对 应该轻症就吃。所以走到现在这个地步。
意大利的问题是老龄化太严重了 疫区的老年人实在太多 有基础病的这些药你都不能用的
金鸡纳类好像是对心肌有风险我记得，心脏不好的吃不来。
处方药在欧洲也能随便买吗？
上周开始药房说，FEMA在收这个药。希望他们有存货现在可以发放
“这是黄种人的病毒”，“黄种人???表达比白人高5倍”，这是当时的观点
同意，轻症氯喹，不过Gilead 药有的话中症要上，托朱更重点儿在用
氯喹在欧洲是只要说需要去疟疾带travel就可以买的 而且会给多余的量以备万一
去非洲玩就是要预备好抗疟疾药品的 但是不一定是氯喹 也可能是其他类别的
希望如此啊，口罩不都没跟上嘛
不知原料药是中国还是印度，几天前看到新闻说印度禁了出口
那的先有脸吧。
没了的是硫酸
磷酸的一下子就可以造出来很多。。。而且应该有储备 就是吃了上吐下泻更厉害= =
当然是美国本土制造，这边好几家Generics公司都生产的。
这些民主党的真是有党性没人性！这句话能在美国派上用场真是太讽刺了！
今天知道密歇根那个woman州长是一个。
不解禁可以和批准的州做對比實驗，打川普的臉。
克力芝 是无效，多国医疗体系都证实了。
Let’s treat 130,000 Americans with a drug that had 100% efficacy in a case study with a sample size of 6 patients?
Is the author of this article really a plastic surgeon from Kansas?
— wsj comments
我也算了一下
1/sqrt(6) ~= 41%
这还是 1 standard deviation
In other words, any study on a sample size of 6 cannot be conclusive
所以才会有主楼里说的no scientific evidence
这楼里居然还有那么多语言暴力的川粉
还有得Lupas的病人都快完全吃不到药了，遇上这样的总统真是倒霉透了
扭腰的测试参照组是用的是抗艾滋药物
证明巨巨的特效药并没有更有效
所以才会产生狼来了的怀疑啊
一会儿双黄连，一会儿抗艾滋药，一会儿MERS用药
真有效就不会现在上海二次告急了
扭腰的测试没有证明巨巨的特效药比抗艾滋药物更有效
本来这药不会缺
因为各大药厂都捐了很多
后来被巨巨一叫又加上各网站火上浇油般的宣传误导，平时要吃这种药救命的都买不到了
现在不是光安全用药的问题，是本来需要的人都被恐慌性囤积的人搞的买不到了
这和口罩草纸和鸡蛋都要囤一年的有什么差别啊？你囤一年，就要有十几家连一个月的量都买不到了
曾经的大拜耳人感到自豪，希望药快快到位！
肯定有人乘机又囤了呗
不然怎么会草纸鸡蛋都告急了呢
捐的不是硫酸氯喹 硫酸的没人拿来治疗疟疾的 是给红斑狼疮用的
其他氯喹有的是 副作用大一些 但是之前FDA没给greenlight谁敢用
搞笑，ny trial就周二周三才开始，一个疗程都没完，你哪看的纽约说没效果？cnn这些左臂媒体都是用什么国内的烂paper来黑，。。。fda吃饱了才今天紧急批准？
早就不准市面卖了。你放心好了。
你没有见过就都是fake news吧
巨巨在没有科学证明的情况下拿个anecdotal的药乱传，人命关天的大事
那是不是因为已经囤了的人造成了很恶劣的结果呢？
嗯，川普是个common sense比较强的人。
你看这个新闻了吗？和纽约完全无关，说的就是浙江大学的烂paper，实际上浙江校正剂量以后已经说有效了。 意大利，韩国，英国，全世界都开始用，你们左臂为了反川抵制？脑子坏了？而且硫酸羟氯喹的副作用什么视力减退，呕吐都是短期的，几十年的老药比起可能救命孰轻孰重？
川普出来说这个药的时候就已经定了政策的了。这种药首先要处方，再且市面上流通的本来很少，那些大宗的根本没有流入市面。可能部分原先吃过这个药的人在某些州受到影响（暂时还没有看到新闻说原先吃这个药的病人买不到了），但是显然不可能个人能囤太多。
All I am asking for is one legit clinical trial to prove it’s as effective as Trump claimed.
没有强证据FDA不会批的好吗，服了你了。要不你去FDA让他们取消这个批准？
I think the production is scaled for on-label use originally, and there is a legit concern for patients who needed them for survival unrelated to Covid 19
下次不要选这种光会耍嘴皮子的
你去看一下1楼，有没有强证
这个药说了也没法囤积，都需要医生处方，哪里来的囤积。又不像草纸，店里网上随便买
等事情过了，你又会喜欢这种说的比唱的还好听的
国内不让寄
怎么寄过来，能说一下吗。
可以科普下具体用量和服用后的反应吗？