Tobacco-use disparity in gene expression of ACE2, the receptor of2019-nCovGuoshuai CaiDepartment of Environmental Health Sciences, Arnold School of Public Health, University ofSouth Carolina, Columbia, SC 29208
Abstract In current severe global emergency situation of 2019-nCov outbreak, it is imperative to identify vulnerable and susceptible groups for effective protection and care. Recently, studies found that 2019-nCov and SARS-nCov share the same receptor, ACE2. In this study, we analyzed four large-scale datasets of normal lung tissue to investigate the disparities related to race, age, gender and smoking status in ACE2 gene expression. No significant disparities in ACE2 gene expression were found between racial groups (Asian vs Caucasian), age groups (>60 vs <60) or gender groups (male vs female). However, we observed significantly higher ACE2 gene expression in smoker samples compared to nonsmoker samples. This indicates the smokers may be more susceptible to 2019-nCov and thus smoking history should be considered in identifying susceptible population and standardizing treatment regimen. Key words Wuhan 2019-nCov, ACE2, expression, susceptibility, race, age, gender, smoking
Tobacco-use disparity in gene expression of ACE2, the receptor of2019-nCovGuoshuai CaiDepartment of Environmental Health Sciences, Arnold School of Public Health, University ofSouth Carolina, Columbia, SC 29208
Abstract In current severe global emergency situation of 2019-nCov outbreak, it is imperative to identify vulnerable and susceptible groups for effective protection and care. Recently, studies found that 2019-nCov and SARS-nCov share the same receptor, ACE2. In this study, we analyzed four large-scale datasets of normal lung tissue to investigate the disparities related to race, age, gender and smoking status in ACE2 gene expression. No significant disparities in ACE2 gene expression were found between racial groups (Asian vs Caucasian), age groups (>60 vs <60) or gender groups (male vs female). However, we observed significantly higher ACE2 gene expression in smoker samples compared to nonsmoker samples. This indicates the smokers may be more susceptible to 2019-nCov and thus smoking history should be considered in identifying susceptible population and standardizing treatment regimen. Key words Wuhan 2019-nCov, ACE2, expression, susceptibility, race, age, gender, smoking oncebluemoon 发表于 2/17/2020 2:01:18 PM
Abstract
In current severe global emergency situation of 2019-nCov outbreak, it is imperative to
identify vulnerable and susceptible groups for effective protection and care. Recently,
studies found that 2019-nCov and SARS-nCov share the same receptor, ACE2. In this
study, we analyzed four large-scale datasets of normal lung tissue to investigate the
disparities related to race, age, gender and smoking status in ACE2 gene expression. No
significant disparities in ACE2 gene expression were found between racial groups (Asian vs
Caucasian), age groups (>60 vs <60) or gender groups (male vs female). However, we
observed significantly higher ACE2 gene expression in smoker samples compared to nonsmoker samples. This indicates the smokers may be more susceptible to 2019-nCov and
thus smoking history should be considered in identifying susceptible population and
standardizing treatment regimen.
Key words
Wuhan 2019-nCov, ACE2, expression, susceptibility, race, age, gender, smoking
印度人北部人种可能少，南部可能多。需要证据。
所以亚裔男性发病率高是因为吸烟多？