显然，单从传染能力上来说，这次的新型冠状病毒（SARS-CoV-2）要比SARS病毒（R0：0.85-3）强的多。 既然新型冠状病毒与SARS病毒都是依赖病毒表面的S蛋白与细胞表面的血管紧张素转换酶2（ACE2）结合，才得以进入细胞， 那新型冠状病毒的传染性为什么比SARS病毒强呢？ 美国德克萨斯大学奥斯汀分校的Jason S. McLellan团队，今天在预印版平台bioRxiv上发表研究论文[2]，给了我们一个可能的解释。 McLellan团队的研究人员利用冷冻电镜技术解析了新型冠状病毒的S蛋白结构，还利用表面等离子共振技术（SPR）分析了S蛋白与ACE2的亲和力。 他们发现，ACE2蛋白与新型冠状病毒的亲和力竟是SARS病毒的10到20倍，而不是之前的比SARS病毒弱。这也解释了为什么新冠病毒的传染性如此之强。 这里是文章的 link
Cryo-EM Structure of the 2019-nCoV Spike in the Prefusion Conformation
The outbreak of a novel betacoronavirus (2019-nCov) represents a pandemic threat that has been declared a public health emergency of international concern. The CoV spike (S) glycoprotein is a key target for urgently needed vaccines, therapeutic antibodies, and diagnostics. To facilitate medical countermeasure (MCM) development we determined a 3.5 Å-resolution cryo-EM structure of the 2019-nCoV S trimer in the prefusion conformation. The predominant state of the trimer has one of the three receptor-binding domains (RBDs) rotated up in a receptor-accessible conformation. We also show biophysical and structural evidence that the 2019-nCoV S binds ACE2 with higher affinity than SARS-CoV S. Additionally we tested several published SARS-CoV RBD-specific monoclonal antibodies and found that they do not have appreciable binding to nCoV-2019 S, suggesting antibody cross-reactivity may be limited between the two virus RBDs. The cryo-EM structure of 2019-nCoV S should enable rapid development and evaluation of MCMs to address the ongoing public health crisis. Corresponding author Jason S McLellan The University of Texas at Austin
Jan 29 Huge variance across populations, with East Asians usually at the top (meaning highest risk infection), and Europeans usually at the bottom (meaning lowest risk infection).
Associationof angiotensin-converting enzyme 2 gene polymorphism and enzymatic Medicine(Baltimore). 2018 Oct;97(42):e12917. doi: 10.1097/MD.0000000000012917. ACE2polymorphisms associated with cardiovascular risk in Uygurs with type 2 10.1186/s12933-018-0771-3.PubMed PMID: 30227878; PubMed Central PMCID: theStroke Recurrence in Chinese Population. J Stroke Cerebrovasc Dis. 2018 Jul26. PubMed PMID: 30056001. 4:Chen YY, Liu D, Zhang P, Zhong JC, Zhang CJ, Wu SL, Zhang YQ, Liu GZ, He M, ACEinhibitors. J Hum Hypertens. 2016 Dec;30(12):766-771. doi: Nodularglomerulosclerosis and renin angiotensin system in Chinese patients with 10.1016/j.mce.2016.03.008.Epub 2016 Mar 10. PubMed PMID: 26973293. 6:Meng N, Zhang Y, Ma J, Li H, Zhou F, Qu Y. Association of polymorphisms of amongChinese individuals. Eye (Lond). 2015 Feb;29(2):266-71. doi: PMCID:PMC4330274. 7:Li J, Feng M, Wang Y, Li Y, Zhang Y, Li L, Xiong J, Lu C, Wang B, Cheng Z, hypertensionamong northeastern Han Chinese. J Renin Angiotensin Aldosterone PubMedPMID: 25143330. 8:Wang SX, Tao T, Fu ZQ, Xie XZ, Wang H, Wang YT. Polymorphisms of Chinesemale patients. Chin Med J (Engl). 2013;126(24):4608-11. PubMed PMID: CM,Su SL. Impact of interaction of cigarette smoking with angiotensin-converting JRenin Angiotensin Aldosterone Syst. 2015 Mar;16(1):203-10. doi: CaoJ, Li J, Li H, He J, Liu DP, Gu D. Polymorphisms of ACE2 are associated with 2012Aug;25(8):937-42. doi: 10.1038/ajh.2012.61. Epub 2012 May 31. PubMed PMID: S.Association of angiotensin I converting enzyme, angiotensin II type 1 receptor type2 diabetic patients of Chinese Han origin. J Endocrinol Invest. 2012 GuoXX, Hu YH, Lee LM. Interactions of renin-angiotensin system gene Pharmacogenomics.2011 May;12(5):735-43. doi: 10.2217/pgs.11.2. Epub 2011 Mar 31. angiotensin-convertingenzyme 2 gene polymorphisms to essential hypertension and Chinese.PubMed PMID: 20813695. 14:Fan XH, Wang YB, Wang H, Sun K, Zhang WL, Song XD, Cheng JZ, Wu HY, Zhou XL, associatedwith orthostatic blood pressure dysregulation in hypertensive Epub2009 Aug 17. PubMed PMID: 19684612; PubMed Central PMCID: PMC4007186. 15:Zhou JB, Yang JK. Meta-analysis of association of ACE2 G8790A polymorphism 2009Mar;10(1):31-4. doi: 10.1177/1470320309103047. PubMed PMID: 19286756. 16:Niu W, Qi Y, Hou S, Zhou W, Qiu C. Correlation of angiotensin-converting 2007Dec;150(6):374-80. Epub 2007 Jul 2. PubMed PMID: 18022600. 17:Furuichi T, Kannan K, Suzuki K, Tanaka S, Giesy JP, Masunaga S. Occurrence of EnvironSci Technol. 2006 Dec 15;40(24):7896-902. PubMed PMID: 17256545. 18:Huang W, Yang W, Wang Y, Zhao Q, Gu D, Chen R. Association study of hypertensionin northern Han Chinese. J Hum Hypertens. 2006 Dec;20(12):968-71. angiotensin-convertingenzyme 2 gene A/G polymorphism and elevated blood pressure Feb;147(2):91-5.PubMed PMID: 16459167. 20:Liu TB, Shang HP, Zhang KX, Chen LH, Zhu XL, Zhang Y, Zhu DL, Huang W. essentialhypertension in Chinese]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2005 Oct;22(5):569-71.Chinese. PubMed PMID: 16215952.
Jan 29 Huge variance across populations, with East Asians usually at the top (meaning highest risk infection), and Europeans usually at the bottom (meaning lowest risk infection).
Cryo-EM Structure of the 2019-nCoV Spike in the Prefusion Conformation
The outbreak of a novel betacoronavirus (2019-nCov) represents a pandemic threat that has been declared a public health emergency of international concern. The CoV spike (S) glycoprotein is a key target for urgently needed vaccines, therapeutic antibodies, and diagnostics. To facilitate medical countermeasure (MCM) development we determined a 3.5 Å-resolution cryo-EM structure of the 2019-nCoV S trimer in the prefusion conformation. The predominant state of the trimer has one of the three receptor-binding domains (RBDs) rotated up in a receptor-accessible conformation. We also show biophysical and structural evidence that the 2019-nCoV S binds ACE2 with higher affinity than SARS-CoV S. Additionally we tested several published SARS-CoV RBD-specific monoclonal antibodies and found that they do not have appreciable binding to nCoV-2019 S, suggesting antibody cross-reactivity may be limited between the two virus RBDs. The cryo-EM structure of 2019-nCoV S should enable rapid development and evaluation of MCMs to address the ongoing public health crisis.
Single-cell RNA expression profiling of ACE2, the putative receptor of Wuhan 2019-nCov Yu Zhao, Zixian Zhao, Yujia Wang, Yueqing Zhou, Yu Ma, Wei Zuo doi: https://doi.org/10.1101/2020.01.26.919985
A novel coronavirus (2019-nCov) was identified in Wuhan, Hubei Province, China in December of 2019. This new coronavirus has resulted in thousands of cases of lethal disease in China, with additional patients being identified in a rapidly growing number internationally. 2019-nCov was reported to share the same receptor, Angiotensin-converting enzyme 2 (ACE2), with SARS-Cov. Here based on the public database and the state-of-the-art single-cell RNA-Seq technique, we analyzed the ACE2 RNA expression profile in the normal human lungs. The result indicates that the ACE2 virus receptor expression is concentrated in a small population of type II alveolar cells (AT2). Surprisingly, we found that this population of ACE2-expressing AT2 also highly expressed many other genes that positively regulating viral reproduction and transmission. A comparison between eight individual samples demonstrated that the Asian male one has an extremely large number of ACE2-expressing cells in the lung. This study provides a biological background for the epidemic investigation of the 2019-nCov infection disease, and could be informative for future anti-ACE2 therapeutic strategy development.
Single-cell RNA expression profiling of ACE2, the putative receptor of Wuhan 2019-nCov Yu Zhao, Zixian Zhao, Yujia Wang, Yueqing Zhou, Yu Ma, Wei Zuo doi: https://doi.org/10.1101/2020.01.26.919985
A novel coronavirus (2019-nCov) was identified in Wuhan, Hubei Province, China in December of 2019. This new coronavirus has resulted in thousands of cases of lethal disease in China, with additional patients being identified in a rapidly growing number internationally. 2019-nCov was reported to share the same receptor, Angiotensin-converting enzyme 2 (ACE2), with SARS-Cov. Here based on the public database and the state-of-the-art single-cell RNA-Seq technique, we analyzed the ACE2 RNA expression profile in the normal human lungs. The result indicates that the ACE2 virus receptor expression is concentrated in a small population of type II alveolar cells (AT2). Surprisingly, we found that this population of ACE2-expressing AT2 also highly expressed many other genes that positively regulating viral reproduction and transmission. A comparison between eight individual samples demonstrated that the Asian male one has an extremely large number of ACE2-expressing cells in the lung. This study provides a biological background for the epidemic investigation of the 2019-nCov infection disease, and could be informative for future anti-ACE2 therapeutic strategy development.
Cryo-EM Structure of the 2019-nCoV Spike in the Prefusion Conformation
The outbreak of a novel betacoronavirus (2019-nCov) represents a pandemic threat that has been declared a public health emergency of international concern. The CoV spike (S) glycoprotein is a key target for urgently needed vaccines, therapeutic antibodies, and diagnostics. To facilitate medical countermeasure (MCM) development we determined a 3.5 Å-resolution cryo-EM structure of the 2019-nCoV S trimer in the prefusion conformation. The predominant state of the trimer has one of the three receptor-binding domains (RBDs) rotated up in a receptor-accessible conformation. We also show biophysical and structural evidence that the 2019-nCoV S binds ACE2 with higher affinity than SARS-CoV S. Additionally we tested several published SARS-CoV RBD-specific monoclonal antibodies and found that they do not have appreciable binding to nCoV-2019 S, suggesting antibody cross-reactivity may be limited between the two virus RBDs. The cryo-EM structure of 2019-nCoV S should enable rapid development and evaluation of MCMs to address the ongoing public health crisis.
新聞來源:
https://mp.weixin.qq.com/s/83nvH2B-RKY_zjTADv2cug
[/url] 前几天，中国国家疾控中心等研究机构联合发表的近九千例新冠肺炎（COVID-19）确诊病例和疑似病例数据显示，
新冠肺炎的基本传染数R0则高达3.77。
显然，单从传染能力上来说，这次的新型冠状病毒（SARS-CoV-2）要比SARS病毒（R0：0.85-3）强的多。
既然新型冠状病毒与SARS病毒都是依赖病毒表面的S蛋白与细胞表面的血管紧张素转换酶2（ACE2）结合，才得以进入细胞， 那新型冠状病毒的传染性为什么比SARS病毒强呢？
美国德克萨斯大学奥斯汀分校的Jason S. McLellan团队，今天在预印版平台bioRxiv上发表研究论文[2]，给了我们一个可能的解释。
McLellan团队的研究人员利用冷冻电镜技术解析了新型冠状病毒的S蛋白结构，还利用表面等离子共振技术（SPR）分析了S蛋白与ACE2的亲和力。
他们发现，ACE2蛋白与新型冠状病毒的亲和力竟是SARS病毒的10到20倍，而不是之前的比SARS病毒弱。 这也解释了为什么新冠病毒的传染性如此之强。
这里是文章的 link
是biorxiv的文章
自己看
https://www.biorxiv.org/content/10.1101/2020.02.11.944462v1
Cryo-EM Structure of the 2019-nCoV Spike in the Prefusion Conformation
The outbreak of a novel betacoronavirus (2019-nCov) represents a pandemic threat that has been declared a public health emergency of international concern. The CoV spike (S) glycoprotein is a key target for urgently needed vaccines, therapeutic antibodies, and diagnostics. To facilitate medical countermeasure (MCM) development we determined a 3.5 Å-resolution cryo-EM structure of the 2019-nCoV S trimer in the prefusion conformation. The predominant state of the trimer has one of the three receptor-binding domains (RBDs) rotated up in a receptor-accessible conformation. We also show biophysical and structural evidence that the 2019-nCoV S binds ACE2 with higher affinity than SARS-CoV S. Additionally we tested several published SARS-CoV RBD-specific monoclonal antibodies and found that they do not have appreciable binding to nCoV-2019 S, suggesting antibody cross-reactivity may be limited between the two virus RBDs. The cryo-EM structure of 2019-nCoV S should enable rapid development and evaluation of MCMs to address the ongoing public health crisis. Corresponding author
Jason S McLellan
The University of Texas at Austin
🔥 最新回帖
这个不好说吧。
1. 党内斗争。自己人一向对自己人狠2. 黄种人不止中国人
3. 只想搞出一个狠的病毒，开始并不知道ACE2强弱
4. 实验室管理不严，迟早出事，赶上冬季适合病毒流传
这个出处是哪里
👍
🛋️ 沙发板凳
那个一共，国家给了你这么多钱买电镜，你就不能抢发几篇CNS为国增光么？
因为研究表明亚裔的ACE2亲和度比他族裔高。
请给个出处。
这个倒是符合现有的数据。日本的感染率是除中国外最多的？
Cdc如果不是提前知道点啥，淡定的也太奇怪了。
基因自带的，生活环境不会改变这个基因
These are all variants known to positively influence the amount of ACE2-expressing cells:
https://ncbi.nlm.nih.gov/snp/rs233575
East Asian A=1.00
African A=0.988
South Asian A=0.82
American A=0.79
Europe A=0.66
Jan 29
https://ncbi.nlm.nih.gov/snp/rs714205
East Asian G=0.54
South Asian G=0.47
American G=0.30
Europe G=0.20
African G=0.101
Jan 29
http://ncbi.nlm.nih.gov/snp/rs1978124
East Asian C=0.99
African C=0.900
South Asian C=0.78
American C=0.71
Europe C=0.53
Jan 29
http://ncbi.nlm.nih.gov/snp/rs879922
East Asian G=0.96
South Asian G=0.71
American G=0.72
Europe G=0.65
African G=0.454
Jan 29
http://ncbi.nlm.nih.gov/snp/rs2048683
East Asian G=0.99
African G=0.807
South Asian G=0.80
American G=0.75
Europe G=0.65
Jan 29
http://ncbi.nlm.nih.gov/snp/rs1877752
East Asian C=0.98
South Asian C=0.71
American C=0.71
Europe C=0.64
African C=0.453
Jan 29
Huge variance across populations, with East Asians usually at the top (meaning highest risk infection), and Europeans usually at the bottom (meaning lowest risk infection).
所以美加政府都不着急，定向针对亚裔
哇，这个太可怕了
基因决定的
另, 虽然这病毒超厉害
我不认为是生物武器
演化也有可能 optimize S protein 也许就是那麽倒楣也不一定
就算是大家说的泄漏
我感觉更像一个为了要拚 nature, science paper 而搞出的悲剧
要知道 virus reverse genetic (infectious clone) 是很常用来研究病毒的技术
就是把 virus 的 RNA 转为 DNA 载体
很多 virus 的 paper 都是把 infectious clone 的某个蛋白改一下
然後报导活性
只不过大部分人都不敢玩那麽恐怖的病毒罢了
华人里高人很多啊，都深藏不露。
必要时，一个个就露出来。
上次，华为事件也一样。
我先抓个图吧。这种事自有公论
所以呢？有必要还在自己交通枢纽、人口多人员庞杂、气候阴冷适合病毒扩散的城市武汉，还是在自己人流通最广泛的阖家团圆的春节放出来？？病毒浓度如此之高，就随便一个泄漏？谁对自己下手这么狠？！
我记得那个帖子当时被踩是正常的
因为是繁体字 加上表述有些危言耸听的味道
自己搞自己的逻辑不难懂，难懂的是自己搞自己但同时要确保不要搞到小白人，尼玛，这就无法理解了
自己搞自己往死里搞啊？tg再蠢也不会这么搞
针对台湾和香港的呗。
我觉得定向撒毒可能性高
你幼稚了，昧着良心没有伦理的人搞出来扬了名，之后的事她能控制?所有事情失控不就现在这样子。
有些人繁体简体转换的，本帖里就有。
这个事情的确很奇怪，
就和武汉病毒所在疫情初期一声不吭一样，
该shining的时候居然很低调。
难道中国的那帮电镜科学家也参与了病毒的设计？？？？？
饿死三千万的逻辑呢？为什么自己人饿死也要卖粮食出口换黄金？文化大革命的逻辑呢？因为一些人不够血忠，就右派，就该死？计划生育的逻辑呢？自己的胎儿、婴儿要杀死？中国共产党杀中国人需要逻辑吗？非常简单的回答给你，就是到时间了，又来了。至于它是内斗也好，还是泄漏也好，还是管理官僚无能也罢，总之每隔十几年就得搞死一批人，然后维护某撮人的利益。
还美国特工，你当党妈政审是儿戏吗?你再胡白白，更会拖国家被制裁。你别以为华人上就你们和轮子，别人都看着呢。你们领导谁啊，该把你提回去，培训好了再来
病毒泄漏+无知掩饰+等皇上拍板+皇上无心考虑就拖了一阵子
现实就是这么荒诞
一党专政，一人极权，最后肯定会出事儿
这种事情没什么阴谋论的，就是每个人都想不负责，又要逃避上级问责
每个官员，都无需考虑群众的呼声，只要舔好上级屁眼
自然就是这样喽
还是那句话，不要乱说，拖累党妈。国家经费那么高，怎么培训的。
这个图能给个出处吗？后面给的出处看不太明。我之前看的cui下面文章说，不是中国人ACE2高，而是抽烟的人高。正高兴呢觉果就看到你这图了😭
https://www.preprints.org/manuscript/202002.0051/v1/download
https://www.biorxiv.org/content/10.1101/2020.01.26.919985v1.full
我只有查到这一篇
可是它用得样本数只有八个?
我没仔细看
不过以下是样本的截图
Asian 只有一个 且有吸菸
和以前的实验室泄露信息结合起来，为啥要灭自己的族？
我没看到 ACE2 expression level 在 asian 高的文章
只能搜出以下文章
Associationof angiotensin-converting enzyme 2 gene polymorphism and enzymatic Medicine(Baltimore). 2018 Oct;97(42):e12917. doi: 10.1097/MD.0000000000012917.
ACE2polymorphisms associated with cardiovascular risk in Uygurs with type 2 10.1186/s12933-018-0771-3.PubMed PMID: 30227878; PubMed Central PMCID:
theStroke Recurrence in Chinese Population. J Stroke Cerebrovasc Dis. 2018 Jul26. PubMed PMID: 30056001. 4:Chen YY, Liu D, Zhang P, Zhong JC, Zhang CJ, Wu SL, Zhang YQ, Liu GZ, He M, ACEinhibitors. J Hum Hypertens. 2016 Dec;30(12):766-771. doi:
Nodularglomerulosclerosis and renin angiotensin system in Chinese patients with 10.1016/j.mce.2016.03.008.Epub 2016 Mar 10. PubMed PMID: 26973293. 6:Meng N, Zhang Y, Ma J, Li H, Zhou F, Qu Y. Association of polymorphisms of amongChinese individuals. Eye (Lond). 2015 Feb;29(2):266-71. doi: PMCID:PMC4330274. 7:Li J, Feng M, Wang Y, Li Y, Zhang Y, Li L, Xiong J, Lu C, Wang B, Cheng Z, hypertensionamong northeastern Han Chinese. J Renin Angiotensin Aldosterone PubMedPMID: 25143330. 8:Wang SX, Tao T, Fu ZQ, Xie XZ, Wang H, Wang YT. Polymorphisms of Chinesemale patients. Chin Med J (Engl). 2013;126(24):4608-11. PubMed PMID:
CM,Su SL. Impact of interaction of cigarette smoking with angiotensin-converting JRenin Angiotensin Aldosterone Syst. 2015 Mar;16(1):203-10. doi:
CaoJ, Li J, Li H, He J, Liu DP, Gu D. Polymorphisms of ACE2 are associated with 2012Aug;25(8):937-42. doi: 10.1038/ajh.2012.61. Epub 2012 May 31. PubMed PMID:
S.Association of angiotensin I converting enzyme, angiotensin II type 1 receptor type2 diabetic patients of Chinese Han origin. J Endocrinol Invest. 2012
GuoXX, Hu YH, Lee LM. Interactions of renin-angiotensin system gene Pharmacogenomics.2011 May;12(5):735-43. doi: 10.2217/pgs.11.2. Epub 2011 Mar 31.
angiotensin-convertingenzyme 2 gene polymorphisms to essential hypertension and Chinese.PubMed PMID: 20813695. 14:Fan XH, Wang YB, Wang H, Sun K, Zhang WL, Song XD, Cheng JZ, Wu HY, Zhou XL, associatedwith orthostatic blood pressure dysregulation in hypertensive Epub2009 Aug 17. PubMed PMID: 19684612; PubMed Central PMCID: PMC4007186. 15:Zhou JB, Yang JK. Meta-analysis of association of ACE2 G8790A polymorphism 2009Mar;10(1):31-4. doi: 10.1177/1470320309103047. PubMed PMID: 19286756. 16:Niu W, Qi Y, Hou S, Zhou W, Qiu C. Correlation of angiotensin-converting 2007Dec;150(6):374-80. Epub 2007 Jul 2. PubMed PMID: 18022600. 17:Furuichi T, Kannan K, Suzuki K, Tanaka S, Giesy JP, Masunaga S. Occurrence of EnvironSci Technol. 2006 Dec 15;40(24):7896-902. PubMed PMID: 17256545. 18:Huang W, Yang W, Wang Y, Zhao Q, Gu D, Chen R. Association study of hypertensionin northern Han Chinese. J Hum Hypertens. 2006 Dec;20(12):968-71.
angiotensin-convertingenzyme 2 gene A/G polymorphism and elevated blood pressure Feb;147(2):91-5.PubMed PMID: 16459167. 20:Liu TB, Shang HP, Zhang KX, Chen LH, Zhu XL, Zhang Y, Zhu DL, Huang W. essentialhypertension in Chinese]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2005 Oct;22(5):569-71.Chinese. PubMed PMID: 16215952.
像你这种，土生的中国人，估计派回去下毒是无比引以为傲的。
我点进去看了每个 SNP 的 Relate publication
没半个跟 ACE2 表达量有关
有兴趣的可以自己点点看
万一他们是打着医疗的名义去收集第一手数据，为研制下一代病毒做准备的呢？派去的可都是病毒专家，这病毒可是偏向传染黄种人的！
那更可怕了，我们在美国的亚裔岂不是唾手可得？这怎么听着和国内的阴谋论一致
是biorxiv的文章
自己看
https://www.biorxiv.org/content/10.1101/2020.02.11.944462v1
Cryo-EM Structure of the 2019-nCoV Spike in the Prefusion Conformation
The outbreak of a novel betacoronavirus (2019-nCov) represents a pandemic threat that has been declared a public health emergency of international concern. The CoV spike (S) glycoprotein is a key target for urgently needed vaccines, therapeutic antibodies, and diagnostics. To facilitate medical countermeasure (MCM) development we determined a 3.5 Å-resolution cryo-EM structure of the 2019-nCoV S trimer in the prefusion conformation. The predominant state of the trimer has one of the three receptor-binding domains (RBDs) rotated up in a receptor-accessible conformation. We also show biophysical and structural evidence that the 2019-nCoV S binds ACE2 with higher affinity than SARS-CoV S. Additionally we tested several published SARS-CoV RBD-specific monoclonal antibodies and found that they do not have appreciable binding to nCoV-2019 S, suggesting antibody cross-reactivity may be limited between the two virus RBDs. The cryo-EM structure of 2019-nCoV S should enable rapid development and evaluation of MCMs to address the ongoing public health crisis.
biorxiv 的文章
作者是
Jason S McLellan
The University of Texas at Austin
wm们以为这里的人脑子也像被洗过的那些一样不会独立思考，放个仿真证据点了火煽个风大家就会一拥而上开骂。他们究竟明不明白这里多少人是读paper出身的…
我图表是直接从 paper 截图的好吗
请看原文 pdf
Single-cell RNA expression profiling of ACE2, the putative receptor of Wuhan 2019-nCov
Yu Zhao, Zixian Zhao, Yujia Wang, Yueqing Zhou, Yu Ma, Wei Zuo
doi: https://doi.org/10.1101/2020.01.26.919985
A novel coronavirus (2019-nCov) was identified in Wuhan, Hubei Province, China in December of 2019. This new coronavirus has resulted in thousands of cases of lethal disease in China, with additional patients being identified in a rapidly growing number internationally. 2019-nCov was reported to share the same receptor, Angiotensin-converting enzyme 2 (ACE2), with SARS-Cov. Here based on the public database and the state-of-the-art single-cell RNA-Seq technique, we analyzed the ACE2 RNA expression profile in the normal human lungs. The result indicates that the ACE2 virus receptor expression is concentrated in a small population of type II alveolar cells (AT2). Surprisingly, we found that this population of ACE2-expressing AT2 also highly expressed many other genes that positively regulating viral reproduction and transmission. A comparison between eight individual samples demonstrated that the Asian male one has an extremely large number of ACE2-expressing cells in the lung. This study provides a biological background for the epidemic investigation of the 2019-nCov infection disease, and could be informative for future anti-ACE2 therapeutic strategy development.
这研究就是只有用八个患者的 data
很不严谨
https://www.biorxiv.org/content/10.1101/2020.01.26.919985v1.full.pdf
这个版本有道理
非常赞同，只有八个sample，只有一个asian male。通过数据观察是合理的，但是得出专门针对亚裔的结论不够充分。难道没有考虑个体差异？有可能那个亚裔本身免疫力不行导致与病毒易结合
BTW，前几天拿着的印度马工的那篇新冠是人工合成病毒，在鲜花high了多少高楼的文章，就是发表在这个biorxiv。当然那篇文章发表没两天就被expert们骂的撤稿了。
我觉得这里面的也不可靠。第一个例子是那8个人的paper，第二个例子没准就是那个图？但是啥细节也没有，图就有个logo是1000 genomes project
隔壁楼那个图看着倒像正经paper里面出来的
https://forums.huaren.us/showtopic.aspx?topicid=2506692&forumpage=1
这是土工自己的内部斗争， 而且土工现在还没有胆量用生化武器给西方。 但是如果它继续壮大， 那就不一定了
少让美国背锅。 土工自己的政治斗争，关人家啥事
SARS 病毒也是通过ACE2, 而SARS当年在加拿大的流行速度和致死率一点不低。这说明ACE2的表达降低一点不足以引起质变
请问有link吗？很多感染一家子老老小小的都不抽烟啊
可以看得出，这个版上的大妈们双标的都没边了。
一篇合成病毒的文章，无数跟贴点赞，因为可以给她们支持的GCD生化战阴谋论添砖贴瓦。
一篇病毒对亚裔更有攻击力的文章，就开始质疑了，因为这显然让她们的阴谋论原地绕圈绕不出去了。
所以完全是从论点来决定论据的“真假”性。
哈哈，用大妈们阴谋论的思维方式来分析一下：当然得拒绝了！你见过邀请嫌疑凶手到受害人家里来侦查谁是杀人凶手的吗？！