Abstract: We are currently witnessing a major epidemic caused by the 2019 novel coronavirus (2019- nCoV). The evolution of 2019-nCoV remains elusive. We found 4 insertions in the spike glycoprotein (S) which are unique to the 2019-nCoV and are not present in other coronaviruses. Importantly, amino acid residues in all the 4 inserts have identity or similarity to those in the HIV- 1 gp120 or HIV-1 Gag. Interestingly, despite the inserts being discontinuous on the primary amino acid sequence, 3D-modelling of the 2019-nCoV suggests that they converge to constitute the receptor binding site. The finding of 4 unique inserts in the 2019-nCoV, all of which have identity /similarity to amino acid residues in key structural proteins of HIV-1 is unlikely to be fortuitous in nature. This work provides yet unknown insights on 2019-nCoV and sheds light on the evolution and pathogenicity of this virus with important implications for diagnosis of this virus.
Abstract: We are currently witnessing a major epidemic caused by the 2019 novel coronavirus (2019- nCoV). The evolution of 2019-nCoV remains elusive. We found 4 insertions in the spike glycoprotein (S) which are unique to the 2019-nCoV and are not present in other coronaviruses. Importantly, amino acid residues in all the 4 inserts have identity or similarity to those in the HIV- 1 gp120 or HIV-1 Gag. Interestingly, despite the inserts being discontinuous on the primary amino acid sequence, 3D-modelling of the 2019-nCoV suggests that they converge to constitute the receptor binding site. The finding of 4 unique inserts in the 2019-nCoV, all of which have identity /similarity to amino acid residues in key structural proteins of HIV-1 is unlikely to be fortuitous in nature. This work provides yet unknown insights on 2019-nCoV and sheds light on the evolution and pathogenicity of this virus with important implications for diagnosis of this virus.
那么多顶级欧美科学家都没提出疑问，要等到一个印度科学家来发现这么个没高科技含量的发现 — 病毒sequence一出来，就blast 里里外外分析过多少遍了。信这个的人，脑子里得进多少水啊 下面是网上人对此的一个评论： ” I've worked pretty closely with gag in my PhD thesis. Gag is the conglomerate protein that gets cut by the protease to generate the hiv capsid, matrix, and carrier proteins. Gp120 is the receptor protein. This is a really fucking dumb study and these scientists should be ashamed. Those amino acids are so short. They just went and looked for a virus to match. You can go and blast the amino acids yourself. Just copy and paste from the journal entry into NCBIs BLASTp. I did it and there's hundreds of matches to those sequences. HIV didn't even come up in the first 100. The 4th residue is missing like 6 amino acids. There are conserved regions in viruses.”
瞎扯。贴文前看看bioxRiv是什么。。。。 这个只是一个网络archive，收集生物科学方面一些投稿而已。跟peer reviewed journal完全不一样。 ＂印度科学家认为＂好吓人的标题 LOL https://www.reddit.com/r/China_Flu/comments/ewuotw/discussion_biorxiv_preprint_on_2019ncov_spike/?utm_medium=android_app&utm_source=share 2 hours ago What do you think about this comment: This study is crap. My comment from another thread. This paper isn't peer reviewed or published. It's just an online journal. I've worked pretty closely with gag in my PhD thesis. Gag is the conglomerate protein that gets cut by the protease to generate the hiv capsid, matrix, and carrier proteins. Gp120 is the receptor protein. This is a really fucking dumb study and these scientists should be ashamed. Those amino acids are so short. They just went and looked for a virus to match. You can go and blast the amino acids yourself. Just copy and paste from the journal entry into NCBIs BLASTp. I did it and there's hundreds of matches to those sequences. HIV didn't even come up in the first 100. The 4th residue is missing like 6 amino acids. There are conserved regions in viruses. Their "gp120" match compares 6 amino acids out of 850 in the whole protein for example. They found 4 sections that were in the new virus but not SARS. They then took these differences and ran them against all known viral proteins. They only looked at proteins with 100% matches, but if you look at the table they didn't match 100% for alignment. So like one is ABCEFG and they match it to an HIV protein that is ABCXYZEFG and they are calling those total matches. There's also tons of viruses that match these tiny sequences, they just noticed all 4 have HIV matches so they ignore the other matches and only looked at HIV. Go blast it yourself if you want. level 1 BurrShotFirst1804 46 points · 1 hour ago Gag sequence: MGARASVLSG GELDRWEKIR LRPGGKKKYK LKHIVWASRE LERFAVNPGL LETSEGCRQI LGQLQPSLQT GSEELRSLYN TVATLYCVHQ RIEIKDTKEA LDKIEEEQNK SKKKAQQAAA DTGHSNQVSQ NYPIVQNIQG QMVHQAISPR TLNAWVKVVE EKAFSPEVIP MFSALSEGAT PQDLNTMLNT VGGHQAAMQM LKETINEEAA EWDRVHPVHA GPIAPGQMRE PRGSDIAGTT STLQEQIGWM TNNPPIPVGE IYKRWIILGL NKIVRMYSPT SILDIRQGPK EPFRDYVDRF YKTLRAEQAS QEVKNWMTET LLVQNANPDC KTILKALGPA ATLEEMMTAC QGVGGPGHKA RVLAEAMSQV TNSATIMMQR GNFRNQRKIV KCFNCGKEGH TARNCRAPRK KGCWKCGKEG HQMKDCTERQ ANFLGKIWPS YKGRPGNFLQ SRPEPTAPPE ESFRSGVETT TPPQKQEPID KELYPLTSLR SLFGNDPSSQ Alleged "gag" match: QTNS--------PRRA Actual gag sequence: QTNSSILMQRSNFKGPRRA To begin with this is such a tiny random part of gag. Like 1%. It's also not a 100% match. They just ignore the middle part and call it a match anyway. Except this isn't your standard HIV sequence for gag. It's a unique isotype labs found in India. This sequence is NOT found in actual standard gag. Which is super confusing in general. Also the other matches are from 3 other strains of HIV. So it's not even 4 of the same subtype which just makes this even more ridiculously terrible of a paper.
Abstract:
We are currently witnessing a major epidemic caused by the 2019 novel coronavirus (2019- nCoV). The evolution of 2019-nCoV remains elusive. We found 4 insertions in the spike glycoprotein (S) which are unique to the 2019-nCoV and are not present in other coronaviruses. Importantly, amino acid residues in all the 4 inserts have identity or similarity to those in the HIV- 1 gp120 or HIV-1 Gag. Interestingly, despite the inserts being discontinuous on the primary amino acid sequence, 3D-modelling of the 2019-nCoV suggests that they converge to constitute the receptor binding site. The finding of 4 unique inserts in the 2019-nCoV, all of which have identity /similarity to amino acid residues in key structural proteins of HIV-1 is unlikely to be fortuitous in nature. This work provides yet unknown insights on 2019-nCoV and sheds light on the evolution and pathogenicity of this virus with important implications for diagnosis of this virus.
https://biorxiv-cache.s3-us-west-2.amazonaws.com/2020.01.30.927871.full.pdf
更新： 我朋友认为不可信。
https://imgur.com/FIC9q6E
超過七個鹼基的四段，都一樣。大概就跟一首歌有四小節弦律都一樣(?人工斧鑿的痕跡很深
re 虽然这次国内官僚作风又暴露了 印度人那科研水平还是给我闭嘴吧
本以为可以用瘟疫控制人口，没想到瘟疫不是那么受人控制？
肯定是美帝亡我之心不死
那你讲讲
我朋友的comment：
他们会说，信了又能怎么样？
那你还贴出来干嘛? 我不是专家，但是如果是这么爆炸性的发现，直接submit给nature，。science， lancet不是更有影响力嘛?
引发讨论是我的目的。
还有，老夫发什么与你有关系吗？不爱看自个玩去。
哈哈，准你发还不准我评论了?你不愿意看就别看啊，散布谣言，哗众取宠，吃人血馒头的就是你。 这个paper在华人上被贴了前前后后也得有十几次了吧，您觉得讨论的还不够?
这个时候传这种无聊的谣言，唯恐天下不乱吗？
我禁评了？ 你要是评论反驳，我欢迎之至。你要诛心，那我就请你滚。
贴了十几遍了？第一我没看到；第二，即便贴一万遍了，老夫想发就发。
这怎么叫谣言？这是正经的学术文章，公开发表，上线就是给人评论的。
何况，本人还贴了反方的论点。你们在心虚什么？
35楼的反驳还weak？你但凡有一点生物的常识都应该看明白是多strong的反证！噢，我忘了，你和你同事都不懂英文，还在用Google translate看文献呢😂😂
呵呵
是的
美帝专家有不少为了自己发paper方便（需要国内给病毒序列）也狂踩这篇文章
这篇文章其实思路可以的，可能结论有点夸大了
可以存疑
me three
well
至少指出了一个被忽略的盲点
这个是要用来称霸宇宙地，只是p4的蠢所长带了一群蠢驴没保护好，泄漏出来了
re，而且好多早期华人注册号的id。